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Integrated Research (integrate + research)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Need for Integrated Research for a Sustainable Future in Tropical Dry Forests

CONSERVATION BIOLOGY, Issue 2 2005
G. ARTURO SÁNCHEZ-AZOFEIFA
No abstract is available for this article. [source]

Closing the gap: collaborative learning as a strategy to embed evidence within occupational therapy practice

JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 2 2006
Amanda Welch Dip COT Pg Dip ED MSc
Abstract Rationale, The principles of clinical governance apply as guidelines for good practice to all practitioners. However, evidence-based practice (EBP) is proving a challenge for practitioners who lack the confidence to consume published research. For therapists not wishing to undertake formal study there is a risk of becoming disempowered within a culture of EBP. Opportunities to develop skills in consuming research have focused on the information dissemination model that has limited effect. Mutual reflective learning processes are recommended to empower practitioners to bridge the theory-practice gap. Aim, An action research approach investigated practice based collaborative learning as a catalyst to increase therapist's competence and confidence in consuming research and to explore the transition toward EB practitioner. Method and Results, A diagnostic survey reaffirmed therapist's lack of confidence in EBP. Formative interviews (n = 5) found an over reliance on professional craft and personal knowledge. Research knowledge was not included in participants' construct of a good practitioner and engagement in higher order critical reflection was limited. Collaborative learning groups (n = 6) embedded in practice integrated research, theory, practice and critical reflection. Supported by the collegial learning environment, a learning package developed participants' confidence and competence in consuming published research. Summative interviews (n = 5) evaluated the group and found that therapists were empowered to incorporate propositional knowledge into their clinical reasoning, engage in critical reflection and challenge their practice. They felt confident to incorporate EBP into their continuing professional development plans. Sustainability of these changes requires commitment from the therapists and the workplace. [source]

Cenozoic Exhumation and Thrusting in the Northern Qilian Shan, Northeastern Margin of the Tibetan Plateau: Constraints from Sedimentological and Apatite Fission-Track Data

ACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 3 2009
Zhaojie GUO
Abstract: The Qilian Shan lies along the northeastern edge of the Tibetan Plateau. To constrain its deformation history, we conducted integrated research on Mesozoic,Cenozoic stratigraphic sections in the Jiuxi Basin immediately north of the mountain range. Paleocurrent measurements, sandstone compositional data, and facies analysis of Cenozoic stratigraphic sections suggest that the Jiuxi Basin received sediments from the Altyn Tagh Range in the northwest, initially in the Oligocene (,33 Ma), depositing the Huoshaogou Formation in the northern part of the basin. Later, the source area of the Jiuxi Basin changed to the Qilian Shan in the south during Late Oligocene (,27 Ma), which led to the deposition of the Baiyanghe Formation. We suggest that uplift of the northern Qilian Shan induced by thrusting began no later than the Late Oligocene. Fission-track analysis of apatite from the Qilian Shan yields further information about the deformation history of the northern Qilain Shan and the Jiuxi Basin. It shows that a period of rapid cooling, interpreted as exhumation, initiated in the Oligocene. We suggest that this exhumation marked the initial uplift of the Qilian Shan resulting from the India,Asia collision. [source]

Aiming towards effective preventive medicine against Japanese cedar pollinosis: epidemiology, patient investigation and integrated research including genotype analyses

CLINICAL & EXPERIMENTAL ALLERGY REVIEWS, Issue 2 2005
N. Terada
Summary Environmental rather than genetic factors appear to play the major role in the recent increased prevalence of Japanese cedar pollinosis in Japan. However, investigating the genes that determine IgE levels and analysing gene polymorphisms may assist in finding new methods of treatment and establishing preventive medicine against this disease. Among a total of 219 asymptomatic individuals who were anti-Japanese cedar pollen IgE antibody positive as determined by radioallergosorbent test (RAST), only a handful subsequently developed symptoms of Japanese cedar pollinosis or secondary onset of Japanese cedar pollinosis over 5,14 years of follow-up. Among those who subsequently developed secondary onset of disease, >50% were found to have high initial RAST scores, suggesting that the incidence of Japanese cedar pollinosis is correlated with RAST score. Hence, it may be prudent to advise asymptomatic individuals with high RAST scores to avoid exposure to Japanese cedar pollen so as to delay onset of the disease. Analysis of sequence variants of the Fc,RI, gene revealed that patients with nasal allergy exhibit a single-nucleotide polymorphism in which the amino acid at 237 of the intracellular domain changes from glutamine to glycine more frequently than individuals without nasal allergy. Furthermore, Il homo polymorphism of the IL-4R, gene is associated with higher serum nonspecific IgE and Japanese cedar pollen-specific IgE levels than are seen in individuals showing Il,Val hetero and Val homo expression types. When the age of pollinosis onset was compared among these three genotypes, it was found to be significantly lower among Il homo type than the other two expression types, suggesting that Il homo type individuals seem characteristically pre-disposed to early onset of pollinosis. Studies comparing eosinophil-associated gene polymorphism in healthy and pollinosis phenotypes have revealed several relationships among the various genotypes and specific disease parameters and suggest that Eotaxin G (123G/A) and IL5 (,703C/T) genotypes can affect the timing of symptom onset after sensitization as well as nasal mucosal hyper-responsiveness. [source]