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And Validation (and + validation)

Distribution by Scientific Domains
Life Sciences50%

Kinds of And Validation

  • testing and validation
    		•

    Selected Abstracts

    A kaleidoscope as a cyberworld and its animation: linear architecture and modeling based on an incrementally modular abstraction hierarchy

    COMPUTER ANIMATION AND VIRTUAL WORLDS (PREV: JNL OF VISUALISATION & COMPUTER ANIMATION), Issue 3-4 2006
    Tosiyasu L. Kunii
    Abstract An incrementally modular abstraction hierarchy is known to effectively linearize cyberworlds and virtual worlds, which are combinatorially exploding and hardly managed. It climbs down from general level to specific model preserving the higher level modules as invariants. It not only prevents the combinatorial explosion but also benefits the reuse, development, testing and validation of cyberworld resources. By applying this incrementally modular abstraction hierarchy to a kaleidoscope animation, its architecture and modeling is also specified in this paper as a typical case of cyberworlds. In particular, a homotopy lifting property and a homotopy extension property, which satisfy a duality relation, are also described to show how a kaleidoscope world is systematically created top-down from the whole system and bottom-up from the components. Copyright © 2006 John Wiley & Sons, Ltd. [source]

    The validation of some methods of notch fatigue analysis

    FATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 5 2000
    Taylor
    This paper is concerned with the testing and validation of certain methods of notch analysis which the authors have developed theoretically in earlier publications. These methods were developed for use with finite element (FE) analysis in order to predict the fatigue limits of components containing stress concentrations. In the present work we tested and compared these methods using data from standard notches taken from the literature, covering a range of notch geometries, loading types, R -ratios and materials: a total of 47 different data sets were analysed. The greatest predictive success was achieved with critical-distance methods known as the point, line and area methods: 94% of these predictions fell within 20% of the experimental fatigue limits. This was a significant improvement on previous methods of this kind, e.g. that of Klesnil and Lucas [(1980) Fatigue of Metallic Materials, Elsevier Science]. Methods based on the Smith and Miller [(1978) Int. J. Mech. Sci. 20, 201,206] concept of crack-like notches were successful in 42% of cases; they experienced difficulties dealing with very small notches, and could be improved by using an ElHaddad-type correction factor, giving 87% success. An approach known as ,crack modelling' allowed the Smith and Miller method to be used with non-standard stress concentrations, where notch geometry is ill defined; this modification, with the same short-crack correction, had 68% success. It was concluded that the critical-distance approach is more accurate and can be more easily used to analyse components of complex shape, however, the crack modelling approach is sometimes preferable because it can be used with less mesh refinement. [source]

    Identification of individual tigers (Panthera tigris) from their pugmarks

    JOURNAL OF ZOOLOGY, Issue 1 2005
    Sandeep Sharma
    Abstract An objective multivariate technique is described for identification of individual tigers Panthera tigris from their pugmarks. Tracings and photographs of hind pugmarks were obtained from 23 pugmark-sets of 19 individually known tigers (17 wild and two captive tigers). These 23 pugmark-sets were then divided into two groups, one of 15 pugmark-sets for model building and another of eight pugmark-sets for model testing and validation. A total of 93 measurements were taken from each pugmark along with three gait measurements. We used CV ratio, F -ratio and removed highly correlated variables to finally select 11 variables from these 93 variables. These 11 variables did not differ between left and right pugmarks. Stepwise discriminant function analysis (DFA) based on these 11 variables correctly classified pugmark-sets to individual tigers. A realistic population estimation exercise was simulated using the validation dataset. The algorithms developed here correctly allocated each pugmark-set to the correct individual tiger. The effect of extraneous factors, i.e. soil depth and multiple tracers, was also tested and pugmark tracings compared with pugmark photographs. We recommend collecting pugmarks from soil depths ranging between 0.5 and 1.0 cm, and advocate the use of pugmark photographs rather than pugmark tracings to eliminate the chance of obtaining substandard data from untrained tracers. Our study suggests that tigers can be individually identified from their pugmarks with a high level of accuracy and pugmark-sets could be used for population estimation of tigers within a statistically designed mark,recapture framework. [source]

    Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach

    PROTEOMICS - CLINICAL APPLICATIONS, Issue 6-7 2010
    Wendy Rodenburg
    Abstract Purpose: Transgenic mouse models for cancer circumvent many challenges that hamper human studies aimed at biomarker discovery. Lower biological variances among mice combined with controllable factors such as food uptake and health status may enable the detection of more subtle protein expression differences. This is envisioned to result in the identification of biomarkers better discriminating cancer cases from controls. Experimental design: The current study used two innovative mouse models for breast-cancer to identify new serum biomarkers. Multi-analyte profiling technique was used to analyze 70 proteins in individual serum samples of non-tumor and mammary tumor-bearing Tg.NK (MMTV/c-neu) mice. Results: A small set of proteins fully differentiated tumor samples from controls. These comprised osteopontin, interleukin-18, cystatin C and CD40 antigen. Comparison of protein expression in another breast-cancer mouse model, the humanized p53.R270H mice, showed common discriminatory expression of osteopontin. However, other biomarkers showed distinct expression in the two different breast-cancer models, indicating that different mammary tumor sub-types with respect to molecular and estrogen receptor status reveal divergent serum biomarker sets. Conclusions and clinical relevance: The current study supports the concept that serum proteins can discriminate mammary tumor cases from controls, and yielded interesting biomarkers that need further testing and validation in human studies. [source]