Home About us Contact
|
Home About us Contact | ||
|
|
||
And Biochemistry (and + biochemistry)
Kinds of And Biochemistry Selected AbstractsCover Picture: Electrophoresis 22'2008ELECTROPHORESIS, Issue 22 2008Article first published online: 26 NOV 200 Regular issues provide a wide range of research and review articles covering all aspects of electrophoresis. Here you will find cutting-edge articles on methods and theory, instrumentation, nucleic acids, CE and CEC, miniaturization and microfluidics, proteomics and two-dimensional electrophoresis. Selected topics of issue 22 are: Microfluidics: Applications for analytical purposes in chemistry and biochemistry ((http://doi.wiley.com/10.1002/elps.200800121)) Simultaneous laser-induced fluorescence and retro-reflected beam interference detection for CE ((http://doi.wiley.com/10.1002/elps.200800292)) Quantitative Proteomics by Fluorescent Labeling of Cysteine Residues using a Set of Two Cyanine-based or Three Rhodamine-based Dyes ((http://doi.wiley.com/10.1002/elps.200800092)) Chemometric resolution of fully overlapped capillary electrophoresis peaks: quantitation of carbamazepine in human serum in the presence of several interferences ((http://doi.wiley.com/10.1002/elps.200800400)) Identification of inorganic ions in post-blast explosive residues using portable capillary electrophoresis instrumentation and capacitively-coupled contactless conductivity detection ((http://doi.wiley.com/10.1002/elps.200800226)) [source] Properties and applications of supports for enzyme-mediated transformations in solid phase synthesisJOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 10 2006Alessandra Basso Abstract With the increasing interest in automated synthesis and screening protocols, solid supported chemistry and biochemistry have become attractive technologies. Furthermore, the use of enzymes in solid phase synthesis has opened the route to selective and mild processes. The efficiency of enzymes in transforming substrates that are bound on solid supports is strictly related to the availability of polymers endowed with specific properties, above all permeability to enzymes. This review describes how the recent developments of this rapidly evolving area have made possible novel challenging applications of enzymes in solid phase synthesis. Copyright © 2006 Society of Chemical Industry [source] Isotope effects: recent developments in chemistry and biochemistryJOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 11-12 2007Erwin Buncel [source] Tetrahedral intermediates in reactions of carboxylic acid derivatives with nucleophiles,JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 3 2005Martin Adler Abstract Transacylation reactions of carboxylic acids, carboxylic acid esters, carboxylic acid amides and other carboxylic acid derivatives are among the most widespread and most important reactions in chemistry and biochemistry. Already in 1887, Claisen suggested a tetrahedral intermediate in transformations of carboxylic acid derivatives with nucleophiles. A historical overview gives insight into the studies to detect possible tetrahedral intermediates in such reactions. However, only in recent years has detailed information concerning the structures of such species become available. In this review, neutral, cationic and anionic tetrahedral intermediates are described which serve as models for transacylations under neutral, acid-catalysed or basic conditions. The characteristically different structures correspond nicely with experimental experience with reactions of carboxylic acid derivatives and with quantum chemical model calculations on tetrahedral intermediates. Finally, by means of model calculations, an explanation is given for the fast reactions of Weinreb amides, RC(O)N(CH3)OCH3, with organolithium and even with Grignard reagents: the reactions are determined by comparatively stable chelate transition states. Copyright © 2004 John Wiley & Sons, Ltd. [source] Chemistry, Urease Inhibition, and Phytotoxic Studies of Binuclear Vanadium(IV) ComplexesCHEMISTRY & BIODIVERSITY, Issue 1 2007Rifat Ara Abstract Vanadium plays an important role in biological systems and exhibits a variety of bioactivities. In an effort to uncover the chemistry and biochemistry of vanadium with nitrogen- and oxygen-containing ligands, we report herein the synthesis and spectroscopic characterization of vanadium(IV) complexes with hydrazide ligands. Substituents on these ligands exhibit systematic variations of electronic and steric factors. Elemental and spectral data indicate the presence of a dimeric unit with two vanadium(IV) ions coordinated with two hydrazide ligands along with two H2O molecules. The stability studies of these complexes over time in coordinating solvent, DMSO, indicates binding of the solvent molecules to give [V2O2L2(H2O)2(DMSO)2]2+ (L=hydrazide ligand) and then conversion of it to a monomeric intermediate species, [VOL(DMSO)3]1+. Hydrazide ligands are inactive against urease, whereas vanadium(IV) complexes of these ligands show significant inhibitory potential against this enzyme and are found to be non-competitive inhibitors. These complexes also show low phytotoxicity indicating their usefulness for soil ureases. Structure,activity relationship studies indicate that the steric and/or electronic effects that may change the geometry of the complexes play an important role in their inhibitory potential and phytotoxicity. [source] | ||||||||||