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Instances
Kinds of Instances Selected AbstractsJudicial Review of European Anti-Terrorism Measures,The Yusuf and Kadi Judgments of the Court of First InstanceEUROPEAN LAW JOURNAL, Issue 1 2008Christina Eckes It accepted that the Community uses its competence to adopt state sanctions in combination with Article 308 EC to freeze the assets of civil persons, including European citizens. The court also reduced its jurisdiction to a basic scrutiny of whether jus cogens was violated. The Court of First Instance's decisions can be criticised on various grounds. First, the application of these Articles is contrary to the wording of the Treaty and the case-law of the European Court of Justice (ECJ). Further, as a consequence of the Court of First Instance's judgments, decisions of the UN Sanctions Committee become the supreme law within the EU, provided they meet the requirements of jus cogens as defined by the Court of First Instance. In addition, the individual is deprived of all fundamental rights guaranteed under European law. [source] Interoperability and Other Issues at the IP,Anti-trust Interface: The EU Microsoft CaseTHE JOURNAL OF WORLD INTELLECTUAL PROPERTY, Issue 4 2008Dr Duncan Curley The judgment in 2007 of the Court of First Instance in Microsoft Corporation v European Commission was the culmination of one of the biggest anti-trust battles ever to have taken place in the European Union. Although most aspects of the European Commission's original decision of 2004 were upheld, the Microsoft case remains interesting at several levels. The judgment deals with the question of when it is permissible, in the public interest, to encroach upon the exclusivity of intellectual property rights-holders, by requiring the grant of licences to third parties seeking to enter or remain on the market. The case provides an illustration of Community policy objectives being implemented through the medium of the competition rules, namely the opening up of the software industry to more competition and the encouragement of innovation in information technology. It also provides an illustration of differing attitudes to the anti-trust regulation of unilateral conduct by companies with a dominant market position in Europe and the United States. [source] Instance-based learning in dynamic decision makingCOGNITIVE SCIENCE - A MULTIDISCIPLINARY JOURNAL, Issue 4 2003Cleotilde Gonzalez Abstract This paper presents a learning theory pertinent to dynamic decision making (DDM) called instancebased learning theory (IBLT). IBLT proposes five learning mechanisms in the context of a decision-making process: instance-based knowledge, recognition-based retrieval, adaptive strategies, necessity-based choice, and feedback updates. IBLT suggests in DDM people learn with the accumulation and refinement of instances, containing the decision-making situation, action, and utility of decisions. As decision makers interact with a dynamic task, they recognize a situation according to its similarity to past instances, adapt their judgment strategies from heuristic-based to instance-based, and refine the accumulated knowledge according to feedback on the result of their actions. The IBLT's learning mechanisms have been implemented in an ACT-R cognitive model. Through a series of experiments, this paper shows how the IBLT's learning mechanisms closely approximate the relative trend magnitude and performance of human data. Although the cognitive model is bounded within the context of a dynamic task, the IBLT is a general theory of decision making applicable to other dynamic environments. [source] Fashioned Forest Pasts, Occluded Histories?DEVELOPMENT AND CHANGE, Issue 1 2000International Environmental Analysis in West African Locales This article considers how environmental problematics are produced and interpreted, using case material from West Africa's humid forest zone. Examing the experiences of several countries over the long term, it is possible to identify a deforestation discourse produced through national and international institutions. This represents forest and social history in particular ways that structure forest conservation but which obscure the experience and knowledge of resource users. Using fine-grained ethnography to explore how such discourse is experienced and interpreted in a particular locale, the article uncovers problems with ,discourse' perspectives which produce analytical dichotomies which confront state and villager, and scientific and ,local' knowledges. The authors explore the day-to-day encounters between villagers and administrators, and the social and historical experiences which condition these. Instances where the deforestation discourse becomes juxtaposed with villagers' alternative ideas about landscape history prove relatively few and insignificant, while the powerful material effects of the discourse tend to be interpreted locally within other frames. These findings present departures from the ways relations between citizen sciences and expert institutions have been conceived in recent work on the sociology of science and public policy. [source] Historical biogeography of some river basins in central Mexico evidenced by their goodeine freshwater fishes: a preliminary hypothesis using secondary Brooks parsimony analysisJOURNAL OF BIOGEOGRAPHY, Issue 8 2006Omar Domínguez-Domínguez Abstract Aims, Our aim was to uncover and describe patterns of historical biogeography of the main river basins in central Mexico, based on a secondary Brooks parsimony analysis (BPA) of goodeine fishes, and to understand the processes that determine them with respect to the molecular clock of the goodeines and the geological events that have taken place in the region since the Miocene. Location, The region covered in this study includes central Mexico, mostly the so-called Mesa Central of Mexico, an area argued to be a transitional zone comprising several major river drainages from their headwaters at high elevations along the Transmexican Volcanic Belt to the coast of the Gulf of Mexico and the Pacific Ocean. Methods, Based on a previous phylogenetic hypothesis regarding the Goodeidae, we built a data matrix using additive binary coding. First, we conducted a primary BPA to provide general explanations of the historical biogeography of Central Mexico. As ambiguity was found, a secondary BPA was conducted, and some areas were duplicated in order to explain the reticulated history of the area. Area cladograms were obtained by running a parsimony analysis. Instances of vicariance and non-vicariance processes were described with reference to the cladogram obtained from secondary BPA. Results, The study area was divided into 18 discrete regions. Primary BPA produced nine equally parsimonious cladograms with 129 steps, and a consistency index (CI) of 0.574. A strict consensus cladogram shows low resolution among some areas, but other area relationships are consistent. For secondary BPA, five of the 18 regions were duplicated (LEA, COT, AYU, CUT, PAN); one was triplicated (BAL); and one was quadruplicated (AME), suggesting that the pattern of distribution of species in these areas reflects multiple independent events. These areas correspond with the regions exhibiting the highest levels of diversification and the most complex geological history, and those for which river piracy events or basin connections have been proposed. The secondary BPA produced a single most parsimonious cladogram with 118 steps, and a CI of 0.858. This cladogram shows that none of the duplicated areas are nested together, reinforcing the idea of a reticulated history of the areas and not a single vicariant event. Main conclusions, Although our results are preliminary and we cannot establish this as a general pattern, as the BPA is based on a single-taxon cladogram, resolution obtained in the secondary BPA provides some insights regarding the historical biogeography of this group of fishes in river basins of central Mexico. Secondary BPA indicates that the historical biogeography of central Mexico, as shown by their goodeine freshwater fishes, is complex and is a result of a series of vicariant and non-vicariant events such as post-dispersal speciation and post-speciation dispersal. [source] Historical male-mediated introgression in horseshoe bats revealed by multilocus DNA sequence dataMOLECULAR ECOLOGY, Issue 7 2010XIUGUANG MAO Abstract Instances of hybridization between mammalian taxa in the wild are rarely documented. To test for introgression between sibling species of horseshoe bat (Rhinolophus yunanensis and R. pearsoni) and two subspecies of the latter (R. p. pearsoni and R. p. chinensis), we sequenced two mtDNA and two ncDNA markers in individuals sampled from multiple localities within their overlapping ranges. The interspecific mtDNA gene tree corresponded to the expected taxonomic divisions, and coalescent-based analyses suggested divergence occurred around 4 MYA. However, these relationships strongly conflicted with those recovered from two independent nuclear gene trees, in which R. yunanensis clustered with R. p. pearsoni to the exclusion of R. p. chinensis. This geographically widespread discordance is best explained by large-scale historical introgression of ncDNA from R. yunanensis to R. pearsoni by male-mediated exchange in mixed species colonies during Pleistocene glacial periods, when ranges may have contracted and overlapped more than at present. Further species tree,gene tree conflicts were detected between R. p. pearsoni and R. p. chinensis, also indicating past and/or current introgression in their overlapping regions. However, here the patterns point to asymmetric mtDNA introgression without ncDNA introgression. Analyses of coalescence times indicate this exchange has occurred subsequent to the divergence of these subspecies from their common ancestor. Our work highlights the importance of using multiple data sets for reconstructing phylogeographic histories and resolving taxonomic relationships. [source] A column generation approach for SONET ring assignmentNETWORKS: AN INTERNATIONAL JOURNAL, Issue 3 2006Elder M. Macambira Abstract In this article we consider the SONET ring assignment problem (SRAP) presented in 7. The authors pointed out the inadequacy of solving SRAP instances using their integer programming formulation and commercial linear programming solvers. Similar experiences with IP models for SRAP are reported in 1. In this article we reformulate SRAP as a set partitioning model with an additional knapsack constraint. This new formulation has an exponential number of columns and, to solve it, we implemented a branch-and-price/column generation algorithm. Extensive computational experiments showed that the new algorithm is orders of magnitude faster than standard branch-and-bound codes running on compact IP models introduced earlier. Instances taken from 1, 7, which could not be solved there in hours of computation were solved here to optimality in just a few seconds. © 2006 Wiley Periodicals, Inc. NETWORKS, Vol. 47(3), 157,171 2006 [source] Dominance rank reversals and rank instability among male Lemur catta: The effects of female behavior and ejaculationAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 3 2009Joyce A. Parga Abstract In this study, dominance rank instability among male Lemur catta during mating was investigated. Also, data on agonism and sexual behavior across five consecutive mating seasons in a population of L. catta on St. Catherines Island, USA, were collected. Instances of male rank instability were categorized into three types. Type 1 consisted of a temporary switch in the dominance ranks of two males, which lasted for a period of minutes or hours. Type 2 dyadic male agonistic interactions showed highly variable outcomes for a period of time during which wins and losses were neither predictable nor consistent. Type 3 interactions consisted of a single agonistic win by a lower-ranked male over a more dominant male. More Type 2 interactions (indicating greater dominance instability) occurred when males had not spent the previous mating season in the same group, but this trend was not statistically significant. The majority of periods of male rank instability were preceded by female proceptivity or receptivity directed to a lower-ranked male. As such, exhibition of female mate choice for a lower-ranking male appeared to incite male,male competition. Following receipt of female proceptivity or receptivity, males who were lower-ranking took significantly longer to achieve their first agonistic win over a more dominant male than did males who were higher-ranked. Ejaculation frequently preceded loss of dominance. In conclusion, temporary rank reversals and overall dominance rank instability commonly occur among male L. catta in mating contexts, and these temporary increases in dominance status appear to positively affect male mating success. Am J Phys Anthropol, 2009. © 2008 Wiley-Liss, Inc. [source] Reconciliation in captive cotton-top tamarins (Saguinus oedipus), a cooperative breeding primateAMERICAN JOURNAL OF PRIMATOLOGY, Issue 11 2009Laura Peñate Abstract Reconciliation has been demonstrated in all primate species in which the phenomenon has been studied. However, reconciliation has been studied in only two species of callitrichids, and conclusions remain controversial. The first aim of this study has been to find out whether captive cotton-top tamarins (Saguinus oedipus) reconcile, since this is the first such study on this species. We examined 227 conflicts in three family groups (N=19). Instances in which individuals remained together in t=0 (29; 12.8%) were not analyzed. The cotton-top tamarins showed heightened affiliation between opponents in the postconflict periods (PC) compared with matched control (MC) periods (39.88±5.12% and 3.18±1.27%, respectively), with a corrected conciliatory tendency of 37.17±5.37%, and a "time window" that included the first 180,sec of the PC period. Former opponents were the most likely recipient of affiliative behaviors during the PC periods: 39.83±4.26% vs. 11.36±5.33% during MC periods. The proportion of attracted pairs (47.13±6.25%) was significantly higher than those of dispersed pairs for male,male conflicts (3.79±1.79), but not for male,female conflicts (27.31±9.32 and 4.82±2.9, respectively). In cooperative-breeding species, specific sex-class dyads might differ in how they resolve conflicts. Am. J. Primatol. 71:895,900, 2009. © 2009 Wiley-Liss, Inc. [source] The climatology of small-scale orographic precipitation over the Olympic Mountains: Patterns and processesTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 633 2008Justin R. Minder Abstract The climatology of small-scale patterns of mountain precipitation is poorly constrained, yet important for applications ranging from natural hazard assessment to understanding the geologic evolution of mountain ranges. Synthesizing four rainy seasons of high-resolution precipitation observations and mesoscale model output (from the Penn State/NCAR MM5), reveals a persistent small-scale pattern of precipitation over the ,10 km wide, ,800 m high ridges and valleys of the western Olympic Mountains, Washington State, USA. This pattern is characterized by a 50,70% excess accumulation over the ridge crests relative to the adjacent valleys in the annual mean. While the model shows excellent skill in simulating these patterns at seasonal time-scales, major errors exist for individual storms. Investigation of a range of storm events has revealed the following mechanism for the climatological pattern. Regions of enhanced condensation of cloud water are produced by ascent in stable flow over the windward slopes of major ridges. Synoptically generated precipitation grows by collection within these clouds, leading to enhanced precipitation which is advected by the prevailing winds. Instances of atypical patterns of precipitation suggest that under certain conditions (during periods with a low freezing level, or convective cells) fundamental changes in small-scale patterns may occur. However, case-studies and composite analysis suggest that departures from the pattern of ridge-top enhancement are rare; the basic patterns and processes appear robust to changes in temperature, winds, and background rainfall rates. Copyright © 2008 Royal Meteorological Society [source] `Broken symmetries' in macromolecular crystallography: phasing from unmerged dataACTA CRYSTALLOGRAPHICA SECTION D, Issue 4 2010Marc Schiltz The space-group symmetry of a crystal structure imposes a point-group symmetry on its diffraction pattern, giving rise to so-called symmetry-equivalent reflections. Instances in macromolecular crystallography are discussed in which the symmetry in reciprocal space is broken, i.e. where symmetry-related reflections are no longer equivalent. Such a situation occurs when the sample suffers from site-specific radiation damage during the X-ray measurements. Another example of broken symmetry arises from the polarization anisotropy of anomalous scattering. In these cases, the genuine intensity differences between symmetry-related reflections can be exploited to yield phase information in the structure-solution process. In this approach, the usual separation of the data merging and phasing steps is abandoned. The data are kept unmerged down to the Harker construction, where the symmetry-breaking effects are explicitly modelled and refined and become a source of supplementary phase information. [source] Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: A multicenter active-surveillance reportARTHRITIS & RHEUMATISM, Issue 8 2003Juan J. Gómez-Reino Objective The long-term safety of therapeutic agents that neutralize tumor necrosis factor (TNF) is uncertain. Recent evidence based on spontaneous reporting shows an association with active tuberculosis (TB). We undertook this study to determine and describe the long-term safety of 2 of these agents, infliximab and etanercept, in rheumatic diseases based on a national active-surveillance system following the commercialization of the drugs. Methods We analyzed the safety data actively collected in the BIOBADASER (Base de Datos de Productos Biológicos de la Sociedad Española de Reumatología) database, which was launched in February 2000 by the Spanish Society of Rheumatology. For the estimation of TB risk, the annual incidence rate in patients treated with these agents was compared with the background rate and with the rate in a cohort of patients with rheumatoid arthritis (RA) assembled before the era of anti-TNF treatment. Results Seventy-one participating centers sent data on 1,578 treatments with infliximab (86%) or etanercept (14%) in 1,540 patients. Drug survival rates (reported as the cumulative percentage of patients still receiving medication) for infliximab and etanercept pooled together were 85% and 81% at 1 year and 2 years, respectively. Instances of discontinuation were essentially due to adverse events. Seventeen cases of TB were found in patients treated with infliximab. The estimated incidence of TB associated with infliximab in RA patients was 1,893 per 100,000 in the year 2000 and 1,113 per 100,000 in the year 2001. These findings represent a significant increased risk compared with background rates. In the first 5 months of 2002, after official guidelines were established for TB prevention in patients treated with biologics, only 1 new TB case was registered (in January). Conclusion Therapy with infliximab is associated with an increased risk of active TB. Proper measures are needed to prevent and manage this adverse event. [source] Toddlers' Use of Force against Familiar Peers: A Precursor of Serious Aggression?CHILD DEVELOPMENT, Issue 2 2000Dale F. Hay Possible precursors of serious aggression were identified in toddlers' use of force against peers. Instances of grabbing objects and hitting peers were recorded in a sample of 66 British 18- to 30-month-olds, observed at home with familiar peers and seen again 6 months later. Mothers rated aggressiveness in the context of other personality traits. Girls and boys did not differ in average levels of aggression, nor were they rated differently by the mothers. However, the observed rate of hitting peers and mothers' ratings of aggressiveness were stable over 6 months for girls, but not for boys. Toddlers who were especially sensitive to peers' possible intentions hit their peers more often. They were also more likely to use force proactively, 6 months later. [source] A software player for providing hints in problem-based learning according to a new specificationCOMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 3 2009Pedro J. Muñoz-Merino Abstract The provision of hints during problem solving has been a successful strategy in the learning process. There exist several computer systems that provide hints to students during problem solving, covering some specific issues of hinting. This article presents a novel software player module for providing hints in problem-based learning. We have implemented it into the XTutor Intelligent Tutoring System using its XDOC extension mechanism and the Python programming language. This player includes some of the functionalities that are present in different state-of-the-art systems, and also other new relevant functionalities based on our own ideas and teaching experience. The article explains each feature for providing hints and it also gives a pedagogical justification or explanation. We have created an XML binding, so any combination of the model hints functionalities can be expressed as an XML instance, enabling interoperability and reusability. The implemented player tool together with the XTutor server-side XDOC processor can interpret and run XML files according to this newly defined hints specification. Finally, the article presents several running examples of use of the tool, the subjects where it is in use, and results that lead to the conclusion of the positive impact of this hints tool in the learning process based on quantitative and qualitative analysis. © 2009 Wiley Periodicals, Inc. Comput Appl Eng Educ 17: 272,284, 2009; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20240 [source] A New Approach for Health Monitoring of Structures: Terrestrial Laser ScanningCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 1 2007H. S. Park Three-dimensional (3D) coordinates of a target structure acquired using TLS can have maximum errors of about 10 mm, which is insufficient for the purpose of health monitoring of structures. A displacement measurement model is presented to improve the accuracy of the measurement. The model is tested experimentally on a simply supported steel beam. Measurements were made using three different techniques: (1) linear variable displacement transducers (LVDTs), (2) electric strain gages, and (3) a long gage fiber optic sensor. The maximum deflections estimated by the TLS model are less than 1 mm and within 1.6% of those measured directly by LVDT. Although GPS methods allow measurement of displacements only at the GPS receiver antenna location, the proposed TLS method allows measurement of the entire building's or bridge's deformed shape, and thus a realistic solution for monitoring structures at both structure and member level. Furthermore, it can be used to create a 3D finite element model of a structural member or the entire structure at any instance of time automatically. Through periodic measurements of deformations of a structure or a structural member and performing inverse structural analyses with the measured 3D displacements, the health of the structure can be monitored continuously. [source] Adding tuples to Java: a study in lightweight data structuresCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 5-6 2005C. van Reeuwijk Abstract Java classes are very flexible, but this comes at a price. The main cost is that every class instance must be dynamically allocated. Also, their access by reference introduces pointer de-references and complicates program analysis. These costs are particularly burdensome for small, ubiquitous data structures such as coordinates and state vectors. For such data structures a lightweight representation is desirable, allowing such data to be handled directly, similar to primitive types. A number of proposals introduce restricted or mutated variants of standard Java classes that could serve as lightweight representation, but the impact of these proposals has never been studied. Since we have implemented a Java compiler with lightweight data structures we are in a good position to do this evaluation. Our lightweight data structures are tuples. As we will show, using tuples can result in significant performance gains: for a number of existing benchmark programs we gain more than 50% in performance relative to our own compiler, and more than 20% relative to Sun's Hotspot 1.4 compiler. We expect similar performance gains for other implementations of lightweight data structures. With respect to the expressiveness of Java, lightweight variants of standard Java classes have little impact. In contrast, tuples add a different language construct that, as we will show, can lead to substantially more concise program code. Copyright © 2005 John Wiley & Sons, Ltd. [source] Rh(I) and Pd(II) complexes of methoxy functionalized heterocyclic carbene: Synthesis and characterizationCRYSTAL RESEARCH AND TECHNOLOGY, Issue 6 2006M. E. Günay Abstract A new methoxy functionalized 2-(trichloromethyl)-1,3-diarylimidazolidin (6) was synthesized as the precursor for N-heterocyclic carbene complexes of Pd(II) and Rh(I) by the condensation of N,N'-bis(2,4-dimethoxyphenyl)-1,2-diaminoethane with chloral. The structures of all compounds have been elucidated by a combination of multinuclear NMR spectroscopy, elemental analysis and in one instance, by single crystal X-ray diffraction. Compound 8, C27H34N2O4ClRh, crystallizes in the triclinic space group P-1 with cell dimensions a = 9.7642(12)Å, b = 11.1914(11)Å, c = 13.0102(14)Å, , = 104.034(9)°, , = 106.658(9)°, , = 99.658(9)° with Z = 2. The molecular structure of 8 shows the geometry around the Rh metal to be a slightly distorted square planar. The crystal structure shows the formation of centrosymmetric dimers via intermolecular C-H...Cl hydrogen bonds. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variantsDIAGNOSTIC CYTOPATHOLOGY, Issue 8 2006Jerzy Klijanienko M.D. Abstract Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues. Although it is well defined in the cytology literature, particular histologic subtypes such as "ancient," cellular and epitheliod variants could be a source of diagnostic difficulties. We have reviewed cytology aspirates and corresponding histologic sections from 34 schwannomas diagnosed at Institut Curie. Histologically, 24 cases were classic, 5 were "ancient," 4 were cellular, and 1 was epithelioid schwannomas. No example of melanotic schwannoma was recorded. Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases. There were no major differences between classical, "ancient," cellular, and epithelioid variants on cytology smears. Myxoid stroma, mast cells, and intranuclear inclusions were limited to classical subtype. Similarly, cyto-nuclear atypia was more frequent in classical subtype than in other subtypes. Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions. Diagn. Cytopathol. 2006;34:517,522. © 2006 Wiley-Liss, Inc. [source] Indirect Perceptual Realism and Multiple ReferenceDIALECTICA, Issue 3 2008Derek Brown Indirect realists maintain that our perceptions of the external world are mediated by our ,perceptions' of subjective intermediaries such as sensations. Multiple reference occurs when a word or an instance of it has more than one reference. I argue that, because indirect realists hold that speakers typically and unknowingly directly perceive something subjective and indirectly perceive something objective, the phenomenon of multiple reference is an important resource for their view. In particular, a challenge that A. D. Smith has recently put forward for indirect realists can be overcome by appreciating how multiple reference is likely to arise when a projectivist variety of indirect realism is interpreted by speakers adhering to a naïve direct realism. [source] Functional Interpretations of Constructive Set Theory in All Finite TypesDIALECTICA, Issue 2 2008Justus Diller Gödel's dialectica interpretation of Heyting arithmetic HA may be seen as expressing a lack of confidence in our understanding of unbounded quantification. Instead of formally proving an implication with an existential consequent or with a universal antecedent, the dialectica interpretation asks, under suitable conditions, for explicit ,interpreting' instances that make the implication valid. For proofs in constructive set theory CZF - , it may not always be possible to find just one such instance, but it must suffice to explicitly name a set consisting of such interpreting instances. The aim of eliminating unbounded quantification in favor of appropriate constructive functionals will still be obtained, as our ,-interpretation theorem for constructive set theory in all finite types CZF, - shows. By changing to a hybrid interpretation ,q, we show closure of CZF, - under rules that , in stronger forms , have already been studied in the context of Heyting arithmetic. In a similar spirit, we briefly survey modified realizability of CZF, - and its hybrids. Central results of this paper have been proved by Burr 2000a and Schulte 2006, however, for different translations. We use a simplified interpretation that goes back to Diller and Nahm 1974. A novel element is a lemma on absorption of bounds which is essential for the smooth operation of our translation. [source] Knowledge and Varieties of Epistemic LuckDIALECTICA, Issue 4 2001Hamid Vahi It is generally thought that knowledge is incompatible with epistemic luck as the post-Gettier literature makes it abundantly clear. Examples are produced where although a belief is true and justified, it nevertheless falls short of being an instance of knowledge because of the intrusion of luck. Knowledge is regarded as being distinct from lucky guesses. It is, nevertheless, acknowledged by a number of epistemologists that some kind of luck is in fact an inevitable component of the process of knowledge acquisition. In this paper I wish to delineate varieties of epistemic luck in the light of the Gettier literature, and specify the kind that should be tolerated in the process of acquiring knowledge. To do this, it would be best to start by examining some of the recent attempts at analyzing the concept of luck and its bearing on the concept of knowledge. [source] T-type calcium channels: an emerging therapeutic target for the treatment of painDRUG DEVELOPMENT RESEARCH, Issue 4 2006Terrance P. Snutch Abstract It has become generally accepted that presynaptic high voltage,activated N-type calcium channels located in the spinal dorsal horn are a validated clinical target for therapeutic interventions associated with severe intractable pain. Low voltage,activated (T-type) calcium channels play a number of critical roles in nervous system function, including controlling thalamocortical bursting behaviours and the generation of spike wave discharges associated with slow wave sleep patterns. There is a growing body of evidence that T-type calcium channels also contribute in several ways to both acute and neuropathic nociceptive behaviours. In the one instance, the Cav3.1 T-type channel isoform likely contributes an anti-nociceptive function in thalamocortical central signalling, possibly through the activation of inhibitory nRT neurons. In another instance, the Cav3.2 T-type calcium channel subtype acts at the level of primary afferents in a strongly pro-nociceptive manner in both acute and neuropathic models. While a number of classes of existing clinical agents non-selectively block T-type calcium channels, there are no subtype-specific drugs yet available. The development of agents selectively targeting peripheral Cav3.2 T-type calcium channels may represent an attractive new avenue for therapeutic intervention. Drug Dev. Res. 67:404,415, 2006. © 2006 Wiley-Liss, Inc. [source] Factors affecting writing achievement: mapping teacher beliefsENGLISH IN EDUCATION, Issue 1 2004Claire Wyatt-Smith Abstract The intersection of teacher beliefs with writing achievement in schooling is a key concern of this paper. The paper reports part of a two-year Australian study that set out to examine in detail how it is that teachers judge Year 5 students' literacy achievement using writing as the case instance. In what follows, we examine the data in the form of concept maps that the teachers them selves made available showing their beliefs about, and insights into the factors that affect student writing achievement. Drawing on these maps, we highlight the range of teacher-identified factors, including those relating to in-class behaviour, motivation, attitudes to school learning, social and cultural backgrounds, oracy and even life circumstances. Additionally, we address how the identified factors function, operating either as standalone elements or within a dynamic network of inter-relationships. [source] "A mercer ye wot az we be": The Authorship of the Kenilworth Letter ReconsideredENGLISH LITERARY RENAISSANCE, Issue 2 2008Elizabeth Goldring The authorship of the Kenilworth Letter, an account of the festivities staged at Kenilworth Castle during Queen Elizabeth I's 1575 progress, has long been a matter of debate, with some scholars suggesting that the work was a pseudonymous hoax foisted upon an unwitting Robert Langham. New findings, together with a re-examination of the existing evidence, suggest the following: first, that the Letter began life as a bona fide missive from Langham to his fellow mercer Humphrey Martin, which, though envisioned for circulation in manuscript, was almost certainly not , in the first instance at least , intended for publication; and second, that William Patten, to whom the Letter sometimes has been attributed in the past, may have been instrumental in the initial efforts to print the work, albeit without Langham's knowledge or permission. Also considered is the wider context of Elizabethan mercery, with particular reference to the close (but often overlooked) political, economic, and cultural ties between the court and the City of London. In addition, this article explores the extent to which the Letter offers a reliable guide to the people, places, and events it describes. [source] Mating compatibility, life-history traits, and RAPD-PCR variation in Bemisia tabaci associated with the cassava mosaic disease pandemic in East AfricaENTOMOLOGIA EXPERIMENTALIS ET APPLICATA, Issue 1 2001M.N. Maruthi Abstract The pandemic of a severe form of cassava mosaic virus disease (CMVD) in East Africa is associated with abnormally high numbers of its whitefly vector, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae). To determine whether a novel B. tabaci biotype was associated with the CMVD pandemic, reproductive compatibility, fecundity, nymphal development, and random amplified polymorphic DNA (RAPD) variability were examined in, and between, B. tabaci colonies collected from within the CMVD pandemic and non-pandemic zone in Uganda. In a series of reciprocal crosses carried out over two generations among the six CMVD pandemic and four non-pandemic zone cassava B. tabaci colonies, there was no evidence of mating incompatibility. All the crosses produced both female and male progeny in the F1 and F2 generations, which in a haplo-diploid species such as B. tabaci indicates successful mating. There also were no significant differences between the sex ratios for the pooled data of experimental crosses, between individuals from two different colonies and control crosses between individuals from the same colony. Only one instance of mating incompatibility occurred in a control cross between cassava B. tabaci from Uganda and cotton B. tabaci from India. Measures of fecundity of the pandemic and non-pandemic zone B. tabaci on four cassava varieties showed no significant differences in their fecundity, nymphal development or numbers surviving to adult eclosion. Cluster analysis of 26 RAPD bands using six 10-mer primers was concordant with the mating results, grouping the pandemic and non-pandemic zone colonies into a single large group, also including a B. tabaci colony collected from cassava in Tanzania. These results suggest that it is unlikely that the severe CMVD pandemic in East Africa is associated with a novel and reproductively isolated B. tabaci biotype. [source] Treatment of the myeloproliferative disorders with 32PEUROPEAN JOURNAL OF HAEMATOLOGY, Issue 1 2000Nathaniel I. Berlin After World War II when 32P became widely available, it was used extensively to treat the chronic leukemias and polycythemia vera. Its use in the treatment of essential thrombocythemia began later in 1950. Today it is not widely used in the treatment of the chronic leukemia, if at all, its use in polycythemia vera appears to have decreased substantially and replaced by hydroxyurea, and its use in the management of essential thrombocythemia is not widespread. In each instance it has been replaced by a drug developed for use in cancer chemotherapy, and in some instances by interferon. It probably has wider use in polycythemia vera in the rest of Western Europe than in the UK, and there are cogent reasons to suggest that it may be the best tool for the treatment of polycythemia vera. Thus have we discarded a treatment modality that in polycythemia vera may be the best? [source] Nucleophilic Addition of Water and Alcohols to Dicyanonitrosomethanide: Ligands with Diverse Bonding Modes in Magnetically Coupled d-Block ComplexesEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 1 2010Anthony S. R. Chesman Abstract Ligands resulting from the transition-metal-promoted nucleophilic addition of water or an alcohol to dicyanonitrosomethanide ions (dcnm) have been utilised in the formation of a large series of polynuclear complexes. Addition of water to dcnm results in formation of carbamoylcyanonitrosomethanide (ccnm); deprotonation of this ligand gives amidocarbonyl(cyano)nitrosomethanide (acnm), which has been incorporated into the trinuclear complex [Cu3(acnm)2(dmae)2(H2O)2] [dmae = 2-(dimethylamino)ethoxide] (1) which shows strong antiferromagnetic coupling with an exchange coupling constant, J = ,500 cm,1. [Cu(acnm)(NH3)2], (2) marks the first instance of acnm facilitating the formation of a coordination polymer, namely a 1D chain with intramolecular hydrogen bonding. Attempts to synthesise 2 through different reaction conditions instead resulted in the mononuclear [Cu(acnm)(NH3)2(py)] (py = pyridine) (3). The addition of ethanol to dcnm results in cyano[imino(ethoxy)methyl]nitrosomethanide (cenm) which features in the mononuclear [Cu(cenm)2(H2O)2] (4) and polymeric {[Cu(cenm)2]2·H2O}, (5). The latter is the first example of the cenm ligand in a coordination polymer and has a highly unusual coordination mode through the nitrile groups and extremely weak antiferromagnetic coupling. {[Mn3(ccnm)2(EtOH)2(OAc)4]·2EtOH}, (6) and (Et4N)2[Cu(ccnm)4] (7) contain previously unobserved coordination modes of the ccnm ligand while the complex [Mn(cmnm)3Mn(bipy)(MeOH)](ClO4) (8) {cmnm = cyano[imino(methoxy)methyl]nitrosomethanide, bipy = 2,2,-bipyridine} displays weak antiferromagnetic coupling between manganese atoms with J = ,1.44 cm,1. A change in the solvent systems used in the synthesis of 7 results in the formation of the mononuclear complexes [Mn(bipy)2(dcnm)2] (9) or [Mn(bipy)2(H2O)(dcnm)](dcnm)·H2O (10) and [Mn(bipy)2(dcnm)(H2O)](dcnm) (11). The addition of ethlyene glycol monomethyl ether to dcnm gives cyano[imino(2-methoxyethoxy)methyl]nitrosomethanide (cgnm) and the formation of [Cu(cgnm)2(H2O)2] (12). [source] Breaking Infinite CuI Carboxylate Helix Held by Cuprophilicity into Discrete Cun Fragments (n = 6, 4, 2)EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 2 2008Yulia Sevryugina Abstract A new copper(I) carboxylate complex with 3,5-bis(trifluoromethyl)benzoate ligands, [Cu(O2C(3,5-CF3)2C6H3)] (1), has been prepared in high yield and fully characterized. An X-ray diffraction study revealed a remarkable infinite double-helical chain motif held together by cuprophilic interactions ranging from 2.69 to 3.14 Å. Both left- and right-handed helices are present in the unit cell of the centrosymmetric structure of 1 thus making the crystalline compound racemic. Complex 1 shows bright emission at ca. 594 nm upon UV/Vis radiation in the solid state (,ex = 350 nm). The Cu···Cu contacts in 1 are easily broken in the gas phase to afford copper clusters of ascertained nuclearity upon sublimation with various polyaromatic hydrocarbons. Several polyarenes such as fluoranthene (C16H10), pyrene (C16H10), and coronene (C24H12) were selected to cover a broad temperature range from 130 to 220 °C for the gas-phase co-deposition reactions. As a result of the successive temperature increase, cleavage of the infinite copper(I) chain into [Cun(O2C(3,5-CF3)2C6H3)n] fragments of decreasing nuclearity, n = 6, 4, and 2, has been achieved. The isolation of these units represents the first instance where various polynuclear copper(I) complexes are prepared and structurally characterized for the same carboxylate ligand.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source] Electrocardiographic ST-segment Elevation: Correct Identification of Acute Myocardial Infarction (AMI) and Non-AMI Syndromes by Emergency PhysiciansACADEMIC EMERGENCY MEDICINE, Issue 4 2001William J. Brady MD Abstract. Objective: To determine the emergency physician's (EP's) ability to identify the cause of ST-segment elevation (STE) in a hypothetical chest pain patient. Methods: Eleven electrocardiograms (ECGs) with STE were given to EPs; the patient in each instance was a 45-year-old male with a medical history of hypertension and diabetes mellitus with the chief complaint of chest pain. The EP was asked to determine the cause of the STE and, if due to acute myocardial infarction (AMI), to decide whether thrombolytic therapy (TT) would be administered (the patient had no contraindication to such treatment). Rates of TT administration were determined; appropriate TT administration was defined as that occurring in an AMI patient, while inappropriate TT administration was defined as that in the non-AMI patient. Results: Four hundred fifty-eight EPs completed the questionnaire; levels of medical experience included the following: postgraduate year 2-3, 193 (42%); and attending, 265 (58%). The overall rate of correct interpretation of the study ECGs was 94.9% (4,782 correct interpretations out of 5,038 instances). Acute myocardial infarction with typical STE, ventricular paced rhythm, and right bundle branch block were never misinterpreted. The remaining conditions were misinterpreted with rates ranging between 9% (left bundle branch block, LBBB) and 72% (left ventricular aneurysm, LVA). The overall rate of appropriate thrombolytic agent administration was 83% (1,525 correct administrations out of 1,832 indicated administrations). The leading diagnosis for which thrombolytic agent was given inappropriately was LVA (28%), followed by benign early repolarization (23%), pericarditis (21%), and LBBB without electrocardiographic AMI (5%). Thrombolytic agent was appropriately given in all cases of AMI except when associated with atypical STE, where it was inappropriately withheld 67% of the time. Conclusions: In this survey, EPs were asked whether they would give TT based on limited information (ECG). Certain syndromes with STE were frequently misdiagnosed. Emergency physician electrocardiographic education must focus on the proper identification of these syndromes so that TT may be appropriately utilized. [source] Five Danish referendums on the European Community and European Union: A critical assessment of the Franklin thesisEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 6 2002Palle Svensson Denmark had five referendums in the period from 1972 to 1998 dealing with Danish membership in the European Community, the Single European Act, the Maastricht Treaty, the Edinburgh Agreement and the Amsterdam Treaty. Did the Danes really address these issues and involve themselves actively in the policy,making process on a vital issue or did they merely vote for or against the current government? The latter option represents the ,second order' elections argument advanced by Mark Franklin and others (see Franklin's article in this issue). If correct in this instance, it may have important and negative consequences for the potential of referendums to involve citizens more directly in the way they are governed. In this article, the Franklin thesis is assessed on the basis of data on voting behaviour in five Danish referendums on Europe and the democratic implications of these findings are discussed. [source] | |||||||||||||||||||||||||||||||||||||||||||