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Kinds of Information Available Selected AbstractsPregnancy after liver transplantationLIVER TRANSPLANTATION, Issue 6 2000Vincent T. Armenti The first known posttransplantation pregnancy was in 1958 in a renal transplant recipient who had received a kidney from her identical twin sister. The first known posttransplantation pregnancy in a liver transplant recipient was in 1978. Information available from female kidney transplant recipients helped in the decision making involved in the management of this case, as well as those that followed. Over the last 20 years, issues specific to liver transplantation and pregnancy have been identified. Similar to the kidney transplant recipient population, when prepregnancy recipient graft function is stable and adequate, pregnancy appears to be well tolerated. Also similar to kidney transplant recipients, there has been no evidence of a specific malformation pattern among the children, and although prematurity and low birth weight occur, overall newborn outcomes have been favorable. Pregnancy in the setting of recurrent liver disease, such as recurrent hepatitis C, poses a potential problem among liver transplant recipients, as well as the possible adverse effects of immunosuppression on maternal kidney function. Also of significance, peripartum graft deterioration has more severe consequences in this transplant recipient population. Therefore, pregnancy must be considered carefully in this transplant recipient group. Since 1991, the National Transplantation Pregnancy Registry (NTPR) has studied the safety of pregnancy outcomes in solid-organ transplant recipients. The purpose of this review is to catalog studies in the literature, as well as to present current data from the registry with management guidelines. [source] Ethics and Genetic Selection in Purebred DogsREPRODUCTION IN DOMESTIC ANIMALS, Issue 1 2003VN Meyers-Wallen Contents There is an ongoing revolution in medicine that is changing the way that veterinarians will be counselling clients regarding inherited disorders. Clinical applications will emerge rapidly in veterinary medicine as we obtain new information from canine and comparative genome projects (Meyers-Wallen 2001: Relevance of the canine genome project to veterinary medical practice. International Veterinary Information Service, New York). The canine genome project is described by three events: mapping markers on canine chromosomes, mapping gene locations on canine chromosomes (Breen et al. 2001: Genome Res. 11, 1784,1795), and obtaining the nucleotide sequence of the entire canine genome. Information from such research has provided a few DNA tests for single gene mutations [Aguirre 2000: DNA testing for inherited canine diseases. In: Bonagura, J (ed), Current Veterinary Therapy XIII. Philadelphia WB Saunders Co, 909,913]. Eventually it will lead to testing of thousands of genes at a time and production of DNA profiles on individual animals. The DNA profile of each dog could be screened for all known genetic disease and will be useful in counselling breeders. As part of the pre-breeding examination, DNA profiles of prospective parents could be compared, and the probability of offspring being affected with genetic disorders or inheriting desirable traits could be calculated. Once we can examine thousands of genes of individuals easily, we have powerful tools to reduce the frequency of, or eliminate, deleterious genes from a population. When we understand polygenic inheritance, we can potentially eliminate whole groups of deleterious genes from populations. The effect of such selection on a widespread basis within a breed could rapidly improve health within a few generations. However, until we have enough information on gene interaction, we will not know whether some of these genes have other functions that we wish to retain. And, other population effects should not be ignored. At least initially it may be best to use this new genetic information to avoid mating combinations that we know will produce affected animals, rather than to eliminate whole groups of genes from a population. This is particularly important for breeds with small gene pools, where it is difficult to maintain genetic diversity. Finally, we will eventually have enough information about canine gene function to select for specific genes encoding desirable traits and increase their frequencies in a population. This is similar to breeding practices that have been applied to animals for hundreds of years. The difference is that we will have a large pool of objective data that we can use rapidly on many individuals at a time. This has great potential to improve the health of the dog population as a whole. However, if we or our breeder clients make an error, we can inadvertently cause harm through massive, rapid selection. Therefore, we should probably not be advising clients on polygenic traits or recommend large scale changes in gene frequencies in populations until much more knowledge of gene interaction is obtained. By then it is likely that computer modelling will be available to predict the effect of changing one or several gene frequencies in a dog population over time. And as new mutations are likely to arise in the future, these tools will be needed indefinitely to detect, treat and eliminate genetic disorders from dog populations. Information available from genetic research will only be useful in improving canine health if veterinarians have the knowledge and skills to use it ethically and responsibly. There is not only a great potential to improve overall canine health through genetic selection, but also the potential to do harm if we fail to maintain genetic diversity. Our profession must be in a position to correctly advise clients on the application of this information to individual dogs as well as to populations of dogs, and particularly purebred dogs. [source] Real-Time OD Estimation Using Automatic Vehicle Identification and Traffic Count DataCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 1 2002Michael P. Dixon A key input to many advanced traffic management operations strategies are origin,destination (OD) matricies. In order to examine the possibility of estimating OD matricies in real-time, two constrained OD estimators, based on generalized least squares and Kalman filtering, were developed and tested. A one-at-a-time processing method was introduced to provide an efficient organized framework for incorporating observations from multiple data sources in real-time. The estimators were tested under different conditions based on the type of prior OD information available, the type of assignment available, and the type of link volume model used. The performance of the Kalman filter estimators also was compared to that of the generalized least squares estimator to provide insight regarding their performance characteristics relative to one another for given scenarios. Automatic vehicle identification (AVI) tag counts were used so that observed and estimated OD parameters could be compared. While the approach was motivated using AVI data, the methodology can be generalized to any situation where traffic counts are available and origin volumes can be estimated reliably. The primary means by which AVI data was utilized was through the incorporation of prior observed OD information as measurements, the inclusion of a deterministic link volume component that makes use of OD data extracted from the latest time interval from which all trips have been completed, and through the use of link choice proportions estimated based on link travel time data. It was found that utilizing prior observed OD data along with link counts improves estimator accuracy relative to OD estimation based exclusively on link counts. [source] Parallel processing of remotely sensed hyperspectral imagery: full-pixel versus mixed-pixel classificationCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 13 2008Antonio J. Plaza Abstract The rapid development of space and computer technologies allows for the possibility to store huge amounts of remotely sensed image data, collected using airborne and satellite instruments. In particular, NASA is continuously gathering high-dimensional image data with Earth observing hyperspectral sensors such as the Jet Propulsion Laboratory's airborne visible,infrared imaging spectrometer (AVIRIS), which measures reflected radiation in hundreds of narrow spectral bands at different wavelength channels for the same area on the surface of the Earth. The development of fast techniques for transforming massive amounts of hyperspectral data into scientific understanding is critical for space-based Earth science and planetary exploration. Despite the growing interest in hyperspectral imaging research, only a few efforts have been devoted to the design of parallel implementations in the literature, and detailed comparisons of standardized parallel hyperspectral algorithms are currently unavailable. This paper compares several existing and new parallel processing techniques for pure and mixed-pixel classification in hyperspectral imagery. The distinction of pure versus mixed-pixel analysis is linked to the considered application domain, and results from the very rich spectral information available from hyperspectral instruments. In some cases, such information allows image analysts to overcome the constraints imposed by limited spatial resolution. In most cases, however, the spectral bands collected by hyperspectral instruments have high statistical correlation, and efficient parallel techniques are required to reduce the dimensionality of the data while retaining the spectral information that allows for the separation of the classes. In order to address this issue, this paper also develops a new parallel feature extraction algorithm that integrates the spatial and spectral information. The proposed technique is evaluated (from the viewpoint of both classification accuracy and parallel performance) and compared with other parallel techniques for dimensionality reduction and classification in the context of three representative application case studies: urban characterization, land-cover classification in agriculture, and mapping of geological features, using AVIRIS data sets with detailed ground-truth. Parallel performance is assessed using Thunderhead, a massively parallel Beowulf cluster at NASA's Goddard Space Flight Center. The detailed cross-validation of parallel algorithms conducted in this work may specifically help image analysts in selection of parallel algorithms for specific applications. Copyright © 2008 John Wiley & Sons, Ltd. [source] Middleware adaptation with the Delphoi serviceCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 13 2006Jason Maassen Abstract Grid middleware needs to adapt to changing resources for a large variety of operations. Currently, however, there is only low-level information available about Grid resources, coming from various but functionally isolated monitoring and information systems. In this paper, we present the Delphoi service. It provides a unified interface to the necessary information, and also matches the abstraction level needed by middleware services to adapt their behavior. We describe Delphoi's architecture, the information it provides, and we evaluate the quality of its performance information. Delphoi has been developed as part of the EC-funded GridLab project and is currently being deployed on the project's testbed for adding adaptivity to GridLab's middleware services. Copyright © 2006 John Wiley & Sons, Ltd. [source] FS04.6 Dose/unit area and time , key factors influencing the elicitation capacity of MCI/MICONTACT DERMATITIS, Issue 3 2004Claus Zachariae The objective of the study was to investigate, using the Repeated Open Application Test (ROAT), two key parameters of exposure , allergen concentration (dose/unit area) and time in terms of the elicitation capacity of methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) in MCI/MI-sensitised individuals and to explore the inter-relationship between these two key factors. The study was designed as a double-blind, placebo-controlled, dose-response ROAT preceded by a Diagnostic Patch Test (DPT). 79 patients with a known MCI/M allergy were contacted, 29 were diagnostically patch tested and 25 had their allergy confirmed. 25 MCI/M-allergic subjects and 10 healthy non-allergic control subjects were challenged with 2 ppm of MCI/MI/unit area of skin for 4 weeks. After a wash out period of at least 4 weeks the subjects were challenged with 7.5 ppm of MCI/MI/unit area of skin for 4 weeks. A ROAT with 2 drops of solution twice a day was conducted on the volar aspect of the left and right forearms on a 3 × 3 cm area resulting in dose/unit area of MCI/MI of 0.025 mg/cm2 and 0.095 mg/cm2 for 2 ppm and 7,5 ppm MCI/MI respectively. The elicitation capacity of MCI/MI in MCI/MI sensitive patients is dependent on the exposure dose/unit area and time The results of this study will be a useful addition to the risk assessment information available for MCI/MI. The risk assessment for the use of MCI/MI in rinse off consumer products is unaffected by the results of this study. [source] The mental health of female sex workersACTA PSYCHIATRICA SCANDINAVICA, Issue 2 2010W. Rössler Rössler W, Koch U, Lauber C, Hass A-K, Altwegg M, Ajdacic-Gross V, Landolt K. The mental health of female sex workers. Objective:, There is limited information available about the mental health of female sex workers. Therefore, we aimed to make a comprehensive assessment of the mental status of female sex workers over different outdoors and indoors work settings and nationalities. Method:, As the prerequisites of a probability sampling were not given, a quota-sampling strategy was the best possible alternative. Sex workers were contacted at different locations in the city of Zurich. They were interviewed with a computerized version of the World Health Organization Composite International Diagnostic Interview. Additional information was assessed in a structured face-to-face interview. Results:, The 193 interviewed female sex workers displayed high rates of mental disorders. These mental disorders were related to violence and the subjectively perceived burden of sex work. Conclusion:, Sex work is a major public health problem. It has many faces, but ill mental health of sex workers is primarily related to different forms of violence. [source] Probable trigeminal autonomic cephalgia in a 3-month-old male infantDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 4 2010IRENE VAZ To my knowledge trigeminal autonomic cephalgias (TACs) have not previously been reported in infancy. The diagnosis is dependent on an accurate history, including parents noting any physical signs at the time of the episode. Obtaining a clear history can be challenging when such symptoms occur in preverbal children. Similarly, physical signs, being transient, may have resolved by the time the parents take the child to a doctor. In addition, the investigations may also be normal. In such circumstances, taking a photograph during an episode can confirm the diagnosis. I describe a case of probable trigeminal autonomic cephalgia starting in a 3-month-old male infant who presented with screaming episodes associated with characteristic changes seen on his face. Investigations, including cranial magnetic resonance imaging, electroencephalography, and urinary catecholamines, were normal. The diagnosis was confirmed from a photograph taken by the parents at the time of the attack. As the condition is very rare in young children, there is little information available in the literature on using treatment for prophylaxis or for aborting acute episodes in this age group. [source] Religion and Science: What Is at Stake?DIALOG, Issue 3 2007Lynne Lorenzen Abstract:, "Religion and Science: What Is at Stake" looks at the latest information available on global warming from the International Panel on Climate Change and puts it in the context of the current culture war between progressives and conservatives. We worry that the science will become captive to ideological concerns that are theological, economic, and therefore political. The ideological domination of science may make a sustainable response to global warming even more difficult. It is vitally important that Christian theologians learn enough about the science to be articulate and support the scientists in their endeavors to promote our care of the creation. [source] Ultrastructural changes in skeletal muscle of the tail of the lizard Hemidactylus mabouia immediately following autotomyACTA ZOOLOGICA, Issue 4 2010Tomaz Henrique Araújo Abstract Araújo, T.H., Faria, F.P., Katchburian, E. and Freymüller, E. (2009). Ultrastructural changes in skeletal muscle of the tail of the lizard Hemidactylus mabouia immediately following autotomy. ,Acta Zoologica (Stockholm) 91: 440,446. Although autotomy and subsequent regeneration of lizard tails has been extensively studied, there is little information available on ultrastructural changes that occur to the muscle fibers at the site of severance. Thus, in the present study, we examine the ultrastructure of the musculature of the remaining tail stump of the lizard Hemidactylus mabouia immediately after autotomy. Our results show that exposed portions of the skeletal muscle fibers of the stump that are unprotected by connective tissue bulge to produce large mushroom-like protrusions. These exposed portions show abnormal structure but suffer no leakage of cytoplasmic contents. Many small and large vesicular structures appeared between myofibrils in the interface at this disarranged region (distal) and the other portion of the fibers that remain unchanged (proximal). These vesicles coalesce, creating a gap that leads to the release of the mushroom-like protrusion. So, our results showed that after the macroscopic act of autotomy the muscular fibers release part of the sarcoplasm as if a second and microscopic set of autotomic events takes place immediately following the macroscopic act of autotomy. Presumably these changes pave the way for the formation of a blastema and the beginning of regeneration. [source] The International Adult Literacy Survey in Britain: Impact on policy and practiceDYSLEXIA, Issue 2 2003Angela J. Fawcett Abstract There is increasing concern for the skills of the workforce in the UK and elsewhere, but despite this concern until recently there has been little information available which objectively measures basic skills in adults. In this paper, evidence derived from the prose scale of the International Adult Literacy Survey (IALS, 1996) is outlined, with emphasis on the performance of adults at the lowest levels, 1 and 2 in the United Kingdom. A new analysis based on the 183 adults who self-reported learning disabilities demonstrates that over 50% of this group perform at level 1 on the prose scale. Over 60% report that these disabilities persist into adult life, although this number falls to 50% in the youngest age group, reflecting changes in recognition of learning disabilities within the education system. The paper concludes with a case study of the redefinition of basic skill levels in Britain based on the IALS levels. The impact of the IALS findings on policy and practice, and in particular through the recommendations of the Moser report, are discussed. Copyright © 2002 John Wiley & Sons, Ltd. [source] The Accuracy and Completeness of Data Collected by Prospective and Retrospective MethodsACADEMIC EMERGENCY MEDICINE, Issue 9 2005J. Tobias Nagurney MD Abstract Objectives: To describe and test a model that compares the accuracy of data gathered prospectively versus retrospectively among adult emergency department patients admitted with chest pain. Methods: The authors developed a model of information flow from subject to medical record to the clinical study case report form, based on a literature review. To test this model, a bidirectional (prospective and retrospective) study was conducted, enrolling all eligible adult patients who were admitted with a chief complaint of chest pain. The authors interviewed patients in the emergency department to determine their chest pain history and established a prospective database; this was considered the criterion standard. Then, patient medical records were reviewed to determine the accuracy and completeness of the information available through a retrospective medical record review. Results: The model described applies the concepts of reliability and validity to information passed on by the study subject, the clinician, and the medical record abstractor. This study was comprised of 104 subjects, of which 63% were men and the median age was 63 years. Subjects were uncertain of responses for 0,8% of questions and responded differently upon reinterview for subsets of questions 0,30% of the time. The sensitivity of the medical record for risk factors for coronary artery disease was 0.77 to 0.93. Among the 88 subjects (85%) who indicated that their chest pain was substernal or left chest, the medical record described this location in 44%. Timing of the chest pain was the most difficult item to accurately capture from the medical record. Conclusions: Information obtained retrospectively from the abstraction of medical records is measurably less accurate than information obtained prospectively from research subjects. For certain items, more than half of the information is not available. This loss of information is related to the data types included in the study and by the assumptions that a researcher performing a retrospective study makes about implied versus explicitly stated responses. A model of information flow that incorporates the concepts of reliability and validity can be used to measure some of the loss of information that occurs at each step along the way from subject to clinician to medical record abstractor. [source] Reliability of Intraoperative Transesophageal Echocardiography During Tetralogy of Fallot RepairECHOCARDIOGRAPHY, Issue 4 2000JAMES J. JOYCE M.D. There is limited information available concerning the accuracy of intraoperative transesophageal echocardiography (TEE) in predicting the extent of residual abnormalities after recovery from surgical repair of tetralogy of Fallot. Therefore, we investigated differences between the results of final postbypass TEE and those of postrecovery (mean, 6 days after surgery) transthoracic echocardiography in a total of 28 consecutive pediatric patients who underwent repair of tetralogy of Fallot with biplane or multiplane TEE. Both postbypass and postrecovery echocardiographic examinations included measurements of the right ventricle (RV)-main pulmonary artery (PA) and the main PA-branch PA peak instantaneous gradients, the degree of pulmonary valvar insufficiency, and color Doppler interrogation of the ventricular septum for residual defects. The RV-main PA gradient did not change significantly: 15 ± 13 vs 18 ± 14 mmHg (postbypass versus postrecovery, mean ± SD). None of the patients had a decrease of , 10 mmHg; and only one patient had an increase of ,: 15 mmHg. There also was no change in the degree of pulmonary insufficiency (3.0 ±1.2 versus 3.1 ± 1.1, using a scale of 0 to 4). Only one of the seven very small (, 2 mm) residual ventricular septal defects was not discovered during postbypass TEE. However, postrecovery transthoracic echocardiography detected significant branch PA stenosis (peak gradient, , 15 mmHg) in five patients (18%) that was not detected during postbypass TEE (P < 0.03). Of the branch PA stenoses that were not detected during TEE, four were left and one was right. Conclusions: Postbypass TEE after tetralogy of Fallot repair reliably predicts residual postrecovery hemodynamic abnormalities, except for branch PA stenosis. [source] Using neutral landscapes to identify patterns of aggregation across resource pointsECOGRAPHY, Issue 3 2006Jill Lancaster Many organisms are aggregated within resource patches and aggregated spatially across landscapes with multiple resources. Such patchy distributions underpin models of population regulation and species coexistence, so ecologists require methods to analyse spatially-explicit data of resource distribution and use. I describe a method for analysing maps of resources and testing hypotheses about how resource distribution influences the distribution of organisms, where resource patches can be described as points in a landscape and the number of organisms on each resource point is known. Using a mark correlation function and the linearised form of Ripley's K-function, this version of marked point pattern analysis can characterise and test hypotheses about the spatial distribution of organisms (marks) on resource patches (points). The method extends a version of point pattern analysis that has wide ecological applicability, it can describe patterns over a range of scales, and can detect mixed patterns. Statistically, Monte Carlo permutations are used to estimate the difference between the observed and expected values of the mark correlation function. Hypothesis testing employs a flexible neutral landscape approach in which spatial characteristics of point patterns are preserved to some extent, and marks are randomised across points. I describe the steps required to identify the appropriate neutral landscape and apply the analysis. Simulated data sets illustrate how the choice of neutral landscape can influence ecological interpretations, and how this spatially-explicit method and traditional dispersion indices can yield different interpretations. Interpretations may be general or context-sensitive, depending on information available about the underlying point pattern and the neutral landscape. An empirical example of caterpillars exploiting food plants illustrates how this technique might be used to test hypotheses about adult oviposition and larval dispersal. This approach can increase the value of survey data, by making it possible to quantify the distribution of resource points in the landscape and the pattern of resource use by species. [source] Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspectiveELECTROPHORESIS, Issue S1 2009Nicolas Guex Abstract SWISS-MODEL pioneered the field of automated modeling as the first protein modeling service on the Internet. In combination with the visualization tool Swiss-PdbViewer, the Internet-based Workspace and the SWISS-MODEL Repository, it provides a fully integrated sequence to structure analysis and modeling platform. This computational environment is made freely available to the scientific community with the aim to hide the computational complexity of structural bioinformatics and encourage bench scientists to make use of the ever-increasing structural information available. Indeed, over the last decade, the availability of structural information has significantly increased for many organisms as a direct consequence of the complementary nature of comparative protein modeling and experimental structure determination. This has a very positive and enabling impact on many different applications in biomedical research as described in this paper. [source] The use of eco-labels: a review of the literatureENVIRONMENTAL POLICY AND GOVERNANCE, Issue 6 2002Dr Ibon Galarraga Gallastegui Labelling programs seek first to encourage a move towards more environmentally friendly consumption patterns, and second to induce productive structures, governments and other agents to increase the environmental standards of the products and services in the economy. This paper is devoted to revising the relevant literature on the issue. We divide the topic into three areas: (i) the study of demand, where most of the information available on the demand for labelled goods is presented; (ii) the study of supply, devoted to the analysis and summary of the information available in the literature and finally (iii) the market and trade impacts of labelling programmes, where the research carried out so far is carefully presented. The paper reveals the lack of proper and conclusive research to date, as well as the complexity of the topic of research. Copyright © 2002 John Wiley & Sons, Ltd. and ERP Environment. [source] Efficiency of permeable pavement systems for the removal of urban runoff pollutants under varying environmental conditionsENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, Issue 3 2010Kiran Tota-Maharaj Abstract Urban surface water runoff typically contains a high but variable number of pathogens, nutrients, and sediments that require removal before reuse. Permeable pavements can improve the water quality through interception, filtration, sedimentation, nutrient transformation, and microbial removal. There is currently insufficient scientific information available on the treatment efficiencies of permeable pavements combined with earth energy systems with regards to the removal of storm water pollutants such as nutrients, sediments, and microbial pollutants. This study evaluates the efficiency of 12 tanked combined systems during a medium-term study. The research assessed weekly the removal of the microbial indicators total coliforms, Escherichia coli, and fecal Streptococci, as well as the key nutrients ammonia-nitrogen, nitrate-nitrogen, and ortho-phosphate-phosphorus, and physical variables such as suspended solids and turbidity. Total coliforms, E. coli, and fecal Streptococci were removed by 98,99%. The ammonia-nitrogen and ortho-phosphate-phosphorus removal efficiencies were 84.6% and 77.5%, respectively. An analysis of variance indicated that the presence or absence of a geotextile did result in a very highly statistically significant difference (P < 0.001) with respect to the removal of both ammonia-nitrogen and ortho-phosphate-phosphorus. Suspended solids, turbidity, and biochemical oxygen demand were reduced by 91%, 82%, and 88%, respectively. These results indicate the potential of the proposed novel system in urban runoff pollutant removal and subsequent reuse of the treated water. © 2010 American Institute of Chemical Engineers Environ Prog, 2010 [source] In vivo and in vitro toxicity of decabromodiphenyl ethane, a flame retardantENVIRONMENTAL TOXICOLOGY, Issue 4 2010Tarja Nakari Abstract Toxicity of a relative new flame retardant, namely decabromodiphenyl ethane (DBDPE), marketed as an alternative to decabromodiphenyl ether (BDE-209) was assessed both in vivo and in vitro using the freshly separated fish hepatocyte assay and standardized water flea and zebrafish egg-larvae tests. The fish hepatocyte assay, based on the synthesis and secretion of vitellogenin from isolated male liver cells produced a clear dose-response curve in the presence of DBDPE. DBDPE induced the induction of hepatic ethoxyresorufin-O-deethylase (EROD) activity at low test concentrations, but started to inhibit the activity at higher concentrations. Also, the induction of the hepatocyte conjugation activity, uridinediphosphoglucuronosyltransferase (UDPGT), was induced with no signs of inhibition even at the highest test concentration. The reduced EROD activity resulted in a drop in the production of vitellogenin by the cells. In vivo tests showed that DBDPE was acutely toxic to water fleas, the 48 h EC-50 value being 19 ,g/L. Moreover, DBDPE reduced the hatching rates of exposed zebra-fish eggs and raised significantly the mortality of hatched larvae. Because there is hardly any information available on the effects of DBDPE on the aquatic environments, it is crucial to obtain more data on the effects and effective concentrations of DBDPE along with its occurrence in the environment. Such data would enable reliable assessments of the risks posed by this flame retardant. © 2009 Wiley Periodicals, Inc. Environ Toxicol 25: 333,338, 2010. [source] What level of effect is a no observed effect?ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 2 2000Mark Crane Abstract The no observed effect concentration (NOEC) is currently a major summary statistic in ecotoxicity testing. Its use is heavily criticized, partly because it is a poor estimator of "safe" chemical concentrations. In this short communication, we review the limited information available on the percentage effect that corresponds with the NOEC, a value designated the ECNOEC, and calculate ECNOEC values for fish growth data. The average ECNOEC for different test protocols was found to vary widely, with values for chronic studies ranging from 10 to 34%. Individual results varied even more widely. This analysis suggests that the NOEC is neither a consistent summary statistic nor an indicator of safe concentrations of toxic chemicals. [source] Return to work following unilateral enucleation in 34 horses (2000,2008)EQUINE VETERINARY JOURNAL, Issue 2 2010M. E. UTTER Summary Reasons for study: The effect of unilateral enucleation on vision and potential loss of performance in horses has received little study. Objective: To evaluate the likelihood of return to prior discipline following unilateral enucleation in horses, assessing the role of age at enucleation, equine discipline, reason for enucleation, time to vision loss and eye enucleated. Hypothesis: Unilateral enucleation has no significant effect on likelihood of return to work in horses, for both right and left eyes, across age and discipline. Method: A retrospective review of medical records identified 92 horses that underwent unilateral enucleation at the University of Pennsylvania New Bolton Center from April 2000,April 2008. Case variables determined from the medical record included breed and sex of horse, age at enucleation, which eye was enucleated, reason for enucleation and onset of vision loss. Pre- and post operative occupations were determined by telephone interview with the owner or trainer of each horse. Results: Based on hospital surgery logs, 92 enucleations were performed over the 8 year period and 77 records were available for review, with follow-up information available for 34 horses. Of these, 29/34 (85%) horses returned to work in pleasure or trail riding (11/13), flat racing (7/10), hunter/jumpers (4/4), dressage (3/3), group lessons (1/1), eventing (1/1), steeplechase (1/1) and as a broodmare (1/1). Four of 5 horses (4/34, or 12% sample) that did not return to work (2 pleasure and 2 racing) were retired due to anticipated or perceived decrease in performance or behaviour change following unilateral enucleation, with the remaining horse retired from racing for lameness issues unrelated to enucleation. Twenty-two of 25 horses (88%) with acute vision loss and 7/9 horses (78%) with gradual vision loss returned to their previous discipline. Conclusions: Horses are able to return to a variety of occupations after unilateral enucleation. [source] Longitudinal development of equine conformation from weanling to age 3 years in the ThoroughbredEQUINE VETERINARY JOURNAL, Issue 7 2004T. M. ANDERSON Summary Reasons for performing study: There is little information available to define conformational changes with age using an objective but practical method of recording specific body measurements. Objective: To analyse conformation objectively in a population of racing Thoroughbreds and describe the changes from weanling to age 3 years. Methods: Annual photographs were taken over 4 years and conformation measurements made from photographs using specific reference points marked on the horses. Results: Correlation analysis revealed highly significant, moderate to strong relationships between long bone lengths and wither height for all ages. All long bone lengths showed moderate to strong relationships with each other for all ages. The front and rear pastern angles were significantly correlated with the angle of the dorsal surface of the front and rear hooves, respectively, for all. Wither height, croup height and length of neck topline, neck bottomline, scapula, humerus, radius and femur increased significantly from age 0,1 year and age 1,2 years. Hoof lengths (medial and lateral, right and left) grew significantly between the ages of 0 and 1 and 1 and 2 years, but decreased in length between age 2 and 3 years. Horses became more offset in the right limb between weanling and age 3 years, but the offset ratios did not change with age on the left limb. The angle of the scapula (I), shoulder and radiometacarpus significantly increased between all age groups (became more upright). The angle of the dorsal surface of the hooves (both front and hind) decreased significantly from ages 0 to 1 and 1 to 2 years, but showed no significant difference between ages 2 and 3 years. Conclusions: A strong relationship between long bone lengths and wither height for all ages supports the theory that horses are proportional. Longitudinal bone growth in the distal limb increased only 5,7% from weanling to age 3 years and is presumably completed prior to the yearling year. Several growth measures increased from ages 0 to 1 and 1 to 2 years, but did not increase from age 2,3 years; indicating that growth rate either showed or reached a plateau at this time. Potential relevance: This study provides objective information regarding conformation and skeletal growth in the Thoroughbred which can be utilised for selection and recognition of significant conformational abnormalities. [source] Who is Looking for Nutritional Food Labels?: Wer sucht nach Nährwertangaben auf Lebensmitteln?: Mais qui donc s'occupe du contenu nutritionnel sur les étiquettes?EUROCHOICES, Issue 1 2005Andreas C. Drichoutis Summary Who is Looking for Nutritional Food Labels? Obesity amongst the population in Europe is increasing at an alarming rate. Consequently, nutritional and lifestyle factors are implicated in the huge increase in several chronic diseases in Europe. The Southern Europeans tend to be amongst the worst, mth Greece being first in adult obesity mainly due to the replacement of the Mediterranean diet with ready-made and fast foods. People want to see change towards an environment that makes it easier to make healthy choices. The EU, in order to assist consumers make healthy food choices, tried to make nutritional information available to consumers through a food labelling law framework, which currently works on a voluntary basis with the perspective to change towards a mandatory system. We conducted a study in Greece in order to assess consumer use of nutritional food labels and determine which consumers use certain types of nutrient content information. We found that almost a third of consumers often use food labels and these are the more educated, who are more nutritionally knowledgeable. Many others do not, and to increase their chances of reading the labels one should improve their knowledge of nutrition havlng in mind that they are not big users of the media but get their information from informd sources. Mais qui donc s'occupe du contenu nutritionnel sur les etiquettes? La prevalence de I'obesitk augmente a un t a u toujours plus preoccupant en Europe. Les facteurs nutritionnels et les styles de vie sont par consequent impliquks dans l'Cnorme accroissement constati: de diverses pathologies chroniques. La situation est specialement mauvaise en Europe du sud, ou la Grece detient le record du taux d'obesite dans la population adulte, en particulier du fait du remplacement du fameux ,regime mediterraneen' par les plats prepares et la restauration rapide. Les gens souhaitent un environnement susceptible de leur faciliter le choix d'une alimentation saine. C'est pour cela que l'Union europkenne a tente de mettre des informations nutritionnelles a la disposition des consommateurs, en instituant un cadre legal pour l'etiquetage alimentaire Il fonctionne actuellement sur la base du volontariat, mais il a pour vocation d'evoluer vers un systeme obligatoire. Il est rendu compte ici d'une enquOte effectuee en Grkce pour determiner quels types de consommateurs utilisent quels genres dindications de contenu nutritionnel portees sur les etiquettes alimentaires, et dans quelle mesure. Environ un tiers des consommateurs utilisent souvent les contenus nutritionnels. Ce sont les plus eduques et les mieux informks. La plupart des autres negligent les etiquettes. Pour accroitre les chances que ces dernieres soient lues, il faudrait donc arneliorer les connaissances nutritionnelles, en gardant a l'esprit que les personnes concernkes utilisent peu les mkdias et tirent leurs informations de sources informelles. Wer sucht nach Nährwertangaben auf Die Fettleibigkeit in der europaischen Bevolkerung nimmt alarmierend schnell zu. Folglich spiegeln sich Ernahrung und Lebensstil in dem hohen Anstieg zahlreicher chronischer Erkrankungen in Europa wider. Fur die Sudeuropaer ergeben sich einige der schlechtesten Werte, wobei in Griechenland die Erwachsenenfettleibigkeit am ausgepriigtesten ist. Dies liegt hauptsachlich daran, dass die mediterrane Erniihrung von Fertiggerichten und Fast-Food abgelost wurde. Die Bevolkerung wiinscht sich eine Veriinderung hin zu einer Umgebung, die sie darin unterstutzt, der Gesundheit zutr;dgliche Entscheidungen zu treffen. Die EU wollte den Verbrauchern gesundheitlich relevante Informationen durch eine Kennzeichnung der Inhaltsstoffe der Lebensmittel verschaffen. Dieses System sieht gegenwartig lediglich eine freiwillige Kennzeichnung vor, ist aber als obligatorisch geplant. Wir fiihrten in Griechenland eine Studie durch, um zu beurteilen, inwiefern Nahrwertangaben auf Lebensmitteln den Verbrauchern nutzen, und um festzustellen, welche Verbraucher auf bestimmte Nahrwertangaben achten. Wir fanden heraus, dass beinahe ein Drittel aller Verbraucher auf die Lebensmittelkennzeich nung achten. Diese Verbraucher verfiigen uber eine hohere Bildung und kennen sich in Erniihrungsfragen relativ gut aus. Ein großer Anted der Verbraucher verfiigt uber keinerlei gesundheitliche Grundkenntnisse; um diesen Verbrauchern das Lesen der Etiketten zu ermoglichen, sollte man ihre Kenntnisse in Sachen Ernahrung verbessern und sich dabei vor Augen fiihren, dass diese Verbraucher die Medien nicht allzu intensiv nutzen, sondern ihre Informationen aus informellen Quellen beziehen. [source] Four-year water degradation of a resin-modified glass-ionomer adhesive bonded to dentinEUROPEAN JOURNAL OF ORAL SCIENCES, Issue 1 2004Jan De Munck Glass-ionomers are auto-adhesive to tooth tissue through combined micro-mechanical and chemical bonding. How much each of the two bonding components contributes to the actual bonding effectiveness is, however, not known and there is not much information available on long-term stability. The objective of this study was to assess the bonding effectiveness of a resin-modified glass-ionomer adhesive to dentin after 4 yr of water storage. Fuji Bond LC (GC) was applied without (i) and with pretreatment using (ii) a polyalkenoic acid conditioner and (iii) a 37.5% phosphoric acid etchant. The etchant was used to exclude any chemical interaction with hydroxyapatite. The micro-tensile bond strength (µTBS) to dentin decreased significantly over the 4 yr period in all three experimental groups. After 24 h and 4 yr, the lowest µTBS was recorded when dentin was not pretreated. The highest µTBS was obtained following polyalkenoic acid pretreatment, although this was not significantly different from specimens that were pretreated using phosphoric acid. Pretreating dentin with phosphoric acid intensified micromechanical interlocking at the expense of chemical bonding potential to hydroxyapatite. Nevertheless, correlating the µTBS data with failure analysis through scanning electron microscopy and transmission electron microscopy indicated that combined micro-mechanical and chemical bonding involving pretreatment with the polyalkenoic acid conditioner yielded the most durable bond. [source] Bidding behaviour and electricity market simulationEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 4 2007T. Chandarasupsang Abstract To trade effectively and profitably in new electricity market structures, participants need to identify how best to use information available to them. In many cases only incomplete information will be available for short-term planning, trading and decision-making. This paper simulates a group of generators who adapt bidding behaviours in different segments of liberalised electricity markets based on historic market information, observed strategies and their view of other market participants. Results show that even in the incomplete information case efficient bidding strategy for market participants can be identified. Specifically, this paper presents some key findings from an active electricity market and utilises them within an electricity market simulation. The benefit of market simulation for participants is identified and reported. Copyright © 2007 John Wiley & Sons, Ltd. [source] Television Shopping for Apparel in the United States: Effects of Perceived Amount of Information on Perceived Risks and Purchase IntentionsFAMILY & CONSUMER SCIENCES RESEARCH JOURNAL, Issue 3 2000Minjeong Kim In a two-part study, the amount and types of information available in television-shopping segments selling apparel were examined. In Phase 1, a content analysis of 60 segments selling apparel was conducted. In Phase 2, using an experimental format, a convenience sample of 128 middle-aged women (M = 46 years) viewed a 6-minute television-shopping segment selling apparel and assessed perceived risk, perceived amount of information available in the segment, and purchase intentions, and they answered some open-ended questions about their information-searching activities. Taken together, results of Phases 1 and 2 revealed that when making apparel purchases, participants needed product and customer service information; however, in some segments, that information was never available or was available in less than half the segments coded. Results also revealed that the amount of information perceived from a television-shopping segment selling apparel was negatively related to perceived risk and positively related to purchase intent. [source] Seed-based systematic discovery of specific transcription factor target genesFEBS JOURNAL, Issue 12 2008Ralf Mrowka Reliable prediction of specific transcription factor target genes is a major challenge in systems biology and functional genomics. Current sequence-based methods yield many false predictions, due to the short and degenerated DNA-binding motifs. Here, we describe a new systematic genome-wide approach, the seed-distribution-distance method, that searches large-scale genome-wide expression data for genes that are similarly expressed as known targets. This method is used to identify genes that are likely targets, allowing sequence-based methods to focus on a subset of genes, giving rise to fewer false-positive predictions. We show by cross-validation that this method is robust in recovering specific target genes. Furthermore, this method identifies genes with typical functions and binding motifs of the seed. The method is illustrated by predicting novel targets of the transcription factor nuclear factor kappaB (NF-,B). Among the new targets is optineurin, which plays a key role in the pathogenesis of acquired blindness caused by adult-onset primary open-angle glaucoma. We show experimentally that the optineurin gene and other predicted genes are targets of NF-,B. Thus, our data provide a missing link in the signalling of NF-,B and the damping function of optineurin in signalling feedback of NF-,B. We present a robust and reliable method to enhance the genome-wide prediction of specific transcription factor target genes that exploits the vast amount of expression information available in public databases today. [source] K+ fluxes in Schizosaccharomyces pombeFEMS YEAST RESEARCH, Issue 1 2003Fernando Calero Abstract All living cells accumulate high concentrations of K+ in order to keep themselves alive. To this end they have developed a great diversity of transporters. The internal level of K+ is the result of the net balance between the activities of the K+ influx and the K+ efflux transporters. Potassium fluxes have been extensively studied and characterized in Saccharomyces cerevisiae. However, this is not the case in the fission yeast and, in addition, the information available indicates that both yeasts present substantial and interesting differences. In this paper we have reviewed and summarized the information on K+ fluxes in Schizosaccharomyces pombe. We have included some unpublished results recently obtained in our laboratory and, in particular, we have highlighted the significant differences found between the well-known yeast S. cerevisiae and the fission yeast Sch. pombe. [source] Institutional Investors and Shareholder LitigationFINANCIAL MANAGEMENT, Issue 2 2008Sergey S. Barabanov We examine whether institutional investors are able to avoid future litigation. Our results show that institutions provide a fiduciary role by decreasing or eliminating their positions in sued firms well before litigation begins. We also find that institutional groups with high monitoring ability (independent investment advisors and mutual funds) are more proactive in their trading behavior than are institutions with low monitoring ability (banks, insurance companies, and unclassified institutions such as endowments, foundations, and self-managed pension funds). We find that percentage changes in institutional ownership are correlated with public information available more than two quarters before litigation. [source] Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient miceGENES TO CELLS, Issue 8 2009Takeshi Inagaki Histone H3 lysine 9 (H3K9) methylation is a crucial epigenetic mark of heterochromatin formation and transcriptional silencing. Recent studies demonstrated that most covalent histone lysine modifications are reversible and the jumonji C (JmjC)-domain-containing proteins have been shown to possess such demethylase activities. However, there is little information available on the biological roles of histone lysine demethylation in intact animal model systems. JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) catalyses removal of H3K9 mono- and dimethylation through iron and ,-ketoglutarate dependent oxidative reactions. Here, we demonstrate that JHDM2a also regulates metabolic genes related to energy homeostasis including anti-adipogenesis, regulation of fat storage, glucose transport and type 2 diabetes. Mice deficient in JHDM2a (JHDM2a,/,) develop adult onset obesity, hypertriglyceridemia, hypercholesterolemia, hyperinsulinemia and hyperleptinemia, which are hallmarks of metabolic syndrome. JHDM2a,/, mice furthermore exhibit fasted induced hypothermia indicating reduced energy expenditure and also have a higher respiratory quotient indicating less fat utilization for energy production. These observations may explain the obesity phenotype in these mice. Thus, H3K9 demethylase JHDM2a is a crucial regulator of genes involved in energy expenditure and fat storage, which suggests it is a previously unrecognized key regulator of obesity and metabolic syndrome. [source] Molecular cytogenetic characterization of proximal-type epithelioid sarcomaGENES, CHROMOSOMES AND CANCER, Issue 3 2004Elena Lualdi Proximal-type epithelioid sarcoma is a recently described soft-tissue tumor that is distinguished from conventional-type epithelioid sarcoma by a far more aggressive clinical course, frequent location in the proximal anatomic regions, and variable rhabdoid morphology. Because of their rarity and peculiar morphology, proximal-type epithelioid sarcomas frequently pose serious diagnostic dilemmas, being easily misdiagnosed as a variety of other malignant neoplasms. To date, the information available on the genetic alterations associated with this tumor entity has been confined to single conventional cytogenetic reports. In this article, we present the results of a conventional and molecular cytogenetic analysis of six proximal-type epithelioid sarcomas. Spectral karyotyping analysis of these cases deciphered the characteristics of several marker chromosomes and complex translocations, leading to the recognition of recurrent rearrangements. The most frequently involved chromosome arm was 22q, and the identification of two cases with a similar translocation, t(10;22), suggests a role for one or more genes on chromosome 22 in the pathogenesis of this tumor and provides an opportunity for finely mapping the translocation-associated breakpoints. Chromosome arm 8q gain was also a frequent event and correlated with gain of MYC gene copy number, as demonstrated by fluorescence in situ hybridization. A review of both cases reported in the literature and those presented in this study reinforced the involvement of chromosomes 8 and 22 and also indicated frequent rearrangements of chromosomes 7, 14, 18, and 20. © 2004 Wiley-Liss, Inc. [source] | ||||||||||||||||||||||||||||||||||||||||