Home About us Contact
|
Home About us Contact | ||
|
|
||
Infertility Treatment (infertility + treatment)
Selected AbstractsInfertility, infertility treatment and psychomotor development: the Danish National Birth CohortPAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 2 2009Jin Liang Zhu Summary Babies born of infertile couples, regardless of treatment, have a higher risk of preterm birth and low birthweight, conditions associated with delayed development. We examined developmental milestones in singletons as a function of parental infertility [time to pregnancy (TTP) > 12 months] and infertility treatment. From the Danish National Birth Cohort (1997,2003), we identified 37 897 singletons born of fertile couples (TTP , 12 months), 4351 born of infertile couples conceiving naturally (TTP > 12 months), and 3309 born after infertility treatment. When the children were about 18 months old, mothers reported 12 developmental milestones by responding to structured questions. We defined a failure to achieve the assessed milestone or the minimal numbers of milestones in a summary (motor, or cognitive/language skills) as delay. Naturally conceived children born of infertile couples had a pattern of psychomotor development similar to that of children born of fertile couples, but increasing TTP correlated with a modest delay. When the analysis was restricted to infertile couples (treated and untreated), children born after treatment showed a slight delay in cognitive/language development (odds ratio 1.24, [95% confidence interval 1.01, 1.53]) for not meeting at least three out of six cognitive/language milestones); children born after intracytoplasmic sperm injection (ICSI) had the highest estimated relative risk of delay for most milestones, especially motor milestones. These results suggest that a long TTP may be associated with a modest developmental delay. Infertility treatment, especially ICSI, may be associated with a slight delay for some of these early milestones. [source] Interaction between leucocytes and human spermatozoa influencing reactive oxygen intermediates releaseINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 2 2004Monika Fr Summary The relationship between the presence of white blood cells (WBCs) and the fertilizing potential of human semen is still an open question. It is well known that the presence of leucocytes in human semen can be related to the production of reactive oxygen intermediates (ROI). Semen samples were obtained from 15 normozoospermic men and leucocytes were isolated from heparinized blood drawn from 15 volunteers. Lucigenin and luminol-mediated chemiluminescence assays were used to determine reactive oxygen species (ROS) generation by non-activated or activated leucocytes through 12-myristate-13-acetate or N-formyl-methionyl-leucyl-phenyalanine (FMLP) before the addition of spermatozoa isolated by swim-up or Percoll procedures. All spermatozoal fractions used in this study were characterized by defining their motility, morphology and viability. The levels of ROS formation by non-activated as well as stimulated leucocytes were significantly decreased after addition of swim-up separated spermatozoa (p < 0.01). The ability to inhibit the basal chemiluminescence was of lower degree for spermatozoa isolated from 90% Percoll fractions than for swim-up sperm. However, addition of sperm cells from 47% Percoll fraction was found to increase both lucigenin and luminol signals. Moreover, the determined ROI levels changed depending on the type of inducing factor used for oxidative burst. Then, spermatozoa selected by swim-up procedure although with only slightly higher viability and morphology than sperm obtained from 90% Percoll fraction clearly exhibited much higher capacity to inhibit ROI secretion by receptor-stimulated leucocytes (FMLP-activation) than Percoll fractionated sperm. Such results may indicate that within normal semen may exist sperm subpopulations with different biochemical mechanisms controlling the interaction between spermatozoa and contaminating leucocytes. When ROI levels contained in normozoospermic semen are dependent on the WBCs activation, it seems that spermatozoa with preserved normal functional competence are able to defend themselves against leucocytes-derived ROI. Also for normozoospermic ejaculates, swim-up sperm may improve semen antioxidant characteristics when comparing with Percoll (90%) separated sperm. It may help for optimal sperm preparation when assisting to infertility treatment. [source] Isolated right-sided varicocele as a salvage pathway for portal hypertensionINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 6 2005G-M. Pinggera Summary Retrograde blood flow can occur in the testicular veins and in the pampiniformis plexus in the absence of valves or if the valves are incompetent, resulting in tortuosity and dilatation of the veins. These abnormal alterations in the anatomy of the veins, termed varicoceles, are associated with infertility in the male. Most varicoceles occur on the left. We report the case of a rare isolated right-sided varicocele in a male evaluated for infertility in whom extensive work-up revealed venous anomalies and a spontaneous porto-systemic shunt. In such cases, standard approaches to infertility treatment are fruitless. [source] De-escalation after repeated negative feedback: emergent expectations of failureJOURNAL OF BEHAVIORAL DECISION MAKING, Issue 5 2004Brian J. Zikmund-FisherArticle first published online: 26 NOV 200 Abstract Research on willingness to make marginal investments (e.g., the escalation and sunk cost literatures) has often focused on project completion decisions, such as the "radar-blank plane." This paper discusses a fundamentally different type of marginal investment decision, that of couples deciding whether to continue infertility treatment in the face of repeated failures. Two experiments based on this context show that when people face multiple independent chances to achieve a valued goal but are unsure about chances of success, premature quitting or "de-escalation" is the norm. Repeated negative feedback appears to induce individuals to see each successive failure as more and more diagnostic. As a result, even a short series of failed attempts evokes beliefs that future attempts will also fail. These emergent expectations of failure, generated by causal attribution processes, associative learning, and/or discounting of ambiguous information, appear very compelling and induce people to forgo profitable marginal investments. Copyright © 2004 John Wiley & Sons, Ltd. [source] Infertile couples' experience of family stress while women are hospitalized for Ovarian Hyperstimulation Syndrome during infertility treatmentJOURNAL OF CLINICAL NURSING, Issue 4 2008Shiu-Neng Chang MS Aims and objectives., The aim of this study was to explore the essential structure of family stress among hospitalized women receiving infertility treatment with Ovarian Hyperstimulation Syndrome. Background., When hospitalization is necessary for infertile women with Ovarian Hyperstimulation Syndrome, they face health-illness transition stress and their families are traumatized by the pressure of hospitalization. Most literature on infertility treatment has dealt with the infertile women's physio-psychological reactions, the impact on the couples' relationships and the influence of social support on infertile couples. Design., A descriptive phenomenological design consistent with Husserl's philosophy. Methods., Ten married couples from a Taipei medical centre participated in the study. All the couples were receiving infertility treatment because the female partners were suffering from moderate or severe Ovarian Hyperstimulation Syndrome and this required hospitalized. An open in-depth interview technique encouraged parents to reflect on their experience, which raised their feelings to a conscious level. Data were analysed using Colaizzi's approach. Results., This study explored infertile women's experiences from the couples' perspectives and the results identify the overall stresses that the family face. Five themes emerged from the study, namely, the stress of ,carrying on the ancestral line', the psychological reactions of the couple, a disordering of family life, reorganization of family life and external family support. Conclusions., The results demonstrate that the experience of family stress involves impacts that range across the domains of individual, marital, family and social interactions and there is a need to cope with these when the wife is hospitalized for moderate to severe Ovarian Hyperstimulation Syndrome. Relevance to clinical practice., The findings indicated that nurses should provide infertile couples with family-centred perspectives that are related to Chinese cultural family values. Nurses should supply information on infertility treatment and assist couples to cope with their personal and family stress. [source] Infertility, infertility treatment and psychomotor development: the Danish National Birth CohortPAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 2 2009Jin Liang Zhu Summary Babies born of infertile couples, regardless of treatment, have a higher risk of preterm birth and low birthweight, conditions associated with delayed development. We examined developmental milestones in singletons as a function of parental infertility [time to pregnancy (TTP) > 12 months] and infertility treatment. From the Danish National Birth Cohort (1997,2003), we identified 37 897 singletons born of fertile couples (TTP , 12 months), 4351 born of infertile couples conceiving naturally (TTP > 12 months), and 3309 born after infertility treatment. When the children were about 18 months old, mothers reported 12 developmental milestones by responding to structured questions. We defined a failure to achieve the assessed milestone or the minimal numbers of milestones in a summary (motor, or cognitive/language skills) as delay. Naturally conceived children born of infertile couples had a pattern of psychomotor development similar to that of children born of fertile couples, but increasing TTP correlated with a modest delay. When the analysis was restricted to infertile couples (treated and untreated), children born after treatment showed a slight delay in cognitive/language development (odds ratio 1.24, [95% confidence interval 1.01, 1.53]) for not meeting at least three out of six cognitive/language milestones); children born after intracytoplasmic sperm injection (ICSI) had the highest estimated relative risk of delay for most milestones, especially motor milestones. These results suggest that a long TTP may be associated with a modest developmental delay. Infertility treatment, especially ICSI, may be associated with a slight delay for some of these early milestones. [source] Transfusion-Related Risks of Intradermal Allogeneic Lymphocyte Immunotherapy: Single Cases in a Large Cohort and Review of the LiteratureAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 3 2006Christiane Kling Problem, Lymphocyte immunotherapy (LIT) is applied in infertility treatment. Moreover, it has been suggested for prevention of rhesus D-hemolytic disease and as a vaccine for reduction of human immunodeficiency virus-1 susceptibility. Although transfusion-related problems have been rarely reported they were a matter of debate. Here we discuss extensive single-center experience with intradermal LIT for implantation failure and recurrent miscarriages. Method of study, Retrospective 2- to 3-year follow-up of in vitro fertilization couples treated during 1996,2002 (feedback 2848/3041 = 93%), registering 930 deliveries. Prospective survey for acute reactions for 2000,2003 (feedback 2687/3246 = 83%). Review of the literature. Results, Infections of the patient and transplant rejection later in life are minor residual risks. Post-transfusion purpura was suspected once but not verified. Anaphylaxis or malignancy were not promoted. Fetal/newborn alloimmune disease (severe hemolytic disease, thrombocytopenia, neutropenia) were not observed. Conclusion, Based on microbiological, immunological, and hematological testing the risks of intradermal LIT are low. [source] Lifestyle factors in people seeking infertility treatment , A reviewAUSTRALIAN AND NEW ZEALAND JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Issue 1 2010Kirsty ANDERSON Background:, Clinical infertility is a prevalent problem with significant financial and psychosocial costs. Modifiable lifestyle factors exist that may affect a person's time to conception and their chance of having a healthy, live birth. However, no guideline delineates what preconception advice should be offered to people presenting for infertility treatment. Aim:, The aim of this article is to review the literature regarding modifiable lifestyle factors in people seeking infertility treatment. Results:, A person's time to pregnancy and their chance of having a healthy, live birth may be affected by factors such as weight, vitamin and iodine intake, alcohol and caffeine consumption, smoking, substance abuse, stress, environmental pollutants, vaccinations and oxidative stress. Conclusions:, Advice on modifiable lifestyle factors should be given to people presenting for infertility treatment to help them make positive changes that may improve their chances of pregnancy and delivering a healthy, live baby. Developing a guideline for this would be a prudent step towards helping clinicians to implement this aspect of preconception care. [source] Relationships between multiple births and autism spectrum disorders, cerebral palsy, and intellectual disabilities: autism and developmental disabilities monitoring (ADDM) network,2002 surveillance year,AUTISM RESEARCH, Issue 5 2008Kim Van Naarden Braun Abstract Since the 1970s, the prevalence of multiple births (MBs) in the United States has increased significantly. This has been attributed, in large part, to iatrogenic MBs resulting from infertility treatments that include ovulation stimulation. A past study has indicated that children from MBs have an increased prevalence of cerebral palsy (CP). Other studies also have suggested an association between MBs and intellectual disabilities (ID) and autism spectrum disorders (ASDs); however, results have been inconsistent. From the Autism and Developmental Disabilities Monitoring (ADDM) Network, a surveillance project among several US populations, we obtained MB estimates among children born in 1994 and classified by 8 years of age as having: an ASD (n=1,626 total children from 11 sites; 50 born as part of an MB); CP (n=302 total children from 3 sites; 25 born as part of an MB); or ID (n=1,195 total children from 3 sites; 45 born as part of an MB). All three MB estimates were notably higher than age-adjusted expected estimates of naturally conceived MBs derived from 1971 US natality data. However, when MB estimates from the ADDM Network were compared with expected MB estimates derived from 1994 natality data for the states corresponding to the relevant ADDM Network sites, we observed no association with ASDs (observed/expected=1.08 [0.78,1.38]), a moderate, but not statistically significant association with ID (observed/expected=1.34 [0.95,1.73]), and a strong association with CP (observed/expected=2.96 [1.80,4.12]). Further investigation of specific types of MBs (natural vs. iatrogenic) is warranted. [source] An Embryonic Nation: Life Against Health in Canadian Biotechnological DiscourseCOMMUNICATION THEORY, Issue 1 2005Rebecca Sullivan This article traces the protracted public debate over reproductive and genetic technologies in Canada through an examination of the federal government's efforts to pass legislation in the area. Four attempts were made, in 1997, 2000, 2003, and finally 2004, before a bill was passed that regulated the use of embryos in both infertility treatments and nonreproductive genetic therapies. At stake in the debate was the supremacy of health over life as a fundamental value of Canadian national identity, and the role of biotechnology in ushering Canada into a new era of prosperity and global leadership. Using a feminist cultural framework, the author challenges notions of modernity versus postmodernity in the social construction of bodies, nations, and knowledge. She critiques the legal intrusions on women's bodies in particular for the way that they, perhaps inadvertently, offer some limited form of autonomy for embryos as valuable commodities in scientific progress. [source] | ||||||||||