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Infection Leading (infection + leading)

Distribution by Scientific Domains
Medical Sciences83%

Selected Abstracts

Peripheral blood candidosis infection leading to spurious platelet and white blood cell counts

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 5 2009
J. F. LESESVE
Summary We report a patient with thrombocytopenia secondary to disseminated stomach adenocarcinoma and sepsis whose platelet and white blood cells were falsely enumerated by two automated haematology analyzers. The cause of the spurious counts became obvious when numerous yeast forms were observed on the peripheral blood smear. Artefactual automated analyzer results are detailed. [source]

Subacute immune response to primary EBV infection leading to post-transplant lymphoproliferative disease in a renal transplant patient

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 5 2004
S. Leaver
Summary A 23-year-old man sero-negative for Epstein,Barr virus (EBV) developed recurrent sore throats 3 and 6 months after a renal transplant from an EBV sero-positive donor. Tonsillar biopsy at 9 months post-transplant showed post-transplant lymphoproliferative disease (PTLD) caused by EBV. Following reduction of immunosuppressive treatment, he developed further signs and symptoms, and serological evidence of infectious mononucleosis followed by resolution of lymphadenopathy. This case emphasizes the difficulty in interpreting EBV serology in immunosuppressed patients and the importance of pre-transplant EBV serology. [source]

ORIGINAL ARTICLE: Pregnancy Does not Deter the Development of a Potent Maternal Protective CD8+ T-Cell Acquired Immune Response Against Listeria Monocytogenes Despite Preferential Placental Colonization

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 1 2010
Lakshmi Krishnan
Problem Listeria monocytogenes (LM) preferentially colonizes the placenta and causes fetal loss and systemic disease during pregnancy. As systemic CD8+ T-cell memory is critical in controlling LM infection, we addressed the issue as to whether it is modulated during pregnancy. Method of study Pregnant mice were infected with LM and their immune response was quantified relative to the non-pregnant cohort using advanced immunological techniques. Results Pregnant mice exhibited progressive and massive placental LM infection leading to fetal resorptions. In contrast, they harbored significantly lower bacteria in spleen and liver relative to non-pregnant controls, and rapidly cleared systemic infection. Both pregnant and non-pregnant mice exhibited similar activation of systemic innate immunity. Moreover, LM infection in pregnant and non-pregnant hosts evoked strong antigen-specific cytolytic CD8+ T cells that produced IFN-,. Consequently, LM infection initiated during pregnancy afforded long-term protective memory to secondary infection. Conclusion Maternal hosts generate a normal Listeria -specific adaptive immunity in particular CD8+ T-cell memory response suggesting that systemic listeriosis during pregnancy may be an immunopathology associated with placental infection. [source]

Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection

CELLULAR MICROBIOLOGY, Issue 7 2006
Philip Rosenstiel
Summary Host immune response influences the clinical outcome of Helicobacter pylori infection leading to ulcer disease, gastric carcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. A genetic risk profile for gastric cancer has been identified, but genetic susceptibility to develop MALT lymphoma is still unclear. We investigated the role of NOD1 and NOD2 as intracellular recognition molecules for pathogen-associated molecules in H. pylori infection in vitro and analysed the influence of single nucleotide polymorphisms on susceptibility to ulcer disease and MALT lymphoma. Expression of NOD1 and NOD2 significantly sensitized HEK293 cells to H. pylori -induced NF-,B activation in a cag pathogenicity island (cagPAI)-dependent manner. In cells carrying the Crohn-associated NOD2 variant R702W the NF-,B response was significantly diminished. NOD1/NOD2 expression levels were induced in the gastric epithelium in H. pylori -positive patients. No mutations were found to be associated with gastritis or gastric ulcer development. However, the R702W mutation in the NOD2/CARD15 gene was significantly associated with gastric lymphoma. Carrier of the rare allele T had a more than doubled risk to develop lymphoma than controls [odds ratio (OR): 2.4, 95% confidence interval (CI): 1.2,4.6; P < 0.044]. H. pylori -induced upregulation of NOD1 and NOD2 in vivo may play a critical role in the recognition of this common pathogen. A missense mutation in the leucine-rich region of CARD15 is associated with gastric lymphoma. [source]

Management of congenital cytomegalovirus infection: an evidence-based approach

ACTA PAEDIATRICA, Issue 4 2010
RS Gandhi
Abstract Despite cytomegalovirus being the most common congenital infection leading to psychomotor impairment and sensori-neural hearing loss, little is known about early identification and management of congenitally infected neonates. This article reviews the literature and devises an algorithm for identification and management of these neonates. Conclusion:, Application of the current knowledge in the management of congenital cytomegalovirus infected neonates could be beneficial, until further evidence is available. [source]

Esophageal perforation secondary to angio-invasive Candida glabrata following hemopoietic stem cell transplantation

CLINICAL MICROBIOLOGY AND INFECTION, Issue 12 2003
H. A. M. Tran
Esophageal perforation due to Candida glabrata is a rare entity. This organism is uncommonly recognized to be angio-invasive and cause gastrointestinal tract perforation. Herein, we describe a case of invasive C. glabrata infection leading to esophageal perforation in a patient undergoing hemopoietic stem cell transplantation. [source]