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Individual Outcomes (individual + outcome)
Selected AbstractsStandardizing Emergency Department,based Migraine Research: An Analysis of Commonly Used Clinical Trial Outcome MeasuresACADEMIC EMERGENCY MEDICINE, Issue 1 2010Benjamin W. Friedman MD Abstract Objectives:, Although many high-quality migraine clinical trials have been performed in the emergency department (ED) setting, almost as many different primary outcome measures have been used, making data aggregation and meta-analysis difficult. The authors assessed commonly used migraine trial outcomes in two ways. First, the authors examined the association of each commonly used outcome versus the following patient-centered variable: the research subject's wish, when asked 24 hours after investigational medication administration, to receive the same medication the next time they presented to an ED with migraine ("would take again"). This variable was chosen as the criterion standard because it provides a simple, dichotomous, clinically sensible outcome, which allows migraineurs to factor important intangibles of efficacy and adverse effects of treatment into an overall assessment of care. The second part of the analysis assessed how sensitive to true efficacy each outcome measure was by calculating sample size requirements based on results observed in previously conducted clinical trials. Methods:, This was a secondary analysis of data previously collected in four ED-based migraine randomized trials performed between 2003 and 2007. In each of these trials, subjects were asked 24 hours after administration of an investigational medication whether or not they would want to receive the same medication the next time they came to the ED with a migraine. Odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for sex and medication received, were calculated as measures of association between the most commonly used outcome measures and "would take again." The sensitivity of each outcome measure to treatment efficacy was determined by calculating the sample size that would be required to detect a statistically significant result using estimates of that outcome obtained in two clinical trials. Results:, Data from 378 subjects were used for this analysis. Adjusted ORs for association of "would take again" and other commonly used primary headache outcomes are as follows: achieving a pain-free state by 2 hours, OR = 3.1 (95% CI = 1.8 to 5.4); sustained pain-free status, OR = 4.5 (95% CI = 1.9 to 11.0); and no need for rescue medication, OR = 3.7 (95% CI = 2.1 to 6.6). An improvement on a standardized 11-point pain scale of ,33% had an adjusted OR = 5.2 (95% CI = 2.2 to 12.4). The best performing alternate outcome, ,33% improvement, correctly classified 288 subjects and misclassified 77 subjects when compared to "would take again." At least 33% improvement and pain-free by 2 hours required the smallest sample sizes, while sustained pain-free and "would take again" required many more subjects. Conclusions:, "Would take again" was associated with all migraine outcome measures we examined. No individual outcome was more closely associated with "would take again" than any other. Even the best-performing alternate outcome misclassified more than 20% of subjects. However, sample sizes based on "would take again" tended to be larger than other outcome measures. On the basis of these findings and this outcome measure's inherent patient-centered focus, "would take again," included as a secondary outcome in all ED migraine trials, is proposed. ACADEMIC EMERGENCY MEDICINE 2010; 17:72,79 © 2010 by the Society for Academic Emergency Medicine [source] A Person-Organization Fit Model of Owner-Managers' Cognitive Style and Organizational DemandsENTREPRENEURSHIP THEORY AND PRACTICE, Issue 1 2007Keith H. Brigham Based on survey responses from 159 owner-managers in small high-technology firms, we examined the association among specific individual characteristics, firm characteristics, and the individual outcomes of satisfaction and intentions to exit. Regression analyses indicated higher satisfaction and lower intentions to exit for owner-managers whose dominant decision-making style complemented the levels of formalization and structure in their firms. In addition, we found that both satisfaction and intentions to exit were significantly associated with actual turnover over a 5-year period. The theoretical and practical implications of these findings are discussed. [source] Sex Composition, Masculinity Stereotype Dissimilarity and the Quality of Men's Workplace Social RelationsGENDER, WORK & ORGANISATION, Issue 5 2003Sharon R. Bird Previous research suggests that the quality of men's work group social relations varies depending on the sex composition of the work unit. Previous studies also suggest that men derive different benefits from working with other men than with women and that the higher status associated with men and masculinity advantages men in their relations with women workers. Previous sex composition studies tell us little, however, about the extent to which the quality of men's work group social relations with women and other men depends on how well a man fits dominant masculinity stereotypes. Drawing on sex composition and gender constructionist approaches to gender and work I investigate in this study the effects of men's individual similarity to masculinity stereotypes on the affective quality of their social relations with coworkers, given the sex composition of their work groups. The data for this study consist of male, mostly white, non-faculty employees of a public university in the northwest United States. I discuss my results in terms of both individual outcomes and implications for understanding sex and gender inequalities in work organizations. [source] The Life Trajectory Interview for Youth (LTI-Y): method development and psychometric properties of an instrument to assess life-course models and achievementINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 4 2006Ryan A. Brown Abstract This paper describes the rationale, development and psychometric properties of the Life Trajectory Interview for Youth (LTI-Y), an instrument designed to assess cognitive models of the life course and life-course achievement. This method was developed over 13 months of pilot research, and applied with a population of 350 participants from the Great Smoky Mountain Study, a longitudinal epidemiological study of mental health in western North Carolina comprising 1420 youths (among them 350 Cherokee Native Americans). The LTI-Y is designed to address gaps in our understanding of the links between large-scale structural conditions and social processes and individual outcomes such as mental health. Scale consistency (n = 350) was good to high, whereas test-retest reliability in a limited sample (n = 18) was moderate to good, depending on the domain and dimension of data considered. Overall, psychometric properties indicate fairly stable and consistent life-course strategies and priorities. Although developed and piloted with youth from Western North Carolina, the methods described could be applied to any population of interest. Copyright © 2006 John Wiley & Sons, Ltd. [source] An Evaluation of Two Mediation Techniques, Negotiator Power, and Culture in Negotiation,JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 5 2001Vairam Arunachalam This study examines the effects of 4 factors in a mediated transfer-pricing negotiation: (a) the mediator's suggestion that negotiators have concern for the other (opposing) negotiator; (b) the mediator's proposal of moderate goals; (c) negotiator power; and (d) culture. In the simulated negotiations that were mediated by a corporate official, participants were 374 subjects from Hong Kong and the United States. Negotiators obtained lower joint outcomes when urged by the mediator to show concern for the other than when not given this admonition. When the mediator proposed moderate (vs. high) goals, the negotiators received lower joint outcomes but had a higher opinion of the mediator. While we expected negotiator power (equal vs. unequal) to interact with suggested concern for the other, it did so only for the negotiators' individual outcomes. Finally, culture produced a main effect: Hong Kong negotiators obtained higher joint outcomes than did their U. S. counterparts. [source] Making a life in the field of organization scienceJOURNAL OF ORGANIZATIONAL BEHAVIOR, Issue 7 2007William H. Glick In a provocative address and article, Jeff Pfeffer called for greater consensus and stronger paradigm development in organization science. John Van Maanen and others responded with encouragement for the existing order where a thousand flowers can bloom. More than 10 years after this debate, it appears that many flowers are still blooming. Lost in the original and current discourse, however, is the story of individuals struggling to make a life in a field characterized by weak paradigm development. In this essay, we tell their story, a story of wasted efforts and uncertain outcomes. The degree of dissensus and weak paradigm development in our field has significant implications for junior scholars. These implications will not be ameliorated by calling for stronger paradigm development. Wishing for consensus does not appear to have any impact on our field or on individual outcomes. Rather than despair over the plight of the field and the tremendous costs to individuals, we conclude with a simple proposal designed to aid aspiring scholars. Copyright © 2007 John Wiley & Sons, Ltd. [source] Six-minute walk test in obese children and adolescents: Reproducibility and validity,PHYSIOTHERAPY RESEARCH INTERNATIONAL, Issue 2 2009Gunilla Morinder Abstract Background and Purpose.,The six-minute walk test (6MWT) is increasingly used in clinical practice. The aims of this study were to determine the reproducibility of the 6MWT in obese children and adolescents, to describe walking capacity in this population and compare the results with values from normal-weight children (known group validity), and, finally, to describe the correlation between distance walked and estimated maximum oxygen uptake (VO2max).,Methods.,Reproducibility was determined by a test,retest design and known group validity by a comparative design. The 6MWT was first test,retested in 49 obese children (30 boys, 19 girls, 8,16 years, body mass index [BMI] 24.9,52.1,kg?m,2). Then, for validation, 250 obese children (126 boys, 124 girls, 8,16 years, BMI 23.2,57,kg/m2) and 97 normal-weight children (48 boys, 49 girls, 8,16 years, BMI 13.3,23.2,kg·m,2) performed the 6MWT. The obese children also performed a sub-maximal bicycle ergometry test.,Results.,In the test,retest, the obese children walked 571,m the first test and 57,m the second (p = 0.578). The measurement error (Sw) was 24,m, coefficient of variation (CV): 4.3% and the intraclass correlation (ICC1:1): 0.84. Repeatability was 68,m, and limits of agreement were +71 and ,65,m. In comparison mean (standard deviation), six-minute walk distance (6MWD) in the obese children was 571,m (65.5), and in the normal-weight children, 663,m (61.1) (p < 0.001). The correlation between 6MWD and estimated VO2max (r = 0.34) was low.,Conclusions.,The 6MWT showed good reproducibility and known group validity, and can be recommended for use in clinical practice in the studied population. To evaluate individual outcomes after intervention, the 6MWD needs to change by >68,m to be statistically significant. The 6MWD performed by obese children averaged 86% of the distance normal-weight children walked. In obese children, the correlation between 6MWD and estimated VO2max was low, hence the 6MWT cannot substitute a bicycle ergometry test. Copyright © 2008 John Wiley & Sons, Ltd. [source] Bayesian Multivariate Logistic RegressionBIOMETRICS, Issue 3 2004Sean M. O'Brien Summary Bayesian analyses of multivariate binary or categorical outcomes typically rely on probit or mixed effects logistic regression models that do not have a marginal logistic structure for the individual outcomes. In addition, difficulties arise when simple noninformative priors are chosen for the covariance parameters. Motivated by these problems, we propose a new type of multivariate logistic distribution that can be used to construct a likelihood for multivariate logistic regression analysis of binary and categorical data. The model for individual outcomes has a marginal logistic structure, simplifying interpretation. We follow a Bayesian approach to estimation and inference, developing an efficient data augmentation algorithm for posterior computation. The method is illustrated with application to a neurotoxicology study. [source] Deinstitutionalization in Ontario, Canada: Understanding Who Moved WhenJOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES, Issue 3 2010Lynn Martin Abstract The results of deinstitutionalization are well known, but less information is available on the process of deinstitutionalization itself. This study sought to understand the process of deinstitutionalization in Ontario by examining the timing of individuals' transitions to the community and the characteristics of individuals who experienced a change in the timing of their move. Data used were based on census information collected between 2005 and 2008 using the interRAI Intellectual Disability assessment instrument on all persons residing in Ontario's specialized institutions. Analyses of characteristics at baseline by the anticipated transition year revealed the existence of significant differences between the groups. Comparisons of anticipated and actual transition years revealed that about 40% of individuals experienced a change in their transition year. Age, bladder incontinence, and number of medical diagnoses were associated with increased likelihood of moving earlier than anticipated, whereas family contact, presence of a strong and supportive relationship with family, psychiatric diagnoses, destructive behavior, and aggression were associated with higher likelihood of moving later. Careful attention to characteristics and level of need was paid at the onset of the deinstitutionalization planning process; however, the timing of transitions to the community was not "set in stone." In the future, studies should not only examine the individual's outcomes and quality of life in the community, but also should seek to qualitatively describe the individual's and family's experiences of the transition process. This type of information is invaluable for other jurisdictions in which deinstitutionalization is planned or under way. [source] | |||||||||||||