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Independent Contribution (independent + contribution)

Distribution by Scientific Domains
Medical Sciences35%
Psychology25%
Life Sciences16%
Humanities and Social Sciences9%
4 Other Domains15%

Kinds of Independent Contribution

  • significant independent contribution
    		•

    Selected Abstracts

    Longitudinal correlates of the persistence of irregular eating from age 5 to 14 years

    ACTA PAEDIATRICA, Issue 1 2010
    BM McDermott
    Abstract Aim:, To report the stability of parent-perceived child irregular eating from 6 months to 14 years of age and to investigate a predictive model inclusive of child and parent factors. Methods:, Of the 7223 singleton children in a birth cohort, 5122 children were re-interviewed at 5 years and 4554 for the 14-year analysis. Information was obtained from structured interviews including questions answered by parents of the child at birth, 6 months, 5 years and 14 years; and by teenagers at age 14 years and from physical measures of the child. The mother's perception that the child was an irregular eater at age 14 years was the major outcome variable of interest. Results:, Approximately 40% of irregular eaters at age 5 will still be irregular eaters at age 14 years. This was not related to maternal education or socio-economic class. Significant at multivariate analysis were infant feeding problems and the children's ability to regulate their sleep and mood. Significant maternal factors were greater age, not feeling positive about the baby and persistent maternal anxiety during the child's early years. Conclusion:, Irregular eating behaviour displays considerable continuity from childhood to mid-adolescence. Independent contributions to this behavioural phenotype include child biological and psychological factors and maternal anxiety during the child's early years. [source]

    Carnivore-Livestock Conflicts: Effects of Subsidized Predator Control and Economic Correlates on the Sheep Industry

    CONSERVATION BIOLOGY, Issue 3 2006
    KIM MURRAY BERGER
    Canis latrans; coyotes; depredación; evaluación de política Abstract:,Despite the importance of carnivores in terrestrial ecosystems, many nations have implemented well-coordinated, state-funded initiatives to remove predators, largely because of conflicts with humans over livestock. Although these control efforts have been successful in terms of the number of carnivores removed, their effects on the viability of the industries they seek to protect are less understood. I assessed the efficacy of long-term efforts by the U.S. government to improve the viability of the sheep industry by reducing predation losses. I used regression analysis and hierarchical partitioning of a 60-year data set to explore associations among changes in sheep numbers and factors such as predator control effort, market prices, and production costs. In addition, I compared trends in the sheep industry in the western United States, where predator control is subsidized and coyotes (Canis latrans) are abundant, with trends in eastern states that lack federally subsidized predator control and that were (1) colonized by coyotes before 1950 or (2) colonized by coyotes between 1950 and 1990. Although control efforts were positively correlated with fluctuations in sheep numbers, production costs and market prices explained most of the model variation, with a combined independent contribution of 77%. Trends in sheep numbers in eastern and western states were highly correlated (r ,0.942) independent of the period during which they were colonized by coyotes, indicating either that control has been ineffective at reducing predation losses or that factors other than predation account for the declines in both regions. These results suggest that government-subsidized predator control has failed to prevent the decline in the sheep industry and alternative support mechanisms need to be developed if the goal is to increase sheep production and not simply to kill carnivores. Resumen:,A pesar de la importancia de carnívoros en los ecosistemas terrestres, muchos países han implementado iniciativas bien coordinadas, financiadas por el gobierno, para remover depredadores, principalmente debido a conflictos entre humanos y ganado. Aunque estos esfuerzos de control han sido exitosos en términos del número de carnívoros removidos, sus efectos sobre la viabilidad de las industrias que se busca proteger son poco comprendidos. Evalué la eficacia de los esfuerzos a largo plazo del gobierno de E.U.A. para mejorar la viabilidad de la industria ovina mediante la reducción de pérdidas por depredación. Utilicé análisis de regresión y partición jerárquica de un conjunto de datos de 60 años para explorar asociaciones entre cambios en el número de ovejas y factores como el esfuerzo de control de depredadores, precios de mercado y costos de producción. Adicionalmente comparé las tendencias en la industria ovina en el oeste de Estados Unidos, donde el control de depredadores está subsidiado y los coyotes (Canis latrans) son abundantes, con las tendencias en los estados orientales que carecen de control subsidiado federalmente y que fueron (1) colonizados por coyotes antes de 1950 o (2) colonizados por coyotes entre 1950 y 1990. Aunque los esfuerzos de control se correlacionaron positivamente con las fluctuaciones en el número de ovejas, los costos de producción y los precios de mercado explicaron la mayor parte de la variación del modelo, con una contribución independiente combinada de 77%. Las tendencias en el número de ovejas en los estados orientales y occidentales estaban muy correlacionadas (r , 0.942) independientemente del período en que fueron colonizados por coyotes, lo que indica que el control ha sido ineficiente en la reducción de depredación o que factores, distintos a la depredación, son responsables de las declinaciones en ambas regiones. Estos resultados sugieren que el control subsidiado por el gobierno ha fallado en prevenir la declinación de la industria ovina y que se necesitan desarrollar mecanismos de soporte alternativos si la meta es incrementar la producción de ovejas y no simplemente matar carnívoros. [source]

    Risk factors for adult male criminality in Colombia

    CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2001
    Joanne Klevens
    Objectives This study sought to establish, in Colombia, the importance of factors alleged to be causes or correlates of adult criminality according to the published literature from other countries. Methods A comparison was made of arrested male offenders from ages 18 to 30 (n = 223) and similar community controls (n = 222) selected from five cities in Colombia as to their family background, exposure to abuse, family stressors, perceived care and history of childhood disruptive behaviour problems. Results Compared with neighbourhood controls from similar social classes, offenders were significantly more likely to report having had parents with less education, a mother under the age of 18 or over the age of 35 at time of birth, family members involved in crime, experiencing extreme economic deprivation, parental absence, family conflict, severe punishments, physical abuse, and maternal unavailability, rejection and lack of supervision. Prevalence of childhood disruptive behaviour problems was similar among offenders and controls. These findings appear to be independent of economic status, family size or type, birth order, or primary caregiver. Although the independent contribution of most of these factors is small, once all others have been controlled for, their cumulative effect is strong. Conclusions The findings obtained in this Latin American setting do not support the generalized view that adult antisocial behaviour is necessarily preceded by a history of childhood behaviour problems. However, they do add evidence for the importance of family factors in the risk for adult criminality. Copyright © 2001 Whurr Publishers Ltd. [source]

    Sequence learning in infancy: the independent contributions of conditional probability and pair frequency information

    DEVELOPMENTAL SCIENCE, Issue 6 2009
    Stuart Marcovitch
    The ability to perceive sequences is fundamental to cognition. Previous studies have shown that infants can learn visual sequences as early as 2 months of age and it has been suggested that this ability is mediated by sensitivity to conditional probability information. Typically, conditional probability information has covaried with frequency information in these studies, raising the possibility that each type of information may have contributed independently to sequence learning. The current study explicitly investigated the independent contribution of each type of information. We habituated 2.5-, 4.5-, and 8.5-month-old infants to a sequence of looming visual shapes whose ordering was defined independently by specific conditional probability relations among pair elements and by the frequency of occurrence of such pairs. During test trials, we tested infants' sensitivity to each type of information and found that both types of information independently influenced sequence learning by 4.5 months of age. [source]

    The relationship between local and regional diatom richness is mediated by the local and regional environment

    GLOBAL ECOLOGY, Issue 3 2009
    Sophia I. Passy
    ABSTRACT Aim, In this continental study, species richness at local (LSR) and regional (RSR) scales was correlated and examined as a function of stream (local) and watershed (regional) environment in an effort to elucidate what factors control diatom biodiversity across scales. Location, Conterminous United States. Methods, Data on diatom richness, stream conditions and watershed properties were generated by the US Geological Survey. In the present investigation, RSR was estimated as the total diatom richness in a hydrologic study unit and, together with stream and watershed characteristics, was included in stepwise multiple regressions of LSR. The unique and shared contributions of RSR, stream and watershed environment to the explained variance in LSR were determined by variance partitioning. RSR was regressed against stream and basin features averaged per study unit. Results, LSR responded most strongly to variability in stream manganese concentration and RSR. Other predictors included stream discharge and iron concentration, soil organic matter content and fertilization, and proportions of open water, barren land and forest in the watershed. Variance partitioning revealed that RSR had the lowest independent contribution to explained variance in LSR. Multiple regressions identified average stream iron concentration as the most important predictor of RSR. Main conclusions, Local micronutrient concentration was the major predictor of LSR, followed by RSR. Since average micronutrient supply in the region was the chief determinant of RSR, it is proposed that micronutrients had both a direct effect on LSR and an indirect effect through RSR. The same argument is extended to watershed features with an impact on stream trophic status, because of their substantial contributions to the explained variance in both LSR and RSR. Considering that the major proportion of LSR variance explained by RSR originated from the covariance of RSR with stream and watershed properties, it is concluded that the LSR,RSR relationship was mediated by the local and regional environment. [source]

    Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study ,

    HEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 12 2002
    George P. Browman MD
    Abstract Background. The study objective was to confirm a previous finding that patients with stage III/IV squamous head and neck cancer (SHNC) who smoke during radiotherapy (RT) experience reduced survival. Methods. An observational cohort study. Patients' smoking status was assessed weekly by questionnaire plus blood cotinine. Patients were assessed every 3 to 4 months for survival. Logistic regression and Cox proportional hazards analyses were used to detect the independent contribution of smoking on survival. Results. Of 148 patients, 113 smoked during RT. Blood cotinine and smoking questionnaire responses were highly correlated (Spearman R = .69; p < .0005). Abstainers and very light smokers experienced better survival than light, moderate, and heavy smokers (median, 42 vs 29 months; p = .07). Tumor and nodal status and years smoked were the most important prognostic factors. Smoking during RT was not an independent predictor of survival, but baseline smoking status was (p = .016). Conclusion. Smoking status should be documented in all future trials of RT in SHNC to allow for pooled analyses with sufficient power to address this question. © 2002 Wiley Periodicals, Inc. Head Neck 24: 1031,1037, 2002 [source]

    Attachment behaviour towards support staff in young people with intellectual disabilities: associations with challenging behaviour

    JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 7 2010
    J. C. De Schipper
    Abstract Background Attachment research has shown the importance of attachment behaviour for the prevention of dysregulated behaviour due to emotional distress. The support of an attachment figure may be especially important for people with intellectual disability (ID), because they are less adept in dealing with stressful situations on their own. Our purpose was to examine the role of support staff as targets of attachment behaviour for young people with ID by testing the hypothesis that young people who more often engage in attachment interactions with group care staff are less at risk for challenging behaviours. The study design included professional caregivers' report of young persons' attachment behaviour across different relationships to address the relationship-specific nature of attachment behaviour in a group care context. Methods Support staff rated attachment behaviour of 156 young participants with moderate to severe ID who were attending a group care setting. For each participant, we asked two members of the classroom support staff to fill out the Secure Base Safe Haven Observation list. One of them also rated challenging behaviour (Abberant Behavior Checklist). Results Young people who showed more secure attachment behaviour towards professional caregivers were less irritable, less lethargic and less stereotypic in their behaviour, even if we controlled for developmental age and Autism Spectrum Disorders. Two results point in the direction of relationship-specific attachment behaviour: the absence of high consistency in a person's attachment behaviour towards two different caregivers and the independent contribution of each of these relationships to explaining differences in lethargy and stereotypies. A certain preference in attachment behaviour towards specific caregivers was not associated with challenging behaviour. Conclusions Findings suggest that attachment behaviour may be part of young persons' adaptation to the stresses and challenges of group care. Furthermore, adaptation may be determined by the integration of relationships with support staff, because each relationship with a care staff member bears uniquely on challenging behaviour. [source]

    Car ownership and welfare-to-work

    JOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 2 2002
    Paul M. Ong
    This study examines the role of car ownership in facilitating employment among recipients under the current welfare-to-work law. Because of a potential problem with simultaneity, the analysis uses predicted car ownership constructed from two instrumental variables, insurance premiums and population density for car ownership. The data come from a 1999,2000 survey of TANF recipients in the Los Angeles metropolitan area. The empirical results show a significant independent contribution of car ownership on employment. The presence of an predicted ownership is associated with a 9 percentage point increase in the odds of being employed. Moreover, the results indicate that lowering insurance premiums by $100 can increase the odds of employment by 4 percentage points. © 2002 by the Association for Public Policy Analysis and Management. [source]

    Coping with chronic pain associated with cerebral palsy

    OCCUPATIONAL THERAPY INTERNATIONAL, Issue 4 2006
    Joyce M. Engel
    Abstract Fifty-nine adults with cerebral palsy (CP) were administered, via in-person interviews, measures of pain intensity, pain-related disability, and psychological functioning, in addition to a measure of pain coping (Waldron/Varni Pediatric Pain Coping Inventory; PPCI). Regression analyses indicated that the PPCI scales made a nonsignificant contribution to the prediction of pain intensity, but did make a significant contribution to the prediction of psychological functioning when controlling for pain intensity. Only the PPCI Catastrophizing subscale made a significant independent contribution to the prediction of psychological functioning, and only the PPCI Seek Social Support subscale made a significant independent contribution to the prediction of pain-related disability. These findings support a link between coping and functioning among adults with CP, and suggest that catastrophizing responses and some aspects of support seeking may be maladaptive for coping with CP-related pain. Limitations of the study include a correlational design, a reliance on self-report data, and a small subject population. Experimental research is needed to determine if changes in coping lead to changes in psychological and physical functioning. Copyright © 2006 John Wiley & Sons, Ltd. [source]

    Human Rights Violations, Corruption, and the Policy of Repression

    POLICY STUDIES JOURNAL, Issue 1 2008
    Alok K. Bohara
    Quantitative cross-national research on human rights violations and repression has made considerable progress in identifying and eliminating economic and political factors that influence the use of torture and killing by governments. Warfare tends to increase violations, democracy,notably full democracy,and trade tends to inhibit violations. Where motives have been considered, this research has generally assumed a strategic motivation for government use of repression. Repression is employed to counter threats from the opposition as represented by the presence of warfare. Less attention has been given to the effect of implementation on levels of repression. Theory suggests that agents are likely to make a substantial independent contribution to the level of repression, if given the opportunity. In this article we develop this argument and present cross-country comparative evidence that suggests that agents' opportunities for hidden action measured by perceived levels of financial corruption substantially influences the incidence of torture in a political system, after controlling for the strategic motive of governments and the other factors found influential in earlier research. We show that the results are robust and not sensitive to alternative modeling, measurement, and research-design decisions. [source]

    Dynamics of Interpersonal Political Environment and Party Identification: Longitudinal Studies of Voting in Japan and New Zealand

    POLITICAL PSYCHOLOGY, Issue 4 2005
    Ken'ichi Ikeda
    The dynamical systems theory of groups claims that interpersonal political environment and party identification are dynamically interrelated to provide heuristics under uncertainty. Panel data over the course of a year examined the longitudinal dynamics between social networks, social identifications, and voting behavior among a national sample of registered voters in Japan and a regional sample in Wellington, New Zealand. Respondents with more stable party identification had greater stability in the political preferences of their interpersonal network in both countries; moreover, stability in party identification was predicted by interpersonal political environment and older age in both countries. Stability of party identification predicted voting consistency in both countries, whereas stability of interpersonal political environment made an independent contribution to voting consistency in Japan only. There were cultural differences in levels of interpersonal political environment stability, but the amount of political discussion and ideological stability did not make independent contributions to any of the three main variables. Results provided support for the dynamical systems theory of groups. [source]

    Long QT Syndrome in Patients over 40 Years of Age: Increased Risk for LQTS-Related Cardiac Events in Patients with Coronary Disease

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, Issue 4 2008
    Edward Sze B.A.
    Background: Previous studies of long QT syndrome (LQTS) have focused primarily on the clinical course of affected patients up to 40 years of age to avoid the confounding influence of acquired heart disease on LQTS-related cardiac events in this genetic disorder. Methods: Patients were identified as having coronary disease if they had a history of hospitalization for myocardial infarction, coronary angioplasty, coronary artery bypass graft surgery, or were treated with medication for angina. LQTS-related cardiac events included the first occurrence of syncope, aborted cardiac arrest, or sudden cardiac death without evidence suggestive of an acute coronary event. Cox proportional hazards regression modeling was used to analyze the independent contribution of coronary disease to LQTS-related cardiac events. Results: Time-dependent coronary disease was associated with an increased risk of LQTS-related cardiac events (hazard ratio 2.24, 95% confidence interval 1.23,4.07, P = 0.008) after adjustment for syncopal history before age 40, QTc, and gender. Factors such as diabetes and hypertension that increase the risk for coronary disease were not associated with an increased risk for LQTS-related cardiac events. Conclusions: This is the first study to demonstrate that coronary disease augments the risk for LQTS-related cardiac events in LQTS. The findings highlight the need for more focused preventive therapy in LQTS patients above the age of 40. [source]

    C-reactive protein: an independent predictor of cardiovascular disease in Aboriginal Australians

    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 2010
    Zhiqiang Wang
    Abstract Objectives: We assessed the independent contribution of C-reactive protein to the risk of cardiovascular disease in Aboriginal Australians. Methods: High sensitivity CRP levels were measured in 705 Aboriginal participants aged 20,74 years free from CVD at baseline. Participants were followed for a median of 11 years. Cox proportional hazards models were used to assess the association of CRP with the risk of developing CVD events. Results: A total of 114 participants were diagnosed with CVD. Incidence rates were 5.4 and 21.4 per 1,000 person-years for the lower (<3 mg/l) and the higher (,3 mg/l) CRP groups, respectively. After adjusting for age, sex, total cholesterol, systolic blood pressure, smoking status, diabetes, BMI and waist circumference, the association between CRP and CVD remained significant, with a hazard ratio of 2.40 (95% CI: 1.25, 4.62) for the higher CRP group relative to the lower CRP group. The population attributable risk was 52% (95% CI: 14%, 74%). Conclusions: CRP is an independent predictor of CVD in Aboriginal people. A large proportion of CVD cases are associated with elevated CRP levels. Therefore, controlling the conditions that cause inflammation may be beneficial to cardiovascular health in Aboriginal communities. [source]

    Combining a symptoms index with CA 125 to improve detection of ovarian cancer

    CANCER, Issue 3 2008
    M. Robyn Andersen PhD
    Abstract BACKGROUND. The current study sought to examine whether an index based on the specific pattern of symptoms commonly reported by women with ovarian cancer could be used in combination with CA 125 to improve the sensitivity or specificity of experimental methods of screening for ovarian cancer. METHODS. A prospective case-control study design was used. Participants included 254 healthy women at high risk for disease because of family history, and 75 women with ovarian cancer. Logistic regression analysis was used to determine whether the symptom index predicted cancer. RESULTS. Symptom index information was found to make a significant independent contribution to the prediction of ovarian cancer after controlling for CA 125 levels (P<.05). The combination of CA 125 and the symptom index identified 89.3% of the women with cancer, 80.6% of the early,stage cancers, and 95.1% of the late-stage cancers. The symptom index identified cancer in 50% of the affected women who did not have elevated CA 125 levels. Unfortunately, 11.8% of the high-risk women without cancer also received a positive symptom index score. CONCLUSIONS. The addition of a symptom index to CA 125 created a composite index with a greater sensitivity for the detection of ovarian cancer than CA 125 alone and identified >80% of women with early-stage disease. A composite marker such as this could serve as a first screen in a multistep screening program in which false-positive findings are identified via transvaginal sonography before referral for surgery, leading to an adequate positive predictive value for the multistep program. Cancer 2008. © 2008 American Cancer Society. [source]

    Impact of specific sensitization on asthma and rhinitis in young Brazilian and Chilean adults

    CLINICAL & EXPERIMENTAL ALLERGY, Issue 11 2008
    R. J. Rona
    Summary Background The pattern of associations and the attributable fractions (AF) of atopic conditions due to specific sensitizations vary between countries. Objective To assess the level of associations and AF between sensitization to five allergens and atopic conditions in two settings. Methods We studied 2063 Brazilians and 1231 Chileans of both sexes using representative samples selected at birth in the 1970s. Information on asthma and rhinitis was based on the European Community Respiratory Health Survey questionnaire. We assessed bronchial hyperresponsiveness (BHR) to methacholine and sensitization to Dermatophagoides pteronyssinus, cat, dog, grass blend and Alternaria alternata. Results The prevalence of sensitization to one or more allergens was 50% in Brazilians and 22% in Chileans. The level of associations varied according to the outcome used. Strong associations between sensitization and asthma, defined as wheeze or awakening with breathlessness at night and positive BHR, were found for each of the five allergens in Chileans [varying from odds ratio (OR) 3.24, 95% confidence interval (CI) 1.47, 7.15 for D. pteronyssinus to 8.44, 95% CI 3.82, 18.66 for cat], whereas the level of associations was restricted to D. pteronyssinus, cat and dog in Brazilians and was somewhat weaker (highest OR 3.90, 95% CI 2.80,5.44). The AF of sensitization on asthma was 54% in Brazil and 44% in Chile. D. pteronyssinus and cat made an independent contribution to asthma in the two samples. The patterns of associations between sensitization and rhino-conjunctivitis were similar to those for asthma. Conclusion The associations between sensitization, and asthma and rhinitis were high in Chile and moderately high in Brazil, but the AF were higher in Brazil, reflecting a higher prevalence of sensitization. In Brazil, dust mite had the greatest impact on atopic conditions while in Chile several allergens had an impact. Sensitization is as serious a problem in Chile and Brazil as in developed countries. [source]

    Spatial Reasoning With External Visualizations: What Matters Is What You See, Not Whether You Interact

    COGNITIVE SCIENCE - A MULTIDISCIPLINARY JOURNAL, Issue 7 2008
    Madeleine Keehner
    Abstract Three experiments examined the effects of interactive visualizations and spatial abilities on a task requiring participants to infer and draw cross sections of a three-dimensional (3D) object. The experiments manipulated whether participants could interactively control a virtual 3D visualization of the object while performing the task, and compared participants who were allowed interactive control of the visualization to those who were not allowed control. In Experiment 1, interactivity produced better performance than passive viewing, but the advantage of interactivity disappeared in Experiment 2 when visual input for the two conditions in a yoked design was equalized. In Experiments 2 and 3, differences in how interactive participants manipulated the visualization were large and related to performance. In Experiment 3, non-interactive participants who watched optimal movements of the display performed as well as interactive participants who manipulated the visualization effectively and better than interactive participants who manipulated the visualization ineffectively. Spatial ability made an independent contribution to performance on the spatial reasoning task, but did not predict patterns of interactive behavior. These experiments indicate that providing participants with active control of a computer visualization does not necessarily enhance task performance, whereas seeing the most task-relevant information does, and this is true regardless of whether the task-relevant information is obtained actively or passively. [source]

    Sequence learning in infancy: the independent contributions of conditional probability and pair frequency information

    DEVELOPMENTAL SCIENCE, Issue 6 2009
    Stuart Marcovitch
    The ability to perceive sequences is fundamental to cognition. Previous studies have shown that infants can learn visual sequences as early as 2 months of age and it has been suggested that this ability is mediated by sensitivity to conditional probability information. Typically, conditional probability information has covaried with frequency information in these studies, raising the possibility that each type of information may have contributed independently to sequence learning. The current study explicitly investigated the independent contribution of each type of information. We habituated 2.5-, 4.5-, and 8.5-month-old infants to a sequence of looming visual shapes whose ordering was defined independently by specific conditional probability relations among pair elements and by the frequency of occurrence of such pairs. During test trials, we tested infants' sensitivity to each type of information and found that both types of information independently influenced sequence learning by 4.5 months of age. [source]

    Drop-out from inpatient treatment for anorexia nervosa: can risk factors be identified at point of admission?

    EUROPEAN EATING DISORDERS REVIEW, Issue 2 2004
    Lois J. Surgenor
    Abstract Despite renewed interest in drop-out from eating disorders treatment, few studies have investigated the issue in respect to the most expensive and intensive form of treatment, that is, inpatient treatment for anorexia nervosa (AN). This study investigates whether risk of treatment drop-out can be determined from information routinely collected at point of admission. Using information from a multi-site database collected in Australia and New Zealand, demographic and clinical data at point of admission were collated for 213 inpatient treatment episodes. One in five admissions ended with the patient unilaterally deciding to leave treatment without clinician endorsement. A lower body mass index, AN purging subtype and active fluid restriction made significant independent contributions to this risk. Drop-out remains a highly disruptive method of discharge and while there is utility in predicting those most at risk, few variables commonly collated by clinicians contribute to their identification. The implications for clinical practice and future research are discussed. Copyright © 2003 John Wiley & Sons, Ltd and Eating Disorders Association. [source]

    Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion

    EUROPEAN JOURNAL OF IMMUNOLOGY, Issue 3 2003
    Matthew
    Abstract The mechanisms by which CD40 controls the maturation and antigen presentation functions of dendritic cells (DC) remains largely undefined in this critical cell type. To examine this question, we have employed retroviral transduction of primary bone marrow-derived mouse DC. Mutation of the distinct binding sites for TNF receptor-associated factor 6 (TRAF6) and for TRAF 2, 3, and 5 in the CD40 cytoplasmic domain revealed their independent contributions to DC maturation and activation of NF-,B. In contrast, disruption of the TRAF6 but not the TRAF 2,3,5 binding site markedly decreased IL-12 p40 secretion along with p38 and JNK activation in response to CD154 stimulation. These data document a clear bifurcation of the CD40 signaling cascade in primary DC at the level of thereceptor's two distinct and autonomous TRAF binding sites, and reveal the predominant role of the TRAF6 binding site in CD40-induced pro-inflammatory cytokine production by these cells. [source]

    Distinct contributions of the amygdala and hippocampus to fear expression

    EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 12 2009
    Yogita Chudasama
    Abstract The present study attempted to distinguish the independent contributions of the amygdala and hippocampus to fear expression. Rhesus monkeys (Macaca mulatta) with bilateral excitotoxic amygdala lesions (n = 4), bilateral excitotoxic hippocampal lesions (n = 8) and unoperated controls (n = 9) were allowed to reach over a neutral junk object or fear-provoking stimulus (i.e., a rubber snake or a jumping rubber spider) to retrieve a food reward. Monkeys were exposed to each stimulus for 30 s. On each trial we recorded the monkey's latency to retrieve the food reward and scored their whole-body reactions to the object. Confirming previous work we found that, relative to controls, both operated groups showed shorter food-retrieval latencies and exhibited fewer defensive and more approach behaviors when exposed to the fear-provoking stimuli. However, only monkeys with amygdala lesions showed an abnormal, excessive visual interest in the snake and spider. By contrast, monkeys with hippocampal lesions displayed behaviors that were unrelated to the presence of the fear stimuli, thereby indicating a lack of interest in, and emotional reactivity towards, the snake and spider. These data show that the hippocampus and amygdala contribute independently to the overall expression of defensive responses. [source]

    Surviving the paradoxes of virtual teamwork

    INFORMATION SYSTEMS JOURNAL, Issue 1 2009
    Line Dubé
    Abstract Despite the potential benefits of virtual teams, current literature suggests that virtual teamwork is rife with complex challenges. We frame some of these challenges as paradoxes inherent in the concept of virtual teamwork. Based on interviews with 42 leaders and members of virtual teams, we identify five paradoxes: (1) virtual teams require physical presence; (2) flexibility of virtual teamwork is aided by structure; (3) interdependent work in virtual teams is accomplished by members' independent contributions; (4) task-oriented virtual teamwork succeeds through social interactions; and (5) mistrust is instrumental to establishing trust among virtual team members. In addition, we identify strategies that respondents used to cope with, or ,survive' the paradoxes of virtual teamwork. [source]

    Climate and landscape correlates of African lion (Panthera leo) demography

    AFRICAN JOURNAL OF ECOLOGY, Issue 1 2010
    Gastone G. Celesia
    Abstract Although many studies have documented aspects of lion ecology, they have generally focused on single sites, leaving broader-scaled factors unanalysed. We assessed range-wide effects of eight biotic and 26 abiotic variables on lion distribution and ecology, based on data compiled from published sources on lion population ecology in 27 protected areas in Africa. Lion pride size and composition were independent of lion density; lion density and home range size were inversely related; and lion density was positively related to rainfall, soil nutrients and annual mean temperature, with some interactive effects between rainfall and soil nutrients. Lion demography was associated most strongly with rainfall, temperature and landscape features. Herbivore biomass and lion density were correlated in univariate regression analyses. However, because herbivore biomass was also related to rainfall and temperature, hierarchical partitioning (HP) allowed us to evaluate independent effects of each variable on lion demography revealing that herbivore biomass had negligible independent contributions. HP indicated that climatic parameters explained 62% of overall variance in demographic parameters, whereas landscape features explained only 32%; climatic parameters were fairly balanced between effects of temperature (34%) and rainfall (28%). Prey (herbivore) biomass is important for lion survival, but its effects appear secondary to environmental factors. Résumé Bien que de nombreuses études apportent des informations sur des aspects de l'écologie des lions, elles se sont généralement focalisées sur des sites individuels, laissant de côté les facteurs à plus grande échelle. Nous avons analysé les effets à grande échelle de huit variables biotiques et de 26 variables abiotiques de la distribution et de l'écologie du lion, en nous fondant sur des données compilées à partir de publications portant sur l'écologie de populations de lions dans 27 aires protégées africaines. La taille et la composition des troupes de lions étaient indépendantes de leur densité; la densité et la taille du territoire des lions étaient inversement liées; et la densité des lions était directement liée aux chutes de pluies, aux nutriments du sol et à la moyenne annuelle des températures, certains effets interactifs étant observés entre les chutes de pluies et les nutriments du sol. La démographie des lions était surtout liée aux chutes de pluies, à la température et à certaines caractéristiques du paysage. La biomasse des herbivores et la densité des lions étaient liées dans les analyses de régressions univariées. Cependant, comme la biomasse des herbivores est aussi liée aux chutes de pluies et aux températures, la partition hiérarchique (PH) nous a permis d'évaluer les effets indépendants de chaque variable sur la démographie des lions, ce qui révèle que la biomasse des herbivores, prise indépendamment, représentait une contribution négligeable. La PH indiquait que les paramètres climatiques expliquaient 62% de la variance globale des paramètres démographiques, alors que les caractéristiques du paysage n'en expliquaient que 32%; les paramètres climatiques étaient en assez bon équilibre entre les effets de la température (34%) et ceux des chutes de pluies (28%). La biomasse des proies (herbivores) est importante pour la survie des lions, mais ses effets semblent secondaires par rapport à ceux des facteurs environnementaux. [source]

    Aggressive behavior in response to violence exposure: is it adaptive for middle-school children?,

    JOURNAL OF COMMUNITY PSYCHOLOGY, Issue 8 2008
    Suzanne Salzinger
    The role of aggression in adaptation to family and community violence was examined in a sample of 667 inner-city schoolchildren studied annually over three years in middle school. Regression analyses indicated that the association between Year 1 exposure to family and community violence and Year 2 aggression was mediated by aggression occurring contemporaneously with Year 1 exposure. Cognitive justification of aggression and friends' delinquency made small independent contributions to prediction of Year 2 aggression, delinquency, and externalizing behaviors. Year 2 aggression mediated the association between Year 1 community violence victimization and Year 3 negative adaptation (internalizing problems, anxiety, and depression). Year 2 aggression also mediated the negative association between Year 1 witnessing community violence and Year 3 positive adaptation (self-esteem). Cognitive justification of aggression and friends' delinquency made independent contributions to Year 3 negative adaptation. The pattern of relations among variables infrequently varied by gender. Implications for intervention are discussed. © 2008 Wiley Periodicals, Inc. [source]

    Fitness, fatness and activity as predictors of bone mineral density in older persons

    JOURNAL OF INTERNAL MEDICINE, Issue 5 2002
    K. J. Stewart
    Abstract. Stewart KJ, DeRegis JR, Turner KL, Bacher AC, Sung J, Hees PS, Tayback M, Ouyang P (Johns Hopkins Bayview Medical Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA). Fitness, fatness, and activity as predictors of bone mineral density in older persons. J Intern Med 2002; 252: 381,388. Objectives. To determine relationships of bone mineral density (BMD) with fitness, physical activity, and body composition and fat distribution. Design. Cross-sectional. Setting. General Clinical Research Center, Johns Hopkins Bayview Medical Center, Baltimore, Maryland. Subjects. Men (n = 38) and women (n = 46), aged 55,75 years with high normal blood pressure or mild hypertension but otherwise healthy. Methods. Aerobic fitness (oxygen uptake) on a treadmill, muscle strength by one-repetition maximum, activity by questionnaire, abdominal obesity by magnetic resonance imaging; anthropometrics, and body composition by dual energy X-ray absorptiometry (DXA) which measured total fat and lean mass, and BMD for the total skeleton, lumbar spine (L1,L4) and total hip. Results. Aerobic fitness did not correlate with BMD. Using multivariate analysis to ascertain independent contributions to the variance in BMD, in women, with adjustment for hormone replacement therapy (HRT), total skeleton BMD was independently related to muscle strength and abdominal total fat; total hip BMD to body weight; lumbar spine BMD to abdominal total fat. HRT also influenced BMD in the lumbar spine. In men, lumbar spine BMD was independently related to abdominal total fat physical activity and total hip BMD related to lower body strength. P < 0.05 for all of these correlations. Conclusions. Abdominal obesity and muscle strength emerge as predominant correlates of BMD in older persons with stronger relationships seen in women. Body weight and HRT also explained portions of the variance in BMD in women. Whether abdominal obesity is simply a marker for general obesity or has independent protective effects on bone is yet to be determined. [source]

    Studies on the cellular uptake of substance P and lysine-rich, KLA-derived model peptides,

    JOURNAL OF MOLECULAR RECOGNITION, Issue 1 2005
    Johannes Oehlke
    Abstract In the last decade many peptides have been shown to be internalized into various cell types by different, poorly characterized mechanisms. This review focuses on uptake studies with substance P (SP) aimed at unravelling the mechanism of peptide-induced mast cell degranulation, and on the characterization of the cellular uptake of designed KLA-derived model peptides. Studies on structure,activity relationships and receptor autoradiography failed to detect specific peptide receptors for the undecapeptide SP on mast cells. In view of these findings, a direct interaction of cationic peptides with heterotrimeric G proteins without the participation of a receptor has been proposed. Such a process would require insertion into and translocation of peptides across the plasma membrane. In order to clarify whether a transport of cationic peptides into rat peritoneal mast cells is possible, transport studies were performed by confocal laser scanning microscopy (CLSM) using fluorescence-labeled Arg3,Orn7 -SP and its D -amino acid analog, all- D -Arg3,Orn7 -SP, as well as by electron microscopic autoradiography using 3H-labelled SP and 125I-labelled all- D -SP. The results obtained by CLSM directly showed translocation of SP peptides into pertussis toxin-treated cells. Kinetic experiments indicated that the translocation process was rapid, occurring within a few seconds. Mast cell degranulation induced by analog of magainin 2 amide, neuropeptide Y and the model peptide acetyl-KLALKLALKALKAALKLA-amide was also found to be very fast, pointing to an extensive translocation of the peptides. In order to learn more about structural requirements for the cellular uptake of peptides, the translocation behavior of a set of systematically modified KLA-based model peptides has been studied in detail. By two different protocols for determining the amount of internalized peptide, evidence was found that the structure of the peptides only marginally affects their uptake, whereas the efflux of cationic, amphipathic peptides is strikingly diminished, thus allowing their enrichment within the cells. Although the mechanism of cellular uptake, consisting of energy-dependent and -independent contributions, is not well understood, KLA-derived peptides have been shown to deliver various cargos (PNAs, peptides) into cells. The results obtained with SP- and KLA-derived peptides are discussed in the context of the current literature. Copyright © 2004 John Wiley & Sons, Ltd. [source]

    Family history, self-perceptions, attitudes and cognitive abilities are associated with early adolescent reading skills

    JOURNAL OF RESEARCH IN READING, Issue 1 2006
    Elizabeth G. Conlon
    This study evaluated a model of reading skills among early adolescents (N=174). Measures of family history, achievement, cognitive processes and self-perceptions of abilities were obtained. Significant relationships were found between family history and children's single-word reading skills, spelling, reading comprehension, orthographic processing and children's perceived reading competence. While children with poor reading skills were five times more likely to come from a family with a history of reading difficulties, this measure did not account for additional variance in reading performance after other variables were included. Phonological, orthographic, rapid sequencing and children's perceived reading competence made significant independent contributions towards reading and spelling outcomes. Reading comprehension was explained by orthographic processing, nonverbal ability, children's attitudes towards reading and word identification. Thus, knowledge of family history and children's attitudes and perceptions towards reading provides important additional information when evaluating reading skills among a normative sample of early adolescents. [source]

    Dynamics of Interpersonal Political Environment and Party Identification: Longitudinal Studies of Voting in Japan and New Zealand

    POLITICAL PSYCHOLOGY, Issue 4 2005
    Ken'ichi Ikeda
    The dynamical systems theory of groups claims that interpersonal political environment and party identification are dynamically interrelated to provide heuristics under uncertainty. Panel data over the course of a year examined the longitudinal dynamics between social networks, social identifications, and voting behavior among a national sample of registered voters in Japan and a regional sample in Wellington, New Zealand. Respondents with more stable party identification had greater stability in the political preferences of their interpersonal network in both countries; moreover, stability in party identification was predicted by interpersonal political environment and older age in both countries. Stability of party identification predicted voting consistency in both countries, whereas stability of interpersonal political environment made an independent contribution to voting consistency in Japan only. There were cultural differences in levels of interpersonal political environment stability, but the amount of political discussion and ideological stability did not make independent contributions to any of the three main variables. Results provided support for the dynamical systems theory of groups. [source]

    Do fall predictors in middle aged and older adults predict fall status in persons 50+ with fibromyalgia?

    RESEARCH IN NURSING & HEALTH, Issue 3 2010
    An exploratory study
    Abstract We explored potential predictors of fall status in 70 community-dwelling persons ,50 years of age with fibromyalgia (FM). Over 40% of the sample reported one or more falls in the year prior to the study. A logistic regression model using 10 variables known to predict falls in middle aged and older persons predicted 45% of the variance in fall status. Three variables offered significant independent contributions to the overall model predicting fall status: perception of postural instability, balance performance, and executive function processing speed. The results support prior work in both nonclinical and clinical populations of middle aged and older adults indicating that falls are associated with multiple risk factors. Prospective designs with larger samples are needed to (a) validate and extend these findings, and (b) identify risk factors related to fall status that are unique to persons with FM. © 2010 Wiley Periodicals, Inc. Res Nurs Health 33:192,206, 2010 [source]

    Predictors of treatment outcome in dually-diagnosed antisocial youth: an initial study of forensic inpatients

    BEHAVIORAL SCIENCES & THE LAW, Issue 2 2004
    Richard Rogers Ph.D.
    The safe and effective management of adolescent offenders is a top priority for inpatient forensic programs. Treatment successes were examined for adolescent offenders on four parameters, specifically hospital course, level of improvement, time to discharge, and rapidity of improvement. Hospital course was predicted primarily by the breadth of polysubstance abuse with modest but independent contributions by psychopathic characteristics, and aggressive conduct-disorder symptoms. An important finding for treatment was that level of improvement at discharge was only marginally affected by psychopathic traits. In addition, rapidity of improvement was predicted only by decreased polysubstance abuse. Approximately one-fourth of the adolescent offenders experienced a substantial decrease in psychopathic characteristics. This finding was unexpected because the generic treatment program did not target the core elements of psychopathy. Even in the absence of nontreatment controls, this diminution of psychopathic traits in 25% of adolescent offenders raises important questions about the temporal stability of these traits and their potential amenability to generic interventions. Copyright © 2003 John Wiley & Sons, Ltd. [source]

    Interactions between Conserved Residues in Transmembrane Helices 2 and 7 during Angiotensin AT1 Receptor Activation

    CHEMICAL BIOLOGY & DRUG DESIGN, Issue 5 2006
    Gregory V. Nikiforovich
    Site-directed mutagenesis studies and independent molecular modeling studies were combined to investigate the network of inter-residue interactions within the transmembrane region of the angiotensin AT1a receptor. Site-directed mutagenesis was focused on residues Tyr292, Asn294, Asn295, and Asn298 in transmembrane helix 7, and the conserved Asp74 in helix 2 and other polar residues. Functional interactions between pairs of residues were evaluated by determining the effects of single and double-reciprocal mutations on agonist-induced AT1a receptor activation. Replacement of Tyr292 by aspartate in helix 7 abolished radioligand binding to both Y292D and D74Y/Y292D mutant receptors. Reciprocal mutations of Asp74/Asn294, Ser115/Asn294, Ser252/Asn294, and Asn298/Sen115 caused additive impairment of function, suggesting that these pairs of residues make independent contributions to AT1a receptor activation. In contrast, mutations of the Asp74/Tyr298 pair revealed that the D74N/N298D reciprocal mutation substantially increased the impaired inositol phosphate responses of the D74N and N298D receptors. Extensive molecular modeling yielded 3D models of the TM region of the AT1 receptor and the mutants as well as of their complexes with angiotensin II, which were used to rationalize the possible reasons of impairing of function of some mutants. These data indicate that Asp74 and Asn298 are not optimally positioned for direct strong interaction in the resting conformation of the AT1a receptor. Balance of interactions between residues in helix 2 (as D74) and helix 7 (as N294, N295 and N298) in the AT1 receptors, however, has a crucial role both in determining their functional activity and levels of their expression. [source]