Increasing Quartiles (increasing + quartile)

Distribution by Scientific Domains

Selected Abstracts

Preoperative plasma MMP-2 expression is prognostic in colorectal cancer

M. G. Tutton
Introduction:, The gelatinases (MMP-2 and MMP-9) are important in colorectal cancer invasion and metastasis. Plasma concentrations of the gelatinases correlate with clinical stage in colorectal cancer; however, whether this gives prognostic information is unknown. Method:, Gelatinase mRNA and protein levels in tumour and plasma were determined respectively by RT-PCR, ELISA and gelatin zymography in a prospective study of 75 colorectal cancer patients. At follow-up, 40 patients were alive with a median survival of 75 months (range 72,80). Results:, Expression of the gelatinases was significantly increased within tumour relative to normal colon and within plasma of cancer patients (P < 0.01; Mann,Whitney U -test). Within plasma, total MMP-2 and MMP-9 expression (MMP plus MMP/TIMP complexes), determined by ELISA, and free MMP-2(72 kDa) determined by gelatin zymography, increased significantly with Dukes' stage (P < 0.001; Kruskal,Wallis test). As well as correlating with Dukes' stage, lymphatic and vascular invasion, Kaplan,Meier survival analysis showed that only elevated plasma MMP-2 was significantly associated with a worse prognosis: free MMP-2 (worse prognosis with increasing quartile; P < 0.05) and total MMP-2 (upper quartile cut-off limit; P = 0.04). Discussion:, In addition to being an indicator of colorectal cancer invasion, plasma MMP-2 levels may provide a simple, non-invasive preoperative test for prognosis in colorectal cancer. [source]

Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin

R. G. IJzerman
Abstract Background To investigate whether microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function, we investigated skin microvascular function in individuals with increased coronary heart disease (CHD) risk. Materials and methods Forty-six healthy White individuals aged 30,70 years were studied. Coronary heart disease risk was assessed with the use of the CHD risk score according to the Framingham Heart Study, which is based on the risk factors age, blood pressure, cigarette smoking, total cholesterol, HDL cholesterol and diabetes. Endothelium-dependent and -independent vasodilation in skin were evaluated with laser Doppler after iontophoresis of acetylcholine and sodium nitroprusside. Videomicroscopy was used to measure recruitment of skin capillaries after arterial occlusion. Results Coronary heart disease risk score (i.e. the 10-year probability of CHD) varied from 1,37%. Microvascular function decreased with increasing quartiles of CHD risk (for acetylcholine-mediated vasodilation: 687, 585, 420 and 326%, P = 0002; for nitroprusside-mediated vasodilation: 776, 582, 513 and 366%, P = 002; for capillary recruitment: 499, 446, 272 and 267%, P = 0001). These trends were similar in men and women (P for interaction > 02) and independent of body mass index. Conclusions Increased CHD risk is associated with an impaired endothelium-dependent vasodilatation and capillary recruitment in skin, suggesting that microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function. [source]

Prevalence of abdominal obesity in primary care: the IDEA UK study

J. Morrell
Summary Background:, Abdominal obesity is known to be a risk factor for cardiovascular and metabolic diseases. However, despite the importance of abdominal obesity as a risk factor for cardiovascular and metabolic disease, there are currently no UK-specific data on its prevalence in patients attending primary care. Aim:, The aim of the International Day for the Evaluation of Abdominal obesity (IDEA)-UK observational study was to determine the distribution of waist circumference , a marker of abdominal obesity , and its relationship with cardiovascular risk markers in a UK-based primary care population. Methods:, Patients underwent measurements of height, weight and waist circumference and provided data on reported cardiovascular disease (CVD), diabetes, hypertension and dyslipidaemia. Results:, A total of 1731 patients were assessed within the study, of which 719 were male and 1012 were female. Of these 1731 patients, 1718 had complete datasets for the presence of reported cardiovascular risk factors. Median waist circumference in the male and female populations respectively was 99.0 cm [interquartile range (IQR) 91.0,108.0 cm] and 89.0 cm (IQR 79.0,100 cm). In all, 38.8% of men and 51.2% of women were abdominally obese (waist circumference > 102 cm and > 88 cm respectively) according to the US National Cholesterol Education Program (NCEP) guidelines. Within both male and female populations, the incidence of reported CVD, lipid disorders, hypertension and diabetes increased with increasing quartiles for waist circumference. Conclusion:, Increased waist circumference is widespread in patients attending primary care in the UK and is associated with elevated levels of reported diabetes, hypertension, lipid disorders and CVD. [source]

Bleeding on probing differentially relates to bacterial profiles: the Oral Infections and Vascular Disease Epidemiology Study

Ryan T. Demmer
Abstract Aim: Various bacterial species are differentially prevalent in periodontal health, gingivitis or periodontitis. We tested the independent associations between three bacterial groupings and gingival inflammation in an epidemiological study. Material and Methods: In 706 Oral Infections and Vascular Disease Epidemiology Study (INVEST) participants 55 years, bleeding on probing (BoP), pocket depth (PD) and subgingival plaque samples (n=4866) were assessed in eight sites per mouth. Eleven bacterial species were quantitatively assayed and grouped as follows: (i) aetiologic burden (EB, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia); (ii) putative burden (PB, Campylobacter rectus, Eikenella corrodens, Fusobacterium nucleatum, Micromonas micros, Prevotella intermedia); (iii) health-associated burden (HAB, Actinomyces naeslundii, Veillonella parvula). Results: After mutual adjustment for EB, PB and HAB, the BoP prevalence increased by 45% ( p<0.0001) across increasing quartiles of EB while BoP decreased by 13% ( p<0.0001) across increasing quartiles of HAB. Mean PD increased 0.8 mm and decreased 0.3 mm from the first to fourth quartiles of EB (p<0.0001) and HAB ( p<0.0001), respectively. Among 1214 plaque samples with fourth quartile EB, 60% were collected from sites with PD 3 mm. Conclusion: Bacterial species believed to be aetiologically related to periodontitis were associated with BoP in sites with minimal PD and/or attachment level (AL). Species presumed to be associated with periodontal health demonstrated inverse associations with BoP. [source]