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Increasing Interest (increasing + interest)
Selected AbstractsCord blood banking: ethical and cost,benefit aspectsISBT SCIENCE SERIES: THE INTERNATIONAL JOURNAL OF INTRACELLULAR TRANSPORT, Issue 1 2007S. Querol Cord blood represents a new source of stem cells on the edge of fetal and postnatal life. Increasing interest in stem cell therapy has moulded cord blood banking scope, evolving to a multidisciplinary platform exceeding the classic field of haemotherapy. This review intends to re-analyse this and presents the new aspects of cord blood banking that direct it to a model of cell pharmacy in a globalized world. [source] A new type of magnification system in free microvascular tissue transfer: Varioscope M5MICROSURGERY, Issue 6 2007Ph.D., Stefano Chiummariello M.D. Free microvascular tissue transfers have become today a key instrument for the surgical treatment of wide loss of tissue. These procedures can provide definitive treatment in a single operation but they are expensive and require specialized practitioners. The operating microscope traditionally has provided this requirement; our study is focusing on the prospect of using a new visual system,Varioscope M5,in the reconstructive microsurgery field. Varioscope M5 (Life Optics, Vienna, Austria) has been employed in 21 microvascular anastomoses, where different free flaps were used in head and neck reconstruction. The necessity to operate in a different department, not provided with an operating microscope, brought along the idea of exploring an alternative procedure to classical visualization systems. Specific advantages such as reduced cost, freedom of movement, autofocus, minimal upkeep, a variable range of magnification from 2× to 9× are some of the reasons that convinced the authors to use this new type of magnification system. Increasing interest in microsurgery magnification highlights the need for further technical development in that field. We consider Varioscope M5 a future mean of anastomotic magnification in most free-tissue transfers with specific characteristics that combine the microscope and loupe philosophies. © 2007 Wiley-Liss, Inc. Microsurgery, 2007. [source] Biomarkers of ovulation, endometrial receptivity, fertilisation, implantation and early pregnancy progressionPAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 2006Kenneth L. Campbell Summary Increasing interest in early preconception and periconception exposures and human developmental outcomes has led to studies that monitor subjects from before conception to gestation, birth and childhood. Monitoring ovulation, endometrial receptivity, fertilisation, implantation and gestation requires the non-invasive collection of biological information and samples, and the measurement of biochemical and biological markers (biomarkers) that are associated with the aforementioned physiological events. This paper describes some of the key features of biomarkers needed for epidemiological studies, identifies some existing and potential biomarkers and available measurement devices, and suggests some directions for identification and development of new biomarkers that might be employed in longitudinal studies involving the analysis of female reproductive function and of embryonic development. [source] Comparative Study on Five Different Commercial Extenders for Boar SemenREPRODUCTION IN DOMESTIC ANIMALS, Issue 1 2004P Vyt Contents Increasing interest in a longer preservation of diluted boar sperm raises questions in the field concerning the choice of the extender. The aim of this study was to evaluate the longevity of boar sperm extended in currently used commercial semen extenders. Three long-term extenders and two short-term extenders were compared for different semen quality parameters that can be assessed under routine laboratory conditions. Sperm morphology, motility, pH and bacteriological contamination were investigated during a 7-day period. The number of dead spermatozoa did not differ significantly among the extenders (p > 0.05). Sperm motility was not only related with storage period but most of all with pH, especially in long-term extenders. Differences between the different extenders were prominent (p < 0.05); the sperm preserved in only one long-term extender showed good motility during the whole test period. In all cases, the pH of the extended semen increased by 0.3,0.5 in the first days of storage and was significantly correlated with a decrease in motility. Bacteriological quality had no significant influence on motility or pH of the semen. In conclusion, we can state that in both short-term extenders and in only one long-term extender, sperm longevity, as evaluated by the parameters used in this study, was sufficient during the preservation period. To preserve the quality of diluted boar semen during long-term storage, the choice of the long-term extender is important. In addition, the monitoring of the pH of extended boar semen in our study emphasizes the importance of the buffering capacity of semen extenders. [source] Virtual Cities From Digital ImageryTHE PHOTOGRAMMETRIC RECORD, Issue 96 2000E. Gülch Increasing interest is being expressed in the use of virtual cities for many fields of application, ranging from planning and simulation to business, advertising and the games industry. Currently, the extraction of buildings from imagery is costly. However, recent developments in digital photogrammetry aim to produce more rapid and efficient methods of modelling three dimensional objects in urban environments. This paper presents a semi-automatic system for the extraction of buildings from digital aerial imagery with the aid of volumetric primitives. The user is supported by automated tools, for example matching tools, in order to reach the necessary efficiency. With an extraction time of about 20 s per building primitive, this method is competitive in terms of the performance of classical photogrammetric procedures, and also offers additional features for analysis, texture mapping and Internet applications. [source] Views of the downward extension: comparing the Youth Version of the Psychopathy Checklist with the Youth Psychopathic traits Inventory,BEHAVIORAL SCIENCES & THE LAW, Issue 6 2003Jennifer L. Skeem Ph.D. Increasing interest in "juvenile psychopathy" has been met with scholarly debate about the validity of directly extending the adult construct of psychopathic personality disorder to youth. To inform this debate, this study of 160 serious adolescent offenders compared two alternative, adult-based conceptualizations of juvenile psychopathy: that of the Psychopathy Checklist: Youth Version (PCL:YV) and the self-report Youth Psychopathic traits Inventory (YPI). The results indicate that these two conceptualizations overlap only partially, with the YPI focusing more tightly on core interpersonal and affective features than the PCL:YV. Each conceptualization is reliable and predicts different forms of short-term institutional misbehavior. However, only the YPI possesses a theoretically coherent, inverse association with anxiety. Despite this promise, these conceptualizations of psychopathy are less strongly associated with one another than they are with psychosocial markers of developmental maturity. This raises questions about their divergent validity and ability to identify a disorder that will remain stable during the transition from adolescence into adulthood. Implications for future longitudinal research on the validity, manifestations, and course of juvenile psychopathy are discussed. Copyright © 2003 John Wiley & Sons, Ltd. [source] Three-dimensional culture systems for the expansion of pluripotent embryonic stem cellsBIOTECHNOLOGY & BIOENGINEERING, Issue 4 2010Michael P. Storm Abstract Mouse embryonic stem cell (ESC) lines, and more recently human ESC lines, have become valuable tools for studying early mammalian development. Increasing interest in ESCs and their differentiated progeny in drug discovery and as potential therapeutic agents has highlighted the fact that current two-dimensional (2D) static culturing techniques are inadequate for large-scale production. The culture of mammalian cells in three-dimensional (3D) agitated systems has been shown to overcome many of the restrictions of 2D and is therefore likely to be effective for ESC proliferation. Using murine ESCs as our initial model, we investigated the effectiveness of different 3D culture environments for the expansion of pluripotent ESCs. Solohill Collagen, Solohill FACT, and Cultispher-S microcarriers were employed and used in conjunction with stirred bioreactors. Initial seeding parameters, including cell number and agitation conditions, were found to be critical in promoting attachment to microcarriers and minimizing the size of aggregates formed. While all microcarriers supported the growth of undifferentiated mESCs, Cultispher-S out-performed the Solohill microcarriers. When cultured for successive passages on Cultispher-S microcarriers, mESCs maintained their pluripotency, demonstrated by self-renewal, expression of pluripotency markers and the ability to undergo multi-lineage differentiation. When these optimized conditions were applied to unweaned human ESCs, Cultispher-S microcarriers supported the growth of hESCs that retained expression of pluripotency markers including SSEA4, Tra-1,60, NANOG, and OCT-4. Our study highlights the importance of optimization of initial seeding parameters and provides proof-of-concept data demonstrating the utility of microcarriers and bioreactors for the expansion of hESCs. Biotechnol. Bioeng. 2010;107:683,695. © 2010 Wiley Periodicals, Inc. [source] JOPI: a Java object-passing interfaceCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 7-8 2005Jameela Al-Jaroodi Abstract Recently there has been an increasing interest in developing parallel programming capabilities in Java to harness the vast resources available in clusters, grids and heterogeneous networked systems. In this paper, we introduce a Java object-passing interface (JOPI) library. JOPI provides Java programmers with the necessary functionality to write object-passing parallel programs in distributed heterogeneous systems. JOPI provides a Message Passing Interface (MPI)-like interface that can be used to exchange objects among processes. In addition to the well-known benefits of the object-oriented development model, using objects to exchange information in JOPI is advantageous because it facilitates passing complex structures and enables the programmer to isolate the problem space from the parallelization problem. The run-time environment for JOPI is portable, efficient and provides the necessary functionality to deploy and execute parallel Java programs. Experiments were conducted on a cluster system and a collection of heterogeneous platforms to measure JOPI's performance and compare it with MPI. The results show good performance gains using JOPI. Copyright © 2005 John Wiley & Sons, Ltd. [source] Child behaviour and adult personality: comparisons between criminality groups in Finland and SwedenCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 3 2000Professor Lea Pulkkinen Background; Lately there has been an increasing interest in whether personality traits are associated with criminal behaviour in male and female subjects. Criminality and alcohol abuse are often associated. Delinquent adolescents are impulsive and danger seeking. Childhood aggression may be a precursor of adult criminality. Method Using longitudinal data, adult personality and childhood behaviours were examined for groups of non-criminals and criminals of Finnish (n = 268) and Swedish (n + 169) samples, and crime groups were compared in the two cultures. Karolinska Scales of Personality (KSP) were given at adult age and the participants had been observed and rated by their teachers in respect of behaviour in childhood (at age 8 years and 13 years, respectively). Results Male offenders with alcohol problems (Finnish and Swedish) had significantly higher scores on psychopathy-related personality traits in adulthood than other subgroups, as indicated by higher impulsivity, muscular tension and lower socialization. They also displayed higher scores on teacher-rated aggressiveness in childhood than the non-criminal groups. The female subgroup displaying criminal activity was small. It did not differ significantly from non-offenders in adult personality characteristics. Female offenders, however, showed early indications of lower sociability (in Finland) and higher aggressiveness and disharmony in childhood than non-offenders (in Sweden). Discussion The study suggests that early problem behaviours are precursors of subsequent criminal activity in at least two cultures. The results emphasize the importance of longitudinal research programmes. Copyright © 2000 Whurr Publishers Ltd. [source] Mad scenes in early 19th-century operaACTA PSYCHIATRICA SCANDINAVICA, Issue 4 2000A. Erfurth Objective: It is our objective to examine the phenomenon of mad scenes in bel canto opera from a modern perspective. Method: The development of psychiatry and music at the beginning of the 19th century is described. Common elements of romantic music and mental disorders are discussed. It is shown how bel canto composers represent psychiatric illness by musical means. The psychopathology depicted in a prototypical mad scene is evaluated. Results: Early romantic music is characterized by imagination, illusion and loss of structure; characteristics which can be well expressed in mad scenes. While madness (withdrawal into a utopian world) gained a certain attraction in society, clinical psychiatry increasingly focused on emotional causes of illness and on drug-induction of mental disorders. Conclusion: Mad scenes in bel canto opera can be understood as expression of an increasing interest in emotional aspects in music and society as well as in clinical psychiatry. [source] Treatment of opioid dependence in adolescents and young adults with extended release naltrexone: preliminary case-series and feasibilityADDICTION, Issue 9 2010Marc J. Fishman ABSTRACT Background Opioid dependence is an increasing problem among adolescents and young adults, but in contrast to the standard in the adult population, adoption of pharmacotherapies has been slow. Extended-release naltrexone (XR-NTX) is a promising treatment that has been receiving increasing interest for adult opioid dependence. Clinical chart abstractions were performed on a convenience sample of 16 serial adolescent and young adult cases (mean age 18.5 years) treated for opioid dependence with XR-NTX who attended at least one out-patient clinical follow-up visit. Case descriptions Of these 16 cases, 10 of 16 (63%) were retained in treatment for at least 4 months and nine of 16 (56%) had a ,good' outcome defined as having substantially decreased opioid use, improvement in at least one psychosocial domain and no new problems due to substance use. Conclusions These descriptive results suggest that XR-NTX in the treatment of adolescents and young adults with opioid dependence is well tolerated over a period of 4 months and feasible in a community-based treatment setting, and associated with good outcomes in a preliminary, small non-controlled case-series. This probably reflects an overall trend towards greater adoption of medication treatments for this population. [source] Electrochemical Monitoring of Singlet Oxygen ProductionELECTROANALYSIS, Issue 21 2009Duncan Sharp Abstract The exploitation of singlet oxygen generating compounds as a means of targeted therapies drives the need to develop methods for assessing the efficacy of such compounds and their capacity for generating the reactive oxygen species. Degradation of diphenylisobenzofuran by singlet oxygen is widely used as a spectroscopic probe but its application can be problematic. An alternative detection strategy exploiting the electrochemical monitoring of the quencher concentration, by square wave voltammetry, has been shown to provide a more sensitive and flexible option that could be used to address the increasing interest in photosensitizing materials. [source] Microchip-based small, dense low-density lipoproteins assay for coronary heart disease risk assessmentELECTROPHORESIS, Issue 9 2008Hua Wang Abstract Small, dense low-density lipoprotein (sdLDL) has been accepted as an emerging cardiovascular risk factor, and there has been an increasing interest in analytical methods for sdLDL profiling for diagnosis. Serum sdLDL may be measured by different laboratory techniques, but all these methods are laborious, time-consuming, and costly. Recently, we have demonstrated that a low-temperature bonding of quartz microfluidic chips for serum lipoproteins analysis (Zhuang, G., Jin, Q., Liu, J., Cong, H. et al., Biomed. Microdevices 2006, 8, 255,261). In contrast to this previous study, we chose SDS as anionic surfactant to modify both lipoproteins and the channel surface to minimize lipoprotein adsorption and improve the resolution of lipoprotein separation. Two major LDL subclass patterns including large, buoyant LDL (lLDL), sdLDL, and high-density lipoprotein (HDL) were effectively separated with high reproducibility. RSD values of the migration time (min) and peak areas of standard LDL and HDL were 6.28, 4.02, 5.02, and 2.5%, respectively. Serum lipoproteins of 15 healthy subjects and 15 patients with coronary heart disease (CHD) were separated by microchip CE. No peaks of sdLDL were detected in serum samples of healthy subjects while sdLDL fractional peaks were observed in patients' entire serum samples. These results suggested that the microchip-based sdLDLs assay was a simple, rapid, and highly efficient technique and significantly improved the analysis of CHD risk factors. [source] Mixture toxicity and gene inductions: Can we predict the outcome?ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 3 2008Freddy Dardenne Abstract As a consequence of the nature of most real-life exposure scenarios, the last decade of ecotoxicological research has seen increasing interest in the assessment of mixture ecotoxicology. Often, mixtures are considered to follow one of two models, concentration addition (CA) or response addition (RA), both of which have been described in the literature. Nevertheless, mixtures that deviate from either or both models exist; they typically exhibit phenomena like synergism, ratio or concentration dependency, or inhibition. Moreover, both CA and RA have been challenged and evaluated mainly for acute responses at relatively high levels of biological organization (e.g., whole-organism mortality), and applicability to genetic responses has not received much attention. Genetic responses are considered to be the primary reaction in case of toxicant exposure and carry valuable mechanistic information. Effects at the gene-expression level are at the heart of the mode of action by toxicants and mixtures. The ability to predict mixture responses at this primary response level is an important asset in predicting and understanding mixture effects at different levels of biological organization. The present study evaluated the applicability of mixture models to stress gene inductions in Escherichia coli employing model toxicants with known modes of action in binary combinations. The results showed that even if the maximum of the dose,response curve is not known, making a classical ECx (concentration causing x% effect) approach impossible, mixture models can predict responses to the binary mixtures based on the single-toxicant response curves. In most cases, the mode of action of the toxicants does not determine the optimal choice of model (i.e., CA, RA, or a deviation thereof). [source] On the attempts to optimize the performance and cost-effectiveness of TFPM drives: a crucial challenge for the automotive industryEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 6 2005Ahmed Masmoudi Much attention is currently focused upon transverse flux permanent magnet machines (TFPMs), especially in automotive applications, in so far as, to date, they exhibit the highest power production capability. Different automotive manufacturers are currently involved in R&D programs dealing with TFPM concepts and the possibilities of their integration in electric and hybrid propulsion systems. This paper is devoted to the analysis of two R&D projects developed within the design of TFPMs intended for hybrid propulsion systems of heavy-duty vehicles. In spite of the increasing interest in TFPMs and the significant improvements brought to their earlier topologies, we can firmly state that further investigations remain to be carried out before the TFPM concepts could be regarded as a mature technology for the automotive industry. Copyright © 2005 John Wiley & Sons, Ltd. [source] Online expert systems for fault diagnosis in technical processesEXPERT SYSTEMS, Issue 2 2008Chrissanthi Angeli Abstract: It is generally accepted that there has been an increasing interest in online fault detection and diagnosis techniques for technical processes during the last few years. These techniques come from the artificial intelligence field or are classical numerical methods in combination with artificial intelligence methods. This paper presents a survey of recent research work in online expert systems for fault detection and diagnosis in technical processes. In addition, a short reference to other recent artificial intelligence methods for online fault detection is included and the main advantages and limitations of each method are illustrated. [source] Coherent Accounts of Coping with a Chronic Illness: Convergences and Divergences in Family Measurement Using a Narrative AnalysisFAMILY PROCESS, Issue 4 2003BARBARA H. FIESE Ph.D. Researchers and clinicians have shown increasing interest in family narratives as an avenue for accessing the family meaning-making process. In this study, we examine the convergences and divergences between narrative assessment, family self-report, and verbal accounts of family climate. Sixty-two families with a child with pediatric asthma were interviewed about the impact that asthma had on family life. These interviews were coded for narrative coherence, relationship expectations, and engagement with the interviewer. Primary caregivers were also interviewed using the Five Minute Speech sample (FMSS) and completed self-report assessments of family functioning (Family Assessment Device [FAD] Impact on the Family Scale [IOF]). Contrary to prediction. Narrative coherence was higher in those cases where Emotional Over-involvement (EOI) was present on the FMSS. Narrative coherence and engagement with the interviewer were positively related to self-report of family problem solving, communication, and affective responsiveness as measured on the FAD. Divergences and convergences between different types of family measurement are discussed in light of meaning-making processes associated with coping with a chronic illness. [source] Single amino acid repeats in signal peptidesFEBS JOURNAL, Issue 15 2010abaj There has been an increasing interest in single amino acid repeats ever since it was shown that these are the cause of a variety of diseases. Although a systematic study of single amino acid repeats is challenging, they have subsequently been implicated in a number of functional roles. In general surveys, leucine runs were among the most frequent. In the present study, we present a detailed investigation of repeats in signal peptides of secreted and type I membrane proteins in comparison with their mature parts. We focus on eukaryotic species because single amino acid repeats are generally rather rare in archaea and bacteria. Our analysis of over 100 species shows that repeats of leucine (but not of other hydrophobic amino acids) are over-represented in signal peptides. This trend is most pronounced in higher eukaryotes, particularly in mammals. In the human proteome, although less than one-fifth of all proteins have a signal peptide, approximately two-thirds of all leucine repeats are located in these transient regions. Signal peptides are cleaved early from the growing polypeptide chain and then degraded rapidly. This may explain why leucine repeats, which can be toxic, are tolerated at such high frequencies. The substantial fraction of proteins affected by the strong enrichment of repeats in these transient segments highlights the bias that they can introduce for systematic analyses of protein sequences. In contrast to a general lack of conservation of single amino acid repeats, leucine repeats were found to be more conserved than the remaining signal peptide regions, indicating that they may have an as yet unknown functional role. [source] Silica-Based, Organically Modified Host Material for Waveguide Structuring by Two-Photon-Induced PhotopolymerizationADVANCED FUNCTIONAL MATERIALS, Issue 5 2010Stefan Krivec Abstract The three-dimensional fabrication of optical waveguides has gained increasing interest in recent years to establish interconnections between electrical components on a very small scale where copper circuits encounter severe limitations. In this work the application of optically clear, organically modified porous silica monoliths and thin films as a host material for polymeric waveguides to be inscribed into the solid host structure by two-photon-induced photopolymerization is investigated. Porosity is generated using a lyotropic liquid crystalline surfactant/solvent system as a template for the solid silica material obtained by a sol,gel transition of a liquid precursor. In order to reduce the brittleness of the purely inorganic material, organic,inorganic co-precursor molecules that contain poly(ethylene glycol) chains are synthesized and added to the mixture, which successfully suppresses macroscopic cracking and leads to flexible thin films. The structure of the thus-obtained porous organic,inorganic hybrid material is investigated by atomic force microscopy. It is shown that the modified material is suitable for infiltration with photocurable monomers and functional polymeric waveguides can be inscribed by selective two-photon-induced photopolymerization. [source] Assessing forest growth across southwestern Oregon under a range of current and future global change scenarios using a process model, 3-PGGLOBAL CHANGE BIOLOGY, Issue 1 2001N. C. Coops Summary With improvements in mapping regional distributions of vegetation using satellite-derived information, there is an increasing interest in the assessment of current limitations on forest growth and in making projections of how productivity may be altered in response to changing climatic conditions and management policies. We utilised a simplified physiologically based process model (3-PG) across a 54 000 km2 mountainous region of southwestern Oregon, USA, to evaluate the degree to which maximum periodic mean annual increment (PAI) of forests could be predicted at a set of 448 forest inventory plots. The survey data were pooled into six broad forest types (coastal rain forest, interior coast range forest, mixed conifer, dry-site Douglas-fir, subalpine forest, and pine forest) and compared to the 3-PG predictions at a spatial resolution of 1 km2. We found good agreement (r2 = 0.84) between mean PAI values of forest productivity for the six forest types with those obtained from field surveys. With confidence at this broader level of integration, we then ran model simulations to evaluate the constraints imposed by (i) soil fertility under current climatic conditions, (ii) the effect of doubling monthly precipitation across the region, and (iii) a widely used climatic change scenario that involves modifications in monthly mean temperatures and precipitation, as well as a doubling in atmospheric CO2 concentrations. These analyses showed that optimum soil fertility would more than double growth, with the greatest response in the subalpine type and the least increase in the coastal rain forests. Doubling the precipitation increased productivity in the pine type (> 50%) with reduced responses elsewhere. The climate change scenario with doubled atmospheric CO2 increased growth by 50% on average across all forest types, primarily as a result of a projected 33% increase in photosynthetic capacity. This modelling exercise indicates that, at a regional scale, a general relationship exists between simulated maximum leaf area index and maximum aboveground growth, supporting the contention that satellite-derived estimates of leaf area index may be good measures of the potential productivity of temperate evergreen forests. [source] Using DCE and ranking data to estimate cardinal values for health states for deriving a preference-based single index from the sexual quality of life questionnaireHEALTH ECONOMICS, Issue 11 2009Julie Ratcliffe Abstract There is an increasing interest in using data derived from ordinal methods, particularly data derived from discrete choice experiments (DCEs), to estimate the cardinal values for health states to calculate quality adjusted life years (QALYs). Ordinal measurement strategies such as DCE may have considerable practical advantages over more conventional cardinal measurement techniques, e.g. time trade-off (TTO), because they may not require such a high degree of abstract reasoning. However, there are a number of challenges to deriving the cardinal values for health states using ordinal data, including anchoring the values on the full health,dead scale used to calculate QALYs. This paper reports on a study that deals with these problems in the context of using two ordinal techniques, DCE and ranking, to derive the cardinal values for health states derived from a condition-specific sexual health measure. The results were compared with values generated using a commonly used cardinal valuation technique, the TTO. This study raises some important issues about the use of ordinal data to produce cardinal health state valuations. Copyright © 2009 John Wiley & Sons, Ltd. [source] Recent Progress in Exploring Magnetocaloric MaterialsADVANCED MATERIALS, Issue 45 2009B. G. Shen Abstract The magnetic refrigeration technique based on the magnetocaloric effect (MCE) has attracted increasing interest because of its high efficiency and environment friendliness. In this article, our recent progress in exploring effective MCE materials is reviewed with emphasis on the MCE in the LaFe13,xSixbased alloys discovered by us. These alloys show large entropy changes over a wide temperature range near room temperature. The effects of magnetic rare-earth doping, interstitial atoms and high pressure on the MCE have been systematically studied. Special issues, such as appropriate approaches to determining the MCE associated with the first-order magnetic transition, the depression of magnetic and thermal hysteresis, and the key factors determining the magnetic exchange in alloys of this kind, are discussed. The applicability of giant MCE materials to magnetic refrigeration near ambient temperature is evaluated. A brief review of other materials with significant MCE is also presented. [source] The role of human factors in flexibility management: A surveyHUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES, Issue 1 2002Sami Kara Flexibility can be defined as the ability to respond effectively to the ever-changing and increasing needs of the customer. For this demand to be satisfied, flexibility should be built into the total chain of acquisition, processing, and distribution stages. As a result, there is an increasing interest in flexibility and flexibility enabling mechanisms/parameters to achieve the best strategy for obtaining the right and desired output. Although quite a number of flexibility definitions and mechanisms can be found in the literature, flexibility remains poorly understood and utilized in practice. That is due to the lack of standardization in the terminology about the flexibility definitions and mechanisms. This article presents the finding of an extensive literature survey to determine the Intra flexibility mechanisms/parameters. These mechanisms/parameters are then classified, according to their contribution to the supply chain stages and their interaction with Inter Flexibility mechanisms (e.g., Organizational structure flexibility, Technology flexibility, Information system flexibility, and Human resource flexibility). In addition, the crucial role of human factors and its relationship with flexibility mechanisms are investigated, and related flexibility mechanisms are identified. © 2002 John Wiley & Sons, Inc. [source] Layer-by-Layer Hydrogen-Bonded Polymer Films: From Fundamentals to ApplicationsADVANCED MATERIALS, Issue 30 2009Eugenia Kharlampieva Abstract Recent years have seen increasing interest in the construction of nanoscopically layered materials involving aqueous-based sequential assembly of polymers on solid substrates. In the booming research area of layer-by-layer (LbL) assembly of oppositely charged polymers, self-assembly driven by hydrogen bond formation emerges as a powerful technique. Hydrogen-bonded (HB) LbL materials open new opportunities for LbL films, which are more difficult to produce than their electrostatically assembled counterparts. Specifically, the new properties associated with HB assembly include: 1) the ease of producing films responsive to environmental pH at mild pH values, 2) numerous possibilities for converting HB films into single- or two-component ultrathin hydrogel materials, and 3) the inclusion of polymers with low glass transition temperatures (e.g., poly(ethylene oxide)) within ultrathin films. These properties can lead to new applications for HB LbL films, such as pH- and/or temperature-responsive drug delivery systems, materials with tunable mechanical properties, release films dissolvable under physiological conditions, and proton-exchange membranes for fuel cells. In this report, we discuss the recent developments in the synthesis of LbL materials based on HB assembly, the study of their structure,property relationships, and the prospective applications of HB LbL constructs in biotechnology and biomedicine. [source] Cumulative parenting stress across the preschool period: relations to maternal parenting and child behaviour at age 5INFANT AND CHILD DEVELOPMENT, Issue 2 2005Keith A. Crnic Abstract Despite increasing interest in the effects of parenting stress on children and families, many questions remain regarding the nature of parenting stress and the mechanism through which stress exerts its influence across time. In this study, cumulative parenting stress was assessed across the preschool period in a sample of 125 typically developing children and their mothers. Indices of parenting stress included both major life events stress-assessed annually from age 3 to 5, and parenting daily hassles assessed every 6 months across the same period. Naturalistic home observations were conducted when children were age 5, during which measures of parent and child interactive behaviour as well as dyadic pleasure and dyadic conflict were obtained. Mothers also completed the CBCL to assess children's behaviour problems. Results indicated that parenting daily hassles and major life stress are relatively stable across the preschool period. Both cumulative stress indices also proved to be important predictors of parent and child behaviour and dyadic interaction, although the predictions were somewhat differential. Despite meaningful relations between the stress factors and child well being, no evidence was found to support the premise that parent behaviour mediates the association between parenting stress and child outcomes. Results are discussed within a developmental framework to understand the stability and complexity of cumulative stress associations to early parent,child relationships. Copyright © 2005 John Wiley & Sons, Ltd. [source] New proteomic approaches for biomarker discovery in inflammatory bowel diseaseINFLAMMATORY BOWEL DISEASES, Issue 7 2010Giulia Roda MD Abstract There is an increasing interest in the discovery of new inflammatory bowel disease (IBD) biomarkers able to predict the future patterns of disease and to help in diagnosis, treatment, and prognosis. A biomarker is a substance that can be measured biologically and is associated with an increased risk of the disease. Biomarkers can be a genetic testing factor or proteins in biological samples such as serum, plasma, and cellular subpopulations. All of them should be studied to find out their utility in the management of IBD. Ulcerative colitis and Crohn's disease are relapsing and remitting chronic IBDs characterized by a global immune defect. The gold standard of their diagnosis is histological evaluation performed during endoscopic procedures. Several studies have focused on the identification and combination of less invasive diagnostic serum biomarkers. Nowadays, diagnostic serum tests are not able either to determine whether and when the relapse will occur once the disease is in remission state or to select a patient phenotype more responsive to a specific therapy and more susceptible to different types of complication. In this review we analyze and report the current understanding in IBD biomarkers and discuss potential future biomarkers and new developments of proteomics, such as subproteomics, as an innovative approach for the classification of patients according to their pattern of protein expression. (Inflamm Bowel Dis 2010) [source] Nanopatterning Soluble Multifunctional Materials by Unconventional Wet LithographyADVANCED MATERIALS, Issue 10-11 2009Massimiliano Cavallini Abstract Molecular multifunctional materials have potential applications in many fields of technology, such as electronics, optics and optoelectronics, information storage, sensing, and energy conversion and storage. These materials are designed exhibit enhanced properties, and at the same time are endowed with functional groups that control their interactions, and hence self-organization, into a variety of supramolecular architectures. Since most of the multifunctional materials are soluble, lithographic methods suitable for solutions are attracting increasing interest for the manufacturing of the new materials and their applications. The aim of this paper is to highlight some of the recent advances of solution-based fabrication of multifunctional materials. We explain and examine the principles, processes, materials, and limitations of this class of patterning techniques, which we term unconventional wet lithographies (UWLs). We describe their ability to yield patterns and structures whose feature sizes range from nanometers to micrometers. In the following sections, we focus our attention on micromolding in capillaries, lithographically controlled wetting, and grid-assisted deposition, the most used methods demonstrated to lead to fully operating devices. [source] Numerical simulation of gaseous fuel injection: A new methodology for multi-dimensional modellingINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 6 2010Luca Andreassi Abstract The use of natural gas (instead of liquid or solid fuels) is nowadays drawing an increasing interest in many applications (gas turbines, boilers, internal combustion engines), because of the greater attention to environmental issues. To facilitate the development of these applications, computer models are being developed to simulate gaseous injection, air entrainment and the ensuing combustion. This paper introduces a new method for modelling the injection process of gaseous fuels that aims to hold down grid requirements in order to allow the simulation also of other phenomena, like combustion or valve and piston motion, in reciprocating internal combustion engines. After a short overview of existing models, the transient jet model and the evaluation of inflow conditions are described in detail. Then a basic study of the grid effects on the jet evolution is presented. The model is updated and validated by comparing numerical results with available experimental data for two different operating conditions: a subsonic and a supersonic under-expanded case. The model demonstrates to be fast enough to be used in a multi-dimensional code and accurate enough to follow the real gas jet evolution. Copyright © 2009 John Wiley & Sons, Ltd. [source] Communication and the reflective practitioner: a shared perspective from sociolinguistics and organisational communicationINTERNATIONAL JOURNAL OF APPLIED LINGUISTICS, Issue 2 2004Deborah Jones This paper provides an overview of an interdisciplinary project which draws together sociolinguistic analyses of workplace discourse and recent work in the field of organisational studies. The starting point for this collaboration was a set of questions which arose from attempts to apply the findings of a large-scale sociolinguistic study into workplace language: (i) How can sociolinguistic tools and models generate useful feedback for practitioners and contribute to organisational learning? (ii) How can the understanding researchers have developed of workplace discourse help individuals and teams critically reflect on their own communication practices? (iii) What can the action research process add to our theoretical knowledge about workplace discourse? The authors explore these questions in the context of a number of current issues in the field of organisational studies, including an increasing interest in language and communication; emerging critical perspectives on the notion of competence in workplaces; and debates over the relationships between expert and practitioner knowledges. The concept of ,reflective practice' is presented as a framework to address these issues in the evaluation and development of workplace communication. [source] A peer-to-peer IPTV service architecture for the IP multimedia subsystemINTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 6-7 2010A. Bikfalvi Abstract During these last years the Internet Protocol Television (IPTV) service and the different peer-to-peer (P2P) technologies have generated an increasing interest for the developers and the research community that find in them the solution to deal with the scalability problem of media streaming and reducing costs at the same time. However, despite of the benefits obtained in Internet-based applications and the growing deployment of commercial IPTV systems, there has been a little effort in combining them both. With the advent of the next-generation-network platforms such as the IP Multimedia Subsystem (IMS), which advocates for an open and inter-operable service infrastructure, P2P emerges as a possible solution in situations where the traditional streaming mechanisms are not possible or not economically feasible. In this paper, we propose an IPTV service architecture for the IMS that combines a centralized control layer and a distributed, P2P-like, media layer that relies on the IMS devices or peers located in the customers' premises to act as streaming forwarding nodes. We extend the existing IMS IPTV standardization work that has already been done in 3GPP and ETSI TISPAN in order to require a minimum number of architectural changes. The objective is to obtain a system with a similar performance to the one in currently deployed systems and with the flexibility of P2P. One of the main challenges is to achieve comparable response times to user actions such as changing and tuning into channels, as well as providing a fast recovery mechanism when streaming nodes leave. To accomplish this we introduce the idea of foster peers as peers having inactive multimedia sessions and reserved resources. These peers are on stand-by until their functionality is required and at that moment, they are able to accept downstream peers at short notice for events requiring urgent treatment like channel changing and recovery. Copyright © 2009 John Wiley & Sons, Ltd. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||