Home About us Contact
|
Home About us Contact | ||
|
|
||
Increasing Importance (increasing + importance)
Selected AbstractsA methodology for simulating power system vulnerability to cascading failures in the steady stateEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 8 2008Murali Kumbale Abstract Simulations of power system conditions and event sequences leading to either local or widespread blackout has acquired increasing importance following wide-impact network collapses that have occurred over the past several years in North America and Europe. This paper summarizes an analytical framework that has been developed, implemented, and practically used by Southern Company to evaluate system vulnerability to cascading failures using the steady state model. This methodology was first used by Southern Company in 1999. The studies performed at Southern Company have already influenced and motivated certain transmission development projects. Future improvements to the method could include better modeling and sequencing of cascading steps, including time sequence of failures using equipment response time. Significant interest exists in developing preventive methods and procedures and in the application of this technology in the infrastructure security arena. Copyright © 2008 John Wiley & Sons, Ltd. [source] Asymmetric Information and Dividend PolicyFINANCIAL MANAGEMENT, Issue 4 2008Kai Li We examine how informational asymmetries affect firms' dividend policies. We find that firms that are more subject to information asymmetry are less likely to pay, initiate, or increase dividends, and disburse smaller amounts. We show that our main results are not driven by our sample and that our results persist after accounting for the changing composition of payout over the sample period, the increasing importance of institutional shareholdings, and catering incentives. We conclude that there is a negative relation between asymmetric information and dividend policy. Our results do not support the signaling theory of dividends. [source] Present status, and social and economic significance of inland fisheries in GermanyFISHERIES MANAGEMENT & ECOLOGY, Issue 4-5 2001H. Wedekind The Federal Republic of Germany is situated in the central part of Europe and covers an area of 358 000 km2. The climate is maritime in the north and continental in the south with precipitation varying between 600 and 2000 mm year,1. Lakes and farm ponds are common in the north-eastern part of the country and in the alpine and pre-alpine regions to the south. A great number of small natural and artificial water bodies exist all over the country. There are about 800 000 ha of inland waters. The population of 82 million people are concentrated around a number of large conurbations. Over the last 150 years, intense use of the water resources by industry led to pollution and a severe decrease in river and lake fisheries. Only 587 inland fishing enterprises still existed in the early 1990s. Catches from commercial fisheries are decreasing with a total of 3469 t being caught in 1998. The Lake Constance fishery, which landed about 840 t in 1998, is an exception to the general trend. Strong competition for the aquatic resource is affecting commercial fisheries, whilst recreational fisheries have gained increasing importance over the last decades. Recent studies provided basic information on anglers' habits, social structure and economic significance as well as their effects on the waters. Aquaculture mainly produces rainbow trout, Oncoryhnchus mykiss (Walbaum) 20 000 t and carps (12 000 t) e.g. Cyprinus carpio L. Despite pressures from industry and conservation movements, regional support for fisheries and their development has intensified, leading to improved water quality. There are even attempts to re-establish abandoned fisheries. Co-operation with conservationists provides an opportunity for the future survival and development of fisheries. The fisheries and aquaculture sectors changed drastically after the reunification of Germany. The collapse of the infrastructure in the eastern part of Germany led to a decline in production and to a special investigation on recent developments of this sector. [source] Abrasiveness Testing, Quo Vadis?GEOMECHANICS AND TUNNELLING, Issue 1 2008A Commented Overview of Abrasiveness Testing Methods The growing economic pressure on tunnelling and mining operations has lead to an increasing importance of investigation methods for assessing the abrasiveness of rock and soil. Such investigations can be based on a wide variety of testing procedures and standards covering a wide span of scale, ranging from real-scale tests on site to model tests with simplified tools and microscopic and chemical analyses of rocks and minerals. This paper gives an overview over some of the most important procedures, technical aspects of their application, classification of testing results and the current state of experience. Abrasivitätstest, quo vadis? Ein kommentierter Überblick über Abrasivitäts-Testverfahren Der stetig zunehmende wirtschaftliche Druck auf Tunnelbau und Rohstoffgewinnung führt zu einer steigenden Bedeutung von Untersuchungsverfahren zur Bewertung der Abrasivität von Fest- und Lockergesteinen. Derartige Untersuchungen können mit einer Vielzahl von Verfahren durchgeführt werden, die von Untersuchungen vor Ort im Realmaßstab über Modellversuche mit vereinfachten Werkzeugen bis hin zu mikroskopischen oder chemischen Untersuchungen eine weite Bandbreite an Untersuchungsmaßstäben einschließen. Der vorliegende Beitrag soll einen Überblick über die derzeit wesentlichsten Untersuchungsverfahren, versuchstechnische Aspekte, angewandte Klassifizierungsschlüssel sowie Einsatzerfahrungen mit den jeweiligen Verfahren geben. [source] Reconfiguring ,post-socialist' regions: cross-border networks and regional competition in the Slovak and Ukrainian clothing industryGLOBAL NETWORKS, Issue 3 2008ADRIAN SMITH Abstract The global garment industry is currently being reshaped in dramatic ways through processes of trade liberalization, delocalization and interfirm and interregional competition. There has been much speculation about the increasing importance of factor (especially labour) costs in fuelling further rounds of de-localization of garment production towards low-cost production locations, such as China and India. However, the extent to which these processes mean the end to garment production in higher factor-cost locations, including those neighbouring the major clothing markets of the USA and the EU, is open to question. In this article we interrogate the interregional shifts in garment sourcing taking place in Europe and its surrounding regions. While factor costs (including labour) are important determinants of the geography of sourcing, a range of other costs (logistical and policy costs) are important in structuring the geographies of global and regional production. Firms in the Slovak Republic are responding to increasing competitive pressures and we assess how trans-border sourcing, subcontracting and FDI are being integrated into strategies to sustain European production networks. We highlight the emergence of cross-border production relocation to Ukraine as one specific strategy. We examine the product specificity of these changes and the ways in which they are embedded within already existing production networks, forms of cross-border contracting and central European trade regimes. In other words, we explore some of the forces that shape the somewhat tentative continuation of garment production for export to EU markets in central Europe despite the ,spectre of China'. [source] The Christian Religion in Modern European and World History: A Review of The Cambridge History of Christianity, 1815,2000HISTORY COMPASS (ELECTRONIC), Issue 6 2008David Lindenfeld Volumes 8 and 9 of the Cambridge History, representing the work of 72 scholars, reflect two major recent historiographical trends: 1) the increased attention paid to religion in modern European history, and 2) the increasing importance of Christianity in as a topic in world history. While these volumes serve to summarize the work already done in the first field, with articles on a wide variety of European countries, they should significantly move the second field forward by bringing together the work of specialists on many different parts of the world in a single place. Volume 8 summarizes scholarship on the Western religious revivals of the nineteenth century, both Catholic and Protestant. By integrating religion and politics, it also presents a more complex picture of the formation of European national identities than Benedict Anderson's Imagined Communities suggests. One third of the volume is devoted to the spread of Christianity to the non-Western world. In Volume 9, the European and world history perspectives are more evenly interspersed. Major themes include the papacy, ecumenism, colonialism, Pentecostalism, and the independent churches of Africa and Asia. The 1960s emerge as a turning point, if for different reasons in different parts of the world. This was the decisive period of secularization in Europe, and the final section documents the social and cultural impact of that shift, particularly on the arts. Although there are inevitable gaps in coverage, these volumes will serve as an invaluable research tool for years to come. [source] Preference for green packaging in consumer product choices , Do consumers care?INTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 5 2008Joonas Rokka Abstract In this paper, consumer environmental choice is studied by analysing the relative importance of green packaging when compared with other relevant product attributes. The empirical study is based on a choice-based conjoint analysis of preferences for functional drink products of a sample of 330 consumers using these products. Our choice-based approach on environmental behaviour brings new insights to previous research, which predominantly relies on attitude models. Results indicate that consumers differ in their preferences for packaging, brand, price and convenience of use of daily products. In addition, various distinctive consumer segments can be identified on the market. Contrary to several previous studies, we found that the largest consumer segment, one-third of consumers, favoured environmentally labelled packaging as the most important criteria in their choice. The findings emphasize the increasing importance of ethical and environmental dimension in product choices. We also propose that the attention in environmental consumer research should be shifted from general attitude studies towards the study of actual product choices. [source] Capacity building as a tool for assessing training and development activity: an Indian case studyINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 2 2008R. Krishnaveni In recognition of its increasing importance, many organizations make periodic assessments of their training and development activity. The objective of the present study was to extend the concept of capacity building to the assessment of training and development activity in an automobile component manufacturing organization, using a developed and validated instrument. The study subjects were 36 middle-level managers selected on a stratified basis. The research described here provides a new methodology for the evaluation of training and development activity. Perception-based, consensus-oriented assessment is proposed as a valuable tool for evaluating and improving training and development activity. Brainstorming sessions led to suggestions for enhancing capacity in identified lag areas. In addition, this assessment serves as a platform for subsequent evaluation of the effectiveness of training and development activity. [source] Housing satisfaction for persons with psychiatric disabilitiesJOURNAL OF COMMUNITY PSYCHOLOGY, Issue 6 2003Sam Tsemberis Provision of residential services to people with mental illness has assumed increasing importance since deinstitutionalization and as community- based services have increased. This large-scale multisite study of housing programs specifically for persons with mental illness examines one of the factors that lead to successful residential tenure for persons with serious mental illness. To date, the Lehman Quality of Life Scale has been used primarily to assess satisfaction with housing in studies of residential services. This article reports on a new measure of housing satisfaction. This new 25-item instrument was developed, field tested in a variety of housing settings across the country, and analyzed for reliability and validity by a group of housing researchers and clinicians. The implications of using this instrument for future evaluation and research on housing for persons with mental illness are examined. © 2003 Wiley Periodicals, Inc. J Comm Psychol 31: 581,590, 2003. [source] The Construction of Normal ExpectationsJOURNAL OF INDUSTRIAL ECOLOGY, Issue 2 2008Consumption Drivers for the Danish Bathroom Boom Summary The gradual upward changes of standards in normal everyday life have significant environmental implications, and it is therefore important to study how these changes come about. The intention of the article is to analyze the social construction of normal expectations through a case study. The case concerns the present boom in bathroom renovations in Denmark, which offers an excellent opportunity to study the interplay between a wide variety of consumption drivers and social changes pointing toward long-term changes of normal expectations regarding bathroom standards. The study is problem-oriented and transdisciplinary and draws on a wide range of sociological, anthropological, and economic theories. The empirical basis comprises a combination of statistics, a review of magazine and media coverage, visits to exhibitions, and qualitative interviews. A variety of consumption drivers are identified. Among the drivers are the increasing importance of the home as a core identity project and a symbol of the unity of the family, the opportunities for creative work, the convenience of more grooming capacity during the busy family's rush hours, the perceived need for retreat and indulgence in a hectic everyday life, and the increased focus on body care and fitness. The contours of the emerging normal expectations are outlined and discussed in an environmental perspective. [source] BURIAL HISTORY RECONSTRUCTION USING LATE DIAGENETIC PRODUCTS IN THE EARLY PERMIAN SILICICLASTICS OF THE FARAGHAN FORMATION, SOUTHERN ZAGROS, IRANJOURNAL OF PETROLEUM GEOLOGY, Issue 2 2009S. M. Zamanzadeh In spite of the increasing importance to hydrocarbon exploration and production of the Palaeozoic succession in the Zagros area of SW Iran, few burial history and palaeothermal modelling studies of the interval have been carried out. This paper attempts to assess the burial and palaeotemperature history of the Lower Permian Faraghan Formation which is composed of stromatolitic dolomites overlain by mainly cross-bedded sandstones. The formation grades up into the thick bedded carbonates of the Upper Permian Dalan Formation. The Faraghan and Dalan Formations are major hydrocarbon reservoir units in SW Iran and are time-equivalents of the Unayzah and Khuff Formations in Saudi Arabia, respectively. The Faraghan Formation consists of shallow-marine siliciclastics and foreshore deposits, including tidal-flat and tidal-channel, estuarine, sabkha, shoreface and offshore facies. In this study, diagenetic constituents are used to evaluate the formation's burial history in the Southern Zagros, an area for which only limited subsurface data is available. A burial history diagram for the formation was constructed for well Finu # 1 using WinBuryTM software. The diagram shows that the formation underwent progressive burial at variable rates between its deposition and the mid-Tertiary, since when it has undergone rapid uplift. Burial diagenetic products in the Faraghan Formation comprise saddle, ferroan and zoned dolomites, together with dickite, illite/sericite and chlorite minerals. Additional burial-related features include stylolites and dissolution seams. Isotopic signatures (,18O versus ,13C) of the ferroan dolomites suggest a burial trend for the formation. Reconstruction of the paragenetic sequence together with the burial history diagram suggests a maximum burial depth of about 5000 m and a wide palaeotemperature range of 80-160°C. However considering the saddle dolomites as a palaeothermometer, the temperature range narrows to 78 to 138 °C. The burial depth and temperature ranges closely correlate with the main stage of oil generation to the dry gas zone. [source] The tenth anniversary of Suzuki polycondensation (SPC)JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 10 2001A. D. Schlüter Abstract This article describes the successful transfer of the Suzuki cross-coupling (SCC) reaction to polymer synthesis, one of the major developments within the last decade of polymer synthesis. The polymers prepared by Suzuki polycondensation (SPC) and its Ni-catalyzed reductive counterpart are soluble and processable poly(arylene)s that, because of their rigid and conjugated backbones, are of interest for the materials sciences. Achievable molar masses easily compete with those of traditional polyesters and polyamides. This article also provides insight into some synthetic problems associated with the transfer of SCC from low molar mass organic chemistry to high molar mass polymer chemistry by addressing issues such as monomer purity, stoichiometric balance, achievable molar masses, and defects in the polymer structure. Although the emphasis of this article is synthetic and structural issues, some potential applications of the polyarylenes obtained are briefly mentioned. Together with the enormous developments in the areas of metallocene, ring-opening metathesis, and acyclic diene metathesis polymerization, the success of SPC impressingly underlines the increasing importance of transition-metal-catalyzed CC-bond-forming reactions in polymer synthesis. © 2001 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 39: 1533,1556, 2001 [source] Interfirm Alliances in the Small Business: The Role of Social NetworksJOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 3 2002Anat BarNir In light of the increasing importance of strategic alliances in shaping competition, this study explored whether the social network of small firm executives can be leveraged to facilitate the establishment of interfirm alliances. Analyses are based on a mail survey of 149 small manufacturing firms in the northeast United States. Results indicate that the social networks of senior executives account for 11,22 percent of the variance in the degree to which firms engage in alliances, depending on the type of alliance. Results also show that the number of interfirm alliances is positively related to several networking properties (propensity to network, strength of ties, and network prestige). Findings are discussed in the context of network theory, social embeddedness, and the overall implications for management researchers and practitioners. [source] Improving patient outlook in rheumatoid arthritis: Experience with abataceptJOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 10 2008MA (Nurse Manager), Mary Coughlin RN Abstract Purpose: To examine the importance of improving patient outlook in rheumatoid arthritis (RA) and to discuss the role of the nurse practitioner (NP) who, through the assessment of patient-reported outcomes and in acting as an advocate for the patient with the wider healthcare team, has a crucial part to play in managing the overall well-being of the patient. This article will draw on the clinical experience to date with abatacept, a first-in-class therapy that has been approved for the treatment of RA in patients with an inadequate response to either traditional disease-modifying antirheumatic drugs (DMARDs), such as methotrexate, or biological DMARDs, such as tumor necrosis factor-, antagonists. Data sources: A comprehensive literature search was performed using the National Library of Medicine (MEDLINE), EMBASE, and BIOSIS databases (restricted to articles posted between January 2000 and February 2007) with the search terms CTLA-4Ig, abatacept, and primary clinical trial publications in patients with RA. The clinical data are summarized in this review along with safety data presented in the prescribing information. Conclusions: Recent changes in the approach to RA treatment, particularly the advent of biological therapies, have impacted the role of the NP. The role of the NP is integral to the management of RA and in maximizing patient outcomes, through educating patients to make informed choices regarding their treatment, ensuring the safe administration of therapies and monitoring response to therapy, and in acting as an advocate for the patient within the wider healthcare team. Implications for practice: The use of more patient-centered measures of response are gaining increasing importance both in clinical trials and in clinical practice, and as such the NP has an important role in ensuring that both the physical and the psychological needs of patients are met. Clinical trials to date have shown that abatacept provides significant and clinically meaningful improvements in patient-reported outcomes, as well as demonstrating significant clinical benefits and a consistent safety profile, thus representing a valuable treatment option within the RA treatment armamentarium. [source] Intellectual structure of human resources management research: A bibliometric analysis of the journal Human Resource Management, 1985,2005JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 1 2009Mariluz Fernandez-Alles The multidisciplinary character of the theories supporting research in the discipline of human resources management (HRM), the increasing importance of a more rigorous approach to HRM studies by academics, and the impact of HRM on the competitive advantage of firms are just some of the indicators demonstrating the relevance of this discipline in the broader field of the social sciences. These developments explain why a quantitative analysis of HRM studies based on bibliometric techniques is particularly opportune. The general objective of this article is to analyze the intellectual structure of the HRM discipline; this can be divided into two specific objectives. The first is to identify the most frequently cited studies, with the purpose of identifying the key topics of research in the HRM discipline. The second objective is to represent the networks of relationships between the most-cited studies, grouping them under common themes, with the object of providing a diagrammatic description of the knowledge base constituted by accumulated works of research in the HRM field. The methodology utilized is based on the bibliometric techniques of citation analysis. [source] Cartilage tissue engineering using resorbable scaffoldsJOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Issue 6 2007Nicole Rotter Abstract Cartilage tissue engineering holds considerable promise for orthopaedic and reconstructive head and neck surgery. With an increasingly ageing population, the number of patients affected by arthritis and recurrent joint pain is constantly growing, along with the associated socio-economic costs. In head and neck surgery reconstructive procedures gain increasing importance in multimodal tumour therapies. These procedures require the harvesting of large amounts of donor tissue, which causes significant donor site morbidity. Therefore, in vitro -engineered cartilage may provide for a cost-effective and clinically valuable medical need. This article presents an overview of the clinical background as well as considerations for engineered cartilage in the head and neck, and provides examples of cartilage tissue engineering based on various scaffolds. Copyright © 2007 John Wiley & Sons, Ltd. [source] Specific recommendations for PROs and HRQoL assessment in allergic rhinitis and/or asthma: a GA2LEN taskforce position paperALLERGY, Issue 8 2010F. Braido To cite this article: Braido F, Bousquet PJ, Brzoza Z, Canonica GW, Compalati E, Fiocchi A, Fokkens W, Gerth van Wijk R, La Grutta S, Lombardi C, Maurer M, Pinto AM, Ridolo E, Senna GE, Terreehorst I, Todo Bom A, Bousquet J, Zuberbier T, Baiardini I. Specific recommendations for PROs and HRQoL assessment in allergic rhinitis and/or asthma: a GA2LEN taskforce position paper. Allergy 2010; 65: 959,968. Abstract The GA2LEN taskforce on Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HRQoL) published in 2009 a position paper concerning PROS and HRQoL assessment in clinical trials on allergy. Because of the specificity of this topic in asthma and rhinitis, specific recommendations are needed. The aim of this position paper is to define PROs and their meaning in asthma and rhinitis research, explore the available tools to provide criteria for a proper choice, identify patient-related factor which could influence PROs assessment, define specific recommendations for assessment, analysis and results spreading, underline the unexplored areas and unmet needs. PROs assessment is gaining increasing importance, and it must be performed with a rigorous methodological procedure and using validated tools. This approach enables to better understand patient-related factors influencing clinical trials and real-life management outcomes, identify patients subgroups that can benefit from specific treatment and management plan and tailor treatment to address PROs (not only physician-defined targets) to improve asthma and rhinitis management. [source] Thin discs, thick dwarfs and the effects of stellar feedbackMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY: LETTERS (ELECTRONIC), Issue 1 2010R. Sánchez-Janssen ABSTRACT We investigate the role of stellar mass in shaping the intrinsic thickness of galaxy discs by determining the probability distribution of apparent axial ratios (b/a) for two different samples that probe the faint end of the galaxy luminosity function. We find that the b/a distribution has a characteristic ,U-shape' and identify a limiting mass M*, 2 × 109 M, below which low-mass galaxies start to be systematically thicker. This tendency holds for very faint (MB,,8) dwarfs in the local volume, which are essentially spheroidal systems. We argue that galaxy shape is the result of the complex interplay between mass, specific angular momentum and stellar feedback effects. Thus, the increasing importance of turbulent motions in lower mass galaxies leads to the formation of thicker systems, a result supported by the latest hydrodynamical simulations of dwarf galaxy formation and other theoretical expectations. We discuss several implications of this finding, including the formation of bars in faint galaxies, the deprojection of H i line profiles and simulations of environmental effects on the dwarf galaxy population. [source] Toward an improved legislative framework for China's land degradation controlNATURAL RESOURCES FORUM, Issue 1 2008Zhou Ke Abstract The Chinese government has recently been attaching increasing importance to the application of effective legal tools to tackle land degradation (LD) issues. Based on the concept of sustainable development, China began developing and reaping the benefits of environmental and natural resources legislation including LD control regulations in the 1990s. In the past three years, some central-western provinces in China have been implementing a "People's Republic of China/Global Environment Facility (PRC/GEF) Partnership on LD Control of Dryland Ecosystems", which is based on an integrated ecosystem management (IEM) approach. IEM is designed to achieve a balanced, scientific and participatory approach to natural resources management, which creates the potential to improve the quality of Chinese environmental law and policy procedures. The paper studies the existing Chinese national laws and regulations pertinent to LD control within 9 areas covering land, desertification, soil erosion, grassland, forest, water, agriculture, wild animals and plants, and environment protection in detail, against IEM principles and basic legal elements. The main objective is to identify problems and provide feasible solutions and recommendations for the improvement of the existing laws and regulations. The authors conclude that the development of an improved national legislative framework is essential if LD control is to be successfully achieved. The paper is partly based on Component 1 , Improving Policies, Laws and Regulations for Land Degradation Control under PRC/GEF Partnership on Land Degradation in Dryland Ecosystems (TA 4357). [source] The Age of Migration in ChinaPOPULATION AND DEVELOPMENT REVIEW, Issue 3 2001Zai Liang Using data from the 1987 and 1995 China One Percent Population Sample Surveys, this article examines migration patterns during 1982,95, a period of sweeping social and economic changes in China. Several major patterns are evident: the increase in overall migration and especially in temporary migration, the increasing importance of inter-provincial migration, and the concentration of migrants in the coastal region. Over time, migrants of rural origin were more likely to choose cities as destinations than towns. The consequences and implications of the changes in migration patterns are explored. [source] Predicting deflagration to detonation transition in hydrogen explosionsPROCESS SAFETY PROGRESS, Issue 3 2008Prankul Middha Abstract Because of the development in computational resources, Computational Fluid Dynamics (CFD) has assumed increasing importance in recent years as a tool for predicting the consequences of accidents in petrochemical and process industries. CFD has also been used more and more for explosion predictions for input to risk assessments and design load specifications. The CFD software FLACS has been developed and experimentally validated continuously for more than 25 years. As a result, it is established as a tool for simulating hydrocarbon gas deflagrations with reasonable precision and is widely used in petrochemical industry and elsewhere. In recent years the focus on predicting hydrogen explosions has increased, and with the latest release the validation status for hydrogen deflagrations is considered good. However, in many of these scenarios, especially involving reactive gases such as hydrogen, deflagration to detonation transition (DDT) may be a significant threat. In previous work, FLACS was extended to identify whether DDT is likely in a given scenario and indicate the regions where it might occur. The likelihood of DDT has been expressed in terms of spatial pressure gradients across the flame front. This parameter is able to visualize when the flame front captures the pressure front, which is the case in situations when fast deflagrations transition to detonation. Reasonable agreement was obtained with experimental observations in terms of explosion pressures, transition times, and flame speeds. The DDT model has now been extended to develop a more meaningful criterion for estimating the likelihood of DDT by comparison of the geometric dimensions with the detonation cell size. This article discusses the new models to predict DDT, and compare predictions with relevant experiments. © 2007 American Institute of Chemical Engineers Process Saf Prog 2008 [source] Demand and Production Management with Uniform Guaranteed Lead TimePRODUCTION AND OPERATIONS MANAGEMENT, Issue 4 2005Uday S. Rao Recently, innovation-oriented firms have been competing along dimensions other than price, lead time being one such dimension. Increasingly, customers are favoring lead time guarantees as a means to hedge supply chain risks. For a make-to-order environment, we explicitly model the impact of a lead time guarantee on customer demands and production planning. We study how a firm can integrate demand and production decisions to optimize expected profits by quoting a uniform guaranteed maximum lead time to all customers. Our analysis highlights the increasing importance of lead time for customers, as well as the tradeoffs in achieving a proper balance between revenue and cost drivers associated with lead-time guarantees. We show that the optimal lead time has a closed-form solution with a newsvendor-like structure. We prove comparative statics results for the change in optimal lead time with changes in capacity and cost parameters and illustrate the insights using numerical experimentation. [source] A liquid chromatography/tandem mass spectrometry method for detecting UGT-mediated bioactivation of drugs as their N -acetylcysteine adducts in human liver microsomesRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 5 2009Hiroshi Harada The detection of the reactive metabolites of drugs has recently been gaining increasing importance. In vitro trapping studies using trapping agents such as glutathione are usually conducted for the detection of reactive metabolites, especially those of cytochrome P450-mediated metabolism. In order to detect the UDP-glucuronosyltransferase (UGT)-mediated bioactivation of drugs, an invitro trapping method using N -acetylcysteine (NAC) as a trapping agent followed by liquid chromatography/tandem mass spectrometry (LC/MS/MS) was developed in this study. After the test compounds (diclofenac and ketoprofen) had been incubated in human liver microsomes with uridine diphosphoglucuronic acid (UDPGA) and NAC, the NAC adducts formed through their acyl glucuronides were analyzed using LC/MS/MS with electrospray ionization (ESI). The NAC adduct showed a mass shift of 145 units as compared to its parent, and the characteristic ion fragmentations reflected the parent. This is a concise and high-throughput method for evaluating reactive metabolites by UGT-mediated bioactivation. Copyright © 2009 John Wiley & Sons, Ltd. [source] Vestibular Effects of Cochlear Implantation,THE LARYNGOSCOPE, Issue S103 2004Craig A. Buchman MD Abstract Objectives/Hypothesis: Cochlear implantation (CI) carries with it the potential risk for vestibular system insult or stimulation with resultant dysfunction. As candidate profiles continue to evolve and with the recent development of bilateral CI, understanding the significance of this risk takes on an increasing importance. Study Design: Between 1997 to 2001, a prospective observational study was carried out in a tertiary care medical center to assess the effects of unilateral CI on the vestibular system. Methods: Assessment was performed using the dizziness handicap inventory (DHI), vestibulo-ocular reflex (VOR) testing using both alternate bithermal caloric irrigations (ENG) and rotational chair-generated sinusoidal harmonic accelerations (SHA), and computerized dynamic platform posturography (CDP) at preoperative, 1-month, 4-month, 1-year and 2-year postimplantation visits. CI was carried out without respect to the preoperative vestibular function test results. Results: Specifically, 86 patients were entered into the study after informed consent. For the group as a whole, pair wise comparisons revealed few significant differences between preoperative and postoperative values for VOR testing (ENG and SHA) at any of the follow-up intervals. Likewise, DHI testing was also unchanged except for significant reductions (improvements) in the emotional subcategory scores at both the 4-month and 1-year intervals. CDP results demonstrated substantial improvements in postural sway in the vestibular conditions (5 and 6) as well as composite scores with the device "off" and "on" at the 1-month, 4-month, 1-year, and 2-year intervals. Device activation appeared to improve postural stability in some conditions. Excluding those patients with preoperative areflexic or hyporeflexic responses in the implanted ear (total [warm + cool] caloric response , 15 deg/s), substantial reductions (,21 deg/s maximum slow phase velocity) in total caloric response were observed for 8 (29%) patients at the 4-month interval. These persisted throughout the study period. These changes were accompanied by significant low frequency phase changes on SHA testing confirming a VOR insult. Of interest, no significant changes were detected in the DHI or CDP, and there were no effects of age, sex, device manufacturer, or etiology of hearing loss (HL) for these patients. Conclusions: Unilateral CI rarely results in significant adverse effects on the vestibular system as measured by the DHI, ENG, SHA, and CDP. On the contrary, patients that underwent CI experienced significant improvements in the objective measures of postural stability as measured by CDP. Device activation in music appeared to have an additional positive effect on postural stability during CDP testing. Although VOR testing demonstrated some decreases in response, patients did not suffer from disabling vestibular effects following CI. The mechanism underlying these findings remains speculative. These findings should be considered in counseling patients about CI. [source] The Hindlimb Muscles of Rhea americana (Aves, Palaeognathae, Rheidae)ANATOMIA, HISTOLOGIA, EMBRYOLOGIA, Issue 5 2010M. B. J. Picasso With 13 figures Summary The Greater Rhea is the largest cursorial Ratitae bird native to South America. Due to its increasing importance in farming and therefore in the sustainable use of this species, a comprehensive knowledge of their anatomy is essential. The goal of this study was to provide an anatomical description of the hindlimb muscles of Rhea americana. Six adult birds of both sexes were macroscopically studied analysing the origin and insertion of thigh and shank muscles. The thigh showed the highest number of muscles, whereas the shank showed the lowest number; this feature minimizes inertia and allows achieving high stride frequencies. The muscles of the shank showed long tendons of insertion that reduce the energetic cost during running. The major muscles responsible for extension of the hip and the ankle joints were massive and robust indicating their importance for cursorial locomotion. The pelvic limb muscles of Rhea americana resemble those of other cursorial Ratitae and their features are consistent with specialization for high-speed locomotion. [source] EVALUATING HISTOLOGICAL METHODS FOR ASSESSING HAIR FIBRE DEGRADATIONARCHAEOMETRY, Issue 3 2010A. S. WILSON The hair shaft has increasing importance in bioarchaeology, since it is now possible to retrieve detailed biomolecular information on recent life history using individual fibres (e.g., on diet, drug use and DNA). Data on hair condition is an important cornerstone to ensuring that reliable information is obtained. The following study defines morphological features of degradative change in human terminal scalp hair using different microscopy techniques. Evidence of degradative change is translated into a ranked histology for assessing hair sample condition. The approach is applied to samples of cut modern scalp hair subjected to degradation under soil burial/simulated grave conditions. [source] Small area population disease burdenAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 4 2001Richard Taylor Small area health statistics has assumed increasing importance as the focus of population and public health moves to a more individualised approach of smaller area populations. Small populations and low event occurrence produce difficulties in interpretation and require appropriate statistical methods, including for age adjustment. There are also statistical questions related to multiple comparisons. Privacy and confidentiality issues include the possibility of revealing information on individuals or health care providers by fine cross-tabulations. Interpretation of small area population differences in health status requires consideration of migrant and Indigenous composition, socio-economic status and rural-urban geography before assessment of the effects of physical environmental exposure and services and interventions. Burden of disease studies produce a single measure for morbidity and mortality-disability adjusted life year (DALY)-which is the sum of the years of life lost (YLL) from premature mortality and the years lived with disability (YLD) for particular diseases (or all conditions). Calculation of YLD requires estimates of disease incidence (and complications) and duration, and weighting by severity. These procedures often mean problematic assumptions, as does future discounting and age weighting of both YLL and YLD. Evaluation of the Victorian small area population disease burden study presents important cross-disciplinary challenges as it relies heavily on synthetic approaches of demography and economics rather than on the empirical methods of epidemiology. Both empirical and synthetic methods are used to compute small area mortality and morbidity, disease burden, and then attribution to risk factors. Readers need to examine the methodology and assumptions carefully before accepting the results. [source] Development of a Characterization Method for the Combustion Behavior of Solid Recovered FuelsCHEMICAL ENGINEERING & TECHNOLOGY (CET), Issue 7 2004O. Kock Apart from coal, fuels like solid biogenic or recovered fuels will gain increasing importance in power generation plants because of their potential to lower CO2 emissions. In order to produce a constant fuel quality and to guarantee a safe power plant operation, it is rather important to know the combustion behavior of the different fuel types. A characterization method is proposed by which the combustion behavior of solid fuels can be analyzed with low-cost equipment and reliable results. [source] Sensitivity improvement of circular dichroism detection in HPLC by using a low-pass electronic noise filter: Application to the enantiomeric determination purity of a basic drugCHIRALITY, Issue 2 2007Marie Lorin Abstract The quality control of chiral drugs requires the determination of their enantiomeric purity. Nowadays, circular dichroism (CD) spectroscopy is gaining increasing importance in pharmaceutical analysis because of the commercially available CD detector in liquid chromatography. The separation of the two enantiomers of a basic drug (efaroxan) was achieved by high performance liquid chromatography using an amylose-derivated column with both UV and CD detections. A baseline-resolved separation (resolution: 5) was obtained after optimization of the mobile phase composition with hexane-ethanol-diethylamine (90:10:0.05; v/v/v). The use of a commercial low-pass electronic noise filter of the CD signal has improved the signal-to-noise ratio by a factor twelve and allowed the quantitation of each enantiomer in the 1.25,300 ,g ml,1 concentration range. The CD linear calibration curve, expressed in terms of stereoisomer height ratio versus concentration ratio, was plotted over the 0.4,6% range. A correlation coefficient greater than 0.999 was obtained by least-squares regression and the limit of detection for the distomer/eutomer ratio was estimated at 0.14%. Although the method validation showed good repeatability on the retention times (RSD < 0.9%), on the peak height ratios (RSD < 8.7%) of each enantiomer only up to 99.2% enantiomeric purity was achieved. Chirality, 2006. © 2006 Wiley-Liss, Inc. [source] | ||||||||||||||||||||||||||||