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Innovative Methodology (innovative + methodology)
Selected AbstractsCover Picture: Electrophoresis 19'2010ELECTROPHORESIS, Issue 19 2010Article first published online: 29 SEP 2010 Issue no. 19 is a special issue on "CE and CEC Innovations" comprising 1 Fast Track manuscript and 20 manuscripts distributed over 5 separate parts. Part I has 5 research articles on novel trends in CEC. Part II has 4 research articles dealing with innovative methodologies. Part III reports a variety of interactive CE systems described in 5 research articles. Proteins and biomarkers are treated in 3 research articles making up part IV. The last 3 articles in this issue (Part V) are on detection approaches. The FAST TRACK article describes "An automated capillary electrophoresis system for high speed separation of DNA fragments based on a short capillary". [source] Educational and Research Implications of Portable Human Patient Simulation in Acute Care MedicineACADEMIC EMERGENCY MEDICINE, Issue 11 2008Leo Kobayashi MD Abstract Advanced medical simulation has become widespread. One development, the adaptation of simulation techniques and manikin technologies for portable operation, is starting to impact the training of personnel in acute care fields such as emergency medicine (EM) and trauma surgery. Unencumbered by cables and wires, portable simulation programs mitigate several limitations of traditional (nonportable) simulation and introduce new approaches to acute care education and research. Portable simulation is already conducted across multiple specialties and disciplines. In situ medical simulations are those carried out within actual clinical environments, while off-site portable simulations take place outside of clinical practice settings. Mobile simulation systems feature functionality while moving between locations; progressive simulations are longer-duration events using mobile simulations that follow a simulated patient through sequential care environments. All of these variants have direct applications for acute care medicine. Unique training and investigative opportunities are created by portable simulation through four characteristics: 1) enhancement of experiential learning by reframing training inside clinical care environments, 2) improving simulation accessibility through delivery of training to learner locations, 3) capitalizing on existing care environments to maximize simulation realism, and 4) provision of improved training capabilities for providers in specialized fields. Research agendas in acute care medicine are expanded via portable simulation's introduction of novel topics, new perspectives, and innovative methodologies. Presenting opportunities and challenges, portable simulation represents an evolutionary progression in medical simulation. The use of portable manikins and associated techniques may increasingly complement established instructional measures and research programs at acute care institutions and simulation centers. [source] Near-Term Travel Speed Prediction Utilizing Hilbert,Huang TransformCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 8 2009Khaled Hamad In this study, we propose an innovative methodology for such prediction. Because of the inherently direct derivation of travel time from speed data, the study was limited to the use of speed only as a single predictor. The proposed method is a hybrid one that combines the use of the empirical mode decomposition (EMD) and a multilayer feedforward neural network with backpropagation. The EMD is the key part of the Hilbert,Huang transform, which is a newly developed method at NASA for the analysis of nonstationary, nonlinear time series. The rationale for using the EMD is that because of the highly nonlinear and nonstationary nature of link speed series, by decomposing the time series into its basic components, more accurate forecasts would be obtained. We demonstrated the effectiveness of the proposed method by applying it to real-life loop detector data obtained from I-66 in Fairfax, Virginia. The prediction performance of the proposed method was found to be superior to previous forecasting techniques. Rigorous testing of the distribution of prediction errors revealed that the model produced unbiased predictions of speeds. The superiority of the proposed model was also verified during peak periods, midday, and night. In general, the method was accurate, computationally efficient, easy to implement in a field environment, and applicable to forecasting other traffic parameters. [source] Using a modified shepards method for optimization of a nanoparticulate cyclosporine a formulation prepared by a static mixer techniqueJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 2 2008Dionysios Douroumis Abstract An innovative methodology has been used for the formulation development of Cyclosporine A (CyA) nanoparticles. In the present study the static mixer technique, which is a novel method for producing nanoparticles, was employed. The formulation optimum was calculated by the modified Shepard's method (MSM), an advanced data analysis technique not adopted so far in pharmaceutical applications. Controlled precipitation was achieved injecting the organic CyA solution rapidly into an aqueous protective solution by means of a static mixer. Furthermore the computer based MSM was implemented for data analysis, visualization, and application development. For the optimization studies, the gelatin/lipoid S75 amounts and the organic/aqueous phase were selected as independent variables while the obtained particle size as a dependent variable. The optimum predicted formulation was characterized by cryo-TEM microscopy, particle size measurements, stability, and in vitro release. The produced nanoparticles contain drug in amorphous state and decreased amounts of stabilizing agents. The dissolution rate of the lyophilized powder was significantly enhanced in the first 2 h. MSM was proved capable to interpret in detail and to predict with high accuracy the optimum formulation. The mixer technique was proved capable to develop CyA nanoparticulate formulations. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:919,930, 2008 [source] Toward the ,Rights of the Poor' Human Rights in Liberation TheologyJOURNAL OF RELIGIOUS ETHICS, Issue 3 2000Mark Engler In this article, the author traces the response of liberation theologians to human rights initiatives through three distinct stages over the past thirty years: from an initial avoidance of the concept, to an early critique, and then to a nuanced theological appropriation. He contends that liberation theology brings a thoroughgoing concern for the poor and an innovative methodology of historicization to the discussion of human rights. In clarifying the treatment of human rights within a specific religious movement, the author also addresses larger questions about the specific role of human rights language. To this end, the article shows how liberation theologians have grappled concretely with the divisions among different ,generations' of rights, various rights discourses, and diverse options for rights advocacy. [source] Implied correlation index: A new measure of diversificationTHE JOURNAL OF FUTURES MARKETS, Issue 2 2005Vasiliki D. Skintzi Most approaches in forecasting future correlation depend on the use of historical information as their basic information set. Recently, there have been some attempts to use the notion of "implied" correlation as a more accurate measure of future correlation. This study proposes an innovative methodology for backing-out implied correlation measures from index options. This new measure called implied correlation index reflects the market view of the future level of the diversification in the market portfolio represented by the index. The methodology is applied to the Dow Jones Industrial Average index, and the statistical properties and the dynamics of the proposed implied correlation measure are examined. The evidence of this study indicates that the implied correlation index fluctuates substantially over time and displays strong dynamic dependence. Moreover, there is a systematic tendency for the implied correlation index to increase when the market index returns decrease and/or the market volatility increases, indicating limited diversification when it is needed most. Finally, the forecast performance of the implied correlation index is assessed. Although the implied correlation index is a biased forecast of realized correlation, it has a high explanatory power, and it is orthogonal to the information set compared to a historical forecast. © 2005 Wiley Periodicals, Inc. Jrl Fut Mark 25:171,197, 2005 [source] A sensemaking approach to trade-offs and synergies between human and ecological elements of corporate sustainabilityBUSINESS STRATEGY AND THE ENVIRONMENT, Issue 4 2010Tamsin Angus-Leppan Abstract This paper considers the complex relationships between the human and ecological elements of sustainability that exist in the minds of stakeholders and argues that a sensemaking approach allows these to be better understood and compared. This is supported by the results of a study, set in a financial institution, exploring the relationships between these non-financial elements of corporate sustainability. The viewpoints of middle management, branch and contact centre employees, executives, a community consultative council, suppliers and a community partner of a large Australian bank obtained in in-depth interviews are analysed and compared utilizing an innovative methodology of semantic analysis. We find that these stakeholders' perceptions of the human,ecological relationship differ by group, containing different mixes of trade-offs and synergies between the non-financial elements of corporate sustainability. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment. [source] 3 Taking a History from the Challenging Patient in the Emergency DepartmentACADEMIC EMERGENCY MEDICINE, Issue 2008Bruce Becker This exhibit will use DVD footage, written material, and live real-time interaction to demonstrate an innovative methodology to teaching residents and medical students to gain comfort and expertise in communicating with and taking a history from challenging patients in the ED. I teach this course at our institution every year. Professional actors with improvisational experience play out unscripted interactions with students based on a character or characters, a set scene, and predefined goals and endpoints. Their dialogue and choices evolve from the student's response and the tone, direction, and approach that the student takes. These scenarios are much more realistic and educational than OSCEs which are often described as artificial and flat. Some of the scenarios that I will present include: Daughter trying to make End-of-life choices for her mother, type A man with chest pain trying to sign out, a woman with "dental pain" who is seductive and drug-seeking, an intoxicated attending MD brought in from a motor vehicle crash (MVC) who uses power in a manipulative way. Many of the scenarios contain potential ethical, sexual, gender, racial issues that the student must address along with the medical problems. [source] | ||||||||||