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Initial Test (initial + test)
Selected AbstractsEmotion avoidance in patients with anorexia nervosa: Initial test of a functional modelINTERNATIONAL JOURNAL OF EATING DISORDERS, Issue 5 2010Jennifer E. Wildes PhD Abstract Objective: This study aimed to evaluate emotion avoidance in patients with anorexia nervosa (AN) and to examine whether emotion avoidance helps to explain (i.e., mediates) the relation between depressive and anxiety symptoms and eating disorder (ED) psychopathology in this group. Method: Seventy-five patients with AN completed questionnaires to assess study variables. Rates of emotion avoidance were compared to published data, and regression models were used to test the hypothesis that emotion avoidance mediates the relation between depressive and anxiety symptoms and ED psychopathology in AN. Results: Patients with AN endorsed levels of emotion avoidance that were comparable to or higher than other psychiatric populations and exceeded community controls. As predicted, emotion avoidance significantly explained the relations of depressive and anxiety symptoms to ED psychopathology. Discussion: Findings confirm that emotion avoidance is present in patients with AN and provide initial support for the idea that anorexic symptoms function, in part, to help individuals avoid aversive emotional states. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010 [source] Personality Trait Profiles of Missionary AdolescentsJOURNAL OF TRAVEL MEDICINE, Issue 6 2000Terry L. Dwelle Background: The study objective was to compare the Taylor-Johnson Temperament Analysis secondary population norms for adolescents, to test results of Assemblies of God missionary adolescents, and determine if the mission's experience had significant impact on personality traits. Methods: A retrospective record review study of Taylor-Johnson Temperament Analysis test results administered to all missionary adolescents aged 13- to 18-years-old, having attended a yearly school of missions from 1986 to 1994, was performed. A two-sample, two-tailed t -test was used for statistical analysis. Test results were compared with standard adolescent and adult norms. Initial, and second test results when available, were compared for significant personality trait changes in adolescents over a 2,3 year interval, while in the mission's program. Subpopulation norms were calculated for the study group. Results: Initial tests from 438 study group adolescents demonstrated significant differences in 7 of 9 personality trait categories for males, and 8 of 9 for females, compared with test adolescent norms. Initial, and second test comparisons were performed in 67 adolescents, and showed no significant changes in the personality trait scores in males and females. Personality trait profiles for females more closely resembled adult than adolescent norms, with 8 of the 9 personality trait categories showing no significant difference between adult female norms and study females. Conclusions: Clinicians and mission's sending agencies should be aware of the unique Taylor-Johnson Temperament Analysis test patterns for missionary adolescents, and that Taylor-Johnson Temperament Analysis norm tables for adolescents seem inadequate in evaluating missionary adolescents. Appropriate subpopulation norms are likely necessary. The impact of missions on personality trait categories of missionary adolescents seems negligible, but needs further research with methods that assure follow-up testing. These considerations could apply to other subpopulations and psychological tests. [source] Study of the metal dusting behaviour of high-temperature alloysMATERIALS AND CORROSION/WERKSTOFFE UND KORROSION, Issue 11 2003F. Di Gabriele Metal dusting; Nickelbasis-Legierungen; Aufkohlung Abstract The corrosion phenomenon named metal dusting has been observed in many high-temperature industrial plants. An experimental research programme is being carried out into the degradation resistance of wrought and cast commercial and development high-temperature alloys in H2/CO gas mixtures at temperatures of 550°C to 750°C. Emphasis is placed on very high carbon activities, consistent with the next generation of steam-reforming and similar plants that are susceptible to metal dusting. The overall programme is concerned with the mechanisms of initiation and propagation of dusting and the sensitivity to damage of the more resistant alloys, as a function of environmental parameters. Initial tests have been carried out on a number of commercial alloys: Alloy 600, 693, 602CA, 601, 603 XL, 671, 617, 690 (wrought), and H46M (cast). The specimens were exposed to a gas mixture of high carbon activity at 650°C for a total of 1000 hours. Many of the alloys showed at least the initial stages of metal dusting. Preliminary analysis using electron microscopy revealed that initiation of metal dusting is influenced by microstructure, stress state and composition. In some cases, attack was enhanced at stress points, such as corners and edges. Sample holders were found to influence strongly the length of the initiation period for the onset of the corrosion phenomenon. The reaction layers in the alloy beneath areas of damage were analysed by EDX and EPMA. Mechanical characterisation of such areas has been carried out using nanoindentation methods. These early results are discussed in terms of the effectiveness of oxide scales in inhibiting the onset of damage and presence of impurities in the ceramic holder in initiating the onset of damage. [source] Structure,properties relations in titanium-based thermoplastic fiber,metal laminatesPOLYMER COMPOSITES, Issue 3 2006P. Cortés This paper investigates the interfacial, tensile, and fatigue properties of a titanium alloy fiber,metal laminate (Ti-FML) based on woven glass-fiber-reinforced polyetherimide (GF/PEI). Initial tests, using the single cantilever beam (SCB) geometry have shown that it is not necessary to surface treat the titanium alloy in order to achieve a high value of metal,composite interfacial fracture toughness. Tensile tests have shown that the mechanical properties of the FML lie between those offered by its constituent materials. Tension,tension fatigue tests have shown that the fatigue lives of these laminates are superior to those offered by the plain titanium alloy. The mechanical properties of this glass fiber/PEI FML have also been compared with those offered by an FML based on a unidirectional carbon-fiber-reinforced polyetheretherketone (CF/PEEK) composite. Here, it has been shown that although the fatigue properties of this woven GF/PEI composite are inferior to those of the CF/PEEK FML, they do offer a higher temperature capability due to the higher glass transition temperature of the PEI matrix. Polym. Compos. 27:264,270, 2006. © 2006 Society of Plastics Engineers. [source] Psychometric evaluation of the acute coronary syndrome (ACS) response indexRESEARCH IN NURSING & HEALTH, Issue 6 2007Barbara Riegel Abstract Knowledge, attitudes, and beliefs of persons with ischemic heart disease are important predictors of delay in seeking treatment. We tested the psychometric profile of the Acute Coronary Syndrome (ACS) Response Index, a measure assessing patient knowledge, attitudes and beliefs about ACS symptoms and response, in 3,522 patients. On factor analysis, 21 dichotomous knowledge items loaded onto four factors (alpha .82). In a separate factor analysis, another five items loaded on two attitude factors, and seven items loaded on two belief factors (alpha .76). The scales discriminated between patients previously exposed to medical experts. Scale scores were significantly correlated but without evidence of multicolinearity. Initial tests of reliability and validity support further testing of this new instrument. © 2007 Wiley Periodicals, Inc. Res Nurs Health 30:584,594, 2007 [source] Child Health Assessment at School Entry (CHASE) project: evaluation in 10 London primary schoolsCHILD: CARE, HEALTH AND DEVELOPMENT, Issue 2 2005S. Edmunds Abstract Aims To assess the feasibility of implementing the Child Health Assessment at School Entry (CHASE) questionnaire, developed to capture the multiple dimensions of the health of children in their first year at school, and to evaluate data quality, reliability and validity. Methods Parents of 278 year-1 children, from 10 primary schools in two London boroughs, received a parent questionnaire and school nurses completed a separate questionnaire from health and education records for children whose parents consented. Additional data on free school meal eligibility and ethnicity were obtained from the two Local Education Authorities. The parent questionnaire included the Strengths and Difficulties Questionnaire (SDQ) and four dimensions of the Child Health Questionnaire Parent Form-28 (CHQ-PF28). Results Response rate was 61%. The association between school free school meals eligibility and response rate in each school approached significance (r = ,0.62, P = 0.05). Data completeness of the parent questionnaire was high (mean 98%). Data completeness of the school nurse questionnaire was more variable (mean 82%). Cronbach's Alpha was greater than 0.6 for four of the five SDQ scales and greater than 0.7 for the two CHQ-PF28 multi-item scales. Relative to parents with qualifications, parents with no qualifications rated their children as having significantly more conduct problems, peer problems, and overall mental health problems (P < 0.01) as assessed by the SDQ, and significantly lower global health (P < 0.01) as assessed by the CHQ-PF28. Children with special educational needs and children with long-standing illness or disability were rated as having significantly lower global health (P < 0.05) than children without these. Sample tables of inter-school and inter-borough comparison of key findings demonstrate considerable differences in physical and mental health status. Discussion The questionnaire was acceptable to parents and school nurses, and feasible to implement within existing school resources. Initial tests of internal reliability and validity are satisfactory. These data have the potential to inform interventions and service provision at school and borough level, and public health trends over time. [source] Targeted screening for undiagnosed diabetes reduces the number of diagnostic tests.DIABETIC MEDICINE, Issue 8 2004Inter99(8) Abstract Aims To determine the cost and performance of a Danish risk score, fasting plasma glucose (FPG), and HbA1c as single screening tests and in combination with targeted screening. Subjects and methods In the Inter99 study, 12 934 inhabitants of Copenhagen County were invited to participate. All participants underwent anthropometric measurements, blood samples, and a 75-g standardized oral glucose tolerance test [N = 6784 (52.5%)]. Results Of the 6117 individuals included in the analysis, 252 (4.1%) had previously undiagnosed diabetes. As a stand-alone test, the FPG had the highest performance expressed by a significantly higher area under the receiver,operating curve [0.89; 95% confidence interval (CI) 0.86, 0.99] compared with the Danish risk score (0.78; 95% CI 0.76, 0.81) and HbA1c (0.76; 95% CI 0.72, 0.80). Targeted screening where the initial test was a risk score reduced the FPG measurements by 72% (100% vs. 27.8%). Using FPG in population-based screening, the cost per newly diagnosed diabetic individual was 583 euro compared with 270 euro if screened by questionnaire followed by FPG. The sensitivity and specificity were 78.6% and 87.7% for FPG, and 61.5% and 89.2% for the combination of the questionnaire and FPG, respectively. Conclusions The performance of FPG was superior to a questionnaire and HbA1c used as single tests. However taking into account workload, the burden on the population and the cost per identified person with undiagnosed diabetes, targeted screening using a questionnaire followed by FPG appears to be the strategy of choice. Diabet. Med. (2004) [source] Visual Function is Stable in Patients Who Continue Long-Term Vigabatrin Therapy: Implications for Clinical Decision MakingEPILEPSIA, Issue 4 2001Scott R. Paul Summary: ,Purpose: Vigabatrin (VGB) has been shown to cause visual field constriction and other forms of mild visual dysfunction. We determined the safety of continuing VGB therapy in patients who had received prolonged treatment (>2 years) with the drug by serially monitoring changes in visual function over a 1-year period of continued therapy. We also followed up patients who discontinued VGB to see whether alternative therapies are effective. Methods: Fifteen of 17 patients who continued VGB therapy had visual-function testing (visual acuity, color vision, kinetic and static perimetry) every 3 months for 1 year. Eighteen patients who discontinued VGB were given alternative antiepileptic drugs (AEDs); their seizure responses were measured after ,3 months of treatment. Results: Patients continuing VGB showed no worsening of visual acuity, color vision, or visual-field constriction beyond that measured in the initial test. Many patients who discontinued VGB had good seizure control with either newer or previously unsuccessful AEDs. Conclusions: For patients who have an excellent response to VGB and only mild visual changes, continued therapy may be safe with close visual monitoring. Patients who do not have a significant reduction in seizures or who experience considerable visual dysfunction with VGB may respond well to alternative therapies. [source] Testing of fine motor skills in dental studentsEUROPEAN JOURNAL OF DENTAL EDUCATION, Issue 1 2000Olaf Luck Manual skills form only a part of the capabilities required of future dentists, but they are a very important component, which should be tested. With regard to the dental specialities, the present study tested speciality-independent fine motor skills. No objective, practical solution has been found up to now. 88 dental students and, as a control group, 23 medical students were examined in the longitudinal study. In the course of the analysis, 4 fine motor tests were carried out at the beginning of the 2nd and 6th semesters. The tests comprised the tremometer test, the tremometer test with a mirror, the 2-hand sinusoid test and archery using the Game Gear by SEGA. The test devices facilitate primarily the testing of components of accuracy of movements, indirect working methods, and eye-hand coordination. In the comparison of performances on test day A, the medical students' performance was noticeably better. As testing progressed, results showed stagnation in the performance of the medical students and a significant improvement in the performance of the dental students. That means that the test system can be used for a test over the course of study, but not as an initial test. [source] Dual fluorescent protein reporters for studying cell behaviors in vivoGENESIS: THE JOURNAL OF GENETICS AND DEVELOPMENT, Issue 10 2009M. David Stewart Abstract Fluorescent proteins (FPs) are useful tools for visualizing live cells and their behaviors. Protein domains that mediate subcellular localization have been fused to FPs to highlight cellular structures. FPs fused with histone H2B incorporate into chromatin allowing visualization of nuclear events. FPs fused to a glycosylphosphatidylinositol anchor signal sequence label the plasma membrane, highlighting cellular shape. Thus, a reporter gene containing both types of FP fusions would allow for effective monitoring of cell shape, movement, mitotic stage, apoptosis, and other cellular activities. Here, we report a binary color-coding system using four differently colored FP reporters that generates 16 distinct color codes to label the nuclei and plasma membranes of live cells in culture and in transgenic mice. As an initial test of this system in vivo, the promoter of the human Ubiquitin C (UBC) gene was used to widely express one of the color-code reporters. Widespread expression of the reporter was attained in embryos; however, both male and female transgenic mice were infertile. In contrast, the promoter of the mouse Oct4/Pou5f1 gene linked to two different color-code reporters specifically labeled blastocysts, primordial germ cells, and postnatal germ cells, and these mice were fertile. Time-lapse movies of fluorescently-labeled primordial germs cells demonstrate the utility of the color-code system to visualize cell behaviors. This set of new FP reporters should be a useful tool for labeling distinct cell populations and studying their behaviors in complex tissues in vivo. genesis 47:708,717, 2009. © 2009 Wiley-Liss, Inc. [source] Confirmatory factor analysis and recommendations for improvement of the Autonomy-Preference-Index (API)HEALTH EXPECTATIONS, Issue 3 2010Daniela Simon PhD Dipl Psych Abstract Objective, Validation of the German version of the Autonomy-Preference-Index (API), a measure of patients' preferences for decision making and information seeking. Methods, Stepwise confirmatory factor analysis was conducted on a sample of patients (n = 1592) treated in primary care for depression (n = 186), surgical and internal medicine inpatients (n = 811) and patients with minor trauma treated in an emergency department (n = 595). An initial test of the model was done on calculation and validation halves of the sample. Both local and global indexes-of-fit suggested modifications to the scale. The scale was modified and re-tested in the calculation sample and confirmed in the validation sample. Subgroup analyses for age, gender and type of treatment setting were also performed. Results, The confirmatory analysis led to a modified version of the API with better local and global indexes-of-fit for samples of German-speaking patients. Two items of the sub-scale, ,preference for decision-making', and one item of the sub-scale, ,preference for information seeking', showed very low reliability scores and were deleted. Thus, several global indexes-of-fit clearly improved significantly. The modified scale was confirmed on the validation sample with acceptable to good indices of fit. Results of subgroup analyses indicated that no adaptations were necessary. Discussion and conclusions, This first confirmatory analysis for a German-speaking population showed that the API was improved by the removal of several items. There were theoretically plausible explanations for this improvement suggesting that the modifications might also be appropriate in English and other language versions. [source] Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial testINTERNATIONAL JOURNAL OF CANCER, Issue 5 2009Lyn Schofield Abstract Approximately 1,2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre-symptomatic identification of mutation carriers has been demonstrated to improve survival; however, there is concern that many are not being identified using current practices. We evaluated population-based MSI screening of CRC in young patients as a means of ascertaining mutation carriers. CRC diagnosed in patients aged <60 years were identified from pathology records. No prior information was available on family history of cancer. PCR techniques were used to determine MSI in the BAT-26 mononucleotide repeat and mutation in the BRAF oncogene. Loss of MLH1, MSH2, MSH6 and PMS2 protein expression was evaluated in MSI+ tumours by immunohistochemistry. MSI+ tumours were found in 105/1,344 (7.8%) patients, of which 7 were excluded as possible Lynch syndrome because of BRAF mutation. Of the 98 "red flag" cases that were followed up, 25 were already known as mutation carriers or members of mutation carrier families. Germline test results were obtained for 35 patients and revealed that 22 showed no apparent mutation, 11 showed likely pathogenic mutations and 2 had unclassified variants. The proportion of MSI+ cases in different age groups that were estimated to be mutation carriers was 89% (<30 years), 83% (30,39), 68% (40,49) and 17% (50,59). We recommend MSI as the initial test for population-based screening of Lynch syndrome in younger CRC patients, regardless of family history. © 2008 Wiley-Liss, Inc. [source] The development and initial validation of the Terminally Ill Grief or Depression Scale (TIGDS)INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 4 2005Vyjeyanthi S. Periyakoil Abstract Patients often experience ,preparatory-grief' as they cope with the dying process. Some may be depressed. The Terminally Ill Grief or Depression Scale (TIGDS), comprising grief and depression sub-scales, is a new self-report measure designed to differentiate between preparatory-grief and depression in adult inpatients. The initial 100-item inventory was assembled based on literature review, interviews with clinicians and dying patients and then shortened to 42 items based on consensus expert opinion. Validity and reliability were tested in a sample of 55 terminally ill adults. The consensus clinical opinion was used as the gold standard to differentiate between preparatory grief and depression. The intra-class correlation coefficient was high (it was calculated to estimate the test-retest reliability for the 47 patients who had completed the TIGDS twice , retest was administered 2 to 7 days after the initial test), ranging from 0.86 (grief) to 0.97 (depression). The validity of TIGDS was assessed using a receiver operating characteristic curve analysis, comparing the first test with the clinical criterion. The first and only variable and cut-point was the depression score (chi-square = 18.4,p < 0.001, cut point = 3). The sensitivity of the TIGDS was 0.727 and specificity was 0.886 for the depression = 3 cutoff score. The construct validity of the TIGDS was tested by comparing with the Hospital Anxiety and Depression Scale (HADS). The TIGDS depression subscale showed strong convergent validity and the TIGDS grief subscale showed strong discriminant validity with the HADS total score. Copyright © 2005 John Wiley & Sons, Ltd. [source] Diagnosis and Management of Renovascular Disease and Renovascular HypertensionJOURNAL OF CLINICAL HYPERTENSION, Issue 5 2007Michael J. Bloch MD Renovascular disease is a common but complex disorder, the most common causes of which are fibromuscular dysplasia and atherosclerosis. Clinically, it can present as asymptomatic renal artery stenosis, renovascular hypertension, or ischemic nephropathy. Assessing the clinical index of suspicion remains essential in determining an appropriate diagnostic strategy. For diagnosis in patients with suspected fibromuscular disease, it may be reasonable to proceed directly to renal angiography; however, for most patients with suspected atherosclerotic disease, there are a number of noninvasive tests available that can aid in decision making. The choice of the most appropriate initial test should be based on patient characteristics, clinical presentation, and local expertise. Treatment options include medical, surgical, or percutaneous approaches. Generally, in patients with fibromuscular disease, percutaneous intervention provides durable improvement or cure of hypertension. In patients with atherosclerotic disease, the data are less consistent, and there does appear to be a group of patients who will respond well to medical management alone. As technology advances, the diagnostic and treatment paradigms will continue to evolve. [source] Retrospective accounts of recurrent parental physical abuse as a predictor of adult laboratory-induced aggressionAGGRESSIVE BEHAVIOR, Issue 3 2004Brian K. Moe Abstract Child abuse has been frequently associated with adult aggression in its many forms. The Point Subtraction Aggression Paradigm (PSAP) is a popular laboratory-based procedure derived from the retaliatory responses of participants engaged in a monetary-reinforced computer game. PSAP responses have been found to discriminate between participants with and without violent, antisocial, substance abuse, and even contact-sport athletic histories. The present study provided an initial test of the sensitivity of the PSAP and the Overt Aggression Scale (OAS) in discriminating between college students (n=28) with and without reported histories of recurrent physical abuse as defined by incidents of being pushed, shoved, struck, punched, or threatened with physical violence by a parent more than once every six weeks over 15 years of upbringing. PSAP responses were substantially higher (d=2.1) among participants reporting histories of recurrent parental physical abuse, with 46% (as opposed to 0% for controls) of these individuals generating PSAP responses in excess of 400 (average found for violent parolees). Group differences on the OAS were also considerable (>1 SD). Larger factorial designs examining relationships between a range of developmental variables (e.g., domestic abuse, physical abuse, sexual abuse, parental divorce, family climate, etc.) and adult PSAP responding may help advance present knowledge regarding the impact of childhood adversity on psychological development. Aggr. Behav. 30:217,228, 2004. © 2004 Wiley-Liss, Inc. [source] Research on aging using brain imaging and cognitive tests over 6 years in 145 healthy elderly subjectsPSYCHOGERIATRICS, Issue 4 2008Hirohide KADA Abstract Background:, Changes over a period of 10 years in the cognitive function, head magnetic resonance imaging findings, and daily life of approximately 300 healthy elderly subjects were determined. As part of the larger 10-year study, changes are reported herein over a period of 6 years for 145 individuals. Methods:, One hundred and forty-five healthy elderly subjects were divided into two groups: (i) those who were 69 years of age or younger at the start of the study (Group A); and (ii) those who were 70 years of age or older (Group B). Results:, Changes over time in Benton's visual retention test (BVRT) and enhanced cued recall (ECR), both of which rely mainly on subjects memorizing figures, were seen in Group B. With the coding test, the results from the second phase (initial test) showed differences according to initial age; in addition, the differences became greater with aging. It appears that work speed is reduced with increasing age. Conclusion:, The results of the BVRT and ECR suggest that enlargement of the Sylvian fissure and atrophy of the temporal lobe are indicators of deterioration of memory. [source] Saccharin Test of Maxillary Sinus Mucociliary Function After Endoscopic Sinus SurgeryTHE LARYNGOSCOPE, Issue 1 2000Kazuyasu Asai MD Abstract Objectives: To determine the usefulness of the saccharin time (ST) test for evaluating the mucociliary function of the maxillary sinus after endoscopic sinus surgery (ESS) for chronic sinusitis. Study Design: Methods: This study was conducted on 88 maxillary sinuses of 74 patients after ESS. The maxillary sinus fontanel was broadly opened via the middle meatus using an endoscope, and a saccharin granule was adhered to the bottom of the maxillary sinus mucosa. The time until the patient recognized the sweet taste was recorded. Before the ST test, the bilateral maxillary sinuses were classified into the following four groups on the basis of the post-ESS severity of mucosal edema and swelling as revealed by endoscopic observation: normal (45 sinuses), mild mucosal edema and swelling (24), moderate mucosal finding (14), and severe mucosal finding or filling of the sinus with a polyp(s) (5). Results: The mean ST values in the normal group and the groups with mild, moderate, and severe mucosal edema and swelling were 35.7, 38.1, 63.6, and 88.0 minutes, respectively. Thus the ST increased with the post-ESS severity of the mucosal lesion. However, for the group with mild mucosal edema and swelling, scanning electron microscopic observation of three maxillary sinuses in which the ST exceeded 120 minutes and four sinuses in which the ST was 40 minutes revealed extensive cilia loss in the former sinuses, but not in the latter. A second post-ESS endoscopic observation was performed in 17 patients, revealing improvement in 11 sinuses, no change in 5 sinuses, and aggravation in 1 sinus (compared with the initial test). The ST test was also repeated, revealing that the ST became shorter in most of the endoscopically improved sinus group. However, a few sinuses showed a discrepancy between the change in the endoscopic findings and the ciliary function (ST). Conclusion: Measurement of the maxillary sinus ST is a simple, accurate, and useful technique for assessing the post-ESS mucociliary function in conjunction with endoscopy, and the information gained can help in deciding subsequent therapy. [source] A comparison of three rapid D-dimer methods for the diagnosis of venous thromboembolismBRITISH JOURNAL OF HAEMATOLOGY, Issue 1 2001Michael J. Kovacs We compared three rapid d -dimer methods for the diagnosis of venous thromboembolism. Patients presenting to four teaching hospitals with the possible diagnosis of deep vein thrombosis or pulmonary embolism were investigated with a combination of clinical likelihood, d -dimer (SimpliRED) and initial non-invasive testing. Patients were assigned as being positive or negative for deep vein thrombosis or pulmonary embolism based on their three-month outcome and initial test results. The three d -dimer methods compared were: (a) Accuclot d -dimer (b) IL-Test d -dimer (c) SimpliRED d -dimer. Of 993 patients, 141 had objectively confirmed deep vein thrombosis or pulmonary embolism. The sensitivity of SimpliRED, Accuclot and IL-Test were 79, 90 and 87% respectively. All three d -dimer tests gave similar negative predictive values. The SimpliRED d -dimer was found to be less sensitive than the Accuclot or IL-Test. When combined with pre-test probability all three methods are probably acceptable for use in the diagnosis of venous thromboembolism. [source] A preference-based index for the SF-12HEALTH ECONOMICS, Issue 6 2006D. Stratmann-Schoene Abstract Background: The SF-12 is a widely used generic measure of subjective health. As the scoring algorithms of the SF-12 do not include preference values, different approaches to assign a preference-based index are available that should be tested regarding their feasibility and validity. Objectives: To develop a concept for a preference-based index for the SF-12 on the basis of multi-attribute decision analysis and to perform initial tests of its feasibility and validity in an empirical study. Methods: A multi-attribute preference function for the SF-12 was developed, estimated and tested for validity. Two mail surveys (n = 100, 200) and an interview (n = 72) were conducted with women who had an operation for breast cancer. Visual analogue scale (VAS) and standard gamble (SG) measures elicited preference-based valuations. Results: Eight attributes were identified in the SF-12. Validity tests showed an average difference of 8 VAS score points between directly measured and predicted values for given health states. Conclusion: The initial results show that this approach might allow the direct assignment of a preference-based valuation to the SF-12. The quality of the psychometric features of the multi-attribute value function is encouraging. Future studies should test this concept more extensively, especially by determining parameters for a representative sample of the general population and by comparing performance with other approaches to value the SF-12. Copyright © 2005 John Wiley & Sons, Ltd. [source] Tribological characterisation of hard coatings with and without DLC top layer in fretting testsLUBRICATION SCIENCE, Issue 1 2006D. KlaffkeArticle first published online: 14 DEC 200 Abstract The potential of coatings to protect components against wear and to reduce friction has led to a large variety of protective coatings. In order to check the success of coating modifications and to find solutions for different purposes, initial tests with laboratory tribometers are usually done to give information about the performance of a coating. Different Ti-based coatings (TiN, Ti(C,N), and TiAlN) and NiP were tested in comparison to coatings with an additional diamond-like carbon (DLC) top coating. Tests were done in laboratory air at room temperature with oscillating sliding (gross slip fretting) with a ball-on-disc arrangement against a ceramic ball (Al2O3). Special attention was paid to possible effects of moisture (relative humidity). The coefficient of friction was measured on line, and the volumetric wear at the disc was determined after the test from microscopic measurements of the wear scar and additional profiles. The friction and wear behaviour is quite different for the different coatings and depends more or less on the relative humidity. The DLC coating on top of the other coatings reduces friction and wear considerably. In normal and in moist air the coefficient of wear of the DLC top-layer coating is significantly less than 10,6,mm3/Nm and the coefficient of friction is below 0.1. In dry air, however, there is a certain tendency to high wear and high friction. Copyright © 2006 John Wiley & Sons, Ltd. [source] Isolation and characterization of microsatellite markers from Zale galbanata (Lepidoptera: Noctuidae) and amplification in other members of the genusMOLECULAR ECOLOGY RESOURCES, Issue 3 2002A. Caldas Abstract The noctuid moth Zale galbanata is described as feeding on maples (Acer sp.) in general, but its primary food plant is box elder (Acer negundo). We isolated five microsatellite loci to investigate the association of food plant use and the genetic similarity of populations in these moths. These markers are polymorphic to various degrees (5,13 alleles), and are presented here. Our initial tests show that some of these loci also work on other Zale species. [source] A convection scheme for data assimilation: Description and initial testsTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 606 2005Philippe Lopez Abstract A new simplified parametrization of subgrid-scale convective processes has been developed and tested in the framework of the ECMWF Integrated Forecasting System for the purpose of variational data assimilation, singular vector calculations and adjoint sensitivity experiments. Its formulation is based on the full nonlinear convection scheme used in ECMWF forecasts, but a set of simplifications has been applied to substantially improve its linear behaviour. These include the specification of a single closure assumption based on convective available potential energy, the uncoupling of the equations for the convective mass flux and updraught characteristics and a unified formulation of the entrainment and detrainment rates. Simplified representations of downdraughts and momentum transport are also included in the new scheme. Despite these simplifications, the forecasting ability of the new convective parametrization is shown to remain satisfactory even in seasonal integrations. A detailed study of its Jacobians and the validity of the linear hypothesis is presented. The new scheme is also tested in combination with the new simplified parametrization of large-scale clouds and precipitation recently developed at ECMWF. In contrast with the simplified convective parametrization currently used in ECMWF's operational 4D-Var, its tangent-linear and adjoint versions account for perturbations of all convective quantities including convective mass flux, updraught characteristics and precipitation fluxes. Therefore the new scheme is expected to be beneficial when combined with radiative calculations that are directly affected by condensation and precipitation. Examples are presented of applications of the new moist physics in 1D-Var retrievals using microwave brightness temperature measurements and in adjoint sensitivity experiments. Copyright © 2005 Royal Meteorological Society. [source] | ||||||||||||||||||||||