			Home About us Contact

Initial Online Publication (initial + online_publication)

Distribution by Scientific Domains

Chemistry	50%

Selected Abstracts

Erythropoiesis-stimulating agents: development, detection and dangers,

DRUG TESTING AND ANALYSIS, Issue 6 2009
Stefan E. Franz
Abstract Epoetin alfa, the first member of the family of erythropoiesis stimulating agents (ESAs), was introduced to the market in 1989. Since then development has progressed to epoetins of the third generation. Currently drugs that use alternative approaches to stimulate erythropoiesis are under development. Uptake of all available ESAs into doping has occurred rapidly after their introduction. A multitude of dangers to health are associated with the illicit use of these substances. Different approaches to detect ESAs in doping control have been developed to comply with the very diverse nature of the compounds used. Future developments in the field of ESA require the development of new techniques in doping analysis. This review gives an overview of the development of ESA and its detection methods as well as future developments. [Correction made here after initial online publication] Copyright © 2009 John Wiley & Sons, Ltd. [source]

Oxygen isotope analysis of phosphate: improved precision using TC/EA CF-IRMS,

JOURNAL OF MASS SPECTROMETRY (INCORP BIOLOGICAL MASS SPECTROMETRY), Issue 6 2009
D. F. LaPorte
Abstract Oxygen isotope values of biogenic apatite have long demonstrated considerable promise for paleothermometry potential because of the abundance of material in the fossil record and greater resistance of apatite to diagenesis compared to carbonate. Unfortunately, this promise has not been fully realized because of relatively poor precision of isotopic measurements, and exceedingly small size of some substrates for analysis. Building on previous work, we demonstrate that it is possible to improve precision of ,18OPO4 measurements using a ,reverse-plumbed' thermal conversion elemental analyzer (TC/EA) coupled to a continuous flow isotope ratio mass spectrometer (CF-IRMS) via a helium stream [Correction made here after initial online publication]. This modification to the flow of helium through the TC/EA, and careful location of the packing of glassy carbon fragments relative to the hot spot in the reactor, leads to narrower, more symmetrically distributed CO elution peaks with diminished tailing. In addition, we describe our apatite purification chemistry that uses nitric acid and cation exchange resin. Purification chemistry is optimized for processing small samples, minimizing isotopic fractionation of PO4,3 and permitting Ca, Sr and Nd to be eluted and purified further for the measurement of ,44Ca and 87Sr/86Sr in modern biogenic apatite and 143Nd/144Nd in fossil apatite. Our methodology yields an external precision of ± 0.15, (1,) for ,18OPO4. The uncertainty is related to the preparation of the Ag3PO4 salt, conversion to CO gas in a reversed-plumbed TC/EA, analysis of oxygen isotopes using a CF-IRMS, and uncertainty in constructing calibration lines that convert raw ,18O data to the VSMOW scale. Matrix matching of samples and standards for the purpose of calibration to the VSMOW scale was determined to be unnecessary. Our method requires only slightly modified equipment that is widely available. This fact, and the demonstrated improvement in precision, should help to make apatite paleothermometry far more accessible to paleoclimate researchers. Copyright © 2009 John Wiley & Sons, Ltd. [source]

The William Blake Archive: An Overview

LITERATURE COMPASS (ELECTRONIC), Issue 3 2006
Steven E. Jones
This essay offers an introduction to and summary of The William Blake Archive (WBA) as an online, multimedia, scholarly edition. It covers the history of the WBA's initial online publication in 1996 and then describes the conception and structure of the edition, its editorial principles, and "object-centered" organization, hierarchical structure, and interface. Next the essay surveys the WBA's editorial methods and procedures, including how the resource , which aims for "virtually reunified" corpus , has been produced and managed at The University of Virginia's Institute for Advanced Technology in the Humanities (IATH), and concludes with a look at the method of publication and delivery (including the role of structural markup and the World Wide Web). [source]

Early maladaptive schemas, temperament and character traits in clinically depressed and previously depressed subjects,

CLINICAL PSYCHOLOGY AND PSYCHOTHERAPY (AN INTERNATIONAL JOURNAL OF THEORY & PRACTICE), Issue 5 2009
Marianne Halvorsen
Abstract The Young Schema Questionnaire (YSQ) and the Temperament and Character Inventory (TCI) have been suggested as vulnerability markers for depression. One- hundred forty clinically depressed subjects(CD), previously depressed subjects(PD) and never depressed (ND) controls completed the YSQ, the TCI and the Beck Depression Inventory. Results showed that CD and PD differed significantly on early maladaptive schemas, temperament and character traits compared with ND. In accordance with previous research, higher levels of harm avoidance and lower levels of self-directedness were found in CD and in recovered PD. Moreover, CD and PD showed substantial variability in the scores on the YSQ and the TCI when controlling for concurrent depression severity. In multiple regression analyses, YSQ domain scales of disconnection, impaired autonomy, restricted self-expression and impaired limits emerged as significant predictors of depression severity. Likewise, as concerns TCI higher order scales, high harm avoidance, low self-directedness and high persistence emerged as significant predictors of depression severity. Harm avoidance was positively related to several early maladaptive schemas (EMSs), whereas self-directedness was negatively related to a majority of the EMSs. Our findings indicate the presence of maladaptive personality characteristics in CD and PD. Longitudinal studies are needed to establish their causal role in relation to first-onset and recurrent depression.,Copyright © 2009 John Wiley & Sons, Ltd. Key Practitioner Message: , Early maladaptive schemas, high harm [correction made here after initial online publication] avoidance and low self-directedness may be a part of vulnerability to depression. , The finding of these personality characteristics in subjects recovered from depression indicates malfunctioning to some degree. , Addressing such characteristics in therapy should be considered in order to prevent and treat depression from its relapsing and recurring course. [source]