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Initial Choice (initial + choice)

Distribution by Scientific Domains

Medical Sciences	75%

Selected Abstracts

Doctors' reasons for rejecting initial choices of specialties as long-term careers

MEDICAL EDUCATION, Issue 4 2003
Trevor W Lambert
Objectives, To report on rejected choices of specialty as long-term careers and reasons for rejection. Design, Postal questionnaire survey. Setting, United Kingdom. Participants, All graduates of 1996 and 1999 from UK medical schools during their first year after qualification. Main outcome measures, Any career choice which had been seriously considered and rejected and the reason for its rejection. Results, In all, 33·1% (1871) of respondents named a rejected choice and gave reasons for its rejection. Disproportionately high numbers rejected the surgical specialties, paediatrics and obstetrics and gynaecology (O&G), using the specialty distribution of positive choices as the comparator. Relatively few doctors rejected general practice (GP) after giving it serious consideration. Doctors rejecting the hospital medical and surgical specialties or paediatrics were most likely to specify reasons relating to quality of life. Three-quarters of the graduates of 1999 who rejected O&G did so because of poor career prospects. Conclusions, Quality of life issues, and concerns about working relationships, are sufficiently influential to persuade many doctors to abandon an initial choice of medical career. It is unlikely that much of the decline in entry to GP is attributable to rejection of GP by doctors who initially chose it. The decline must therefore represent an increase in the number of doctors who had never seriously considered it as a long-term career choice. [source]

Surgical Salvage after Failed Irradiation for Vestibular Schwannoma

THE LARYNGOSCOPE, Issue 10 2005
Rick A. Friedman MD
Abstract Objectives/Hypothesis: Compare vestibular schwannoma (VS) surgical outcome between patients with prior irradiation and those not previously treated. Study Design: Retrospective review with matched control group. Methods: Review of tumor adherence to the facial nerve, facial nerve grade, and complications in 38 patients with radiotherapy as a primary procedure before VS surgical removal and a matched random sample of 38 patients with primary surgery. The majority of the irradiated group had gamma knife radiation therapy. Mean time from irradiation to surgical salvage was 3.3 years (SD = 3.2), with a minimum of 5.2 months and a maximum of 15.8 years. Most (89.5%) patients in each group underwent a translabyrinthine approach. Mean tumor size at surgery was 2.6 cm in each group. Results: The irradiated group had more moderate to severe adherence of tumor than the controls (89% vs. 63%, P , .01). They also had a lower rate of good facial function (House-Brackmann grade I/II) (37% vs. 70%) and a higher rate of poor function (grades V or VI) (50% vs. 18%) at follow-up (P , .019). Results were similar when including only those with good preoperative function (50% vs. 72% and 32% vs. 15%) but did not achieve statistical significance. Surgical time and complications did not differ. Conclusion: Patients who have undergone irradiation for VS and require surgical salvage may have a more difficult surgery and poorer outcomes than those not previously irradiated. When making their initial choice of treatment, patients should be counseled that surgery might be more difficult after failed stereotactic irradiation. [source]

Oxytocin and estrogen receptor , and , knockout mice provide discriminably different odor cues in behavioral assays

GENES, BRAIN AND BEHAVIOR, Issue 4 2004
M. Kavaliers
Social behavior involves both the recognition and production of social cues. Mice with selective deletion (knockout) of either the gene for oxytocin (OT) or genes for the estrogen receptor (ER) -, or -, display impaired social recognition. In this study we demonstrate that these gene knockout mice also provide discriminably different social stimuli in behavioral assays. In an odor choice test, which is a measure of social interest and discrimination, outbred female Swiss-Webster mice discriminated the urine odors of male knockouts (KO: OTKO, ,ERKO, ,ERKO) from the odors of their wildtype littermates (WT: OTWT, ,ERWT, ,ERWT). Females showed marked initial choices of the urine odors of OTWT and ,ERWT males over those of OTKO and ,ERKO males, and ,ERKO males over ,ERWT males. The odors of OTKO and ,ERKO males also induced aversive, analgesic responses, with the odors of WTs having no significant effects. Odors of both the ,ERWT and ,ERKO males induced aversive, analgesic responses, with the odors of the WT inducing significantly greater analgesia. The odors of restraint stressed WT and KO males also elicited analgesia with, again, females displaying significantly greater responses to the odors of stressed OTKO and ,ERKO males than their WTs, and significantly lower analgesia to the odors of stressed ,ERKO than ,ERWT males. These findings show that the KO mice are discriminated from their WTs on the basis of odor and that the various KOs differ in the relative attractiveness/aversiveness of their odors. Therefore, in behavioral assays one causal route by which gene inactivation alters the social behavior of knockout mice may be mediated through the partners' modified responses to their odors. [source]