			Home About us Contact

Inhibitory Deficits (inhibitory + deficit)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Inhibitory deficits in tourette's syndrome

DEVELOPMENTAL PSYCHOBIOLOGY, Issue 1 2008
Emily R. Stern
Abstract A developmental approach to the study of psychopathology can broaden understanding of a wide variety of complex psychological disorders. This article reviews research on Tourette's syndrome (TS), a developmental disorder characterized by unwanted motor and vocal tics. Over the past decade, knowledge of the neurobiology and pathophysiology of TS has progressed rapidly. The application of brain imaging techniques, primarily magnetic resonance imaging, to the study of Tourette's has increased knowledge of structural and functional deficits in brain areas associated with behavioral and psychological disturbances in the disorder. By reviewing some of this work, we will describe one way in which knowledge of brain function in TS has both informed and been informed by a developmental science approach. In particular, we will consider the extent to which the cognitive and emotional development of persons with TS may be affected by specific neurobiological characteristics of the disorder. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 50: 9,18, 2008. [source]

Emotional vulnerability and cognitive control in patients with bipolar disorder and their healthy siblings: a pilot study

ACTA NEUROPSYCHIATRICA, Issue 2 2010
Kathrin Houshmand
Scheuch K, Bräunig P, Gauggel S, Kliesow K, Sarkar R, Krüger S. Emotional vulnerability and cognitive control in patients with bipolar disorder and their healthy siblings: a pilot study. Objective: There is evidence that, even in remission, patients with bipolar disorder (BD) have deficits in cognitive function and emotional regulation. Siblings of patients with BD are also reported to exhibit minor dysfunction in neuropsychological domains. In this study, we examined the interference of acute mood state with reaction time (RT) and response inhibition in euthymic patients with BD, in their healthy siblings and in healthy controls. Methods: A total of 34 patients with bipolar I disorder, 22 healthy siblings and 33 healthy controls performed a stop-signal paradigm after induction of a transient intense sadness and a relaxed mood state. The differences in RT and the response inhibition were compared between the groups. Results: Euthymic patients with BD displayed a higher emotional reactivity compared with their siblings and with controls. Compared with controls, patients with BD showed longer RTs in a relaxed mood state and a delay in response inhibition during emotional activation. Conclusions: The present study provides evidence for the clinical observation that patients with BD have shorter RTs when in a state of emotional arousal rather than in a relaxed state. Inhibitory deficits in these patients may be because of a too strong emotional arousal. The results show that in patients with BD, relaxation and emotional arousal are inversely associated with performance in a neuropsychological task. This is in contrast to findings in healthy individuals suggesting a dysbalance in emotional regulation in these patients. [source]

Mismatch Negativity: No Difference Between Controls and Abstinent Alcoholics

ALCOHOLISM, Issue 1 2004
George Fein
Abstract: Background: A number of studies have examined the amplitude of the mismatch negativity (MMN) evoked potential as a measure of a brain inhibitory deficit in alcoholics or those at risk for alcoholism. The current study examined MMN in alcoholics abstinent an average of 6.7 years (with a minimum of six months abstinence) compared to controls. This study examined the association of MMN with alcoholism family history density, with indices of the presence and severity of externalizing disorders (a risk-factor for alcoholism), and with alcohol use variables. Methods: Electroencephalograms were gathered on 76 subjects (38 controls, 38 abstinent alcoholics) during a nonattending mismatch negativity experiment. Measures of alcoholism family history density, disinhibited personality traits, and antisocial symptoms served as measures of risk-factors known to be associated with a genetic liability to alcoholism. Alcohol use variables were used as measures of alcoholism severity. Results: There were no differences in MMN amplitude or latency between controls and abstinent alcoholics. There also were no significant associations between MMN measures and the measures of risk for alcoholism or with the severity of alcohol use or duration of abstinence. Conclusions: The results suggest that MMN is neither affected in chronic alcoholics nor associated with alcoholism vulnerability, and thus does not reflect a trait marker of alcoholism or alcoholism risk. The current results do not address effects on MMN of acute alcohol ingestion or withdrawal from alcohol. [source]

Inhibition deficits of serious delinquent boys of low intelligence

CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 5 2007
Roos Koolhof
Introduction,Studies have shown that low intelligence (IQ) and delinquency are strongly associated. This study focuses on inhibitory deficits as the source for the association between low IQ and delinquency. Further, the authors explore whether serious delinquent boys with a low IQ are exposed to more risk factors than serious delinquent boys with an average to high IQ. They also examine the extent to which low IQ and higher IQ serious delinquents incurred contact with the juvenile court because of their delinquent behaviour. Methods,Cross-sectional and longitudinal data from the Pittsburgh Youth Study were used to constitute four groups of boys: low IQ serious delinquents (n = 39), higher IQ serious delinquents (n = 149), low IQ non-to-moderate delinquents (n = 21) and higher IQ non-to-moderate delinquents (n = 219). Results,Low IQ serious delinquents committed more delinquent acts than higher IQ serious offenders. Low IQ serious delinquent boys also exhibited the highest levels of cognitive and behavioural impulsivity. There were no differences between low IQ and higher IQ serious delinquents on measures of empathy and guilt feelings. Instead, elevations on these characteristics were associated with serious offenders as a whole. Compared with higher IQ serious delinquents, low IQ serious delinquents were exposed to more risk factors, such as low academic achievement, being old for grade, depressed mood and poor housing. Conclusions,Inhibition deficits appear important in the aetiology of delinquency, especially among low IQ boys. Serious delinquent boys are all impulsive, but the higher IQ serious delinquents seem to have a better cognitive control system. Interventions aimed at low IQ boys should focus on the remediation of behavioural impulsivity as well as cognitive impulsivity. Copyright © 2007 John Wiley & Sons, Ltd. [source]