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Important Structure (important + structure)
Selected AbstractsDC electrical stimulation of the pretectal thalamus and its effects on the feeding behavior of the toad (Bufo bufo)DEVELOPMENTAL NEUROBIOLOGY, Issue 7 2007James McConville Abstract The feeding motivation of the common European common toad (Bufo bufo) can be quantified by the feeding sequence of arousal-orientation-approach-fixate-snap. Previous work has found that the optic tectum is an important structure responsible for the mediation of feeding behaviors, and combined electrical and visual stimulation of the optic tectum was found to increase the animals feeding behaviors. However, the pretectal thalamus has an inhibitory influence upon the optic tectum and its lesion results in disinhibited feeding behaviors. This suggests that feeding behavior of anurans is also subject to influence from the pretectal thalamus. Previous studies involving the application of DC stimulation to brain tissue has generated slow potential shifts and these shifts have been implicated in the modulation of the neural mechanisms associated with behavior. The current study investigated the application of DC stimulation to the diencephalon surface dorsal to the lateral posterodorsal pretectal thalamic nucleus in Bufo bufo, in order to assess effects on feeding motivation. The application of DC stimulation increased the incidence of avoidance behaviors to a visual prey stimulus while reducing the prey catching behavior component of approach, suggesting that the DC current applied to the pretectum increased the inhibition upon the feeding elements of the optic tectum. This can be explained by the generation of slow potential shifts. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007. [source] Explicit design formulas for current-mode leap-frog OTA-C filters and 300,MHz CMOS seventh-order linear phase filterINTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS, Issue 4 2010Yichuang Sun Abstract The leap-frog (LF) configuration is an important structure in analogue filter design. Voltage-mode LF OTA-C filters have recently been studied in the literature; however, general explicit formulas do not exist for current-mode LF OTA-C filters and there is also need for current-mode LF-based OTA-C structures for realization of arbitrary transmission zeros. Three current-mode OTA-C structures are presented, including the basic LF structure and LF filters with an input distributor or an output summer. They can realize all-pole characteristics and functions with arbitrary transmission zeros. Explicit design formulas are derived directly from these structures for the synthesis of, respectively, all-pole and arbitrary zero filter characteristics of up to the sixth order. The filter structures are regular and the design formulas are straightforward to use. As an illustrative example, a 300,MHz seventh-order linear phase low-pass filter with zeros is presented. The filter is implemented using a fully differential linear operational transconductance amplifier (OTA) based on a source degeneration topology. Simulations in a standard TSMC 0.18µm CMOS process with 2.5,V power supply have shown that the cutoff frequency of the filter ranges from 260 to 320,MHz, group delay ripple is about 4.5% over the whole tuning range, noise of the filter is 420nA/,Hz, dynamic range is 66,dB and power consumption is 200,mW. Copyright © 2008 John Wiley & Sons, Ltd. [source] The cell membrane complex: Three related but different cellular cohesion components of mammalian hair fibersINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 3 2010C. Robbins J. Cosmet. Sci., 60, 437,465 (July/August 2009) Synopsis The structure, chemistry and physical properties of the cell membrane complex (CMC) of keratin fibers are reviewed, highlighting differences in the three types of CMC. Starting with Rogers' initial description of the CMC in animal hairs, several important developments have occurred that will be described, adding new details to this important structure in mammalian hair fibers. These developments show that essentially all of the covalently bound fatty acids of the beta layers are in the cuticle and exist as monolayers. The beta layers of the cortex are bilayers that are not covalently bonded but are attached by ionic and polar linkages on one side to the cortical cell membranes and on the other side to the delta layer. The delta layer between cortical cells consists of five sublayers; its proteins are clearly different from the delta layer that exists between cuticle cells. The cell membranes of cuticle cells are also markedly different from the cell membranes of cortical cells. Models with supporting evidence are presented for the three different types of cell membrane complex: cuticle,cuticle CMC, cuticle,cortex CMC, and cortex,cortex CMC. [source] Comparative morphology of the foot structure of four genera of Loxosomatidae (Entoprocta): Implications for foot functions and taxonomyJOURNAL OF MORPHOLOGY, Issue 10 2010Tohru Iseto Abstract Entoprocta is a group of mostly cryptic, benthic invertebrates with a sedentary lifestyle. Here, we investigate the morphology of the entoproct foot, which is an important structure in attachment and locomotion. We describe the foot structure of four solitary entoprocts, Loxosoma monilis, Loxosomella stomatophora, Loxocorone allax, and Loxomitra mizugamaensis, by means of light and transmission electron microscopy. Gland cells containing secretory granules were found in the foot of all the four species. In L. monilis, the gland cells densely paved the underside of the disc-shaped foot, but no duct or groove was found. In L. stomatophora and L. allax, a foot gland was present at the frontal end of a foot groove. The foot gland was a solid cell mass in the former species but a sac-like structure in the latter. Two types of groove accessory cells were recognized in both species; groove bulge cells (GBCs) showed large cytoplasmic bulges extending into the groove lumen, while groove microvillus cells have microvillus mats in the lateral wall of the groove. The bulges of GBCs in L. stomatophora are slender and attached to one another with desmosomes, forming appendages that extend down to the substratum, hinting at their contribution to attachment and locomotion. The bulges in L. allax form large swellings that fill the groove lumen and are connected to the surrounding cells with hemidesmosomes. In the liberated buds of L. mizugamaensis, tripartite gland cell masses were found at the basal end of the stalk, but no groove was found. A small invagination, which may be the opening of the gland, was found at the center of the foot tip, where the liberated buds attach themselves to the substratum and then metamorphose into adults. No openings were found at the lateral terminal wings, which support locomotion in Loxomitra species. J. Morphol. 271:1185,1196, 2010. © 2010 Wiley-Liss, Inc. [source] Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic miceJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 7 2007M. EREN Summary.,Background:,Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of plasminogen activators (PAs) and plays a role in the regulation of a number of physiological processes including the degradation of extracellular matrix proteins, cell proliferation and migration, and intracellular signaling. Aim:,To characterize the effects of durable expression of a stable form of human PAI-1 and to characterize important structure,function relationships in PAI-1 in vivo.Methods:,We developed transgenic mice lines overexpressing stable variants of human PAI-1 under the control of the murine preproendothelin-1 promoter and characterized the phenotypic alterations displayed by transgenic mice. Results:,Transgenic mice expressing an active form of human PAI-1 (PAI-1-stab) display complex phenotypic abnormalities including alopecia and hepatosplenomegaly. Reactive site mutant transgenic mice expressing inactive PAI-1 exhibit complete phenotypic rescue, while transgenic mice expressing PAI-1 with reduced affinity for vitronectin manifest all of the phenotypic abnormalities present in PAI-1-stab transgenic mice. Conclusions:,The protease inhibitory activity of PAI-1 toward PAs and/or other serine proteases is necessary and sufficient to promote complex phenotypic abnormalities and mediates many of the physiological effects of PAI-1 in vivo. [source] Extreme body size variability in the golden silk spider (Nephila edulis) does not extend to genitaliaJOURNAL OF ZOOLOGY, Issue 1 2000Gabriele Uhl Abstract Nephila edulis is a spider with large body size variability in males and females. Genital characters show negative allometric values compared to somatic characters. In males, the embolus (the most important structure for sperm transfer) had a significantly lower coefficient of variation than body size. This suggests that male genitalia are under stabilizing selection favouring intermediate size. Female N. edulis showed a trend similar to males regarding allometric values in genitalia. In females, however, the variation coefficient in a specific genital character crucial for successful copulation did not differ from that of indicators for overall body size. This suggests that in Nephila the genitalia of the females experience less stabilizing selection than those of the males. In male and female genitalia, the mode of selection seems to cause developmental instability not in degrees of fluctuating asymmetry but in the degree of data scatter which indicates a lower coefficient of determination. [source] Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed formACTA CRYSTALLOGRAPHICA SECTION D, Issue 8 2004Gali Golan The Escherichia coli DNA repair enzyme endonuclease VIII (EndoVIII or Nei) excises oxidized pyrimidines from damaged DNA substrates. It overlaps in substrate specificity with endonuclease III and may serve as a back-up for this enzyme in E. coli. The three-dimensional structure of Nei covalently complexed with DNA has been recently determined, revealing the critical amino-acid residues required for DNA binding and catalytic activity. Based on this information, several site-specific mutants of the enzyme have been tested for activity against various substrates. Although the crystal structure of the DNA-bound enzyme has been fully determined, the important structure of the free enzyme has not previously been analyzed. In this report, the crystallization and preliminary crystallographic characterization of DNA-free Nei are described. Four different crystal habits are reported for wild-type Nei and two of its catalytic mutants. Despite being crystallized under different conditions, all habits belong to the same crystal form, with the same space group (I222) and a similar crystallographic unit cell (average parameters a = 57.7, b = 80.2, c = 169.7,Å). Two of these crystal habits, I and IV, appear to be suitable for full crystallographic analysis. Crystal habit I was obtained by vapour diffusion using PEG 8000, glycerol and calcium acetate. Crystal habit IV was obtained by a similar method using PEG 400 and magnesium chloride. Both crystals are mechanically strong and stable in the X-ray beam once frozen under cold nitrogen gas. A full diffraction data set has recently been collected from a wild-type Nei crystal of habit I (2.6,Å resolution, 85.2% completeness, Rmerge = 9.8%). Additional diffraction data were collected from an Nei-R252A crystal of habit IV (2.05,Å resolution, 99.9% completeness, Rmerge = 6.0%) and an Nei-E2A crystal of habit IV (2.25,Å resolution, 91.7% completeness, Rmerge = 6.2%). These diffraction data were collected at 95,100 K using a synchrotron X-ray source and a CCD area detector. All three data sets are currently being used to obtain crystallographic phasing via molecular-replacement techniques. [source] A morphometric study of the inferior orbital fissure using three-dimensional anatomical landmarks: Application to orbital surgeryCLINICAL ANATOMY, Issue 6 2009Mehmet Asim Ozer Abstract The inferior orbital fissure (IOF) is an important structure during orbital surgery, however, neither its anatomical features nor the procedures necessary to expose the IOF have been examined in detail. A morphometric analysis of the IOF was performed on 232 orbits using computer software. The longest and shortest borders of the IOF were 18.2 ± 4.9 and 1.9 ± 1.3 mm, respectively. The outer and the inner angles were 138.9 ± 32.7° and 38.4 ± 24.7°, respectively. The perimeter of the IOF was 50.6 ± 13.5 mm and its area was 61.3 ± 39.1 mm2. Eight types of IOF were observed. Type 1 IOF was observed in 42.2% and the Type 2 IOF was identified in 15.9%. A statistically significant relation was found between the longest edge and area and the widest edge and area of the IOF. The findings of our study suggest that the removal of the lateral wall should begin inferiorly, just lateral to the IOF and extended superolaterally. These data may be useful during surgical approaches to the orbit. Clin. Anat. 22:649,654, 2009. © 2009 Wiley-Liss, Inc. [source] Smooth ocular pursuit in Chiari type II malformationDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 4 2007Michael S Salman MRCP PhD Chiari type II malformation (CII) is a congenital anomaly of the cerebellum and brainstem, both important structures for processing smooth ocular pursuit. CII is associated with myelomeningocele and hydrocephalus. We investigated the effects of CII on smooth pursuit (SP) eye movements, and determined the effects of spinal lesion level, number of shunt revisions, nystagmus, and brain dysmorphology on SP. SP was recorded using an infrared eye tracker in 21 participants with CII (11 males, 10 females; age range 8-19y, mean 14y 3mo [SD 3y 2mo]). Thirty-eight healthy children (21 males, 17 females) constituted the comparison group. Participants followed a visual target moving sinusoidally at ± 10° amplitude, horizontally and vertically at 0.25 or 0.5Hz. SP gains, the ratio of eye to target velocities, were abnormal in the CII group with nystagmus (n= 8). The number of shunt revisions (range 0-10), brain dysmorphology, or spinal lesion level (n= 15 for lower and n= 6 for upper spinal lesion level) did not correlate with SP gains. SP is impaired in children with CII and nystagmus. Abnormal pursuit might be related to the CII dysgenesis or to effects of hydrocephalus. The lack of effect of shunt revisions and abnormal tracking in participants with nystagmus provide evidence that it is related primarily to the cerebellar and brainstem malformation. [source] A new approach of selecting real input ground motions for seismic design: The most unfavourable real seismic design ground motionsEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 8 2007Chang-Hai Zhai Abstract This paper presents a new way of selecting real input ground motions for seismic design and analysis of structures based on a comprehensive method for estimating the damage potential of ground motions, which takes into consideration of various ground motion parameters and structural seismic damage criteria in terms of strength, deformation, hysteretic energy and dual damage of Park & Ang damage index. The proposed comprehensive method fully involves the effects of the intensity, frequency content and duration of ground motions and the dynamic characteristics of structures. Then, the concept of the most unfavourable real seismic design ground motion is introduced. Based on the concept, the most unfavourable real seismic design ground motions for rock, stiff soil, medium soil and soft soil site conditions are selected in terms of three typical period ranges of structures. The selected real strong motion records are suitable for seismic analysis of important structures whose failure or collapse will be avoided at a higher level of confidence during the strong earthquake, as they can cause the greatest damage to structures and thereby result in the highest damage potential from an extended real ground motion database for a given site. In addition, this paper also presents the real input design ground motions with medium damage potential, which can be used for the seismic analysis of structures located at the area with low and moderate seismicity. The most unfavourable real seismic design ground motions are verified by analysing the seismic response of structures. It is concluded that the most unfavourable real seismic design ground motion approach can select the real ground motions that can result in the highest damage potential for a given structure and site condition, and the real ground motions can be mainly used for structures whose failure or collapse will be avoided at a higher level of confidence during the strong earthquake. Copyright © 2007 John Wiley & Sons, Ltd. [source] Role of host identity in effects of phytogenic mounds on plant assemblages and species richness on coastal arid dunesJOURNAL OF VEGETATION SCIENCE, Issue 5 2007Magdy I. El-Bana Abstract Question: Phytogenic mounds (nebkhas) - the natural accumulation of wind-blown sediments within or around the canopies of plants - have been proposed as important structures for locally maintaining high species richness in coastal and arid ecosystems. Nebkhas are assumed to increase habitat heterogeneity, but what is the importance of the nebkha host species relative to other nebkha characteristics in determining the associated plant assemblages? Are some host species more effective in creating diversity hotspots, or does a single species-area relationship apply to all nebkhas, regardless of host species? Can the influence of the host be ascribed to its indirect effects on abiotic attributes of the nebkha complex? Methods and location: We investigated plant species richness and composition on nebkhas around six psammophytic species on Mediterranean coastal dunes of the Sinai Peninsula. Results: Plant species richness was significantly related to nebkha size by the single power function according to the general prediction of island biogeography theory, but this relationship was modified - though to a limited degree - by nebkha host species identity. Canonical Correspondence Analysis revealed that nebkha host species identity and nebkha environmental and non-environmental factors significantly explained species composition on the nebkhas, but host species identity did so to a greater extent. The latter might reflect differences in seed trapping ability or free space for colonization between host species. Conclusion: Differences in community composition and richness among nebkhas formed by different host species represent a key factor in the maintenance of plant diversity on arid coastal dunes. [source] Mass spectrometric characterization of 4-oxopentanoic acid and gas-phase ion fragmentation mechanisms studied using a triple quadrupole and time-of-flight analyzer hybrid system and density functional theoryRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 14 2008Basem Kanawati 4-Oxopentanoic acid was characterized experimentally by electrospray ionization using a triple quadrupole and time-of-flight analyzer hybrid system. This compound was chosen as a model substance for small organic compounds bearing an acetyl and a carboxyl group. Collision-induced dissociation experiments at different activation energies were performed to elucidate possible fragmentation pathways. These pathways were also studied on the theoretical level using density functional theory (DFT) B3LYP/6-311++G(3df,3pd)//B3LYP/6-31+G(d)+ZPVE calculations. CO2 ejection from the [M,H], anion of 4-oxopentanoic acid was observed and the fragmentation pathway studied by DFT reveals a new concerted mechanism for CO2 elimination accompanied by an intramolecular proton transfer within a pentagonal transition state structure. Successive elimination of water and CO from the [M,H], anion of 4-oxopentanoic acid was also observed. A rearrangement in the primary deprotonated ketene anion produced after water elimination was found on the theoretical level and leads to CO elimination from the primary product anion [M,H,H2O],. Energy diagrams along the reaction coordinates of the fragmentation pathways are presented and discussed in detail. Mulliken charge distributions of some important structures are presented. Copyright © 2008 John Wiley & Sons, Ltd. [source] The Tabernacle and the Temple in Ancient IsraelRELIGION COMPASS (ELECTRONIC), Issue 1 2007Michael M. Homan According to the Bible, the Tabernacle, a portable and ornate tent shrine, served as the terrestrial home for ancient Israel's deity from its construction at Mount Sinai under the supervision of Moses until it was replaced by Solomon's Temple. Solomon built his Temple in Jerusalem on the summit of Mount Moriah, and this served as God's home for approximately four hundred years. The Babylonians destroyed the Temple in 586 BCE. Zerubbabel oversaw the building of a Second Temple in 520 BCE. This building underwent extensive renovations by Herod in 19 BCE, and the Jerusalem Temple was finally destroyed in 70 CE by the Romans. Many of the most famous events in the Bible and history take place at the Tabernacle and Jerusalem Temple, as they were the most important structures in ancient Israel. For the past two millennia they have been the focus of more attention than any other buildings in antiquity. [source] Structural Analysis of the Multi-layer Detachment Folding in Eastern Sichuan ProvinceACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 3 2010Zongxiu WANG Abstract: A serial of "comb-like and trough-like" folds developed in eastern Sichuan, controlled by the multi-layer detachment folding, is different from the classical Jura-type structure in their development. The key factor resulting in the development of these structures is the occurrence of detachment layers in different parts of Neoprotozoic to Mesozoic stratigraphy of study area, which, from the bottom to the top, are the lower part of Banxi Group, Lower Cambrian (Niutitang Formation), Lower Silurian (Longmaxi Formation and Luoreping Formation), Upper Permian (Wujiaping Formation) and Lower Triassic (Daye Formation). On the basis of field survey combined with sand-box modeling, this study argued that the detachment layer of the lower part of Banxi Group controlled the development of the "comb-like" folds, and the lower part of Cambrian detachment layer controlled the development of "trough-like" folds. Because of several detachment layers occurring in the study area, the development of duplex structures different scales is an important deformation mechanism, and the duplexes are the important structures distinguished from the typical detachment folding structures. Due to these duplexes, the surface structures and structural highs may not be the structural highs in the depth. Meanwhile, the detachment layers are good channels for oil/gas migration benefiting the understanding of accumulation and migration of oil and gas. [source] | ||||||||||||||||||||||