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Important Sign (important + sign)
Selected AbstractsChondrodermatitis nodularis helicis as a marker of internal syndromes associated with microvascular injuryJOURNAL OF CUTANEOUS PATHOLOGY, Issue 5 2005Cynthia M. Magro Chondrodermatitis typically occurs in elderly men where associations with underlying trauma and sun exposure have been postulated as potential inciting triggers. Its association as a marker of systemic disease is not well established. We describe 24 patients with CNH, in whom there were also significant underlying diseases largely associated with vascular injury including those of immune-based etiology and/or conditions which have been previously linked with granuloma annulare, another necrobiotic process of collagen. These patients with concomitant systemic disease were characteristically younger compared to the classic demographics described for CNH. In some cases, chondrodermatitis may represent an ischemic necrobiotic disorder of collagen, potentially defining an important sign of underlying systemic disease in younger patients. [source] Raised intracranial pressure in a neonate presenting as stridorPEDIATRIC ANESTHESIA, Issue 8 2006KATE SOLAN FRCA Summary Neonatal stridor is an important sign of upper airway obstruction. This is most commonly secondary to laryngeal pathology and investigated by otolaryngologists. However neurological causes of stridor, secondary to vocal cord paralysis also occur for a variety of reasons (1). In cases of meningomyelocele up to 20% of infants may develop stridor (2). Respiratory distress may be severe and require prompt surgical and medical intervention. We describe a neonate born with a meningomyelocele, who developed stridor secondary to evolving hydrocephalus after surgical repair of the meningomyelocele. This was treated acutely by direct tapping of cerebrospinal fluid from the right coronal horn via the coronal suture with immediate symptomatic improvement prior to a definitive shunt procedure. [source] Geology, Geochemistry and Minerogenesis of the Shijuligou Zinc,Copper Deposit in Gansu, ChinaACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 6 2009LI Wenyuan Abstract: The Shijuligou deposit was separated by an arcuate ductile shear zone cross the center of the deposit region, resulting in the difference between the southern and northern ore bodies. The lead (Pb) isotopic data of ores of the Shijuligou copper deposit have averages of 206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb in 17.634, 15.444, and 37.312, respectively. It has been shown that ore-forming metals originated from intrusive and extrusive rocks in the upper part of ophiolites. The sulfur isotopic data of pyrite and chalcopyrite in the northern part change from +7.61, to +8.09, and +4.95, to +8.88, in the southern part. Isotopes of ,18O in the Shijuligou copper deposit are between +11.1, and +18.6,, with the calculated ,18OH2O at +0.65,. It is suggested that the mineralized fluid is a mixture of magma fluid, meteorological water, and seawater through circulating and leaching metals from the volcanic rocks. The zircon uranium-lead (U,Pb) dating of gabbro is 457.9±1.2 Ma, and the lower crossing age of the discordant and concordia curves of pyroxene spilite of zircon is 454±15 Ma. It is indicated that the Shijuligou deposit formed in a new ocean crust (ophiolite) of the back-arc basin in the late Ordovician. Mineralization should occur in the intermittence period after strong volcanic activity, and the age should be the late Ordovician. Moreover, the mineralization of ophiolite-hosted massive sulfide deposits in the ancient orogenic belt of the late Ordovician in the northern Qilian Mountains was controlled by the primary fault/fracture, with the forming of a metallogenic hydrothermal system by a mixture of volcanic magma fluid and seawater, which circularly leached the metallogenic metals from the volcanic rocks, resulting in their accumulation. The ore bodies were transformed with morphology and metallogenic elements. Jasperoid is an important sign for prospecting such deposits. There were many island arcs in the continent of China. This study provides evidence for understanding and exploration of ophiolite-hosted massive sulfide deposits in western China, especially in the area of northern Qilian Mountains. [source] Partial generation of periodontal ligament on endosseous dental implants in dogsCLINICAL ORAL IMPLANTS RESEARCH, Issue 4 2005Leila Jahangiri Abstract Objectives: The objective of this pilot study was to investigate the feasibility of periodontal ligament (PDL) generation on an implant surface by approximating a tooth-to-implant contact using orthodontics. Methods: Maxillary second premolars of six beagle dogs were extracted bilaterally. After 2 weeks of healing, hydroxyapatite (HA) coated titanium implants, 5 mm in length and 3.3 mm in diameter, were placed in the extraction sites. One side of the arch was used as control. Orthodontic tooth movement was initiated following implant placement to tip the first premolar roots into contact with the implant. This was achieved in 4,6 weeks as confirmed radiographically. Tooth-to-implant contact was maintained for further 6 weeks after which time, teeth were separated from implant contact orthodontically. After further 2 weeks of stabilization, the animals were sacrificed. Samples were analyzed by Faxitron radiographs before histology. Histology samples were prepared with Stevenel's Blue and Van Gieson stain and were subjected to polarized light microscopy. Results: Histologic analysis revealed transfer and formation of PDL-like structure with formation of cellular cementum on the implant surfaces, in four out of six animals, where tooth-to-implant contact had been achieved. Direct bone-to-implant contact was noted in the areas coronal to the PDL-like tissue, an important sign to distinguish between PDL-like tissue and connective tissue that could originate from the coronal portion of a failing implant. Additionally, at the site of contact, the implant surface revealed some resorption of the HA coating. Conclusion: An animal model was established in which the proximity of tooth-to-implant contact lead to partial generation of PDL on a bioactive implant surface in four out of six animals. Résumé L'objectif de cette étude pilote a été d'analyser la possibilité d'obtenir une régénération du ligament parodontal (PDL) sur une surface implantaire en rapprochant le contact implant-dent par l'orthodontie. Les deuxièmes prémolaires maxillaires de six chiens beagle ont été avulsées bilatéralement. Après deux semaines de guérison, des implants en titane recouverts d'hydroxyapatite de 5 mm de long et de 3,3 mm de diamètre ont été insérés dans les sites d'avulsion. Un site de chaque arche était utilisé comme contrôle. Le mouvement orthodontique de la dent était initialisé après le placement de l'implant pour mettre en contact les raçines des premières prémolaires avec l'implant. Ceci a été réalisé en quatre à huit semaines comme l'a confirmé la radiographie. Le contact dent-implant a été maintenu pour une durée supplémentaire de six semaines après lesquelles les dents ont été séparées du contact des implants de manière orthodontique. Après deux semaines de stabilisation, les animaux ont été euthanasiés. Les échantillons ont été analysés par radiographie Faxitron avant l'histologie. Les échantillons histologiques ont été préparés par les colorations du Bleu de Stevenel et de Van Gieson et ont été analysés au microscope optique à polarisation. L'histologiea révélé un transfert et une formation d'une structure ressemblant à PDL avec la formation d'un cément cellulaire à la surface des implants chez quatre des six animaux chez lesquels le contact dent-implant avaient été réalisés. Le contact direct os-implant a été noté dans les zones coronaires au tissu qui ressemblait à PDL, un signe important pour distinguer le tissu ressemblant à PDL et le tissu conjonctif qui pouvait provenir de la portion coronaire de l'implant qui échoue. De plus, au site de contact, la surface implantaire révélait quelques résorptions du recouvrement d'hydroxyapatite. Un modèle animal a donc étéétabli dans lequel la proximité du contact dent-implant était suivie d'une génération partielle de PDL sur une surface implantaire bioactive chez quatre des six animaux. Zusammenfassung Ziele: Das Ziel dieser Pilotstudie war, zu untersuchen, ob es möglich sei, ein parodontales Ligament (PDL) auf einer Implantatoberfläche durch Herstellung eines Zahn-Implantat-Kontakts mittels Orthodontie zu generieren. Methoden: Bei sechs Beagle-Hunden wurden bilateral die zweiten Prämolaren extrahiert. Nach einer Abheilzeit von zwei Wochen wurden Hydroxyapatit beschichtete Titanimplantate mit einer Länge von 5 mm und einem Durchmesser von 3.3 mm in die Extraktionsstellen eingesetzt. Eine Seite des Zahnbogens diente als Kontrolle. Nach der Implantatplatzierung wurde mit der orthodontischen Zahnbewegung begonnen, um die Wurzeln der ersten Prämolaren in Kontakt mit den Implantaten zu bringen. Es wurde radiologisch bestätigt, dass dies nach 4,6 Wochen erreicht wurde. Der Zahn-Implantat-Kontakt wurde für weitere sechs Wochen belassen, danach wurden die Zähne wieder orthodontisch vom Kontakt mit den Implantaten separiert. Nach weiteren zwei Wochen zur Stabilisierung wurden die Tiere geopfert. Die Proben wurden vor der Histologie mittels Faxitron Röntgen analysiert. Die histologischen Proben wurden mit Stevenel`s Blau und van Gieson Färbungen bearbeitet und durch Lichtmikroskopie mit polarisiertem Licht untersucht. Resultate: Die histologische Analyse zeigte einen Transfer und eine Formation von Parodontalligament ähnlichen Strukturen mit der Bildung von zellulärem Zement auf der Implantatoberfläche bei 4 von 6 Tieren, bei welchen ein Zahn-Implantat-Kontakt erreicht worden war. Koronal des PDL-ähnlichen Gewebes bestand ein direkter Knochen-Implantat-Kontakt. Dies war ein wichtiges Merkmal, um zwischen PDL-ähnlichem Gewebe und Bindegewebe, welches vom koronalen Anteil eines fehlgeschlagenen Implantats stammen könnte, zu unterscheiden. Zusätzlich zeigten die Implantatoberflächen im Bereich der Berührungsfläche etwas Resorption der Hydroxyapatit Beschichtung. Schlussfolgerung: Es wurde ein Tiermodell etabliert, in welchem ein Zahn-Implantat-Kontakt bei 4 von 6 Tieren zu einer partiellen Generation eines PDL auf einer bioaktiven Implantatoberfläche führte. Resumen Objetivos: El objetivo de este estudio piloto fue investigar la viabilidad de generación de ligamento periodontal (PDL) en la superficie de un implante por aproximación de un contacto diente a implante usando ortodoncia. Métodos: Se extrajeron los segundos premolares de seis perros beagle bilateralmente. Tras dos semanas de cicatrización, se colocaron en los lugares de extracción implantes de titanio cubiertos de hidroxiapatita, de 5 mm de longitud y 3.3 mm de diámetro. Un lado del arco se usó como control. El movimiento dental ortodóntico se inició tras la colocación del implante para apuntar las raíces del primer premolar hacia el contacto con el implante. Esto se logró en 4-6 semanas tal como se confirmó radiograficamente. El contacto diente a implante se mantuvo durante seis semanas mas tras lo cual, los dientes se separaron del contacto con el implante ortodonticamente. Tras dos semanas más de estabilización, los animales se sacrificaron. Las muestras se analizaron por medio de radiografías Faxitron antes de la histología. Las muestras histológicas se prepararon con azul de Stevenel y tinción de Van Gieson y se sometieron a microscopio de luz polarizada. Resultados: El análisis histológico reveló transferencia y formación de estructuras tipo ligamento periodontal con formación de cemento celular en las superficies del implante, en 4 de 6 animales, en los que se logró el contacto diente a implante. Se notó contacto en las áreas coronales al tejido tipo PDL, un signo importante para distinguir tejido tipo PDL y tejido conectivo que se podría originar de la parte coronal de un implante en vías de fracaso. Además, en el lugar del contacto, la superficie del implante reveló algo de reabsorción de la cubierta de hidroxiapatita. Conclusión: Se estableció un modelo animal en el que la proximidad del contacto diente a implante llevó a la generación parcial de PDL en una superficie de implante bioactiva en 4 de 6 animales. [source] Patriarchs and republicans: eighteenth-century Virginian planters and classical politicsHISTORICAL RESEARCH, Issue 194 2003Enrico Dal Lago This article argues that the metaphor of George Washington as Father of his Country, or Pater Patriae, must be seen in the context of the culture of the eighteenth-century Virginian planter élite. Classical education and English commonwealthmen's writings had given most planters familiarity with Roman republican figures such as Cicero, who first bore the title of Pater Patriae, and had prompted them to consider independence and disinterestedness for the sake of public good as the most important signs of virtue in the optimal republican citizen. At the same time, patriarchalism , the prominent ethos among Virginian planters , dictated that the representatives of the upper classes ought to display their virtue through an attitude of benevolence towards the lower strata of society, and especially towards the slaves. [source] Characteristics of exploratory eye movements in elderly people: possibility of early diagnosis of dementiaPSYCHOGERIATRICS, Issue 3 2010Youko NAKASHIMA Abstract Background:, Visual cognitive dysfunction is one of the most important signs indicating the early stage of dementia. Thus, visual testing could be used as an aid to the clinical diagnosis of dementia. In the present study, exploratory eye movement was measured to evaluate visual cognitive function in elderly subjects, including those with dementia. Methods:, We analyzed responsive search scores (RSS) from exploratory eye movements of 300 subjects who were examined with an eye mark recorder while viewing S shaped figures. Subjects were divided into three groups (dementia, intermediate, healthy) from the values of the Revised Hasegawa Dementia Scale (HDS-R), the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating. We further divided the intermediate groups into two subgroups, the high score and low score groups, based on RSS. In 202 subjects, Z-scores of voxel-based specific regional analysis system for Alzheimer's disease (VSRAD) were obtained from magnetic resonance imaging (MRI). Results:, RSS of the dementia group were significantly lower than those in the intermediate and healthy groups, in order: dementia < intermediate < healthy groups. RSS of the low score intermediate group was significantly lower than that of the high score intermediate group. There was no significant difference between the low score intermediate and dementia groups, or between the high score intermediate and healthy groups. No significant differences of either HSD-R or MMSE were observed between the low score and the high score intermediate groups. The Z-score of VSRAD using MRI in the low score intermediate group was significantly higher than that in the high score intermediate group. Conclusions:, These findings suggest that RSS using an eye mark recorder is a useful psychophysiological marker to evaluate the early stage of dementia as well as at-risk elderly people. [source] | ||||||||||