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Important Innovation (important + innovation)

Distribution by Scientific Domains

Life Sciences	50%
Business, Economics, Finance and Accounting	50%

Selected Abstracts

Calculation of IBD probabilities with dense SNP or sequence data

GENETIC EPIDEMIOLOGY, Issue 6 2008
Jonathan M. Keith
Abstract The probabilities that two individuals share 0, 1, or 2 alleles identical by descent (IBD) at a given genotyped marker locus are quantities of fundamental importance for disease gene and quantitative trait mapping and in family-based tests of association. Until recently, genotyped markers were sufficiently sparse that founder haplotypes could be modelled as having been drawn from a population in linkage equilibrium for the purpose of estimating IBD probabilities. However, with the advent of high-throughput single nucleotide polymorphism genotyping assays, this is no longer a reasonable assumption. Indeed, the imminent arrival of individual sequencing will enable high-density single nucleotide polymorphism genotyping on a scale for which current algorithms are not equipped. In this paper, we present a simple new model in which founder haplotypes are modelled as a Markov chain. Another important innovation is that genotyping errors are explicitly incorporated into the model. We compare results obtained using the new model to those obtained using the popular genetic linkage analysis package Merlin, with and without using the cluster model of linkage disequilibrium that is incorporated into that program. We find that the new model results in accuracy approaching that of Merlin with haplotype blocks, but achieves this with orders of magnitude faster run times. Moreover, the new algorithm scales linearly with number of markers, irrespective of density, whereas Merlin scales supralinearly. We also confirm a previous finding that ignoring linkage disequilibrium in founder haplotypes can cause errors in the calculation of IBD probabilities. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc. [source]

Social enterprise for work integration in 12 european countries: a descriptive analysis,

ANNALS OF PUBLIC AND COOPERATIVE ECONOMICS, Issue 2 2005
by Roger Spear
And one sector where they have found a particularly important place is in work integration, addressing some of the more difficult problems of social exclusion in labour markets. The study on which this paper is based was a large scale comparative analysis of developments of these social enterprise in 12 European countries While there are clear differences in national contexts, there are also similarities in the forms and characteristics of these social enterprise across Europe. It is argued that this form of social enterprise has proved effective and is an important innovation to address problems of more marginalised groups and individuals, but there remain issues about how to sustain and promote the good models and good practices developed. [source]

INNOVATION CYCLES AND LEARNING AT THE PATENT OFFICE: DOES THE EARLY PATENT GET THE DELAY?,

THE JOURNAL OF INDUSTRIAL ECONOMICS, Issue 2 2010
PIERRE RÉGIBEAU
We study the relationship between the length of patent review and the importance of inventions. We build a simple model of the U.S. patent review process. Among the model predictions are that, controlling for a patent's position in a new technology cycle, more important innovations would be approved more quickly. Also, the approval delay is likely to decrease as an industry moves from the early stages of an innovation cycle to later stages. These predictions are in line with the evidence we obtain from a data set on U.S. patents granted in the field of genetically modified crops from 1983 to 1999. We also show that failing to account for the innovation lifecycle , as previous studies have done , is likely to bias upwards the estimates of the relationship between delay and importance. [source]

Partnering for Greater Success: Local Stakeholders and Research in Tropical Biology and Conservation

BIOTROPICA, Issue 5 2009
Karen A. Kainer
ABSTRACT Local communities are important stakeholders in resource management and conservation efforts, particularly in the developing world. Although evidence is mixed in suggesting that these resident stakeholders are optimal forest stewards, it is highly unlikely that large tracts of tropical forests will be conserved without engaging local people who depend on them daily for their livelihoods. Stakeholders, who reside in biodiverse ecosystems like tropical forests, are the largest direct users and ultimate decision-makers of forest fate, can be important investors in conservation, harbor local ecological knowledge that complements Western science and frequently have long-term legitimate claims on lands where they reside. Research partnerships with local stakeholders can increase research relevance, enhance knowledge exchange and result in greater conservation success. Different phases of the research cycle present distinct opportunities for partnership, with flexibility in timing, approaches and strategies depending on researcher and local stakeholder needs and interests. Despite being the last step in the research process, dissemination of results can be the best starting point for researchers interested in experimenting with local stakeholder engagement. Still, tropical biologists might not choose to partner with local people because of lack of institutional rewards, insufficient training in stakeholder engagement, insecure research infrastructure in community settings, and time and funding limitations. Although not appropriate in all cases and despite significant challenges, some biological scientists and research institutions have successfully engaged local stakeholders in the research process, proving mutually beneficial for investigators and local people alike and resulting in important innovations in tropical biology and conservation. [source]