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Important Hypothesis (important + hypothesis)

Distribution by Scientific Domains
Medical Sciences80%

Selected Abstracts

The role of testosterone in the pathogenesis of prostate cancer

INTERNATIONAL JOURNAL OF UROLOGY, Issue 6 2008
Takashi Imamoto
Abstract: Relationships between androgenic hormones and prostatic tissue growth are complex. It is certainly true that the prostate will not develop without androgens and the gland will atrophy if androgen support is withdrawn. The hormonal hypothesis remains one of the most important hypotheses in the etiology of prostate cancer (PCa), and efforts are continuing to improve the understanding of androgen actions in PCa. Although evidence from epidemiological studies of associations between circulating levels of androgens and PCa risk has been inconsistent, the traditional view that higher testosterone (T) levels represent a risk factor for PCa appears to have little evidentiary support. Reinvestigation of the relationship between T and PCa seems important and necessary if a new, clinically and scientifically rewarding concept is to be constructed. The present review considers the metabolism and intraprostatic action of T, epidemiological evidence, and the association between T and PCa risk. [source]

Complications of type 1 diabetes: new molecular findings

MOUNT SINAI JOURNAL OF MEDICINE: A JOURNAL OF PERSONALIZED AND TRANSLATIONAL MEDICINE, Issue 4 2008
Alin Stirban MD
Abstract Interventions targeting the treatment of diabetic complications have not been nearly as successful as initially estimated, despite a marked improvement in therapeutic options for diabetes. The need for understanding why some very promising interventions have failed demands a closer look at the pathomechanisms of the complications. Great strides have been made in understanding the pathology, and several important hypotheses have emerged in recent years. On this basis, Brownlee and coworkers suggested a unifying hypothesis integrating various mechanisms discussed in past years with an overproduction of reactive oxygen species as an initiating cause. This hypothesis and further hypotheses, as well as mechanisms, are highlighted in this article. The field of pathomechanisms of diabetic complications is very wide, and any attempt to completely cover it within a single article is unrealistic. Therefore, our purpose is to present the most relevant concepts underlying diabetic complications in an attempt to contribute to a better understanding and pinpoint areas that warrant further research. Mt Sinai J Med 75:328,351, 2008. © 2008 Mount Sinai School of Medicine [source]

Pressure boundary condition for the time-dependent incompressible Navier,Stokes equations

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 6 2006
R. L. Sani
Abstract In Gresho and Sani (Int. J. Numer. Methods Fluids 1987; 7:1111,1145; Incompressible Flow and the Finite Element Method, vol. 2. Wiley: New York, 2000) was proposed an important hypothesis regarding the pressure Poisson equation (PPE) for incompressible flow: Stated there but not proven was a so-called equivalence theorem (assertion) that stated/asserted that if the Navier,Stokes momentum equation is solved simultaneously with the PPE whose boundary condition (BC) is the Neumann condition obtained by applying the normal component of the momentum equation on the boundary on which the normal component of velocity is specified as a Dirichlet BC, the solution (u, p) would be exactly the same as if the ,primitive' equations, in which the PPE plus Neumann BC is replaced by the usual divergence-free constraint (, · u = 0), were solved instead. This issue is explored in sufficient detail in this paper so as to actually prove the theorem for at least some situations. Additionally, like the original/primitive equations that require no BC for the pressure, the new results establish the same thing when the PPE approach is employed. Copyright © 2005 John Wiley & Sons, Ltd. [source]

Autoimmunity as an aetiological factor in vitiligo

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 7 2007
N Rezaei
Abstract Vitiligo is a common dermatological disorder characterized by the presence on the skin of depigmented macules resulting from the destruction of cutaneous melanocytes. Autoimmunity is an important hypothesis with regard to vitiligo aetiology and the evidence for autoimmune responses being involved in the pathogenesis of this disorder will be discussed in the present review. All immune system compartments, including innate and adaptive immunity have been implicated in vitiligo development. Particularly relevant are autoantibodies and autoreactive T cells in vitiligo patients that have cytotoxic effects upon pigment cells. Furthermore, predisposition to vitiligo appears to be associated with certain alleles of the major histocompatibility complex class II antigens as well as with other autoimmune-susceptibility genes. Moreover, the association of vitiligo with autoimmune disorders, the animal models of the disease, and the positive response to immunosuppressive therapeutic agents emphasize the role of autoimmunity in the development of this disorder. [source]

Tips and tricks for writing a manuscript

ACTA OPHTHALMOLOGICA, Issue 2009
B DAMATO
Purpose The aims of this presentation are to highlight some pearls and pitfalls in writing scientific articles. Methods It is not possible to write a good manuscript unless you have a good message to share. If you are reporting research results this means that you will need to have conducted the research properly, with good statistics, measures to avoid bias, complete data and, of course, an important hypothesis to test. If possible, expert advice should be obtained before the study is started so as to ensure that the trial design is appropriate and that the statistics are correct. Results The key to writing a good manuscript is to divide the paper into sections and to sub-divide each section into components, making sure that the sequence of ideas is in the correct order. The internet is full of good advice on how to write a good manuscript. This information be summarized in this presentation, which will also guide participants to useful sources of information. Conclusion Writing a manuscript is not difficult and should be a pleasurable and rewarding experience as long as one follows a few simple rules, which will be discussed in this talk. [source]