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Important Fact (important + fact)
Selected AbstractsAdolescent Depression: Important Facts That MatterJOURNAL OF CHILD AND ADOLESCENT PSYCHIATRIC NURSING, Issue 2 2000Lisa M. Pullen PhD PURPOSE. To determine if there are differences in adolescent depression using variables of age, gender, smoking, and alcohol use. METHODS. A comparative, descriptive survey design was used. The adolescents (N = 217) completed either the Beck Depression Inventory or the Children's Depression Inventory and a demographic questionnaire. FINDINGS. The 15- to 2 6-year-olds (p = .016), females (p = .003), and smokers (p = .001) scored significantly higher than the 12- to 14-year-olds on depression. The 15- to 16-year-olds who used alcohol were found to be twice as depressed as the nonusers (p = .002). No significant differences were found in the 17- to 19-year-old age group. CONCLUSIONS. This study confirmed depression increased with age, in females, and with smokers. Nurses are in a unique position to provide interventions to promote healthy lifestyles and reduce the likelihood of depression and alcohol and nicotine abuse in adolescents. [source] The 15N-CPMAS spectra of simazine and its metabolites: measurements and quantum chemical calculationsEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 4 2007A. E. Berns Summary DFT calculations are a powerful tool to support NMR studies of xenobiotics such as decomposition studies in soil. They can help interpret spectra of bound residues, for example, by predicting shifts for possible model bonds. The described bound-residue models supported the hypothesis of a free amino side chain already suspected by comparison with the experimental data of the standards. No match was found between the calculated shifts of amide bondings of the amino side chains (free or substituted) and the experimental NMR shifts of a previous study. In the present paper, first-principles quantum chemical calculations were used to support and check the interpretation of the 15N cross polarization-magic angle spinning nuclear magnetic resonance (15N-CPMAS NMR) spectra of simazine and its metabolites. Density functional theory (DFT) calculations were performed using Gaussian 03 and the nuclear magnetic shielding tensors were calculated using the Gauge-Independent Atomic Orbital (GIAO) method and B3LYP/6,311+G(2d,p) model chemistry. Good agreement was reached between the calculated and measured chemical shifts of the core nitrogens and the lactam and lactim forms of the hydroxylated metabolites could be clearly distinguished. The calculated spectra showed that these metabolites exist preferentially in the lactam form, an important fact when considering the possible interactions of such hydroxylated metabolites with the soil matrix. Although the calculated bound-residue models in the present study only partly matched the experimental data, they were nevertheless useful in helping to interpret the experimental NMR results of a previous study. To get a better match between the calculated and the measured shifts of the side-chain nitrogens the calculations need to be further developed, taking into account the influence of neighbouring molecules in the solid state. Altogether, quantum chemical calculations are very helpful in the interpretation of NMR spectra. In the future, they can also be very useful for the prediction of NMR shifts, in particular when it is not possible to measure the metabolites due to a lack of material or in cases where practical experiments cannot be conducted. [source] Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survivalINTERNATIONAL JOURNAL OF CANCER, Issue 4 2003Christian Sfiligoi Abstract Angiogenic factors produced by tumor cells are essential for tumor growth and metastasis. In our study, the expression of Angiopoietin-1 (ANG1) and Angiopoietin-2 (ANG2) mRNA in archival human breast cancer tumor samples and in 6 breast cancer cell lines was investigated. Total RNA from biopsies of 38 breast cancer patients was extracted and ANG1 and ANG2 mRNA expression was measured by means of quantitative real-time RT-PCR (Taqman®). Matching data with available clinicopathologic and biochemical data revealed a significant association between ANG2 expression and axillary lymph node invasion. Univariate and multivariate survival analysis, by means of Kaplan-Meier method and Cox's proportional hazards model, showed significant and independent association between ANG2 mRNA level and both disease-free (p < 0.0001) and overall survival (p < 0.0003). An important fact is that, notwithstanding the small number of cases examined, this association was confirmed also in the group of lymph node-negative patients (DFS, p < 0.003; OS, p < 0.020). Immunohistochemical analysis demonstrated that Ang2 is expressed by both tumor cells and endothelial elements. Expression in tumor cells was confirmed by studying a panel of human breast carcinoma cell lines in culture by RT-PCR. In ZR75.1 and T47D cells, expression of ANG2 mRNA was increased up to 10-fold by treatment with estrogen within 24 hr. Although preliminary, these data suggest a possible role of ANG2 as a prognostic factor for primary breast cancer. © 2002 Wiley-Liss, Inc. [source] Z+ fading memory and extensions of input,output mapsINTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS, Issue 4 2001Irwin W. Sandberg Abstract An Erratum for this article has been published in the International Journal of Circuit Theory and Applications 30(4) 2002, 179. Much is known about time-invariant non-linear systems with inputs and outputs defined on Z+ that possess approximately-finite memory. For example, under mild additional conditions, they can be approximated arbitrarily well by the maps of certain interesting simple structures. An important fact that gives meaning to results concerning such systems is that the approximately-finite-memory condition is known to be often met. Here we consider the known proposition that if a causal time-invariant discrete-time input,output map H has fading memory on a set of bounded functions defined on all of the integers Z, then H can be approximated arbitrarily well by a finite Volterra series operator. We show that in a certain sense, involving the existence of extensions of system maps, this result too has wide applicability. Copyright © 2001 John Wiley & Sons, Ltd. [source] Nitric oxide increases dramatically in air exhaled from lung regions with occluded vesselsACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 3 2003E. Fernández-Mondéjar Background:, We observed dramatic changes in exhaled nitric oxide concentration (,NOE) during wedge measurements, and hypothesised that occlusion and redistribution of pulmonary blood flow affects NOE. Methods:, We inflated the balloon of the pulmonary artery catheter and measured NOE and central hemodynamics in closed chest anesthetised pigs (n = 11) ventilated with hyperoxic gas (fraction of inspired oxygen [FIO2] = 0.5), before and during lung injury, and in open chest anesthetised pigs (n = 17) before and during left lower lobar (LLL) hypoxia (FIO2 0.05), and during hyperoxic (FIO2 0.8) ventilation of the other lung regions (HL). Results:, In the closed chest pigs NOE increased from 2.0 (0.9) to 3.4 (2.0) p.p.b. (P < 0.001) during wedge, and returned to 2.0 (1.0) p.p.b. when the balloon was deflated. The increase in mean pulmonary artery pressure (MPaP) during wedge was small and insignificant (P > 0.07). When the balloon was inflated in the right pulmonary artery in the open chest pigs, the perfusion of the HL decreased from 2.57 (0.58) to 2.34 (0.55) l min,1 (P < 0.001), and NOEHL increased from 2.5 (0.9) to 6.2 (3.2) p.p.b. (P < 0.001). The perfusion of the LLL increased from 0.33 (0.26) to 0.54 (0.34) l min,1 (P < 0.001), and NOELLL decreased from 1.7 (0.6) to 1.5 (0.5) p.p.b. (P < 0.001). Neither lung injury nor LLL hypoxia had any influence on ,NOE (P > 0.07) during wedge. The correlation coefficient (R2) was 0.66 between changes in regional blood flow and ,NOE, and 0.37 between changes in MPaP and ,NOE. Conclusions:, Nitric oxide concentration increases dramatically from lung regions with occluded vessels, whereas changes in MPaP have minor effects on NOE. This is an important fact to consider when comparing NOE within or between studies, and indicates a possible marker of diseases with occluded lung vessels. [source] Optimal manufacturer's pricing and lot-sizing policies under trade credit financingINTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH, Issue 6 2006Jinn-Tsair Teng Abstract In this paper, we extend Goyal's economic order quantity (EOQ) model to allow for the following four important facts: (1) the manufacturer's selling price per unit is necessarily higher than its unit cost, (2) the interest rate charged by a bank is not necessarily higher than the manufacturer's investment return rate, (3) the demand rate is a downward-sloping function of the price, and (4) an economic production quantity (EPQ) model is a generalized EOQ model. We then establish an appropriate EPQ model accordingly, in which the manufacturer receives the supplier trade credit and provides the customer trade credit simultaneously. As a result, the proposed model is in a general framework that includes numerous previous models as special cases. Furthermore, we provide an easy-to-use closed-form optimal solution to the problem for any given price. Finally, we develop an algorithm for the manufacturer to determine its optimal price and lot size simultaneously. [source] Magnetohydrodynamic turbulence in a strongly magnetised plasmaASTRONOMISCHE NACHRICHTEN, Issue 1 2010S. Sridhar Abstract I present a review of incompressible magnetohydrodynamic (MHD) turbulence in a strongly magnetised plasma. The approach is phenomenological even where a more rigorous theory is available, so that a reader armed with paper, pencil and some determination may be able to work through most of the physics. The focus is on the inertial-range spectra for very large (fluid and magnetic) Reynolds numbers. These theories of the inertial-range are built on two important facts: (i) Kraichnan's insight that the turbulent cascades are a result of nonlinear interactions between oppositely directed wavepackets of Elsasser fields; (ii) these oppositely directed wavepackets do not exchange energy, but contribute only to changing each other's spatial structures. I begin with a description and critique of the Iroshnikov-Kraichnan theory, and explore the fundamental departures necessitated by the anisotropic nature of the turbulence. Derivations of the inertial-range spectra of four regimes of MHD turbulence , the balanced weak, balanced strong, imbalanced weak and the imbalanced strong cascades , are then presented. The need for studying the spectra of imbalanced turbulence when the waves on the outer scale have a short correlation time is briefly discussed (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] | ||||||||||