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Important Details (important + detail)

Distribution by Scientific Domains

Chemistry	40%
Business, Economics, Finance and Accounting	40%

Selected Abstracts

Surgical Approaches for Stable Vitiligo

DERMATOLOGIC SURGERY, Issue 10 2005
Rafael Falabella MD
Background. Vitiligo therapy is difficult. Depending on its clinical presentation, unilateral or bilateral vitiligo lesions respond well with different repigmentation rates, according to age, affected anatomic area, extension of lesions, time at onset, timing of depigmentation spread, and other associated factors. When stable and refractory to medical treatment, vitiligo lesions may be treated by implanting pigment cells on depigmented areas. Objective. To describe the main events of depigmentation and the fundamentals of surgical techniques for repigmenting vitiligo by implanting noncultured cellular or tissue grafts, in vitro cultured epidermis-bearing pigment cells, or melanocyte suspensions. Methods. A description of the available techniques for repigmentation of vitiligo is done, emphasizing the most important details of each procedure to obtain the best repigmentation and minimize side effects. Results. With most of these techniques, adequate repigmentation is obtained, although there are limitations when applying some methods to clinical practice. Conclusions. Restoration of pigmentation may be accomplished with all available surgical procedures in most anatomic locations, but they are of little value for acral areas. Unilateral vitiligo responds well in a high proportion of patients, and bilateral disease may also respond when stable. Appropriate patient selection is important to achieve the best results. [source]

Vacuum drying of wood with radiative heating: I. Experimental procedure

AICHE JOURNAL, Issue 1 2004
Patrick Perré
Abstract Experimental results for the vacuum drying of wood with radiative heating are presented. In particular, the temperature and pressure measurements at different locations within the board are provided, as are the overall drying curves. The heat source is such that the temperature at the end of the process remains low (,150°C), and under these conditions, the drying process resembles convective drying with superheated steam. Further important details concerning the internal transfer mechanisms that are induced by this drying process can be pointed out by comparing results for sapwood and heartwood of different species (Picea abies, Abies alba and Fagus silvatica). These extensive experimental data sets will be used in Part II of this work for the purposes of assessing the accuracy and predictive ability of two different drying models and for analyzing the vacuum drying process further at a fundamental level. © 2004 American Institute of Chemical Engineers AIChE J, 50:97,107, 2004 [source]

Mitochondria and calcium homeostasis: a tale of three luminescent proteins

LUMINESCENCE: THE JOURNAL OF BIOLOGICAL AND CHEMICAL LUMINESCENCE, Issue 2 2001
Paulo J. Magalhães
Abstract In recent years the jellyfish Aequorea victoria has provided the scientific community with a pair of tools of exceptional usefulness: aequorin and the green fluorescent protein (GFP). Whereas the former has played a major role in the study of calcium signalling, the latter has sparked the imagination of researchers into a myriad of elegant experiments. The firefly Photinus pyralis has also been of great use, providing a third luminescent protein, luciferase, which is mostly known for its role as a reporter protein. Concurrent use of these three proteins provides a powerful means of elucidating biological processes with fine spatio-temporal detail. Here we will illustrate how specific molecular engineering of these three proteins provided a set of biological tools capable of generating important data in the field of calcium homeostasis. First, we will show how the use of specifically targeted aequorin chimeras enabled the measurement of regional Ca2+ concentrations; second, how the use of GFP (and derived chromatic mutants) permitted detailed morphological analyses in living cells; third, how luciferase was used to analyse energetic requirements at the subcellular level. Together, these three experimental approaches have provided important details on how mitochondria participate actively in calcium homeostasis. A final note regarding clinical implications demonstrates the practical usefulness of the data obtained. Copyright © 2001 John Wiley & Sons, Ltd. [source]

Performance Funding in Federal Agencies: A Case Study of a Federal Job Training Program

PUBLIC BUDGETING AND FINANCE, Issue 3 2003
Pascal Courty
Our case study highlights important details that enter into developing performance contingent budgeting schemes,details that do not emerge in more general discussions of the subject,and shows how the handling of these details can be crucial to these schemes' success. We study a federal job training program that gives state and local decision makers discretion over the program's operation, but through performance funding holds them accountable for achieving specific objectives. We find that states' modifications to the scheme's construction produced over time highly individualized performance funding schemes that likely varied in their effectiveness. [source]

Submarket Dynamics of Time to Sale

REAL ESTATE ECONOMICS, Issue 3 2006
Gwilym Pryce
We argue that the rush to apply multiple regression estimation to time on the market (TOM) durations may have led to important details and idiosyncrasies in local housing market dynamics being overlooked. What is needed is a more careful examination of the fundamental properties of time to sale data. The approach promoted and presented here, therefore, is to provide an examination of housing sale dynamics using a step-by-step approach. We present three hypotheses about TOM: (i) there is nonmonotonic duration dependence in the hazard of sale, (ii) the hazard curve will vary both over time and across intra-urban areas providing evidence of the existence of submarkets and (iii) institutional idiosyncrasies can have a profound effect on the shape and position of the hazard curve. We apply life tables, kernel-smoothed hazard functions and likelihood ratio tests for homogeneity to a large Scottish data set to investigate these hypotheses. Our findings have important implications for TOM analysis. [source]