Analogues

Distribution by Scientific Domains
Distribution within Chemistry

Kinds of Analogues

  • acid analogue
  • adenosine analogue
  • arginine analogue
  • atp analogue
  • b analogue
  • basal insulin analogue
  • base analogue
  • blue analogue
  • camp analogue
  • camptothecin analogue
  • cgmp analogue
  • chemical analogue
  • cyclic analogue
  • d analogue
  • d3 analogue
  • deuterated analogue
  • distamycin analogue
  • erythropoietin analogue
  • fluorescent analogue
  • glp-1 analogue
  • gnrh analogue
  • heterocyclic analogue
  • hormone analogue
  • hormone-releasing hormone analogue
  • ide analogue
  • insulin analogue
  • its analogue
  • long-acting analogue
  • long-acting insulin analogue
  • luteinizing hormone-releasing hormone analogue
  • modern analogue
  • modified analogue
  • new analogue
  • novel analogue
  • nucleoside analogue
  • nucleotide analogue
  • oligonucleotide analogue
  • other analogue
  • peptide analogue
  • phosphate analogue
  • prussian blue analogue
  • purine analogue
  • rapid-acting insulin analogue
  • silicon analogue
  • simple analogue
  • somatostatin analogue
  • state analogue
  • structural analogue
  • substrate analogue
  • sulfur analogue
  • synthetic analogue
  • thymidine analogue
  • transition state analogue
  • transition-state analogue
  • visual analogue
  • vitamin d analogue
  • vitamin d3 analogue
  • water-soluble analogue

  • Terms modified by Analogues

  • analogue octreotide
  • analogue pain scale
  • analogue scale
  • analogue scale score
  • analogue score
  • analogue study
  • analogue therapy
  • analogue treatment

  • Selected Abstracts


    THE CGP7930 ANALOGUE 2,6-DI- TERT -BUTYL-4-(3-HYDROXY-2-SPIROPENTYLPROPYL)-PHENOL (BSPP) POTENTIATES BACLOFEN ACTION AT GABAB AUTORECEPTORS

    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 9 2008
    David AS Parker
    SUMMARY 1The pharmacological actions of 2,6-di- tert -butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABAB receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. 2At 10 mmol/L, BSPP inhibited the release of [3H]-GABA in the presence of baclofen, but not that of [3H]-glutamic acid. This effect was sensitive to the GABAB receptor antagonist (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid (Sch 50911). 3Alone, BSPP had no effect on the release of [3H]-GABA or [3H]-glutamic acid. 4It is concluded that BSPP selectively potentiates the action of baclofen at GABAB autoreceptors, but not heteroreceptors and may be a useful ligand to discriminate between presynaptic GABAB receptor subtypes. [source]


    BIOACTIVITIES AND MECHANISM OF SPIRO ENOL ETHER ANALOGUES AGAINST PIERIS RAPAE

    INSECT SCIENCE, Issue 1 2004
    Zhi-xiang Zhang
    Abstract, Nineteen kinds of spiro enol ether analogues were screened with larvae of Pieris rapae for antifeedant activity. The results showed that the antifeedant activity of compounds No.20 and No. 12 was higher than others. In non-choice test, AFC50 values within 24 h of compounds No.20 and No. 12 against 3rd instar larvae of P. rapae were 226.93 ,g/mL and 370.00 ,g/mL, and that in choice test against 4th larvae were 280.54 ,g/mL and 398.88 ,g/mL, respectively. Compd. No.20 could prolong the eggs hatch time and reduce the haemolymph content and the protein content in haemolymph of 4th instar larvae obviously. Compd. No.20 could protect tested leaves and control larvae of P. rapae effectively. [source]


    ON PENTAMPLEXUSSCHINDEWOLF, 1940 (ANTHOZOA, RUGOSA) AND ITS POSSIBLE RELATIVES AND ANALOGUES

    PALAEONTOLOGY, Issue 2 2009
    JERZY FEDOROWSKI
    Abstract:, Three ampleximorphic taxa are revised and their most important characters are discussed in terms of possible or apparent relationships. Re-interpretation of its early ontogeny allows the assignment of Pentamplexus Schindewolf, 1940 to the family Polycoeliidae de Fromentel, 1861. Stereolasma variabilisVojnovsky-Krieger, 1934 is established as the type species of Vojnovskytes gen. nov. It resembles the family Polycoeliidae in some characters and the Antiphyllidae Ilina, 1970 or the Laccophyllidae Grabau, 1928 in others. Thus, its family status is not established. Revision of the type material of Fasciculophyllum tripusSchindewolf, 1952 allows its inclusion within the new genus Silesamplus, probably related to the family Laccophyllidae Grabau, 1928. Amplexoid morphology is further shown to be inadequate for the establishment of relationships on the family or subfamily level. Early ontogeny is most important in that respect, but biform vs normal morphology in the tabularium and free vs contratingent development of minor septa must also be considered, where appropriate. [source]


    In Vitro Formation of Nanocrystalline Carbonate Apatite , A Structural and Morphological Analogue of Atherosclerotic Plaques

    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 26 2007
    Lars-Fride Olsson
    Abstract The in vitro formation of carbonate apatite in solutions with ion concentrations comparable to those in human serum was studied. The composition and morphology of the resulting apatite precipitate displayed a hierarchical assembly of elongated plate-shaped nanocrystals of carbonate apatite analogous to previously characterized bioapatites formed in vivo. The main conclusion is that so-called bioapatites may form in vitro and that precipitation inhibitors most likely are essential for the prevention of spontaneous calcification at normal human serum ion concentrations. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source]


    Actinide-Transition Metal Heteronuclear Ions and Their Oxides: {IrUO}+ as an Analogue to Uranyl

    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 17 2006
    Marta Santos
    Abstract Recent theoretical calculations have shown that Ir should behave as a chemical analogue to N, with the result that IrUO+, like known NUO+, is predicted to be a stable species isoelectronic with UO22+, the uranyl dication. The target heterometallic analogue to uranyl has now been prepared by direct laser desorption/ionization of a U/Ir alloy, and by oxidation of UIr+ with N2O and C2H4O. Properties of UIr+, UPt+, and UAu+ bimetallic ions have been studied. They demonstrate direct actinide,transition metal bonding, and support the concept of "autogenic isolobality". (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006) [source]


    Asymmetric Synthesis of a Novel Conformationally Constrained D -Lysine Analogue with a Piperidine Skeleton

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 20 2008
    Pablo Etayo
    Abstract A practical asymmetric synthesis of enantiomerically pure(2R,4R)-1-(tert -butoxycarbonyl)-4-[2-(methoxycarbonylamino)ethyl]pipecolic acid starting from easily accessible (R)-2-[(S)-1,2-bis(benzyloxy)ethyl]-1-[(S)-1-phenylethyl]-4-piperidone in around 33,% overall yield has been performed. The efficiency of the synthetic strategy developed for the synthesis of this novel conformationally constrained D -lysine analogue relies on the high-yielding Wadsworth,Emmons reaction of a 2-substituted 4-piperidone and the diastereoselective reduction of the exocyclic C=C double bond at the 4-position of the piperidine ring.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]


    Synthesis of 1,5-Substituted Iminodibenzo[b,f][1,5]diazocine, an Analogue of Tröger's Base

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 13 2006
    Alessandro Leganza
    Abstract A method for the synthesis of 1,5-disubstituted iminodibenzo[b,f][1,5]diazocines is presented. The synthesis is achieved by the metal-free cyclization of 2-aminophenyl ketimines using the corresponding 2-aminophenyl ketone as the catalyst. The synthesis gives new insight into the mechanism of formation of this class of compounds. The presence of potential sites for hydrogen-bond formation and two aromatic bromine atoms available for functionalization make these targets attractive for further development in supramolecular chemistry. The structure of the complex derived from the iminodibenzo[b,f][1,5]diazocine and PdCl2 was determined by X-ray crystallography. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006) [source]


    Generation of a Small Library of Highly Electron-Rich 2-(Hetero)Aryl-Substituted Phenethylamines by the Suzuki,Miyaura Reaction: A Short Synthesis of an Apogalanthamine Analogue

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 15 2004
    Prasad Appukkuttan
    Abstract The Suzuki,Miyaura reaction is presented as a versatile procedure for the synthesis of a small library of highly electron-rich 2-[4,5-dimethoxy-2-(hetero)arylphenyl]ethylamines. Microwave-irradiation accelerates the reaction tremendously and furnishes superior yields. The difficult oxidative addition of the catalyst to a highly electron-rich and ortho -substituted system could be performed easily, and the proto-deboronation during cross-coupling reactions involving the highly electron-withdrawing (2-formylphenyl)boronic acid could be minimized. Enhanced yields and complete compatibility with aqueous conditions were found. This strategy was developed en route towards the synthesis of an apogalanthamine analogue. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source]


    2,3,6,7,10,11-Hexamethoxytribenzotriquinacene: Synthesis, Solid-State Structure, and Functionalization of a Rigid Analogue of Cyclotriveratrylene

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 11 2004
    Marco Harig
    Abstract The syntheses of several tribenzotriquinacenes bearing six methoxy groups at the outer peripheral positions of the aromatic rings are reported. The centro -methyl derivative is accessible in surprisingly good yield through two-fold cyclodehydration in the final step of a synthesis route which requires special care in the preparation of some electron-rich key intermediates, such as 5,6-dimethoxy-2-methylindane-1,3-dione and bis(3,4-dimethoxyphenyl)methanol. X-ray single-crystal structure analysis of the centro -methyl derivative confirms its C3v -symmetrical molecular structure but, at variance from the parent centro -methyltribenzotriquinacene and the similarly shaped cyclotriveratrylene, the hexamethoxytribenzotriquinacene analog does not form columnar stacks in the solid state. Functionalization of the three benzhydrylic bridgehead positions leads to the tetramethyl analog and the bridgehead triol in good yields. In contrast, attempts to functionalize the ortho positions by nitration or bromination mainly give rise to ring cleavage through electrophilic ipso attack, which parallels the behavior of cyclotribenzylenes and cyclotriveratrylenes. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source]


    Targeted Cytotoxic Analogue of Luteinizing Hormone-Releasing Hormone (LH-RH) Only Transiently Decreases the Gene Expression of Pituitary Receptors for LH-RH

    JOURNAL OF NEUROENDOCRINOLOGY, Issue 1 2002
    M. Kovacs
    Abstract A cytotoxic analogue of LH-RH, AN-207, consisting of 2-pyrrolinodoxorubicin (AN-201) linked to carrier [D-Lys6]LH-RH, was developed for targeted therapy of cancers expressing LH-RH-receptors. To determine its possible side-effects on the pituitary gland, we investigated the gene expression of pituitary LH-RH-receptors and LH secretion in ovariectomized female and normal male rats after treatment with the maximum tolerated dose of AN-207. The effect of AN-207 on the gene expression of the pituitary GH-RH-receptors and GH secretion was also assessed in male rats. Five hours after a single i.v. injection of AN-207 at 175 nmol/kg, there was a 39,51% decrease in mRNA expression for the pituitary LH-RH-receptors in male and female rats. The carrier, at an equimolar dose, caused a similar reduction (37,39%), whereas the cytotoxic radical AN-201, at an equitoxic dose (110 nmol/kg), produced only a 12,24% decrease (NS) in the mRNA expression of LH-RH-receptors. AN-207 and the carrier analogue induced a comparable 90,100-fold increase in serum LH concentrations in male rats, and the same 12-fold elevation in OVX rats at 5 h. Seven days after treatment with AN-207, the mRNA levels for the LH-RH receptors and the serum LH concentration were back to normal in both sexes. AN-207, the carrier, and AN-201 had no significant effect on the expression of mRNA for GH-RH-receptors in the pituitary. In vitro, a continuous perfusion of pituitary cells with 10 nM AN-207 did not affect the hormone-releasing function of the targeted LH cells or the nontargeted GH cells. Our results demonstrate that cytotoxic LH-RH analogue AN-207, at the maximum tolerated dose causes only a transient decrease in the gene expression of the pituitary LH-RH receptors, and the levels of mRNA for LH-RH receptor fully recover within 7 days. Moreover, the carrier hormone moiety, and not the cytotoxic radical in AN-207 is responsible for this transient suppression. Our findings suggest that the therapy with cytotoxic LH-RH analogues will not inflict permanent damage to pituitary function. [source]


    International validation of a health-related quality of life questionnaire in patients with erosive gastro-oesophageal reflux disease

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 6 2009
    G. HOLTMANN
    Summary Background, Although erosive gastro-oesophageal reflux disease (GERD) is a highly prevalent condition, there is no specific, valid, reliable and sensitive questionnaire that allows evaluating treatment-induced changes in health-related quality of life (HRQoL). Aim, To design a self-administered questionnaire, the GERD Analyzer (GERDyzer), for use in clinical studies. Methods, The GERDyzer comprises 10 dimensions each illustrated by pictogram-like drawings, simplifying communication with the patients. Self-assessment is performed by 100 mm Visual Analogue Scales. For validation, a 5-week clinical trial involving 395 patients (per-protocol) with oesophagitis was conducted. Patients were treated with pantoprazole (40 mg o.d.) for 28 days. Psychometric analyses included internal consistency, test,retest reliability, responsiveness and construct validity. Results, Factor analysis showed consistency of the dimensions and no reduction was necessary. Validation of GERDyzer indicated high internal consistency (Cronbach's , = 0.95) and test,retest reliability (intraclass correlation coefficient =0.91). Responsiveness of the total score expressed by nonparametric effect size was 1.38. Comparison of scores with other questionnaires resulted in logical correlation levels depending on the respected concepts measured. Conclusions, GERDyzer proved to be highly valid, reproducible and responsive. It allows reliably assessing treatment-induced changes in HRQoL in erosive GERD. [source]


    Conjunctival effects of a selective nasal pollen provocation

    ALLERGY, Issue 9 2010
    I. Callebaut
    To cite this article: Callebaut I, Spielberg L, Hox V, Bobic S, Jorissen M, Stalmans I, Scadding G, Ceuppens JL, Hellings PW. Conjunctival effects of a selective nasal pollen provocation. Allergy 2010; 65: 1173,1181. Abstract Background:, Several clinical and experimental observations suggest that allergen deposition in the nose may partially be responsible for the induction of conjunctival symptoms in allergic rhinitis. The aims of this study were to evaluate the induction of conjunctival symptoms by selective nasal allergen provocation and to assess the feasibility of the different tools for evaluation of conjunctival allergic inflammation. Methods:, Grass pollen allergic subjects with rhinoconjunctivitis symptoms during the pollen season (n = 12) underwent a nasal sham and grass pollen provocation extra-seasonally. Nasal and conjunctival symptoms were scored using the Visual Analogue Scale (VAS) system at baseline, 15 min, 1 h and 24 h after provocation. In addition to Peak Nasal Inspiratory flow (PNIF) measurements, conjunctival inflammation and vascular congestion were evaluated and histamine and substance P levels in tear fluid were measured. Results:, Selective nasal grass pollen provocation induced ocular pruritus, lacrimation and conjunctival vascular congestion. PNIF values correlated inversely with lacrimation (r = ,0.71, P < 0.001) and ocular pruritus (r = ,0.41, P < 0.05). Four out of 11 patients showed a conjunctival eosinophilic inflammation and levels of histamine (r = 0.73, P < 0.05) and substance P (r = 0.67, P = 0.05) in tear fluid correlated with conjunctival symptoms. Conclusion:, Selective nasal grass pollen provocation induced conjunctival inflammation, ocular pruritus and lacrimation, which correlated with histamine and substance P levels in tear fluid and inversely with the PNIF values. These data show a naso-ocular interaction in allergic rhinitis and offer objective tools for evaluation of conjunctival inflammation in allergic rhinoconjunctivitis. [source]


    Fatigue rating scales critique and recommendations by the Movement Disorders Society task force on rating scales for Parkinson's disease,

    MOVEMENT DISORDERS, Issue 7 2010
    Joseph H. Friedman MD
    Abstract Fatigue has been shown to be a consistent and common problem in Parkinson's disease (PD) in multiple countries and cultures. It is one of the most disabling of all symptoms, including motor dysfunction, and appears early, often predating the onset of motor symptoms. Several studies of the epidemiology of fatigue have been published, often using different scales, but few on treatment. The Movement Disorder Society (MDS) commissioned a task force to assess available clinical rating scales, critique their psychometric properties, summarize their clinical properties, and evaluate the evidence in support of their use in clinical studies in PD. Six clinical researchers reviewed all studies published in peer reviewed journals of fatigue in PD, evaluated the scales' previous use, performance parameters, and quality of validation data, if available. Scales were rated according to criteria provided by the MDS. A scale was "recommended" if it has been used in clinical studies beyond the group that developed it, has been used in PD and psychometric studies have established that it is a valid, reliable and sensitive to change in people with PD. Requiring a scale to have demonstrated sensitivity to change in PD specifically rather than in other areas in order to attain a rating of "recommended" differs from the use of this term in previous MDS task force scale reviews. "Suggested" scales failed to meet all the criteria of a "recommended" scale, usually the criterion of sensitivity to change in a study of PD. Scales were "listed" if they had been used in PD studies but had little or no psychometric data to assess. Some scales could be used both to screen for fatigue as well as to assess fatigue severity, but some were only used to assess severity. The Fatigue Severity Scale was "recommended" for both screening and severity rating. The Fatigue Assessment Inventory, an expanded version of the Fatigue severity Scale, is "suggested" for both screening and severity. The Functional Assessment of Chronic Illness Therapy-Fatigue was "recommended" for screening and "suggested" for severity. The Multidimensional Fatigue Inventory was "suggested" for screening and "recommended" for severity. The Parkinson Fatigue Scale was "recommended" for screening and "suggested" for severity rating. The Fatigue Severity Inventory was "listed" for both screening and severity. The Fatigue Impact Scale for Daily Use, an adaptation of the Fatigue Impact Scale was "listed" for screening and "suggested" for severity. Visual Analogue and Global Impression Scales are both "listed" for screening and severity. The committee concluded that current scales are adequate for fatigue studies in PD but that studies on sensitivity and specificity of the scales are still needed. © 2010 Movement Disorder Society [source]


    Protonation-Induced Formation of a Stable Singlet Biradicaloid Derived from a Modified Sapphyrin Analogue,

    ANGEWANDTE CHEMIE, Issue 34 2010
    Masatoshi Ishida Dr.
    Radikal durch Ansäuern: Das neuartige Sapphyrin-Analogon 1 mit eingebundenem 1,10-Phenanthrolin-System (siehe Schema; R=COOEt, Ar=p -Tolyl) und Alkylidengruppen in meso-Stellung wurde synthetisiert und durch Protonierung in [1,3,H]3+ mit Singulettdiradikal-Charakter überführt. [source]


    Innentitelbild: Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods (Angew. Chem.

    ANGEWANDTE CHEMIE, Issue 50 2009
    50/2009)
    Das Bioengineering von Proteinen mithilfe von Säugerzellen hat die Entwicklung potenzieller pharmazeutischer Erythropoietine (EPOs) mit N-verknüpften Oligosacchariden erleichtert. In der Zuschrift auf S.,9721,ff. berichten Y. Kajihara et,al. über die chemische Synthese eines homogenen bioaktiven EPO-Analogons durch native chemische Ligation zwischen einem synthetischen Glycopeptid-,-thioester mit zwei Sialyloligosacchariden und einer großen Polypeptidkette, die in E.,coli exprimiert wurde. [source]


    Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods,

    ANGEWANDTE CHEMIE, Issue 50 2009
    Kiriko Hirano
    EPO-Doping: Bei Konzentrationen eines Erythropoietin(EPO)-Analogons über 50,pg,mL,1 wurde Zellproliferation beobachtet. Das EPO-Analogon, das zwei humane Sialyloligosaccharide enthält (siehe Bild), wurde mithilfe einer Kombination aus chemischer Synthese und Proteinexpression in E.,coli erhalten. Die beiden Sialyloligosaccharide stören nicht bei der Bindung des EPO-Analogons an einen Rezeptor. [source]


    A Pyrrolysine Analogue for Site-Specific Protein Ubiquitination,

    ANGEWANDTE CHEMIE, Issue 48 2009
    Xin Li
    Die Kunst des Proteinnähens: D -Cys-,-Lys und sein Diastereomer L -Cys-,-Lys lesen durch das UAG-Codon (siehe Schema). Da die gebildeten Proteine in der nativen chemischen Ligation (NCL) eingesetzt werden können, sind so Proteine zugänglich, die chemoselektiv durch eine Peptidseitenkette an der ,-Position eines rational gewählten Lysinrests modifiziert (z.,B. ubiquitinyliert) sind. [source]


    Proline Analogue of Nitrosourea as a New Cytotoxic Prodrug

    ARCHIV DER PHARMAZIE, Issue 11 2009
    Anna Stankiewicz-Kranc
    Abstract Carmustine is frequently used as anticancer drug. High toxicity and low selectivity reduces the application of this drug. Though, there is a necessity to find new compounds characterized by similar therapeutic effects but a higher selectivity and safety. As a result, the proline analogue of nitrosourea, N -[N,-(2-bromophenyl)- N,-nitrosocarbamoyl]proline (AC), has been synthesized. The aim of this study was to compare the influence of carmustine and the proline analogue of nitrosourea on the antioxidant abilities of fibroblasts and leukemia cells, MOLT4. It was shown that carmustine as well as AC cause an increase in hydrogen peroxide concentration in normal and neoplastic cells. Incubation with both compounds led to a diminution of the activity of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and reductase. Changes in activity / level of antioxidant parameters were accompanied by augmentation of lipid and oxidative protein modifications. In conclusion, carmustine and AC cause changes in the antioxidative system of normal and MOLT4 cells and are a reason of oxidative stress formation. [source]


    Disila-Okoumal: A Silicon Analogue of the Ambergris Odorant Okoumal

    CHEMBIOCHEM, Issue 12 2007
    Matthias W. Büttner
    Abstract Two-fold sila-substitution (C/Si exchange) in the saturated ring of the tetrahydronaphthalene skeleton of the ambery odorant okoumal (5) provides disila-okoumal (6). The okoumal isomers 5,a,d were synthesized from 1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)ethanone (7), and the silicon analogues 6,a,d were synthesized from 1-(5,5,8,8-tetramethyl-5,8-disila-5,6,7,8-tetrahydro-2-naphthyl)ethanone (8). Detailed olfactory properties of 5,a,d and 6,a,d are reported, together with the respective threshold values. All enantiomers of okoumal and disila-okoumal exhibit typical ambery odor notes with woody facets, as is characteristic of okoumal and karanal, but a stereocenter at the 2-position was found to be of utmost importance for the odor thresholds; the lowest value of 0.31 ng per L air was measured for the 2R -configured silicon compounds 6,a and 6,c. [source]


    Stabilisation of RNA Bulges by Oligonucleotide Complements Containing an Adenosine Analogue

    CHEMBIOCHEM, Issue 11 2003
    Annemieke Madder
    Abstract Incorporation of 2,-deoxy-2,- , -(1-naphthylmethyl)tubercidin into an oligodeoxyribonucleotide mostly has little or a slightly negative effect on the Tmvalues of complexes with DNA complements. With the same naphthylmethyl-substituted nucleoside at the 3,-end of a 2,-O-methyloligoribonucleotide, however, a stabilisation of 1,2,°C in the corresponding complexes with both DNA and RNA is observed. When the target sequence is an RNA fragment forming a two- or three-nucleotide bulge, complexes with (naphthylmethyl)tubercidin-modified oligodeoxyribonucleotides, as well as with the corresponding 2,-O-methyloligoribonucleotides, give stabilisations of 1,2,°C for the three-nucleotide bulge and of almost 4,°C for the two-nucleotide bulge. This stabilisation is specific to RNA, since the corresponding complexes with the DNA fragments do not display this effect. Thus, the (naphthylmethyl)tubercidin-containing oligonucleotides are the first reported oligonucleotide modifications that specifically stabilise bulged RNA. [source]


    ChemInform Abstract: A Facile Rearrangement of Pyrroloindoline Derivative to Pyrroloquinoline: A New Analogue of Duocarmycins.

    CHEMINFORM, Issue 5 2009
    Naim H. Al-Said
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    ChemInform Abstract: Pilsicainide and Its Oxymethylene Analogue: Facile Alternative Syntheses and in vitro Testing on Human Skeletal Muscle Sodium Channels.

    CHEMINFORM, Issue 1 2008
    Claudio Bruno
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    Single Crystal of a Prussian Blue Analogue Based on Rubidium Manganese Hexacyanoferrate.

    CHEMINFORM, Issue 35 2007
    Hiroko Tokoro
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Synthesis of 16-Mercaptohexadecylphosphocholine, a Miltefosine Analogue with Leishmanicidal Activity.

    CHEMINFORM, Issue 1 2007
    Valentin Hornillos
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Fluorite-Type Solid Solutions in the System Y,Ta,O,N: A Nitrogen-Rich Analogue to Yttria-Stabilized Zirconia (YSZ).

    CHEMINFORM, Issue 35 2006
    H. Schilling
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    A New Teleocidin Analogue from Streptomyces sp.

    CHEMINFORM, Issue 28 2006
    MM216-87F4 Induces Substance P Release from Rat Dorsal Root Ganglion Neurons.
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    A Versatile Synthesis of (.+-.)-Deoxyfebrifugine, an Antimalarial Alkaloid Analogue, and Related Compounds.

    CHEMINFORM, Issue 26 2006
    Joseph P. Michael
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Total Synthesis of Two Naturally Occurring Polyacetylenic Glucosides (-)-Bidensyneoside A1 (Ia) and B (Ib), and an Analogue (Ic) of (-)-Bidensyneoside C (Id).

    CHEMINFORM, Issue 24 2006
    Benjamin W. Gung
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    A New Potential Cyclooxygenase-2 Inhibitor, Pyridinic Analogue of Nimesulide

    CHEMINFORM, Issue 17 2006
    Catherine Michaux
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Synthesis of 6,7-Benzo-3-borabicyclo[3.3.1]nonane and Its 3-Aza Analogue from 2-Allylphenyl(diallyl)borane.

    CHEMINFORM, Issue 8 2006
    Intramolecular Arylboration of the C=C Bond.
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF. [source]