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ICAM-1 Levels (icam-1 + level)

Distribution by Scientific Domains

Medical Sciences	75%

Selected Abstracts

Acute Postdialysis Changes in Plasma ICAM-1 and IL-1 Levels in Hemodialysis Patients

HEMODIALYSIS INTERNATIONAL, Issue 1 2003
S EL-Hefeni
Fifty subjects: 20 controls and 30 hemodialysis patients were included in the study. The acute changes in plasma ICAM-1 and IL-1, levels immediately after dialysis were evaluated using two types of membranes and two types of dialysate. The predialysis ICAM-1 level in the whole patients was significantly higher than controls, while that of IL-1, was significantly lower. The postdialysis ICAM-1 showed insignificant higher level than the predialysis one, while that of IL-1, showed significant higher level than both the predialysis and control levels. Both postdialysis ICAM-1 and IL-1, levels in patients using cuprophane membrane (bioincompatible) showed insignificant higher levels than in those using polysulfone one (biocompatible). The percent increase in ICAM-1 level did not significantly differ in these two subgroups, while the percent increase in IL-1, level showed significantly higher value in those using bioincompatible membrane (108%) than that in those using biocompatible membrane (44%). No significant difference in the levels of either ICAM-1 or IL-1, were found between patients using acetate and bicarbonate dialysate. Conclusion: the bioincompatibility of the membrane is the important factor in the occurrence of the acute reaction during hemodialysis. [source]

Structural myocardial changes after coronary artery surgery

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 11 2000
F. Eberhardt
Background Postoperative contractile dysfunction or ,myocardial stunning' has been described after coronary artery bypass grafting (CABG). In the present study we sought to determine if and to what extent clinical, structural and histochemical evidence of myocardial changes associated with stunning could be found in patients after CABG and cold crystalloid cardioplegia. Materials and methods Left ventricular (LV) biopsies were obtained from CABG patients (n = 10) prior to and at the end of cardiopulmonary bypass (CPB). These biopsies were immunostained for the inducible heat-shock protein 70 (HSP-70i), intercellular adhesion molecule-1 (ICAM-1) and actin. ATP was measured by bioluminescence. Results Biopsies pre-CPB showed no evidence of myocardial damage as HSP-70i was absent and a regular actin cross-striation pattern and only constitutive ICAM-1-expression were present. After CPB we found significantly increased HSP-70i and ICAM-1 levels as well as a deranged actin cross-striation pattern with a widening of actin bands. ATP levels declined from 10 mmol L,1 pre-CPB to 4.9 mmol L,1 after CPB. Correspondingly, coronary sinus effluent showed a significant lactate production. Although, cardiac function determined by transoesophageal echocardiography did not deteriorate, significant inotropic support was necessary to maintain cardiac output. Conclusions Our results present clinical and structural evidence of ,myocardial stunning' after CABG and cold crystalloid cardioplegia. Increased HSP-70i and ICAM-1 expression, as well as a deranged actin cross-striation pattern, might be structural markers to determine ,myocardial stunning' in clinical settings. [source]

Upregulation of intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 after unilateral nerve injury in the peripheral taste system

JOURNAL OF NEUROSCIENCE RESEARCH, Issue 2 2007
Melissa Ann Cavallin
Abstract In the peripheral taste system, activated macrophages are recruited to both sides of the tongue after unilateral sectioning of the chorda tympani nerve (CT). Neural degeneration elicits macrophage entry in other systems by upregulating vascular adhesion molecules. We hypothesized that CT sectioning leads to a bilateral increase in intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression on lingual vessels. To test this hypothesis, rats were euthanized at time points from 6 hr to 7 days post-sectioning. Frozen sections of tongue were processed for immunohistochemical staining for ICAM-1 and VCAM-1. Tongue homogenates from additional rats were analyzed with ELISA. ICAM-1 expression increases first on the denervated side of the tongue at 24 hr post-section and then on the uninjured side at 48 hr post-section. ICAM-1 remains elevated through Day 7 post-sectioning on both sides of the tongue. Dietary sodium restriction, which prevents the macrophage response to nerve sectioning, had no effect on ICAM-1 levels. VCAM-1+ vessels are increased on the denervated side of the tongue at 24,48 hr post-section in control-fed rats. However, dietary sodium restriction prevents the increase. These results indicate that vascular adhesion molecules are differentially regulated by CT sectioning. We suggest that macrophage entry, migration, and modulation of taste function are downstream of dynamic expression of adhesion molecules. © 2006 Wiley-Liss, Inc. [source]

Vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 serum level in patients with chest pain and normal coronary arteries (syndrome X)

CLINICAL CARDIOLOGY, Issue 4 2001
Dimitris Tousoulis M.D., Ph.D.
Abstract Background: Plasma levels of soluble vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (IC AM-1) mediators of leukocyte adhesion to vascular endothelium may implicate in the pathogenesis of the syndrome of chest pain with normal coronary arteries. Hypothesis: We attempted to determine whether markers of endothelial activation are raised in patients with chest pain and normal coronary arteries. Methods: We measured plasma VCAM-1, ICAM-1 (ng/ml) in 36 patients (34 men, 2 women, aged 62 ± 9 years) with stable angina, coronary artery disease (CAD), and a positive response to exercise test; in 21 patients (6 men, 15 women, aged 56 ± 9 years) with chest pain and normal coronary arteriograms (syndrome X); and in 11 healthy control subjects (8 men, 3 women, aged 49 ± 14 years). Results: Plasma ICAM-1 levels were significantly higher both in patients with CAD (mean ± standard error of the mean) (328 ± 26, p<0.05), and in syndrome X (362 ± 22, p<0.01) than in controls (225 ± 29). VCAM-1 levels were also higher in syndrome X (656 ± 42 ng/ml) and in patients with CAD (626 ± 42 ng/ml) than in controls (551 ± 60, p=0.09). Conclusions: ICAM-1 and VCAM-1 levels are increased both in patients with CAD and with syndrome X compared with control individuals. These findings may suggest the presence of chronic inflammation with involvement of the endothelium in patients with anginal chest pain and normal coronary angiograms. [source]