Home  About us  Contact
 

Idiopathic Cases (idiopathic + case)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Red Ear Syndrome and Migraine: Report of Eight Cases

HEADACHE, Issue 2 2002
Vincenzo Raieli MD
We describe eight idiopathic cases of red ear syndrome in seven children and one adult. All were migraineurs with a history of paroxysmally painful and red ear, unilateral or alternating, in isolation or associated with migraine attacks. The reported duration of these episodes varied from 30 minutes to 1 hour. Neurologic examination, brain MRI and CT scans, and x-rays of the cervical spine were normal. The close temporal relationship between the "red ear episodes" and migraine attacks suggests an association between the two conditions. [source]

Management of cancer-associated thrombotic microangiopathy: What is the right approach?

AMERICAN JOURNAL OF HEMATOLOGY, Issue 4 2007
Theresa L. Werner
Abstract A 49-year-old Caucasian woman presented with features suggestive of thrombotic microangiopathy (TMA). She did not respond to treatment with repeated plasma exchange and corticosteroids. A bone marrow biopsy revealed presence of metastatic carcinoma. A limited autopsy revealed presence of breast cancer with rib metastases. Though severe deficiency of von Willebrand factor-cleaving protease was initially proposed as a key pathogenetic factor for thrombotic thrombocytopenic purpura, subsequent studies involving patients with cancer-associated TMA did not find as severe a deficiency of von Willebrand factor-cleaving protease as is seen in idiopathic cases of thrombotic thrombocytopenic purpura. Here we address one approach of management of these patients with cancer-associated TMA. Am. J. Hematol., 2006. © 2006 Wiley-Liss, Inc. [source]

1361: Main anterior entities 2: granulomatous

ACTA OPHTHALMOLOGICA, Issue 2010
F WILLERMAIN
Purpose During uveitis, inflammatory cells and epitheloid cells can aggregates on the corneal endothelium forming keratic precipitates (KPs). Methods On slit lamp examination, KP's can have different forms and locations. Once they are large with a mutton fat appearance, uveitis will be classified as granulomatous. Results Granulomatous uveitis is a heterogeneous group of disease with anterior, intermediate and panuveitis. Granulomatous uveitis can be due to several infectious and non infectious causes, but masquerade syndromes and idiopathic cases must also been ruled out. Conclusion This course will first describe the main clinical characteristics of those different entities. A standard work-up procedure will then be proposed. [source]

Review: Familial Parkinson's disease , genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease

NEUROPATHOLOGY & APPLIED NEUROBIOLOGY, Issue 3 2008
Carola Schiesling
The identification of the first gene in familial Parkinson's disease (PD) only 10 years ago was a major step in the understanding of the molecular mechanisms in neurodegeneration. Alpha-synuclein aggregation was not only recognized as a key event in neurodegeneration in patients carrying mutations in this gene, but it turned out to be the most consistent marker to define Lewy body pathology also in non-heritable idiopathic PD (IPD). Subsequent comprehensive pathoanatomical studies of IPD brains led to a novel concept of an ascending pathological process in variable stages that are reflected by alpha-synuclein aggregation at specific predilection sites. To date, more than seven genes are known to cause familial PD. The fact that these genetic forms of Parkinsonism present with clinical features indistinguishable from IPD, but may display neuropathological features that are not consistent with IPD, underscores the need of a more differentiated approach to familial and sporadic forms of Parkinsonism. Indeed, in distinct populations, mutations in one single gene were found to cause the disease in up to 40% of patients formerly described as ,idiopathic' cases. These findings indicate that IPD, as defined by a late-onset disorder with no (apparent) genetic contribution, is part of a clinical syndrome that becomes more and more heterogeneous in terms of aetiology, with overlapping clinical and pathoanatomical features. Thus in the present review, we discuss clues from familial PD to our understanding of the molecular pathogenesis of neurodegeneration with special consideration of the variable clinical and neuropathological aspects. [source]