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Hypothyroid Patients (hypothyroid + patient)

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Medical Sciences	100%

Selected Abstracts

Hypothyroidism and acquired von Willebrand's syndrome: a systematic review

HAEMOPHILIA, Issue 3 2008
E. MANFREDI
Summary., Acquired von Willebrand's syndrome type I is the supposed main underlying cause of bleeding tendency in hypothyroid patients. The purpose of this systematic review was to summarize the published evidence on the association between hypothyroidism and acquired von Willebrand's syndrome. All published clinical epidemiological and interventional studies, case reports and in vitro studies that investigated the association between hypothyroidism and acquired von Willebrand's syndrome were identified by a computer-assisted search of the MEDLINE and EMBASE electronic databases. A quality assessment was performed for clinical epidemiological studies. A total of 41 papers were included. A total of 22 epidemiological in vivo studies, two in vitro studies and 47 case reports were finally analyzed. No high quality in vivo study was identified. Almost all bleeding episodes described in the case reports were mucocutaneous. von Willebrand factor (VWF) antigen value was available for 23 patients: median value 28 U/dL (range: 4,45); VWF activity was available for 24 patients: median value 28.5 U/dL (range: <3,55); factor VIII activity was available for 16 patients: median value 47 U/dL (range: 9,74). Acquired von Willebrand's syndrome may be the main factor responsible for bleeding diathesis in overt hypothyroid patients. Even if bleeding episodes are mainly mild and mucocutaneous, blood transfusion, drug administration or surgical procedure may be required. [source]

Factors predicting final height in early treated congenital hypothyroid patients

CLINICAL ENDOCRINOLOGY, Issue 5 2006
Maurizio Delvecchio
Summary Objective, To evaluate pubertal development and final height (FH) in early treated patients with congenital hypothyroidism (CH) and to identify the main factors predicting FH. Design, Retrospective. Patients, Eighty-five patients with early diagnosed and treated CH. Measurements, Evaluation of length/height at diagnosis (mean age 26·6 days), at onset of puberty, and at the end of linear growth. Results, Mean FH was 161·7 cm in females and 173·8 cm in males, within ± 0·9 cm of the 50th percentile of Italian growth charts, 5 cm higher than the mean target height (TH). Linear growth did not differ according to thyroid imaging findings. In males, height at onset of puberty was 0·16 standard deviation score (SDS), not statistically different from FH (,0·09 SDS). In females, height both at onset of puberty (0·39 SDS) and at menarche (0·57 SDS) was significantly higher (P < 0·001) than FH (,0·10 SDS). Puberty started at a mean chronological age of 10·2 and 11·6 years in females and males, respectively, with a corresponding bone age. FH correlated with TH and height at diagnosis, at onset of puberty, and at menarche. Multiple regression analysis showed that height at onset of puberty and TH are the most important factors explaining FH variability, although height at onset of puberty is slightly more important. Conclusions, Our results, obtained in the largest reported available group of congenital hypothyroid patients, show that final height is higher than target height in both sexes and that height at onset of puberty is the main factor affecting final height. [source]

Decrease in carotid intima-media thickness in hypothyroid patients after normalization of thyroid function

CLINICAL ENDOCRINOLOGY, Issue 5 2003
Toshiki Nagasaki
Summary objective, This case,control study was carried out to assess whether levothyroxine (L-T4) replacement might cause regression of the enhanced atherosclerosis seen in hypothyroid patients. patients and methods, Intima-media thickness (IMT) in the common carotid artery (CCA) was measured from digitalized still images taken during scanning by high-resolution ultrasonography as an indicator of early atherosclerosis. Thirty-five hypothyroid patients were examined for their CCA IMT before and 1 year after normalization of thyroid function by L-T4 replacement. As control, 35 healthy subjects were enrolled from among the participants in a local health-check programme conducted at the Osaka City University Hospital. results, Basal CCA IMT was significantly higher in hypothyroid patients [0·635 ± 0·018 (mean ± SE) mm] than in control subjects (0·559 ± 0·021 mm, P < 0·005). After 1 year of euthyroidism, 34 out of 35 patients showed a significant decrease of CCA IMT, to 0·552 ± 0·015 mm (P < 0·0001), a level comparable to normal controls. CCA IMT change was closely associated with basal levels of total cholesterol (r = ,0·472, P= 0·0031), low-density lipoprotein (LDL) cholesterol (r = ,0·441, P= 0·0076) and the total/HDL cholesterol ratio (r =,0·435, P= 0·0057), but not with any of the other variables measured except for age (r = ,0·353, P= 0·0296). conclusions, This study demonstrated that L-T4 treatment might have the potential to reverse the progression of atherosclerosis in hypothyroid patients. Furthermore, it suggests that increased levels of LDL cholesterol and the total/HDL cholesterol ratio have an important role in the increased common carotid intima-media thickness in hypothyroid patients. [source]