Hydroxyapatite Particles (hydroxyapatite + particle)

Distribution by Scientific Domains


Selected Abstracts


Structural Characterization and Protein Adsorption Property of Hydroxyapatite Particles Modified With Zinc Ions

JOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 2 2007
Satoshi Hayakawa
Zinc-containing hydroxyapatite particles (Zn/HAp) were prepared by an ion exchange reaction process involving hydroxyapatite (HAp) particles with aqueous solutions containing various amounts of zinc nitrate. The Zn2+ ion was partially substituted for the Ca2+ ion position in the HAp lattice, and hence, the obtained samples had changed little in crystallinity, particle size, and specific surface area. Adsorption of bovine serum albumin (BSA) and ,2 -microglobulin (,2 -MG) in solutions containing both BSA and ,2 -MG was examined. As the Zn2+ ion content in the apatites increased, the adsorbed amount of BSA was almost constant, whereas that of ,2 -MG increased. [source]


Bovine-HA spongiosa blocks and immediate implant placement in sinus augmentation procedures

CLINICAL ORAL IMPLANTS RESEARCH, Issue 4 2002
Histopathological, histomorphometric observations on different histological stainings in 10 consecutive patients
Abstract: Bovine mineral spongiosa block (B-SB) was used as a bone substitute in sinus augmentation procedures in 10 consecutive patients. Implants were placed during the same session. The purpose of this study was to histopathologically examine the healing of the grafted site around the implants at 12 months. Radiographic follow-up showed apparent bone apposition in the augmented area around the implants. Clinically, all 36 implants were stable and integrated with the surrounding tissue. Histopathologically, new bone formation was evident in all specimen hard tissue cores. Hydroxyapatite particles were present in direct contact with the remodeled osseous tissue. Mallory trichrome staining showed different stages of mineralization and maturation of the newly formed bone around the grafted mineral particles. Morphometric evaluation of Picrosirius red stained slides under polarized light microscopy was performed at the peripheral/external and deep section slides of all specimens. The average bone area fraction was 34.2%, with a 1 : 5.4 mean lamellar/woven bone ratio at the peripheral side and 53.0%, with 1 : 2.5 mean ratio at the deep side. The differences of both parameters between the two sites were statistically significant. B-SB proved to be a suitable grafting material with simultaneously placed implants in sinus floor augmentation procedures. [source]


Interaction of Osteoblasts with Macroporous Scaffolds Made of PLLA/PCL Blends Modified with Collagen and Hydroxyapatite,

ADVANCED ENGINEERING MATERIALS, Issue 8 2009
Halil Murat Aydin
To mimic natural bone, a tissue engineering scaffold was developed that combines inorganic and organic components of natural bone, its pore diameter, and its interconnected structure. Collagen was coated onto a PLLA/PCL scaffold and hydroxyapatite particles were delivered throughout the polymer matrix much more easily than with other techniques thanks to the porosity-forming method of combining two porogens, namely, salt leaching and supercritical CO2 extraction. Compared with other coating techniques, this procedure can be performed readily and homogeneous 3D hydroxyapatite coating was achieved. [source]


An ultrastructural study of cellular response to variation in porosity in phase-pure hydroxyapatite

JOURNAL OF MICROSCOPY, Issue 2 2004
B. ANNAZ
Summary Hydroxyapatite has been shown to be biocompatible and bioactive. Incorporation of porosity has been shown to enhance osteointegration; however, difficulty in controlling the extent and type of porosity has limited investigation into determining the role of both macro- and microporosity. The current investigation reports on the synthesis of four types of phase-pure hydroxyapatite with varying levels of porosity (HA1,HA4), and with defined levels of macro- and microporosities. Transmission electron microscopy was used to evaluate qualitatively the effect of these two parameters on cell,material interactions following a 30-day incubation period. Biological mineralization was observed within vesicles and the needle-like minerals were confirmed as hydroxyapatite using X-ray microanalysis. This demonstrated the suitability of primary human osteoblast-like cells as a tool to assess the extent of mineralization. Furthermore, internalization of hydroxyapatite particles was observed. Our findings show that the variation in macro- and microporosity does not affect the extent of cell,material interaction, with collagen synthesis evident in all samples. [source]


Structural Characterization and Protein Adsorption Property of Hydroxyapatite Particles Modified With Zinc Ions

JOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 2 2007
Satoshi Hayakawa
Zinc-containing hydroxyapatite particles (Zn/HAp) were prepared by an ion exchange reaction process involving hydroxyapatite (HAp) particles with aqueous solutions containing various amounts of zinc nitrate. The Zn2+ ion was partially substituted for the Ca2+ ion position in the HAp lattice, and hence, the obtained samples had changed little in crystallinity, particle size, and specific surface area. Adsorption of bovine serum albumin (BSA) and ,2 -microglobulin (,2 -MG) in solutions containing both BSA and ,2 -MG was examined. As the Zn2+ ion content in the apatites increased, the adsorbed amount of BSA was almost constant, whereas that of ,2 -MG increased. [source]