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Hybrid Molecules (hybrid + molecule)

Distribution by Scientific Domains

Chemistry	71%

Selected Abstracts

Molecule,Light Complex: Dynamics of Hybrid Molecule,Surface Plasmon States,

ANGEWANDTE CHEMIE, Issue 46 2009
Adi Salomon Dr.
Ein anregender Austausch: Moleküle und Oberflächenplasmonen können über den Austausch von Photonen wechselwirken (siehe Bild) und so neue Hybridzustände bilden, in denen die photophysikalischen Eigenschaften des Moleküls verändert sind. Dies könnte die Grundlage für das Verändern der Photochemie und sogar der Chemie von Molekülen sein. [source]

Fentanyl Derivatives Bearing Aliphatic Alkaneguanidinium Moieties: A New Series of Hybrid Molecules with Significant Binding Affinity for ,-Opioid Receptors and I2 -Imidazoline Binding Sites.

CHEMINFORM, Issue 16 2004
Christophe Dardonville
No abstract is available for this article. [source]

Functionalized Self-Assembled InAs/GaAs Quantum-Dot Structures Hybridized with Organic Molecules

ADVANCED FUNCTIONAL MATERIALS, Issue 3 2010
Miaoxiang Chen
Abstract Low-dimensional III,V semiconductors have many advantages over other semiconductors; however, they are not particularly stable under physiological conditions. Hybridizing biocompatible organic molecules with advanced optical and electronic semiconductor devices based on quantum dots (QDs) and quantum wires could provide an efficient solution to realize stress-free and nontoxic interfaces to attach larger functional biomolecules. Monitoring the modifications of the optical properties of the hybrid molecule,QD systems by grafting various types of air-stable diazonium salts onto the QD structures surfaces provides a direct approach to prove the above concepts. The InAs/GaAs QD structures used in this work consist of a layer of surface InAs QDs and a layer of buried InAs QDs embedded in a wider-bandgap GaAs matrix. An enhancement in photoluminescence intensity by a factor of 3.3 from the buried QDs is achieved owing to the efficient elimination of the dangling bonds on the surface of the structures and to the decrease in non-radiative recombination caused by their surface states. Furthermore, a narrow photoluminescence band peaking at 1620,nm with a linewidth of 49 meV corresponding to the eigenstates interband transition of the surface InAs QDs is for the first time clearly observed at room temperature, which is something that has rarely been achieved without the use of such engineered surfaces. The experimental results demonstrate that the hybrid molecule,QD systems possess a high stability, and both the surface and buried QDs are very sensitive to changes in their surficial conditions, indicating that they are excellent candidates as basic sensing elements for novel biosensor applications. [source]

Synthesis of Hybrids of D -Glucose and D -Galactose with Pyrrolidine-Based Iminosugars as Glycosidase Inhibitors

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 34 2008
Venkata Ramana Doddi
Abstract Sugar,iminosugar hybrid molecules made up of D -glucose and D -galactose with pyrrolidine-based iminosugars, viz. 1,4-dideoxy-1,4-imino- L -xylitol and 1,4-dideoxy-1,4-imino- L -lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase inhibitors. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]

Perylene,Oligothiophene,Perylene Triads for Photovoltaic Applications

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 17 2005
Jens Cremer
Abstract A series of novel acceptor,donor,acceptor triad systems, consisting of head-to-tail-coupled oligo(3-hexylthiophene)s integrated between two terminal perylenemonoimides are described. These hybrid molecules, which differ by the length of the oligothiophene units from a quaterthiophene up to a dodecithiophene were synthesized by an effective palladium-catalyzed Ullmann-type homo-coupling reaction in good yields. The optical and electrochemical properties of these compounds were determined, and on the basis of this series structure-property relationships have been established which provide vital information for the fabrication of the corresponding photovoltaic devices. Because the synthesized perylenyl-oligothiophenes distinguish themselves by a high absorption between 300 and 550 nm and an almost complete fluorescence quenching of the perylene acceptor, they meet the requirements for organic solar cells. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]

DNA minor groove binders as potential antitumor and antimicrobial agents

MEDICINAL RESEARCH REVIEWS, Issue 4 2004
Pier Giovanni Baraldi
Abstract DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form noncovalent complexes with DNA (e.g., distamycin A, Hoechst 33258, and pentamidine) while others DNA-binding compounds (such as CC-1065) cause cleavages in the DNA backbone. In this article, we have reviewed the minor groove binders currently in preclinical evaluation in the last years. Diarylamidines such as DAPI, berenil, and pentamidine; bis-benzimidazoles such as Hoechst 33258; ecteinascidins, pyrrololo [2,1- c]-[1,4]-benzodiazepines (PBDs), CC-1065, and distamycins are the classes discussed in this review article. A special section has been dedicated to hybrid molecules resulted by the combination of two minor groove binders, especially for derivatives of naturally occurring antitumor agents, such as anthramycin or the alkylating unit of the antibiotic CC-1065, and distamycin frames. © 2004 Wiley Periodicals, Inc. Med Res Rev, 24, No. 4, 475,528, 2004 [source]

Investigation Of AM-36: A Novel Neuroprotective Agent

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 11 2001
Jk Callaway
SUMMARY 1. The neurochemical sequelae following cerebral ischaemia are complex, involving excess release of excitatory amino acids, particularly glutamate, disruption of ionic homeostasis due to Na+ and Ca2+ influx and generation of toxic free radicals, ultimately leading to cell death by both necrosis and apoptosis. 2. Drugs that block components of this biochemical cascade, such as glutamate receptor antagonists, sodium channel blockers and free radical scavengers, have been investigated as putative neuroprotective agents. The knowledge that multiple mechanisms contribute to neuronal injury in ischaemia have led to the general recognition that a single drug treatment is unlikely to be beneficial in the treatment of cerebral ischaemia. 3. AM-36 [1-(2-(4-chlorophenyl)-2-hydroxy)ethyl-4-(3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)methylpiperazine] is one of a series of hybrid molecules designed to incorporate multiple neuroprotective mechanisms within the one structure. Primary screening tests demonstrated that AM-36 inhibited binding to the polyamine site of glutamate receptors, blocked neuronal sodium channels and had potent anti-oxidant activity. In neuronal cell cultures, AM-36 inhibited toxicity induced by N -methyl- D -aspartate (NMDA) and the sodium channel opener veratridine and, in addition, inhibited veratridine-induced apoptosis. 4. In a middle cerebral artery occlusion model of stroke in conscious rats, systemic administration of AM-36 markedly reduced both cortical and striatal infarct volume and significantly improved functional outcome in motor performance, neurological deficit and sensorimotor neglect tests. AM-36 was neuroprotective even when administration was delayed until 3 h systemically, or 5 h intravenously, after induction of stroke. 5. These studies indicate that AM-36 is a unique neuroprotective agent with multiple modes of action, making it an attractive candidate for the treatment of acute stroke in humans. [source]