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Human Newborns (human + newborn)

Distribution by Scientific Domains
Medical Sciences60%

Selected Abstracts

Neuroimaging of cortical development and brain connectivity in human newborns and animal models

JOURNAL OF ANATOMY, Issue 4 2010
Gregory A. Lodygensky
Abstract Significant human brain growth occurs during the third trimester, with a doubling of whole brain volume and a fourfold increase of cortical gray matter volume. This is also the time period during which cortical folding and gyrification take place. Conditions such as intrauterine growth restriction, prematurity and cerebral white matter injury have been shown to affect brain growth including specific structures such as the hippocampus, with subsequent potentially permanent functional consequences. The use of 3D magnetic resonance imaging (MRI) and dedicated postprocessing tools to measure brain tissue volumes (cerebral cortical gray matter, white matter), surface and sulcation index can elucidate phenotypes associated with early behavior development. The use of diffusion tensor imaging can further help in assessing microstructural changes within the cerebral white matter and the establishment of brain connectivity. Finally, the use of functional MRI and resting-state functional MRI connectivity allows exploration of the impact of adverse conditions on functional brain connectivity in vivo. Results from studies using these methods have for the first time illustrated the structural impact of antenatal conditions and neonatal intensive care on the functional brain deficits observed after premature birth. In order to study the pathophysiology of these adverse conditions, MRI has also been used in conjunction with histology in animal models of injury in the immature brain. Understanding the histological substrate of brain injury seen on MRI provides new insights into the immature brain, mechanisms of injury and their imaging phenotype. [source]

Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence

JOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 9 2006
Germaine Escames
Sepsis is a major cause of mortality in critically ill patients and develops as a result of the host response to infection. In recent years, important advances have been made in understanding the pathophysiology and treatment of sepsis. Mitochondria play a central role in the intracellular events associated with inflammation and septic shock. One of the current hypotheses for the molecular mechanisms of sepsis is that the enhanced nitric oxide (NO) production by mitochondrial nitric oxide synthase (mtNOS) leads to excessive peroxynitrite (ONOO,) production and protein nitration, impairing mitochondrial function. Despite the advances in understanding of its pathophysiology, therapy for septic shock remains largely symptomatic and supportive. Melatonin has well documented protective effects against the symptoms of severe sepsis/shock in both animals and in humans; its use for this condition significantly improves survival. Melatonin administration counteracts mtNOS induction and respiratory chain failure, restores cellular and mitochondrial redox status, and reduces proinflammatory cytokines. Melatonin clearly prevents multiple organ failure, circulatory failure, and mitochondrial damage in experimental sepsis, and reduces lipid peroxidation, indices of inflammation and mortality in septic human newborns. Considering these effects of melatonin and its virtual absence of toxicity, the use of melatonin (along with conventional therapy) to preserve mitochondrial bioenergetics as well as to limit inflammatory responses and oxidative damage should be seriously considered as a treatment option in both septic newborn and adult patients. This review summarizes the data that provides a rationale for using melatonin in septic shock patients. [source]

Probing Predispositions: The Pragmatism of a Process Perspective

CHILD DEVELOPMENT PERSPECTIVES, Issue 2 2009
David S. Moore
Abstract, As J. P. Spencer et al. (2009) argue, the theories of some developmental psychologists continue to be nativistic, even though nativism is an inherently nondevelopmental school of thought. Psychologists interested in development study the emergence of human characteristics,including predispositions,and are not content to simply catalogue competences that characterize human newborns; instead, they recognize that all human characteristics, including those present at birth, reflect the circumstances of development. A truly developmental science of behavior requires rejecting the nativism,empiricism debate outright, abandoning ideas such as "core knowledge" and psychological "endowments," and adopting a process perspective that focuses on how traits emerge from the co-actions of biological and experiential factors. Unlike nativism, the process perspective advocated by J. P. Spencer et al. encourages research that can reveal the developmental origins of psychological characteristics of interest. [source]

T cell-mediated immune responses in human newborns: ready to learn?

CLINICAL & EXPERIMENTAL IMMUNOLOGY, Issue 1 2005
A. Marchant
Summary Infections with intracellular pathogens are often more severe or more prolonged in young infants suggesting that T cell-mediated immune responses are different in early life. Whereas neonatal immune responses have been quite extensively studied in murine models, studies of T cell-mediated immunity in human newborns and infants are scarce. Qualitative and quantitative differences when compared with adult immune responses have been observed but on the other hand mature responses to certain vaccines and infectious pathogens were demonstrated during the postnatal period and even during foetal life. Herein, we review the evidence suggesting that under appropriate conditions of stimulation, protective T cell-mediated immune responses could be induced by vaccines in early life. [source]