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Human Body (human + body)
Terms modified by Human Body Selected AbstractsFront and Back Covers, Volume 21, Number 5.ANTHROPOLOGY TODAY, Issue 5 2005October 200 Front and back cover caption, volume 21 issue 5 Front cover Children in the favela (squatter community) of 'Caxambu', in the northern zone of Rio de Janeiro, Brazil. Although favelas are often depicted as dangerous and as the housing option of last resort, they are also characterized by dense and multi-stranded social ties between residents, long histories of occupation and settlement, and multi-generational families. Caxambu (a pseudonym) was originally settled at the beginning of the 20th century, and residents often describe the neighbourhood as a 'big family'. As the photo makes clear, the alleys, street corners and other public spaces in the favela often serve as giant playgrounds for local children. Back cover THE HUMAN BODY The photo on the back cover shows one of the exhibits from Gunther von Hagens' anatomical exhibition Body Worlds, discussed by Uli Linke in this issue. The exhibits in this show are fashioned from human corpses. The male figure shown here, the body of a man holding and gazing at his own skin, attempts to convey something about the human skin. The anatomical museum markets corpses, artfully transformed to appeal to the viewer. Body Worlds has toured internationally, and attracted millions of visitors. Dead bodies are transformed into sensually appealing 'works of art', playing to fantasies of the alluring body common to the dream worlds promoted by multinational media and entertainment industries. In the exhibition anatomy and pedagogy, economy and medical science, pathology and human rights are closely intertwined. But where do the bodies come from? The corpses, contrary to the exhibitor's claims, are not supplied by German donors - they are procured from Eastern Europe, Russia, Kyrgyzstan and China, from places where human rights and bioethical standards are not enforced. Von Hagens insists that bodies displayed are from donors, and his exhibition website (www.bodyworlds.com) welcomes donations to its body donation programme. In his body factory in Dalian, China, thousands of corpses, including the remains of executed prisoners, are flayed and prepared for later use. This trade in bodies, a multi-million-dollar enterprise, is highly problematic. For the trumpeted 'art of anatomy', with its beautified corpses and eroticized installations, also has a violent dimension, with human victims whose bodies are bought and sold for profit. In November 2002, Gunther von Hagens risked prosecution by holding the first public dissection of a (donated) body in the UK since the 1830s, in London's Atlantis Gallery. The issues surrounding procurement, preparation, dissection and display of human remains are central to anthropology, and in this article Uli Linke discusses in particular the various ways in which this exhbition was interpreted in Germany. [source] Vitamins: Their Role in the Human BodyINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 2 2006Charles Brennan Associate Professor No abstract is available for this article. [source] Genes and Spleens: Property, Contract, or Privacy Rights in the Human Body?THE JOURNAL OF LAW, MEDICINE & ETHICS, Issue 3 2007Radhika Rao This article compares three frameworks for legal regulation of the human body. Property law systematically favors those who use the body to create commercial products. Yet contract and privacy rights cannot compete with the property paradigm, which alone affords a complete bundle of rights enforceable against the whole world. In the face of researchers' property rights, the theoretical freedom to contract and the meager interest in privacy leave those who supply body parts vulnerable to exploitation. [source] Quirks of Human Anatomy: An Evo-devo Look at the Human BodyBIOESSAYS, Issue 6 2010Anne Buchanan No abstract is available for this article. [source] Ludwik Maurycy Hirschfeld (1814,1876)CLINICAL ANATOMY, Issue 3 2008Jerzy Reymond Abstract It is rare to encounter exceptional individuals such as Ludwik Maurycy Hirschfeld. He was born into poverty and early on discovered his passion for medicine, particularly anatomy. His life is a testament to what pure human determination can achieve. He overcame societal and financial obstacles, ultimately becoming a physician, anatomist, and scientist. In 1834, Hirshfeld left Poland for France. His first exposure to medical anatomy came while under the direction of the great anatomist Professor Bourgery at École Pratique de Médicine. In 1848, he earned his degree in medicine and published his work "Des injections capillaires." He coupled his love of anatomy with teaching and research. Hirschfeld's skills, as a dissector, enabled him to prepare specimens for illustration, which produced some of the anatomy atlases of modern times. "The Descriptive Anatomy of the Human Body" is one of his most influential works. Dr. Hirschfeld pioneered the initial illustrations of the meninges of brain. There are many anatomical structures named after him, including Hirschfeld's nerves and anastomoses. Hirshfeld remained as a professor until 1875. His death in 1876 was a great loss to the scientific community. His scientific accomplishments were astounding but he should also be remembered as a great humanitarian, an individual who offered medical treatment to the poor, and who strived to instill in his students a passion for anatomy. Clin. Anat. 21: 225,232, 2008. © 2008 Wiley-Liss, Inc. [source] Casualty occurrence mechanism in the collapse of timber-frame houses during an earthquakeEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 12 2004Junji Kiyono Abstract The collapse of timber-frame houses during an earthquake was analyzed by the 2-dimensional (2D) and 3-dimensional (3D) distinct element methods (DEM). The DEM is a numerical analysis technique in which positions of elements are calculated by solving equations of motion step by step. Both individual and group behavior can be simulated. The structure is modeled as an assembly of distinct elements connected by virtual springs and dashpots where elements come into contact. A timber-frame house with simple structural elements; beams, columns, floors, and a roof, was modeled. Injury to human bodies also was considered. Human bodies modeled as circles (2D) or rectangular parallelepipeds (3D) were placed on its floors. The maximum impact acceleration on the human body during an earthquake was calculated. Injury to humans in houses was assessed by the Chest-G index and Head Injury Criteria (HIC) widely used in automobile engineering. Copyright © 2004 John Wiley & Sons, Ltd. [source] Functional brain mapping during free viewing of natural scenesHUMAN BRAIN MAPPING, Issue 2 2004Andreas Bartels Abstract Previous imaging studies have used mostly perceptually abstracted, idealized, or static stimuli to show segregation of function in the cerebral cortex. We wanted to learn whether functional segregation is maintained during more natural, complex, and dynamic conditions when many features have to be processed simultaneously, and identify regions whose activity correlates with the perception of specific features. To achieve this, we used functional magnetic resonance imaging (fMRI) to measure brain activity when human observers viewed freely dynamic natural scenes (a James Bond movie). The intensity with which they perceived different features (color, faces, language, and human bodies) was assessed psychometrically in separate sessions. In all subjects different features were perceived with a high degree of independence over time. We found that the perception of each feature correlated with activity in separate, specialized areas whose activity also varied independently. We conclude that even in natural conditions, when many features have to be processed simultaneously, functional specialization is preserved. Our method thus opens a new way of brain mapping, which allows the localization of a multitude of brain areas based on a single experiment using uncontrolled, natural stimuli. Furthermore, our results show that the intensity of activity in a specialized area is linearly correlated with the intensity of its perceptual experience. This leads us to suggest that each specialized area is directly responsible for the creation of a feature-specific conscious percept (a microconsciousness). Hum. Brain Mapp. 21:75,83, 2004. © 2003 Wiley-Liss, Inc. [source] Places Of Transformation: Building Monuments From Water And Stone In The Neolithic Of The Irish SeaTHE JOURNAL OF THE ROYAL ANTHROPOLOGICAL INSTITUTE, Issue 1 2003CHRIS FOWLER Using the Irish Sea area as a case-study, we argue that both sites and landscapes can be understood as containing a series of components procured from the landscape and from human, animal, and object bodies. These components were organized in a way that commented on and related to specific cultural relationships between these different locations and through the substances found within them. This idea is explored by examining Neolithic monuments, material culture, and natural materials in southwest Wales, northwest Wales, the Isle of Man, and southwest Scotland. We trace some metaphorical schemes which were integral to Neolithic activity in this part of the Irish Sea. In particular, we highlight the metaphorical connections between water and stone in places associated with transformation, particularly the repeated transformation of human bodies. We suggest that the series of associations present in the Neolithic were not invested with a uniform meaning but, instead, were polyvalent, subject to conflicting interpretations, contextually specific and variable through both space and time. The relationship between these elements was therefore dependent on the contexts of their association. Nevertheless, the association of water and stone can be found repeatedly throughout the Neolithic world and may have been the medium of a powerful trope within broader conceptions of the world. This article is intended as a preliminary consideration of these issues (particularly the links between stone, mountains, water, quartz, shell, and human remains) and is offered as a thinking-point for ongoing research in this area. [source] New Alternative Methods to Teach Surgical Techniques for Veterinary Medicine Students despite the Absence of Living Animals.ANATOMIA, HISTOLOGIA, EMBRYOLOGIA, Issue 3 2007Is that an Academic Paradox? Summary Due to a raised ethical mentality, veterinary schools are pursuing methods to preserve animal corpses used for surgical technique classes in an attempt to reduce the use of living animals for teaching. Generally speaking, animal and human bodies are usually preserved with 10% aqueous formalin solution especially for descriptive anatomy classes. Other possibilities include the use of glycerol, alcohol and phenol. At present, new fixatives have been developed to allow a better and longer preservation of animal corpses in order to maintain organoleptic characteristics, i.e. colour, texture, as close as possible to what students will deal with living animals. From 2004, in our college, surgical technique classes no longer use living animals for students' training. Instead, canine corpses chemically preserved with modified Larssen (MLS) and Laskowski (LS) solutions are preferred. The purpose of this study was to investigate comparatively the biological quality of preservation of these two solutions and to evaluate students' learning and acceptance of this new teaching method. Although these fixatives maintain body flexibility, LS solution failed to keep an ordinary tissue colouration (cadavers were intensely red) and tissue preservation was not adequate. By contrast, MLS solution, however, did not alter the colouration of cadavers which was fairly similar to that normally found in living animals. A remarkable characteristic was a very strong and unpleasant sugary odour in LS-preserved animals and therefore the MLS solution was the elected method to preserve cadavers for surgical technique classes. The students' feedback to the use of Larssen-preserved cadavers was very satisfactory, i.e. 96.6% of students were in favour of the use of cadavers for surgical training and on average 91.8% (2002,2003) of students preferred the MLS solution as the chemical preserver, whereas only 8.2% elected LS solution for teaching purposes. From the students' point of view (95.1%) the ideal class would be an initial training in MLS cadavers followed by classes with animals admitted to the Veterinary Hospital. [source] Public health, private bodyAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 1 2001Dorothy Broom A number of comparatively recent epistemological shifts draw attention to the body, among them developments in social (including feminist) theory and gender studies. In many social science and humanities disciplines, there is now considerable research and debate about notions of embodiment. Yet despite the fact that our subject matter is, ultimately, the life and death of human bodies, public health has remained largely silent on the question of what bodies are and how our public health work, whether academic or applied, is shaped by ideas about embodiment. Consequently, public health notions of the body remain implicit, ambiguous, often contradictory and incoherent. In this discussion, I strive to make explicit what some of our implicit ideas might be, to speculate on why bodies are excluded from most public health discourse, how that exclusion is achieved, and the consequences for public health research and practice. In an active consideration of the fundamental subject matter of public health, I invite attention to where and how greater self-consciousness about embodiment and its consequences might instigate shifts in public health thinking and action. [source] Disciplining Society through the City: The Genesis of City Planning in Brazil and Argentina (1894,1945)BULLETIN OF LATIN AMERICAN RESEARCH, Issue 2 2003Joel Outtes This paper looks at the genesis of a discourse on urbanismo (city planning) in Brazil and Argentina between 1894 and 1945 using the ideas of Michel Foucault on discipline and his concept of bio,power. The demographic pattern of the major cities in both countries from 1890 onwards and the renewals of the centres of these cities are also discussed. Other sections are dedicated to the plans proposed for the same cities in the 1920s and to urban representations, such as ideas about social reform, the role of hygiene as a point of departure for planning, and the relationship of ideas on Taylorism (scientific management) and the city. The paper also discusses the planners opposition to elections, when they claimed that they were the only ones qualified to deal with urban problems and therefore they should be employed in the state apparatus. Other concerns of the paper are the use of planning as an element of nation building and ideas defining eugenics (race ,betterment') as an important aspect of city planning. I conclude by arguing that, if implemented, city planning was a way of creating an industrial culture, disciplining society through the city, although the industrial proletariat has never made up the majority of the population in Brazil or Argentina. Even if many aspects of the plans proposed for both countries were not implemented, the discourse of planners can be seen as a will to discipline society through the city. This discipline would affect the freedom of movement of human bodies, and is therefore approached through Foucault's concepts of bio,power and discipline [source] GPU-based interactive visualization framework for ultrasound datasetsCOMPUTER ANIMATION AND VIRTUAL WORLDS (PREV: JNL OF VISUALISATION & COMPUTER ANIMATION), Issue 1 2009Sukhyun Lim Abstract Ultrasound imaging is widely used in medical areas. By transmitting ultrasound signals into the human body, their echoed signals can be rendered to represent the shape of internal organs. Although its image quality is inferior to that of CT or MR, ultrasound is widely used for its speed and reasonable cost. Volume rendering techniques provide methods for rendering the 3D volume dataset intuitively. We present a visualization framework for ultrasound datasets that uses programmable graphics hardware. For this, we convert ultrasound coordinates into Cartesian form. In ultrasound datasets, however, since physical storage and representation space is different, we apply different sampling intervals adaptively for each ray. In addition, we exploit multiple filtered datasets in order to reduce noise. By our method, we can determine the adequate filter size without considering the filter size. As a result, our approach enables interactive volume rendering for ultrasound datasets, using a consumer-level PC. Copyright © 2009 John Wiley & Sons, Ltd. [source] Human motion reconstruction from monocular images using genetic algorithmsCOMPUTER ANIMATION AND VIRTUAL WORLDS (PREV: JNL OF VISUALISATION & COMPUTER ANIMATION), Issue 3-4 2004Jianhui Zhao Abstract This paper proposed an optimization approach for human motion recovery from the un-calibrated monocular images containing unlimited human movements. A 3D skeleton human model based on anatomy knowledge is employed with encoded biomechanical constraints for the joints. Energy Function is defined to represent the deviations between projection features and extracted image features. Reconstruction procedure is developed to adjust joints and segments of the human body into their proper positions. Genetic Algorithms are adopted to find the optimal solution effectively in the high dimensional parameter space by simultaneously considering all the parameters of the human model. The experimental results are analysed by Deviation Penalty. Copyright © 2004 John Wiley & Sons, Ltd. [source] A Data-driven Segmentation for the Shoulder ComplexCOMPUTER GRAPHICS FORUM, Issue 2 2010Q Youn Hong Abstract The human shoulder complex is perhaps the most complicated joint in the human body being comprised of a set of three bones, muscles, tendons, and ligaments. Despite this anatomical complexity, computer graphics models for motion capture most often represent this joint as a simple ball and socket. In this paper, we present a method to determine a shoulder skeletal model that, when combined with standard skinning algorithms, generates a more visually pleasing animation that is a closer approximation to the actual skin deformations of the human body. We use a data-driven approach and collect ground truth skin deformation data with an optical motion capture system with a large number of markers (200 markers on the shoulder complex alone). We cluster these markers during movement sequences and discover that adding one extra joint around the shoulder improves the resulting animation qualitatively and quantitatively yielding a marker set of approximately 70 markers for the complete skeleton. We demonstrate the effectiveness of our skeletal model by comparing it with ground truth data as well as with recorded video. We show its practicality by integrating it with the conventional rendering/animation pipeline. [source] Compression of Human Motion Capture Data Using Motion Pattern IndexingCOMPUTER GRAPHICS FORUM, Issue 1 2009Qin Gu I.3.7 [Computer Graphics]: Three-Dimensional Graphics and Realism; E.4 [Coding and Information Theory]: Data Compaction and Compression Abstract In this work, a novel scheme is proposed to compress human motion capture data based on hierarchical structure construction and motion pattern indexing. For a given sequence of 3D motion capture data of human body, the 3D markers are first organized into a hierarchy where each node corresponds to a meaningful part of the human body. Then, the motion sequence corresponding to each body part is coded separately. Based on the observation that there is a high degree of spatial and temporal correlation among the 3D marker positions, we strive to identify motion patterns that form a database for each meaningful body part. Thereafter, a sequence of motion capture data can be efficiently represented as a series of motion pattern indices. As a result, higher compression ratio has been achieved when compared with the prior art, especially for long sequences of motion capture data with repetitive motion styles. Another distinction of this work is that it provides means for flexible and intuitive global and local distortion controls. [source] Copeptin: A Biomarker of Cardiovascular and Renal FunctionCONGESTIVE HEART FAILURE, Issue 2010Nils G. Morgenthaler MD Congest Heart Fail. 2010;16(4)(suppl 1):S37,S44. ©2010 Wiley Periodicals, Inc. Arginine vasopressin (AVP or antidiuretic hormone) is one of the key hormones in the human body responsible for a variety of cardiovascular and renal functions. It has so far escaped introduction into the routine clinical laboratory due to technical difficulties and preanalytical errors. Copeptin, the C-terminal part of the AVP precursor peptide, was found to be a stable and sensitive surrogate marker for AVP release. Copeptin behaves in a similar manner to mature AVP in the circulation, with respect to osmotic stimuli and hypotension. During the past years, copeptin measurement has been shown to be of interest in a variety of clinical indications, including cardiovascular diseases such as heart failure, myocardial infarction, and stroke. This review summarizes the recent progress on the diagnostic use of copeptin in cardiovascular and renal diseases and discusses the potential use of copeptin measurement in the context of therapeutic interventions with vasopressin receptor antagonists. [source] Terminator or Super Mario: Human/Computer Hybrids, Actual and VirtualDIALOG, Issue 4 2005By Noreen Herzfeld Abstract:, Is a human/computer hybrid feasible: If so, in what ways would such hybridization affect our concept of what it means to be human? There are two forms of such hybridization, the actual and the virtual. Actual hybridization involves the implantation of mechanical devices in the human body. In actual hybridization the computer comes to us and to our body to enhance our functioning in our world. In virtual hybridization we go to the computer, projecting our minds into the world of cyberspace and being formed there. Perhaps the most common form of virtual hybridization is the immersion our children experience in the world of video games. Both forms of hybridization encourage us to think of ourselves only in terms of function, just when most of our theologians find that humans reflect the image of God through our relationships. This emphasis on function best serves the military, but leaves us in the theological community with a dissatisfying concept of what it means to be human. [source] Positron emission tomography and its use to image the occupancy of drug binding sitesDRUG DEVELOPMENT RESEARCH, Issue 2 2003S. John Gatley Abstract The development of positron emission tomography (PET) and the ability to synthesize compounds labeled with the short-lived positron emitters 11C and 18F has made possible the imaging and quantification of drug binding sites in the human body. By conducting PET studies with an appropriate radioligand before and after treatment with a drug, the fraction of the total number of binding sites that is occupied by the drug (the "occupancy" of the site) can often be determined. To the extent that occupancy is a good indicator of pharmacological activity, such PET experiments can aid the development of drug dosage regimens. Some of the general issues involved in PET studies of drug occupancy are discussed. There have been many such studies involving antipsychotic drugs and dopamine D2 receptor radioligands. Since neuroleptics have been extensively reviewed elsewhere, only the major findings are discussed here. Other binding sites (and drug classes) in the dopamine system to which this methodology has been applied include: the dopamine transporter (stimulant drugs) and monoamine oxidase A and B (antidepressant drugs). Occupancy studies are also possible for many drug targets beyond the dopamine system. Drug Dev. Res. 59:194,207, 2003. © 2003 Wiley-Liss, Inc. [source] Casualty occurrence mechanism in the collapse of timber-frame houses during an earthquakeEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 12 2004Junji Kiyono Abstract The collapse of timber-frame houses during an earthquake was analyzed by the 2-dimensional (2D) and 3-dimensional (3D) distinct element methods (DEM). The DEM is a numerical analysis technique in which positions of elements are calculated by solving equations of motion step by step. Both individual and group behavior can be simulated. The structure is modeled as an assembly of distinct elements connected by virtual springs and dashpots where elements come into contact. A timber-frame house with simple structural elements; beams, columns, floors, and a roof, was modeled. Injury to human bodies also was considered. Human bodies modeled as circles (2D) or rectangular parallelepipeds (3D) were placed on its floors. The maximum impact acceleration on the human body during an earthquake was calculated. Injury to humans in houses was assessed by the Chest-G index and Head Injury Criteria (HIC) widely used in automobile engineering. Copyright © 2004 John Wiley & Sons, Ltd. [source] Repellent efficacy of wood vinegar against Culex pipiens pallens and Aedes togoi (Diptera: Culicidae) under laboratory and semi-field conditionsENTOMOLOGICAL RESEARCH, Issue 2 2010Martha W. KIARIE-MAKARA Abstract The repellent efficacy of wood vinegar was assessed against mosquitoes under laboratory conditions at 1, 5, 10, 20, 40, 60 and 80% concentrations. The study evaluated whether wood vinegar is able to repel Culex pipiens pallens Coquillet and Aedes togoi (Theobald) from the human body and if so at what concentrations. The tests were conducted using the arm-in-cage method in 80 × 40 × 40 cm screened mosquito cages. The data were analyzed and compared with those of N,N-Diethyl-3-methylbenzamide (deet) at 10.3% concentration. The results showed that wood vinegar provided mosquito repellence of varying degree depending on the concentration used. The observed repellence averaged from as low as 39.6% at 5.0% concentration to as high as 100% at 80% concentration against Ae. togoi. Repellence against Cx. pipiens pallens was high being 90.3% at 20% concentration, 92.2% at 40% concentration, 93.9% at 60% concentration and 100% at 80% concentration. The duration of protection time tests showed that the 40% and 60% concentrations of the wood vinegar give protection from landing of Ae. togoi for a period of up to 7 h, though the lower concentration gave lower protection after the first five hours. The results indicated that wood vinegar has mosquito repellent characteristics that tend to vary with the concentration used and the species of mosquitoes. Wood vinegar in this case was very effective in repelling Cx. pipiens pallens, even at lower concentrations while higher concentrations were required to repel Ae. togoi. [source] Aluminum induces chromosome aberrations, micronuclei, and cell cycle dysfunction in root cells of Vicia fabaENVIRONMENTAL TOXICOLOGY, Issue 2 2010Min Yi Abstract Aluminum (Al) exists naturally in air, water, and soil, and also in our diet. Al can be absorbed into the human body and accumulates in different tissues, which has been linked to the occurrence of Alzheimer's disease and various neurological disorders. By using Vicia cytogenetic tests, which are commonly used to monitor the genotoxicity of environmental pollutants, cytogenetic effects of aluminum (AlCl3) were investigated in this study. Present results showed that Al caused significant increases in the frequencies of micronuclei (MN) and anaphase chromosome aberrations in Vicia faba root tips exposed to Al over a concentration-tested range of 0.01,10 mM for 12 h. The frequency of micronucleated cells was higher in Al-treated groups at pH 4.5 than that at pH 5.8. Similarly, AlCl3 treatment caused a decrease in the number of mitotic cells in a dose- and pH-dependent manner. The number of cells in each mitotic phase changed in Al-treated samples. Mitotic indices (MI) decreased with the increases of pycnotic cells. Our results demonstrate that aluminum chloride is a clear clastogenic/genotoxic and cytotoxic agent in Vicia root cells. The V. faba cytogenetic test could be used for the genotoxicity monitoring of aluminum water contamination. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010. [source] A review of Mutants: on genetic variety and the human body by A. M. LeroiEVOLUTION AND DEVELOPMENT, Issue 4 2004Kenneth M. Weiss No abstract is available for this article. [source] The skin as a mirror of the ageing process in the human organism , results of the ageing research in the German National Genome Research Network 2EXPERIMENTAL DERMATOLOGY, Issue 8 2006CH. C. Zouboulis Intrinsic human skin ageing is influenced by the individual genetic predisposition and reflects degradation processes of the body. Hormones are decisively involved in intrinsic ageing with reduced secretion of pituitary, adrenal glands, and gonads, which leads to characteristic body and skin phenotypes. A number of advances were recently made in understanding skin ageing mechanisms and major molecular changes, especiallly of the extracellular matrix, were identified. Gene expression patterns compatible with mitotic misregulation and alterations in intracellular transport and metabolism were identified in fibroblasts of ageing humans and humans with progeria. Age-associated changes of extracellular matrix of the skin correlate well with changes been detected in the extracellular matrix of other organs of the human body. Within the National Genome Research Network 2 (NGFN-2) in Germany, the explorative project ,Genetic etiology of human longevity' targets the identification of age-related molecular pathways. For this purpose, skin models of ageing are used. Expression profiling employing cDNA microarrays from known and novel genes and RT-PCR are employed for gene detection and confirmation. Among the potential candidate genes several interesting target genes have been identified. The evaluation of ageing-associated genes in skin models will facilitate the understanding of global molecular ageing mechanisms in the future. [source] Human salivary aggregation in Streptococcus intermedius type g strains: relationship with IgAFEMS IMMUNOLOGY & MEDICAL MICROBIOLOGY, Issue 2 2004Taihei Yamaguchi Abstract Bacterial aggregation is an important step in elimination from the human body to protect against infection. Streptococcus intermedius K1K aggregates in human saliva. In this study, the salivary agglutinin was identified. The aggregation level was very strong in sonic-treated saliva and 1-,m filtrate. Preincubation of human saliva with anti-human , chain serum or anti-human whole saliva serum completely inhibited aggregation, but preincubation with anti-human , chain serum or anti-Fc fragment of human IgG serum had no effect. Agglutinin of human saliva that could aggregate the strain K1K was purified using DEAE,Sepharose CL-6B, Phenyl,Sepharose CL-4B and Sephacryl S200HR gel filtration. Purified salivary agglutinin was characterized with electrophoresis and immunological techniques, indicating that purified material was IgA. Bacterial aggregation was dependent on the presence of calcium. Saliva filtrate specimens from eight healthy men and eight women showed different aggregation activities. Three men and one woman had little activity. These data show that the present bacterial aggregation was an immunoreaction between IgA in saliva and the bacteria dependent on the levels of calcium. In addition, the IgA in human saliva related with possible calcium-dependent antigen(s) on the surface of strain K1K. [source] Investigations on the Structural Damage in Human Erythrocytes Exposed to Silver, Gold, and Platinum NanoparticlesADVANCED FUNCTIONAL MATERIALS, Issue 8 2010P. V. Asharani Abstract Human erythrocytes or red blood cells (RBCs), which constitute 99% of blood cells, perform an important function of oxygen transport and can be exposed to nanoparticles (NPs) entering into the human body during therapeutical applications involving such NPs. Hence, the haemocompatibility of the Ag, Au, and Pt NPs on human RBCs is investigated. The parameters monitored include haemolysis, haemagglutination, erythrocyte sedimentation rate, membrane topography, and lipid peroxidation. The findings suggest that platinum and gold NPs are haemocompatible compared to Ag NPs. Erythrocytes exhibit significant lysis, haemagglutination, membrane damage, detrimental morphological variation, and cytoskeletal distortions following exposure to Ag NPs at a concentration of 100,µg,mL,1. Exposure of Ag+ to RBCs shows no lysis or deterioration, implying that the observed toxicity is solely due to NPs. The haemolyzed erythrocyte fraction has the ability to induce DNA damage in nucleated cells. Additionally, multiple pits and depressions are observed on RBC membrane following exposure to Ag NPs (50,µg,mL,1 onwards). Hence, it is apparent that Ag NPs exhibit toxicity on RBCs and on other cells that are exposed to NP-mediated haemolyzed fractions. [source] Investigation of air gaps entrapped in protective clothing systemsFIRE AND MATERIALS, Issue 3 2002Young Kim Il Air gaps entrapped in protective clothing are known as one of the major factors affecting heat transfer through multiple layers of flexible clothing fabrics. The identification and quantification of the air gaps are two aspects of a multidisciplinary research effort directed toward improving the flame/thermal protective performance of the clothing. Today's three-dimensional (3-D) whole body digitizers, which provide accurate representations of the surface of the human body, can be a novel means for visualizing and quantifying the air gaps between the wearer and his clothing. In this paper we discuss how images from a 3-D whole body digitizer are used to determine local and global distributions of air gaps and the quantification of air gap sizes in single and multilayer clothing systems dressed on a thermal manikin. Examples are given that show concordance between air gap distributions and burn patterns obtained from full-scale manikin fire tests. We finish with a discussion of the application of air gap information to bench-scale testing to improve the protective performance of current flame/thermal protective clothing. Copyright © 2002 John Wiley & Sons, Ltd. [source] Fish venom: pharmacological features and biological significanceFISH AND FISHERIES, Issue 2 2009Gisha Sivan Abstract Nearly 1200 species of marine fish are venomous and they account for two-third of the population of venomous vertebrates. Fish venoms are focused as a potential source of pharmacological agents and physiological tools that have evolved to target vital processes in the human body that appear to have more electivity than many drugs. Fish venoms possess cardiovascular, neuromuscular, oedematic and cytolytic activity. Lethal toxins have been isolated and purified, with some having LD50 values comparable to that of snake venoms. Cardiovascular activity seems to be the dominant effect of fish venoms in experimental models. Piscine venom acts both pre- and post-junctionally to produce depolarization of cell membranes. Studies on cytolytic activity of fish venom found that it produces lysis by forming hydrophilic pores in cell membranes which then result in cell lysis. Almost all fish venoms with neuromuscular activity also possesses cytolytic activity, and it is very likely that the two activities are related. Fish venom is known to induce intense and sustained edematogenic response. As piscine venoms have evolved for the same purpose, they show a number of similarities pharmacologically and it seems likely that most of the biological activities of any given toxin can be traced back to its cytolytic activity. A variety of toxins have been isolated from piscine venom. Although there is a complex balance between the components present in the venom of different fish, all of them seem to share similar activity , functionally and pharmacologically as well as structurally. [source] Designer Biomaterials for NanomedicineADVANCED FUNCTIONAL MATERIALS, Issue 24 2009Nishit Doshi Abstract Nanotechnology has had tremendous impact on medical science and has resulted in phenomenal progress in the field of drug delivery and diagnostics. A wide spectrum of novel nanomaterials including polymeric particles, liposomes, quantum dots, and iron oxide particles have been developed for applications in therapeutic delivery and diagnostics. This has resulted in control over the rate and period of delivery and targeting of drugs to specific organs in the human body. This feature article focuses on the delivery of drugs using polymeric particles. The size, choice of polymer, surface chemistry, shape, and mechanical properties of the particles are parameters that critically affect particle function. Numerous biomaterials and fabrication techniques have been developed in the last decade that focus on novel design parameters, such as shape and mechanical properties and the interplay of these parameters with the size and surface chemistry of particles. Recent advances with particular focus on the importance of particle shape are highlighted, and the challenges that are yet to be fulfilled are underscored. [source] A Protein Appears in a Different LightGERMAN RESEARCH, Issue 1 2005Volker Herzog Prof. Dr. APP is assumed to play a role in causing Alzheimer,s disease. Its biological functions in the human body are currently unknown but of increasing interest in basic research, especially in investigating the process of wound healing [source] Exploring time-dependent symptom outcomes in office staffHUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES, Issue 3 2009Xiaoshu Lu This article illustrates the application of a new mathematical model developed for the study of time-dependent health outcomes for office staff during computer work. The model describes the time-dependent associations of computer usage with outcomes expressed as discomfort in multiple body regions. The association is explicitly presented with a functional relationship that is parameterized by body regions. The validation of the model demonstrated accuracy in reproducing the observed quantities for the study population. Therefore, we used this model to assess the impact of computer-related work exposure on discomfort in different body regions among office staff to better understand the behavior of musculoskeletal and other symptoms. The exposures and outcomes were recorded parallel in time as usage of keyboard and mouse and with diaries of discomfort. The body regions of neck/shoulders, eyes, head, shoulder joint/upper arm, and upper back were identified to have the highest discomfort levels and rates for the development of discomfort parallel with exposures. Most of our findings are consistent with the literature. The developed mathematical methodology may be used to understand how the human body reacts to computer work to further prevent potential musculoskeletal and other disorders. © 2009 Wiley Periodicals, Inc. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||