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Selected AbstractsComparison of the separation of aziridine isomers applying heptakis(2,3-di- O -methyl-6-sulfato),-CD and heptakis(2,3-di- O -acetyl-6-sulfato),-CD in aqueous and nonaqueous systemsELECTROPHORESIS, Issue 20 2005Yaser Bitar Abstract Aziridines are attracting interest as protease inhibitors, which might be used, e.g., for treatment of parasitic diseases. Within the framework of greater projects dealing with the search of new selective protease inhibitors, a huge number of aziridines with two stereogenic centers will be synthesized. Thus, a fast and reliable screening method for the evaluation of the isomeric composition is needed. Robust baseline separations were obtained using heptakis(2,3-di- O -acetyl-6-sulfato),-CD (HDAS) in acidic methanol and sulfated ,-CD in acidic phosphate buffer. With HDAS the resolutions were higher and migration times shorter. Thus, the method will be used as a screening method for further isomeric mixtures of aziridines. [source] Toxicity assessment and public policies: An urgent need for research,ENVIRONMENTAL TOXICOLOGY, Issue 5 2010Eric Vindimian Abstract The new European regulation on chemicals triggers a huge number of new testing. However, more than 2 years after the enforcement of this policy, toxicity assessment and risk assessment are still using single species tests that deliver little information. As it is often the case, the link between science and policy seems to be disrupted. However, policy makers need more than ever information on the fate and effects of chemicals on living systems. Without relevant knowledge for decision making, the application of the precautionary principle is the only reasonable way to manage risks. It is necessary to develop new risk assessment strategies using the last innovations from biology: the omics tools, ecology, ecosystem modeling, chemistry, and computing. This article highlights some of the recent trends in ecotoxicology and calls for a new research strategy. This strategy implies research to be funded by its users. © 2010 Wiley Periodicals, Inc. Environ Toxicol, 2010. [source] Zero-sequence-based relaying technique for protecting power transformers and its performance assessment using unsupervised learning ANNEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 2 2006Guzmán Díaz Abstract In this paper a simple and robust new relaying technique for protecting transformers from internal winding faults is proposed. Based on the measurement of zero sequence current inside a delta winding, the technique greatly simplifies the conventional differential relaying arrangement when a delta winding is available. Despite the number of windings of the transformer and the location of the fault, only measurement of induced zero sequence current within the delta winding is needed. Since the proposed technique has been shown to be prone to generate false pick-up signals during inrush, a simple restraining criterion is proposed and analysed. Additionally, use of projection techniques based on self-organizing maps (SOM) is proposed in this paper as a valuable tool for analysing multivariable data which are generated from the huge number of possible combinations existing between switching instant and fault location. Finite element simulations and laboratory tests have been combined into SOM to validate the proposed relaying technique and the restraining criterion. Copyright © 2005 John Wiley & Sons, Ltd. [source] Remote Monitoring Integrated State Variables for AR Model Prediction of Daily Total Building Air-Conditioning Power ConsumptionIEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING, Issue 5 2010Chuzo Ninagawa Member Abstract It is extremely difficult to predict daily accumulated power consumption of the entire building air-conditioning facilities because of a huge number of variables. We propose new integrated state variables, i.e. the daily operation amount and the daily operation-capacity-weighted average set temperature. Taking advantage of a remote monitoring technology, time series data of the integrated state variables were collected and an autoregressive (AR) model prediction for the daily total power consumption has been tried. © 2010 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc. [source] Twenty-three deaths with ,-hydroxybutyrate overdose in western Sweden between 2000 and 2007ACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 8 2010K. KNUDSEN Background: ,-Hydroxybutyrate (GHB) is a drug of abuse with a status as being safe. In spite of a reputation of low toxicity, a huge number of deaths associated with this drug have been recorded during recent years in Sweden. It is unclear whether coingestion with other drugs or ethanol causes death in GHB overdoses or whether GHB itself is the main cause of death. Objectives: The aim of this study was to analyze the cause of death in GHB-related fatalities seen in our region. Methods: All cases of deaths with GHB during the year 2000,2007 in the region of western Sweden were studied retrospectively. The cases were classified as either GHB poisonings without any, with a minor or a major influence of other drugs on the cause of death. Results: Twenty-three cases were diagnosed as deaths due to GHB overdose. Ninety-one percent coingested other substances. Ninety-one percent of the decedents were male. Age varied between 16 and 46, with the median age at 25 years. Forty-three percent of the cases were classified as GHB poisonings without any or a minor influence of other drugs on the cause of death. Thirty percent also ingested ethanol. Two patients (9%) were only intoxicated with GHB. Conclusions: Intoxication with GHB carries some mortality. Combining GHB with ethanol does not explain the many deaths in our region, nor do extremely high plasma concentrations of GHB. The intake of opioids increases the toxicity of GHB. The drug itself has such biological activities that an overdose is dangerous and may lead to death. [source] Distributed control of event floods in a large telecom networkINTERNATIONAL JOURNAL OF NETWORK MANAGEMENT, Issue 2 2010Chundury Jagadish Events in a failing system can be generated so rapidly that they adversely impact the network as well as the network management system (NMS) manager. They may fail to get delivered and critical information may get lost. This problem becomes worse in a large and congested network. Today, in practice, a management station is often flooded with a huge number of redundant events, making it difficult for the operator to process them and take corrective actions. Methods are needed to limit the volume of event transmission and number of events presented to the operator, while ensuring delivery of important information to the NMS manager. These methods need to take care of the operators' changing needs in monitoring abstraction level, for various network elements (NE) based on time and NE severity state. In this paper we propose novel techniques for distributed control of events flood, by suppressing transient events at the source. These techniques do not add any delay in communicating a failure, while ensuring that only the important events are presented to the operator. Also, the correctness of event state at the NMS is not compromised. Moreover, these methods give flexibility to the operator to dynamically change the abstraction level needed from a network element, and limit the number of events presented to the operator. The implementation of these techniques is tested with real field event traces from various telecom networks. Results show that there is a substantial reduction in the event traffic in the network. Copyright © 2009 John Wiley & Sons, Ltd. [source] Ion channels in toxicologyJOURNAL OF APPLIED TOXICOLOGY, Issue 6 2010Iván Restrepo-Angulo Abstract Ion channels play essential roles in human physiology and toxicology. Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. Regulation of ion channels by several chemicals including those found in air, water and soil represents an interesting potential link between environmental pollution and human diseases; for instance, de novo expression of ion channels in response to exposure to carcinogens is being considered as a potential tool for cancer diagnosis and therapy. Non-specific binding of several drugs to ion channels is responsible for a huge number of undesirable side-effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life-threatening situations including chronic degenerative diseases. Copyright © 2010 John Wiley & Sons, Ltd. [source] Local extent of old-growth woodland modifies epiphyte response to climate changeJOURNAL OF BIOGEOGRAPHY, Issue 2 2009Christopher J. Ellis Abstract Aim, To quantify the interaction between climate and woodland continuity in determining the bioclimatic response of lichen epiphytes. Location, Northern Britain (Scotland). Methods, Indicator-species analysis was used to pre-select lichen epiphytes along parallel gradients in climate and the extent of old-growth woodland. Nonparametric multiplicative regression was used to describe in a predictive model the individualistic response of selected species, which were projected based on climate-change scenarios and contrasting patterns of simulated woodland loss or gain. Species with a similar response were grouped using a novel application of cluster analysis to summarize the potentially huge number of projected outcomes. Projected patterns of occurrence under climate-change scenarios were examined for different levels of old-growth woodland extent. Results, Forty-two lichen species were statistically significant indicator species in oceanic woodlands, and old-growth indicators under suboptimal climatic conditions. Responses to climate-change scenarios were contrasting, with one group comprising species projected to increase in extent in response to climate warming, and other response groups projected to decrease in occurrence, possibly in response to shifting rainfall patterns. The occurrence of all response groups had a positive relationship with old-growth woodland extent. Main conclusions, An ,oceanic' biogeographical group of epiphytes identified using the baseline climatic and present-day woodland setting comprised species with a cyanobacterial photobiont or tropical phytogeographical affinities. However, within this group the individual species responses to climate-change scenarios were contrasting. Additionally, group responses may be poorly matched with simple ecological traits. However, the studied interaction between climate and habitat continuity suggests that the impact of climate change might be offset for certain lichen epiphytes by appropriate management of woodland resources, for example, expansion of native woodland around remnant old-growth stands. [source] The times they are a changinJOURNAL OF NURSING MANAGEMENT, Issue 5 2009Cert Ed, MIKE THOMAS PhD Aim, A discussion paper outlining the potential for a multi-qualified health practitioner who has undertaken a programme of study incorporating the strengths of the specialist nurse with other professional routes. Background and rationale, The concept and the context of ,nursing' is wide and generalized across the healthcare spectrum with a huge number of practitioners in separate branches, specialities and sub-specialities. As a profession, nursing consists of different groups in alliance with each other. How different is the work of the mental health forensic expert from an acute interventionalist, or a nurse therapist, from a clinical expert in neurological deterioration? The alliance holds because of the way nurses are educated and culturalized into the profession, and the influence of the statutory bodies and the context of a historical nationalized health system. This paper discusses the potential for a new type of healthcare professional, one which pushes the intra- and inter-professional agenda towards multi-qualified staff who would be able to work across current care boundaries and be more flexible regarding future care delivery. In September 2003, the Nursing and Midwifery Council stated that there were ,more than 656 000 practitioners' on its register and proposed that from April 2004, there were new entry descriptors. Identifying such large numbers of practitioners across a wide range of specialities brings several areas of the profession into question. Above all else, it highlights how nursing has fought and gained recognition for specialisms and that through this, it may be argued client groups receive the best possible ,fit' for their needs, wants and demands. However, it also highlights deficits in certain disciplines of care, for example, in mental health and learning disabilities. We argue that a practitioner holding different professional qualifications would be in a position to provide a more holistic service to the client. Is there then a gap for a ,new breed' of practitioner; ,a hybrid' that can achieve a balanced care provision to reduce the stress of multiple visits and multiple explanations? Methods, Review of the literature but essentially informed by the authors personal vision relating to the future of health practitioner education. Implications for nursing management, This article is of significance for nurse managers as the future workforce and skill mix of both acute and community settings will be strongly influenced by the initial preregistration nurse education. [source] Can the impact of scholarly images be assessed online?JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 9 2010An exploratory study using image identification technology The web contains a huge number of digital pictures. For scholars publishing such images it is important to know how well used their images are, but no method seems to have been developed for monitoring the value of academic images. In particular, can the impact of scientific or artistic images be assessed through identifying images copied or reused on the Internet? This article explores a case study of 260 NASA images to investigate whether the TinEye search engine could theoretically help to provide this information. The results show that the selected pictures had a median of 11 online copies each. However, a classification of 210 of these copies reveals that only 1.4% were explicitly used in academic publications, reflecting research impact, and the majority of the NASA pictures were used for informal scholarly (or educational) communication (37%). Additional analyses of world famous paintings and scientific images about pathology and molecular structures suggest that image contents are important for the type and extent of image use. Although it is reasonable to use statistics derived from TinEye for assessing image reuse value, the extent of its image indexing is not known. [source] Vorgehensmodell zur Abbildung und Analyse des Lebenszykluserfolges von Werkstoffen , Konzeption und beispielhafte Veranschaulichung.MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK, Issue 6 2010Modeling approach for the life cycle profit of materials, case study, conceptual design Life Cycle Costs; Life Cycle Profit; Modeling Approach; Cost Management Abstract Eine langfristig erfolgreiche Entwicklung, Herstellung und Verwendung von (neuen) Werkstoffen setzt voraus, dass die daran beteiligten, auf wirtschaftlichen Erfolg angewiesenen Unternehmen mit diesen Werkstoffen einen positiven monetären Lebenszykluserfolg erzielen. Die Ermittlung eines solchen Lebenszykluserfolgs ist allerdings eine komplexe Aufgabenstellung, wird dieser doch durch eine Vielzahl verschiedenartiger unternehmensexterner und -interner Größen beeinflusst. Gerade bei derartigen komplexen Problemstellungen bietet es sich an, Vorgehensmodelle für eine systematische und strukturierte Problemanalyse und -zerlegung sowie die darauf basierende Bildung und Auswertung von monetären Lebenszyklusmodellen zu nutzen. Im vorliegenden Beitrag soll daher ein Vorgehensmodell zur Ermittlung und Analyse des Lebenszykluserfolgs von Werkstoffen zunächst konzipiert und anschließend anhand eines Fallbeispiels veranschaulicht werden. Long-term successful development, production and use of (new) materials presuppose that involved companies achieve a positive monetary life cycle benefit with these materials. However, the appraisal of this life cycle profit is a demanding task, since the profit is influenced by a huge number of different internal and external variables. Especially in case of such complex problems procedure models can support the systematic and structured analysis and decomposition of the problems as well as the creation and evaluation of monetary life cycle models basing on that. Therefore, this paper offers a suitable modeling approach for the life cycle profit of materials, which is illustrated by a case study. [source] 4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interestMEDICINAL RESEARCH REVIEWS, Issue 4 2008G. Poli Abstract A comprehensive focus on 4-hydroxynonenal (HNE) as candidate molecule in a variety of pathophysiological conditions occurring in humans is here provided. Despite an active, now well characterized, metabolism in most cells and tissues, HNE can be easily detected and quantified by means of several methods, although with different sensitivity. Measurements of HNE and/or stable metabolites in biological fluids are already applied as lipid peroxidation/oxidative stress markers in a huge number of human disease processes, often sustained by inflammatory reactions. A primary involvement of this aldehydic product of membrane lipid oxidation in inflammation-related events, as well as in regulation of cell proliferation and growth, in necrotic or apoptotic cell death, appears supported by its marked ability to modulate several major pathways of cell signaling and, consequently, gene expression. The actual knowledge of HNE reactivity, metabolism, signaling and modulatory effect in the various human organs should provide a solid background to the investigation of the aldehyde's contribution to the pathogenesis of human major chronic diseases and would likely promote advanced and oriented applications not only in diagnosis and prevention but also in molecular treatment of human diseases. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 4, 569,631, 2008 [source] Mesothelioma in a worker who spun chrysotile asbestos at home during childhoodAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 4 2009Eiji Yano MD Abstract Background Malignant mesothelioma has a long latency period and more commonly found in those exposed to amphibole than chrysotile asbestos. Method A 35 years old asbestos worker in an asbestos textile plant in Chongqing, China, developed mesothelioma after only 4 years of employment. He was born and bred in a company residence of an asbestos plant and manually spun asbestos thread during school age. In the plant, not amphibole but only chrysotile has been used. Results Diagnosis of malignant mesothelioma was confirmed by comprehensive approaches including gross appearance, histology, histochemistry, and immunocytochemistry. In the lung and tumor tissues, huge number of tremolite with exceptional chrysotile was observed despite the reverse proportion in the work environment. Discussion Residential exposure and home spinning of asbestos seemed contributed to the early development of mesothelioma in this subject. Although only chrysotile was used and contamination of tremolite was low in the work environment, chrysotile seemed to be cleared leaving tremolite remain in the tissue. Conclusion Chrysotile with little contamination of tremolite can lead to early development of malignant mesothelioma when heavily exposed from childhood at a company residence with household exposure. There can be several mechanisms for tremolite to remain in the lung tissue, far exceeding chrysotile in number. Am. J. Ind. Med. 52:282,287, 2009. © 2009 Wiley-Liss, Inc. [source] Securing IMS against novel threatsBELL LABS TECHNICAL JOURNAL, Issue 1 2009Stefan Wahl Fixed mobile convergence (FMC) based on the 3GPP IP Multimedia Subsystem (IMS) is considered one of the most important communication technologies of this decade. Yet this all-IP-based network technology brings about the growing danger of security vulnerabilities in communication and data services. Protecting IMS infrastructure servers against malicious exploits poses a major challenge due to the huge number of systems that may be affected. We approach this problem by proposing an architecture for an autonomous and self-sufficient monitoring and protection system for devices and infrastructure inspired by network intrusion detection techniques. The crucial feature of our system is a signature-less detection of abnormal events and zero-day attacks. These attacks may be hidden in a single message or spread across a sequence of messages. Anomalies identified at any of the network domain's ingresses can be further analyzed for discriminative patterns that can be immediately distributed to all edge nodes in the network domain. © 2009 Alcatel-Lucent. [source] An integrated database of flavonoidsBIOFACTORS, Issue 3 2006Takashi Kinoshita Abstract Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Some of these molecules exhibit various physiological activities. Among existing drugs, there are a huge number of compounds bearing a flavonoid-related skeleton. Because of the relevance for pharmaceutical research, it would be beneficial to collect these compounds into a database. Recently, various databases of chemicals were compiled to help biological and/or chemical research, but no comprehensive database of flavonoids with chemical structures and physicochemical parameters, supposedly related to their activity, is available yet. The aim of this research was to merge the information about flavonoids of plant origin and flavonoids used as medicines into a database. Moreover, predictions of activities against various targets were performed using a virtual screening procedure to demonstrate a possible application of the database for pharmaceutical research. [source] Monte Carlo study of cycloamylose: Chain conformation, radius of gyration, and diffusion coefficientBIOPOLYMERS, Issue 2 2002Yasushi Nakata Abstract Cyclic (1 , 4)-,- D -glucan chains with or without excluded volume have been collected from a huge number (about 107) of linear amylosic chains generated by the Monte Carlo method with a conformational energy map for maltose, and their mean-square radii of gyration ,S2, and translational diffusion coefficients D (based on the Kirkwood formula) have been computed as functions of x (the number of glucose residues in a range from 7 to 300) and the excluded-volume strength represented by the effective hard-core radius. Both ,S2,/x and D in the unperturbed state weakly oscillate for x < 30 and the helical nature of amylose appears more pronouncedly in cyclic chains than in linear chains. As x increases, these properties approach the values expected for Gaussian rings. Though excluded-volume effects on them are always larger in cycloamylose than in the corresponding linear amylose, the ratios of ,S2, and the hydrodynamic radius of the former to the respective properties of the latter in good solvents can be slightly lower than or comparable to the (asymptotic) Gaussian-chain values when x is not sufficiently large. An interpolation expression is constructed for the relation between the gyration-radius expansion factors for linear and cyclic chains from the present Monte Carlo data and the early proposed asymptotic relation with the aid of the first-order perturbation theories. © 2002 Wiley Periodicals, Inc. Biopolymers 64: 72,79, 2002 [source] Kaposi's sarcoma-like lesions and other nodules as cutaneous involvement in AIDS-related visceral leishmaniasisBRITISH JOURNAL OF DERMATOLOGY, Issue 6 2000M.J. González-Beato A 40-year-old human immunodeficiency virus (HIV)-positive man had three relapses of visceral leishmaniasis (VL). In the third he developed nodular skin lesions of three types, some reminiscent of Kaposi's sarcoma. Biopsy of each type disclosed abundant dermal macrophages with a huge number of intracellular and extracellular Leishman,Donovan bodies. Rapid improvement of lesions was achieved after antiparasitic treatment. AIDS leads to atypical forms of leishmaniasis. Leishmania has been detected both in normal and pathological skin of these patients due to dissemination during VL. It is suspected that a considerable proportion of the population may be infected in endemic areas, Leishmania being opportunistic in immunosuppressed individuals. It is important to recognize the range of lesions that may occur in patients with HIV and VL, many of which are non-specific and may cause diagnostic difficulty. [source] Drug prescribing by Italian family paediatricians: an exception?ACTA PAEDIATRICA, Issue 5 2010A Clavenna Abstract Aims:, To identify which drugs are considered ,essential' by Italian family paediatricians based on their prescriptions. Methods:, Prescriptions reimbursed by the National Health System, involving 923 177 children < 14 years old, and dispensed during 2005 by the retail pharmacies of 15 local health units (LHUs) in the Lombardy Region, were analysed. The percentage of family paediatricians prescribing each single drug was calculated. A percentage ,75% was considered as a high degree of agreement. Results:, In all, 746 different drugs were prescribed to 486 405 children (52.7%). The median number of drugs prescribed by each paediatrician was 60 (interquartile range 51,71). A total of 22 drugs were prescribed by at least 75% of paediatricians and six were prescribed by all the paediatricians. In all, 95% of the paediatricians prescribed four or more cephalosporins and 92% prescribed four inhaled steroids. Only eight of the 22 most frequent drugs are included in the World Health Organization Essential Medicines for children list. Conclusion:, Despite the huge number of drugs prescribed, only for 22 there was a concordance between family paediatricians. Initiatives to evaluate and promote a more rational use of drugs in Italian children are necessary. [source] Life, the universe and everything, with GAIAASTRONOMY & GEOPHYSICS, Issue 5 2001Gerry Gilmore Great things are expected of the GAIA Observatory, currently expected to launch in 2011. Gerry Gilmore explains how it will provide accurate measurements that will help us understand the formation of the Milky Way and the distribution of dark matter. The GAIA Observatory, ESA's Cornerstone 6 mission, addresses the origin and evolution of our galaxy, and a host of other scientific challenges. GAIA will provide unprecedented positional and radial velocity measurements with the accuracies needed to produce a stereoscopic and kinematic census of about one billion stars in our galaxy and throughout the Local Group, about 1% of the galactic stellar population. Combined with astrophysical information for each star, provided by on-board multicolour photometry, these data will have the precision and depth necessary to address the three key questions which underlie the GAIA science case: l when did the stars in the Milky Way form? l when and how was the Milky Way assembled? l what is the distribution of dark matter in our galaxy? The accurate stellar data acquired for this purpose will also have an enormous impact on all areas of stellar astrophysics, including luminosity calibrations, structural studies, and the cosmic distance scale. Additional scientific products include detection and orbital classification of tens of thousands of extrasolar planetary systems, a comprehensive survey of objects ranging from huge numbers of minor bodies in our solar system, including near-Earth objects, through galaxies in the nearby universe, to some 500 000 distant quasars. GAIA will also provide several stringent new tests of general relativity and cosmology. [source] | ||||||||||||||||||||||