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Terms modified by Hub Selected AbstractsAUF1 and Hu proteins in the developing rat brain: Implication in the proliferation and differentiation of neural progenitorsJOURNAL OF NEUROSCIENCE RESEARCH, Issue 6 2009Dolores Hambardzumyan Abstract Posttranscriptional events such as RNA stabilization are important for cell differentiation, but little is known about the impact of AU-rich binding proteins (AUBPs) on the fate of neural cells. Expression of destabilizing AUBPs such as AUF1 and neuronal-specific stabilizing proteins such as HuB, HuC and HuD was therefore analyzed in the developing central nervous system. Real-time RT-PCR indicated a specific developmental pattern in the postnatal cerebellum, with a progressive down-regulation of AUF1 from P1, whereas HuB was strongly up-regulated at about P7. These changes were accompanied by a progressive increase in AUF1p45 and the disappearance of one HuB isoform from P15, suggesting particular roles for these AUBPs in the developing cerebellum. AUF1 was detected in the three main cerebellar layers, whereas Hu proteins were found only in postmitotic neurons. A role for Hu proteins in the early stages of neuronal differentiation is further supported by arrest of cell proliferation following induction of HuB or HuD expression in a neural stem cell line. The decrease in nestin expression suggest that HuD, but not HuB, favors the transition of neural progenitors into early neuroblasts, but other factors are most probably required for their full differentiation into neurons, insofar as GAP-43 was not detected in HuD-transfected cells. These data suggest critical roles for HuB at the very earliest stages of neuronal differentiation, such as cell cycle exit, and HuD might also be involved in the transition of neural progenitors into early neuroblasts. Taken together, the present results strengthen the importance of AUBPs in brain ontogenesis. © 2008 Wiley-Liss, Inc. [source] Strategy hubs: Domain portals to help find comprehensive informationJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 1 2006Suresh K. Bhavnani Recent studies suggest that the wide variability in type, detail, and reliability of online information motivate expert searchers to develop procedural search knowledge. In contrast to prior research that has focused on finding relevant sources, procedural search knowledge focuses on how to order multiple relevant sources with the goal of retrieving comprehensive information. Because such procedural search knowledge is neither spontaneously inferred from the results of search engines, nor from the categories provided by domain-specific portals, the lack of such knowledge leads most novice searchers to retrieve incomplete information. In domains like healthcare, such incomplete information can lead to dangerous consequences. To address the above problem, a new kind of domain portal called a Strategy Hub was developed and tested. Strategy Hubs provide critical search procedures and associated high-quality links to enable users to find comprehensive and accurate information. We begin by describing how we collaborated with physicians to systematically identify generalizable search procedures to find comprehensive information about a disease, and how these search procedures were made available through the Strategy Hub. A controlled experiment suggests that this approach can improve the ability of novice searchers in finding comprehensive and accurate information, when compared to general-purpose search engines and domain-specific portals. We conclude with insights on how to refine and automate the Strategy Hub design, with the ultimate goal of helping users find more comprehensive information when searching in unfamiliar domains. [source] Forecasting natural gas prices using cointegration techniqueOPEC ENERGY REVIEW, Issue 4 2006Dr Salman Saif Ghouri This paper uses Augmented Dickey-Fuller and Phillips-Perron technique for determining whether individual crude oil prices (West Texas Intermediate, Brent, Japan crude cocktail) and natural gas prices- Henry Hub (HH), National Balancing Point (NBP), European and Japanese liquefied natural gas (LNG) prices are stationary or non-stationary. It then applies Johansen and Juselius cointegration technique for establishing long-run correlation between respective oil prices and natural gas prices. The paper concludes that all individual series pertaining to oil and natural gas prices are non-stationary and indeed having long-run relationship, despite short term drift. Ordinary least square method was used to forecast individual natural gas prices in various markets, assuming of course, that historical relationship continues to hold with respective oil prices throughout the forecasting period. Natural gas prices in each of the markets are expected to be stronger during 2005,25 as compared to respective historical average prices showing the tightness of the market. The mean NBP and HH forecast during 2005,25 are expected to be 92 and 84 per cent stronger than the historical average, whilst LNG prices in Japan continue to exhibit stronger trends during the forecast period as compared to rest of the markets in Europe and North America - showing greater dependency of imports and security of supply considerations. [source] Antimicrobial activity of essential oil and methanol extracts of Achillea sintenisii Hub.PHYTOTHERAPY RESEARCH, Issue 9 2003Mor. (Asteraceae) Abstract The essential oil, obtained by Clevenger distillation, and water-soluble and water-insoluble parts of the methanol extracts of Achillea sintenisii Hub. Mor. were individually assayed for their antimicrobial activities against 12 bacteria and two yeasts, Candida albicans and C. krusei. No activity was exhibited by the water-soluble subfraction, whereas both the water-insoluble subfraction of the methanol extracts and the essential oil were found to be active against some test microorganisms studied. Since the essential oil possessed stronger activity than the other extracts tested, it was further fractionated and the fractions were evaluated for their antimicrobial activity, followed by GC-MS analysis, resulting in the identi,cation of 32 compounds which constituted 90.2% of the total oil. The GC-MS analysis of the oil and its fractions revealed that the main components of the oil, e.g. camphor and eucalyptol, possessed appreciable activity against C. albicans and Clostridium perfringens. The ,ndings presented here also suggest that the other constituents of the oil, e.g. borneol and piperitone can also be taken into account for the activity observed. Copyright © 2003 John Wiley & Sons, Ltd. [source] Latest news and product developmentsPRESCRIBER, Issue 2 2008Article first published online: 11 FEB 200 NICE should evaluate all new medicines NICE should determine the cost effectiveness of all new medicines, the Health Select Committee has concluded in its second review of the Institute. The review, prompted by criticisms from patients, health professionals and the pharmaceutical industry, found that NICE is doing ,a vital job in difficult circumstances'. The Committee called for the costs to carers and society to be included in cost effectiveness estimates (this is currently prohibited) and for cost per QALY thresholds to be aligned with NHS affordability. NICE should publish brief appraisals at the time of a product launch , these could be used to negotiate prices. GPs responsible for unlicensed co-proxamol GPs who prescribe co-proxamol are now responsible for the consequences, the MHRA warns. The Agency agrees that the drug may be needed by ,a small group of patients who are likely to find it very difficult to change from co-proxamol or where alternatives appear not to be effective or suitable'. Following the withdrawal of product licences, stock that is currently in the supply chain may be dispensed but no new stock should be released by suppliers. The Drug Tariff price of co-proxamol has now increased from £2.79 to £20.36 per 100 tablets. Vitamin D deficiency on the increase Pregnant and breastfeeding women may need vitamin D supplements, the Department of Health has warned, and GPs are seeing increasing numbers of patients with vitamin D deficiency. Endogenous synthesis may be low in some ethnic groups and dark-skinned people, and north of Birmingham there is no light of the appropriate wavelength for the synthesis of vitamin D during the winter. The Department says free vitamin supplements are available for eligible patients through its Healthy Start Scheme (www.healthystart.nhs.uk) and may also be supplied at low cost by some PCTs. Innovation and good practice recognised Innovative practice and better outcomes for patients have been recognised through awards from the NHS Alliance and Improvement Foundation presented by the Secretary of State for Health, Rt Hon Alan Johnson, at the annual NHS Alliance conference held in Manchester. The Mountwood Surgery in Northwood, Middlesex, won the CHD QOF GP Practice Award sponsored by Schering Plough for their outstanding multidisciplinary approach to tackling CHD. In addition to having a highly organised in-house cardiology team, they have produced an interactive, patient-empowering booklet for CHD. Mountwood Surgery achieved blood pressure targets of 96.79 per cent in their CHD patients. North Tees PCT wins the CHD QOF PCO Award, also sponsored by Schering Plough, for their support and encouragement to GP practices to ,own' CHD care. They provide timely feedback of performance data using funnel plots and regular communication by the CHD LIT and Cardiac Network. Even though North Tees PCT has a high CHD prevalence, 4.2 per cent vs 3.6 per cent nationally, across the 27 practices 85 per cent of patients achieved cholesterol targets and 91 per cent reached the QOF blood pressure target. The St Benedict's Hospice Day Centre Project (for the Sunderland Teaching Primary Care Trust) won the Guy Rotherham Award for its excellent multidisciplinary team improvement of the palliative care provided. This team demonstrated a thorough understanding of the use of quality improvement methods to improve patient care, and carefully measured the individual improvements they made. Through the use of a referral ,decision tree', nonattenders were reduced by 300 per cent and average waiting times halved. The Extended Primary Care (EPC) Gynaecology Service (for the Practice Based Commissioning Consortium South Manchester Hub) was highly commended for its development of an effective and innovative service offering gynaecological treatment managed within a primary care setting, allowing patients improved access closer to home. The Salford Perinatal Mental Health Project was also highly commended for effectively challenging the high levels of maternal suicides. The awards were also supported by Prescriber, the British Cardiac Patients Association and the British Cardiac Society. Anastrozole superior to tamoxifen in long term A new analysis of the ATAC trial (Lancet Oncology 2008;9:45-53) shows that the advantages of the aromatase inhibitor anastrozole (Arimidex) over tamoxifen as adjuvant therapy for breast cancer persist for at least four years after the end of treatment. After primary treatment with surgery, chemotherapy or radiotherapy, postmenopausal women with localised invasive breast cancer were randomised to five years' treatment with anastrozole or tamoxifen. Among 5216 women who were hormone-receptor positive, anastrozole increased disease-free survival by 15 per cent after 100 months. Time to recurrence and distant recurrence were also increased, though overall survival was similar; the absolute difference in time to recurrence was greater at nine years (4.8 per cent) than at five years (2.8 per cent). Joint symptoms and fractures were more frequent with anastrozole during treatment but not thereafter. Use a steroid with a LABA , MHRA reminder The MHRA has reminded clinicians that patients treated with an inhaled long-acting beta-agonist (LABA) should also use an inhaled steroid. In the latest edition of Drug Safety Update (2008;1:No.6), the Agency reviews the implications of the SMART study (Chest 2006;129:15-26), which reported an increased risk of respiratory- and asthma-related deaths among patients using salmeterol (Serevent). This is contradicted by epidemiological data suggesting that asthma-related admissions have declined since LABAs were introduced. Randomised trials also do not support such a risk, probably because inhaled steroids are used more consistently in trial settings. The latest Update notes that product licences for carisoprodol (Carisoma) have been suspended due to concerns about the risk of abuse and psychomotor effects. It also includes a comprehensive summary of drug interactions with statins, a warning that methylene blue should not be prescribed for a patient taking a drug with serotonergic activity, and a reminder that only oral formulations of desmopressin are now licensed for primary nocturnal enuresis. This issue of Update is available at www.mhra.gov.uk. Copyright © 2008 Wiley Interface Ltd [source] Strategy hubs: Domain portals to help find comprehensive informationJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 1 2006Suresh K. Bhavnani Recent studies suggest that the wide variability in type, detail, and reliability of online information motivate expert searchers to develop procedural search knowledge. In contrast to prior research that has focused on finding relevant sources, procedural search knowledge focuses on how to order multiple relevant sources with the goal of retrieving comprehensive information. Because such procedural search knowledge is neither spontaneously inferred from the results of search engines, nor from the categories provided by domain-specific portals, the lack of such knowledge leads most novice searchers to retrieve incomplete information. In domains like healthcare, such incomplete information can lead to dangerous consequences. To address the above problem, a new kind of domain portal called a Strategy Hub was developed and tested. Strategy Hubs provide critical search procedures and associated high-quality links to enable users to find comprehensive and accurate information. We begin by describing how we collaborated with physicians to systematically identify generalizable search procedures to find comprehensive information about a disease, and how these search procedures were made available through the Strategy Hub. A controlled experiment suggests that this approach can improve the ability of novice searchers in finding comprehensive and accurate information, when compared to general-purpose search engines and domain-specific portals. We conclude with insights on how to refine and automate the Strategy Hub design, with the ultimate goal of helping users find more comprehensive information when searching in unfamiliar domains. [source] Native Hubs: Culture, Community and Belonging in the Silicon Valley and Beyond by Renya K. RamirezAMERICAN ETHNOLOGIST, Issue 2 2008AUDRA SIMPSON First page of article [source] Applying Network Analysis to the Conservation of Habitat Trees in Urban Environments: a Case Study from Brisbane, AustraliaCONSERVATION BIOLOGY, Issue 3 2006MONIKA RHODES conectividad de perchas; fauna que utiliza oquedades; planificación de la conservación; red sin escala; Tadarida australis Abstract:,In Australia more than 300 vertebrates, including 43 insectivorous bat species, depend on hollows in habitat trees for shelter, with many species using a network of multiple trees as roosts. We used roost-switching data on white-striped freetail bats (Tadarida australis; Microchiroptera: Molossidae) to construct a network representation of day roosts in suburban Brisbane, Australia. Bats were caught from a communal roost tree with a roosting group of several hundred individuals and released with transmitters. Each roost used by the bats represented a node in the network, and the movements of bats between roosts formed the links between nodes. Despite differences in gender and reproductive stages, the bats exhibited the same behavior throughout three radiotelemetry periods and over 500 bat days of radio tracking: each roosted in separate roosts, switched roosts very infrequently, and associated with other bats only at the communal roost. This network resembled a scale-free network in which the distribution of the number of links from each roost followed a power law. Despite being spread over a large geographic area (>200 km2), each roost was connected to others by less than three links. One roost (the hub or communal roost) defined the architecture of the network because it had the most links. That the network showed scale-free properties has profound implications for the management of the habitat trees of this roosting group. Scale-free networks provide high tolerance against stochastic events such as random roost removals but are susceptible to the selective removal of hub nodes. Network analysis is a useful tool for understanding the structural organization of habitat tree usage and allows the informed judgment of the relative importance of individual trees and hence the derivation of appropriate management decisions. Conservation planners and managers should emphasize the differential importance of habitat trees and think of them as being analogous to vital service centers in human societies. Resumen:,En Australia, más de 300 vertebrados, incluyendo 43 especies de murciélagos insectívoros, dependen de oquedades en árboles para refugiarse; muchas de ellas perchan en una red de múltiples árboles. Utilizamos datos de cambio de perchas en Tadarida australis (Microchiroptera: Molossidae) para construir una representación reticular de las perchas diurnas en los suburbios de Brisbane, Australia. Los murciélagos fueron capturados en un árbol con un grupo de varios cientos de individuos y liberados con transmisores. Cada percha utilizada por los murciélagos representó un nodo individual en la red, y los movimientos de murciélagos entre perchas constituyeron los eslabones entre los nodos. A pesar de las diferencias de género y etapas reproductivas, los murciélagos mostraron el mismo comportamiento en tres períodos de radiotelemetría y en más de 500 días de seguimiento de murciélagos: cada uno utilizó perchas separadas, cambiaban de percha poco frecuentemente, y se asociaron con otros murciélagos sólo en las perchas comunales. Esta red fue semejante a una red sin escala en la que la distribución del número de eslabones de cada percha cumplió una ley potencial. A pesar de estar dispersas en un área geográfica extensa (>200 km2), cada percha estaba conectada con otras por menos de tres eslabones. Una percha (el centro o percha comunal) definió la arquitectura de la red porque tenía a la mayoría de los eslabones. El hecho de que la red mostrara propiedades libres de escala tiene implicaciones profundas para la gestión de árboles que funcionan como perchas. Las redes libres de escala proporcionan alta tolerancia a eventos estocásticos como la remoción aleatoria de perchas, pero son susceptibles a la remoción selectiva de nodos centrales. El análisis de redes es una herramienta útil para el entendimiento de la organización estructural del uso de de árboles y permite el juicio informado de la importancia relativa de árboles individuales y por lo tanto la derivación de decisiones administrativas apropiadas Los planificadores y gestores de la conservación deberían enfatizar la importancia diferencial de árboles y considerarlos análogos a los centros de servicio vitales en las sociedades humanas. [source] The rise of methamphetamine in Southeast and East AsiaDRUG AND ALCOHOL REVIEW, Issue 3 2008REBECCA McKETIN Abstract Introduction and Aims. Southeast and East Asia has become a global hub for methamphetamine production and trafficking over the past decade. This paper describes the rise of methamphetamine supply and to what extent use of the drug is occurring in the region. Method and Design. The current review uses data collected through the Drug Abuse Information Network for Asia and the Pacific (DAINAP) and other available sources to analyse retrospectively methamphetamine trends within Southeast and East Asia. Results. Southeast and East Asia has experienced a methamphetamine epidemic in the past decade which began around 1997 and peaked in 2000,2001. While the situation has since stabilised in many countries, methamphetamine trafficking and use are still increasing in parts of the Mekong region and there is evidence of large-scale manufacture in Cambodia, Indonesia, Malaysia and the Philippines. Methamphetamine is typically smoked or ingested, but injection of the drug is apparent. Conclusion. While the peak of the methamphetamine epidemic has passed in parts of Southeast and East Asia, attention is needed to minimise the potential consequences of spreading methamphetamine production, trafficking and use in the Mekong region and in the peninsular and archipelago of Southeast Asia. [source] Geographic Scale and Grass-Roots Internationalism: The Liverpool Dock Dispute, 1995,1998,ECONOMIC GEOGRAPHY, Issue 3 2000Noel Castree Abstract: In the context of ongoing debates over the effects of "globalization" on organized labor and, specifically, recent experiments in labor internationalism, this paper examines the geography of the Liverpool dock dispute, 1995,98. The dispute has rarely been subject to a serious analysis of its causes and trajectory. This is surprising since it was not only the most protracted industrial dispute in recent British history but also the hub of a relatively novel form of transnational labor organizing: namely, a form of grass-roots internationalism organized largely outside the formal apparatuses of national and international unionism. In the paper I focus on the nature and dynamics of this "grass-roots internationalism" with a view to making two claims that have a wider thematic and theoretical relevance to the study of labor geographies. First, contrary to an emerging new orthodoxy in labor geography (and labor studies more generally), the Liverpool case in fact suggests that the necessity for labor to "up-scale" solidarity and struggle in the 1990s is much overstated. Second, the Liverpool case suggests that international labor organizing is only efficacious when considered in relation to two scales of struggle often thought increasingly irrelevant or ineffectual in a globalizing world: the local and the national. Thus, while those few analysts who have cited the Liverpool dispute, basing their assessments on secondhand knowledge, have held the dockers up as exemplars of a new form of labor internationalism, in this paper I suggest the need for a more complex and contingent appreciation of the multiscalar dynamics of labor struggles. In short, we have not yet reached the stage, even in a globalizing world, where labor's "spatial fixes" must be preeminently supranational. [source] Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolismEMBO MOLECULAR MEDICINE, Issue 6 2010Randal J. Kaufman Abstract Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses. [source] The New Economy and the Work,Life Balance: Conceptual Explorations and a Case Study of New MediaGENDER, WORK & ORGANISATION, Issue 1 2003Diane Perrons Given the varied claims made about the new economy and its implications for the organization of work and life, this article critically evaluates some conceptualizations of the new economy and then explores how the new media sector has materialized and been experienced by people working in Brighton and Hove, a new media hub. New technologies and patterns of working allow the temporal and spatial boundaries of paid work to be extended, potentially allowing more people, especially those with caring responsibilities, to become involved, possibly leading to a reduction in gender inequality. This article, based on 55 in-depth interviews with new media owners, managers and some employees in small and micro enterprises, evaluates this claim. Reference is made to the gender-differentiated patterns of ownership and earnings; flexible working patterns, long hours and homeworking and considers whether these working patterns are compatible with a work,life balance. The results indicate that while new media creates new opportunities for people to combine interesting paid work with caring responsibilities, a marked gender imbalance remains. [source] USER INNOVATION AND CREATIVE CONSUMPTION IN JAPANESE CULTURE INDUSTRIES: THE CASE OF AKIHABARA, TOKYOGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2010Jakob Nobuoka ABSTRACT. The consumption and export of material and immaterial commodities based upon Japanese popular culture is rapidly growing and continually finds new fans all around the world. In this article, it is suggested that some of the competitiveness of these unique cultural phenomena can be traced to the very dense and vivid area of Akihabara in Tokyo. Its long history as an electronic retail district and a more recent influx of firms and shops focused on popular culture has created a strong place brand that continues to mark Akihabara as the capital of Japanese cultural industries. It is a space where different consumers, specialist subcultures and firms and their products can interact. The area functions as a hub were ideas and values are exchanged, tested and promoted. The article argues that research on innovation milieus must take account of the role of users and their relation to place. [source] Manoeuvring and vibration reduction of a flexible spacecraft integrating optimal sliding mode controller and distributed piezoelectric sensors/actuatorsINTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, Issue 6 2007Qinglei Hu Abstract This investigation is to apply optimal sliding mode (OSM) control theory and distributed piezoelectric sensor/actuator technology to vibration control of a flexible spacecraft. An approximate analytical dynamic model of a slewing flexible spacecraft with surface-bonded piezoelectric sensors/actuators is developed using Hamilton's principle with discretization by assumed model method. To satisfy pointing requirements and simultaneously suppress vibration, two separate control loops are adopted. The first uses the piezoceramics as sensors and actuators to actively suppress certain flexible modes by designing a positive position feedback (PPF) compensators that add damping to the flexible structures in certain critical modes in the inner feedback loop; then a second feedback loop is designed using OSM control to slew the spacecraft. The OSM controller minimizes the expected value of a quadratic objective function consisting of only the states with the constraints that the error states always remain on the intersection of sliding surfaces. The advantage in this method is that the vibration reduction and attitude control are achieved separately in the two separate feedback loops, allowing the pointing requirements and simultaneous vibrations suppression to be satisfied independently of one another. An additional attraction of the design method is that the selection of PPF gain is determined by introducing a cost function to be minimized by the feedback gains which are subject to the stability criterion at the same time, such that the feedback gains are selected in a more systematical way to avoid the arbitrary selecting of feedback gains. The proposed control strategy has been implemented on a flexible spacecraft, which is a hub with a cantilever flexible beam appendage and can undergo a single axis rotation. Both analytical and numerical results are presented to show the theoretical and practical merits of this approach. Copyright © 2006 John Wiley & Sons, Ltd. [source] Pleiotropic function of ezrin in human metastatic melanomasINTERNATIONAL JOURNAL OF CANCER, Issue 12 2009Cristina Federici Abstract The membrane cytoskeleton cross-linker, ezrin, has recently been depicted as a key regulator in the progression and metastasis of several pediatric tumors. Less defined appears the role of ezrin in human adult tumors, especially melanoma. We therefore addressed ezrin involvement in the metastatic phenotype of human adult metastatic melanoma cells. Our results show that cells resected from melanoma metastatic lesions of patients, display marked metastatic spreading capacity in SCID mice organs. Stable transfection of human melanoma cells with an ezrin deletion mutant comprising only 146 N-terminal aminoacids led to the abolishment of metastatic dissemination. In vitro experiments revealed ezrin direct molecular interactions with molecules related to metastatic functions such as CD44, merlin and Lamp-1, consistent with its participation to the formation of phagocitic vacuoles, vesicular sorting and migration capacities of melanoma cells. Moreover, the ezrin fragment capable of binding to CD44 was shorter than that previously reported, and transfection with the ezrin deletion mutant abrogated plasma membrane Lamp-1 recruitment. This study highlights key involvement of ezrin in a complex machinery, which allows metastatic cancer cells to migrate, invade and survive in very unfavorable conditions. Our in vivo and in vitro data reveal that ezrin is the hub of the metastatic behavior also in human adult tumors. © 2009 UICC [source] Cultural Hegemony of Singapore among ASEAN Countries: Globalization and Cultural PolicyINTERNATIONAL JOURNAL OF JAPANESE SOCIOLOGY, Issue 1 2004Kenichi Kawasaki The Singapore Government started to call their city a "Global City for the Arts", making numerous cultural policy changes. They also worked on various cultural experiments to establish their cultural leadership or hegemony among Association of South East Asian Nations (ASEAN) countries. The development of arts policies, cultural industries and people's positive commitment towards cultural exchanges are examples of this change. Singapore therefore is now playing the role of the cultural hub among the ASEAN countries. As an example of this, the present study discusses "Esplanade", which opened as a huge cultural complex in October 2002. Then the paper will also discuss both bright and dark sides of the cultural development in Singapore. As a conclusion, this paper discusses the possibility of the cultural contribution of Singapore to ASEAN countries, in spite of having serious epistemological discontinuity among ASEAN. [source] On the analysis of some orbital contributions to the current density in circulenesINTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Issue 2 2009Guglielmo Monaco Abstract According to the ipsocentric method, the current density stems from a sum of rotationally and translationally allowed transitions: translationally allowed transition are diatropic and rotationally allowed transition must be prevailingly paratropic. Applying this method to circulenes, we show that it can be used, together with simple Hückel theory, to design systems with localized currents on the rim. More importantly, we report the current density maps of coronene2+ and coronene2,. In these systems, a single rotational contribution gives both diatropic and paratropic circulations. This finding has been interpreted by a simple model based on the orbitals of the subsystem, which are the hub and the rim. It turns out that, in such cases, simple inspection of the Hückel orbitals is sufficient to predict the relative tropicities on the rim and the hub. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2009 [source] Development of mobile broadband interactive satellite access system for Ku/Ka bandINTERNATIONAL JOURNAL OF SATELLITE COMMUNICATIONS AND NETWORKING, Issue 2 2006Yun-Jeong Song Abstract It is difficult to implement the broadband satellite Internet and broadcasting service for mobile environment. The paper presents the design and implementation of a mobile broadband satellite access system. In case of the system design, mobile terminal service is considered a critical factor than fixed terminal services, such as resource management, antenna tracking, weak signal recovery. In the paper, mobile broadband interactive satellite access technology system (MoBISAT) is presented. The system network, which is composed of a star network, consists of time division multiplexing-based forward link and multi-frequency time division multiple access-based return link. The MoBISAT provides both Ku-band satellite TV and Ka-band high-speed Internet base on DVB-S/DVB-RCS standards to the passengers and crews for land, maritime and air vehicles. The key factors of hub and mobile terminal are addressed for the design and implementation of the MoBISAT. Especially, the design and implementation of the return link demodulation method, resource management scheme and mobile terminal structure including mobile antenna are described. Copyright © 2006 John Wiley & Sons, Ltd. [source] Darfurian Livelihoods and Libya: Trade, Migration, and Remittance Flows in Times of Conflict and Crisis1INTERNATIONAL MIGRATION REVIEW, Issue 4 2007Helen Young Labor migration and commerce between Sudan and Libya have long been features of livelihoods in Darfur. This paper describes the importance of historical trade and migration links between Darfur and Libya, and provides a background to the political and economic situation in Libya which has influenced opportunities for Sudanese migrant workers. A case study of the situation of the Darfurian migrants in Kufra (an oasis and transnational trade hub in southern Libya) illustrates how the recent Darfur conflict has affected migration patterns from Darfur and remittance flows in the opposite direction. Official estimates of Darfurian migrant workers in Libya were unavailable but were estimated to be between 150,000 and 250,000. The closure of the national border between Sudan and Libya in May 2003, largely a result of insecurity in Darfur, stopped the traffic of migrant workers between northern Darfur and southern Libya (which prevented the onward travel to Sudan of several thousand migrants in Kufra), and curtailed the well-established trade routes, communications, and remittance flows. The current limited economic prospects for migrant workers in Libya, combined with the threat of detention, difficulties of return to Sudan, and loss of contact with and uncertainty about the fate of their families in Darfur, have created a sense of despair among many Darfurians. The paper concludes with a series of recommendations to improve the conditions of the Darfurian migrants in Libya, including an amnesty for illegal migrants, and also to ease the travel of migrants, promote communications between Libya and Darfur, and support the flow of remittances. [source] The Will to Modernize: A Genealogy of Biomedical Research Ethics in Singapore,INTERNATIONAL POLITICAL SOCIOLOGY, Issue 2 2010David Reubi This article is a contribution to the sociological and anthropological literature on the recent globalization of Western biomedical research ethics and bioethics. Focusing on Singapore, the article identifies and traces the genealogy of the concepts, expertise, and techniques that made it possible to introduce and develop a bioethical assemblage in the Southeast Asian city-state at the turn of the twenty-first century. It argues that what made such a development possible was a particular style of reasoning, the "will to modernize," which has characterized the thinking and acting of the Singaporean leadership ever since the country's independence. After describing the elements that make up the will to modernize, most notably the concept of modernization-as-economic-development and the notion of infrastructure, the article shows how these elements have allowed for Singapore's efforts to transform the island into a global hub for the life sciences from the mid-1980s onward. The article also shows how the development of a bioethical assemblage in the Republic was made possible by the fact that, for the governing elite, such an assemblage was conceived as a "(soft) infrastructure" that was necessary to transform Singapore into a global hub for biomedical research. [source] Development of inland lakes as hubs in an invasion networkJOURNAL OF APPLIED ECOLOGY, Issue 1 2005JIM R. MUIRHEAD Summary 1The ability to predict spatially explicit dispersal by non-indigenous species is a difficult but increasingly important undertaking as it allows management efforts to be focused around areas identified as susceptible to invasion. Lakes may serve as useful models for these studies because the habitats are well defined, and vectors of spread may be readily identified and quantified. In this study, we examined patterns of spread of the non-indigenous spiny waterflea Bythotrephes longimanus to inland lakes in Ontario, Canada, to identify lakes for which management efforts to reduce traffic would be most effective. 2We surveyed people using lakes for recreational purposes to quantify movements of trailered boats and other risky activities, to model relative vector traffic from invaded lakes to non-invaded and other invaded lakes. Non-linear functions were developed to describe the cumulative number of invaded and non-invaded destination lakes visited by people leaving five important lakes already invaded by the spiny waterflea (Huron, Simcoe, Muskoka, Panache and Kashagawigamog). The relative difference in these functions was used to identify which lakes will develop into future invasion hubs and will therefore be most important to future dispersal of the species. 3In the recent past, Lake Muskoka has been an important hub from which the spiny waterflea has invaded other lakes. It is unlikely to continue to be a source for waterflea invasion as most outbound traffic is to previously invaded lakes. Conversely, most outbound traffic from Lakes Kashagawigamog and Simcoe is to non-invaded lakes and, therefore, these lakes are likely to develop into hubs in the future. 4Synthesis and applications. These data on zooplankton in lake systems and associated mechanisms of transport indicate patterns not only of intrinsic value to lake management, but also of potential importance in understanding invasions more generally. Frequency distributions of the number of outbound connections to both invaded and non-invaded destinations from invaded sources follow a power function, consistent with scale-free networks. These networks indicate that small proportions of sources function as hubs. Management efforts targeted to remove developing hubs from the invasion network, rather than equal effort applied to outbound vector traffic from all sources, may reduce the predicted rate of new invasions. [source] Empirical Distribution Models for Escherichia coli 57:H7 in Ground Beef Produced by a Mid-size Commercial GrinderJOURNAL OF FOOD SCIENCE, Issue 5 2004R.A. Flores ABSTRACT: The purpose of this research was to develop empirical models that describe the amount and distribution of ground beef contaminated with Escherichia coli O157:H7 when a contaminated beef trim is introduced into a batch of uncontaminated beef before processing in a mid-size commercial grinder (34 g/s). A beef trim was inoculated with a rifampacin-resistant strain of E. coli O157:H7 and added to a batch of noncontaminated trims at the grinding step. To study the distribution of the E. coli O157:H7rif in the ground beef, 6 treatments with different inoculum levels (1 to 6 log10 colony-forming units [CFU]) were tested. Removal or pick up of the residual contamination with E. coli O157:H7rif left in the grinder was evaluated. E. coli O157:H7rif was detected in 9% to 86% of the total ground beef for the 1 to 6 log10 CFU inoculum levels, respectively. E. coli O157:H7rif contamination was detected in the collar that fixes the grinder's die and blade to the hub. An exponential algorithm described the relationship between the quantities of ground beef containing E. coli O157:H7rif and the inoculum level (R2= 0.82). Distribution models based on a Chi-squared algorithm were developed for each inoculum level describing the contamination level as a function of the batch fraction processed (R2= 0.81 to 0.99). The results of this study corroborate that when beef processors test for pathogenic contamination in a mid-scale grinder, they should test the beef residues in the collar that fixes the grinder's die and blade to the hub. [source] Peribulbar blockade with a short needle for phacoemulsification surgeryACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 2 2009W. RIAD Background: Peribulbar blockade is still widely used for phacoemulsification surgery. The potential complications of this technique include central spread, globe perforation and retrobulbar hemorrhage. The 25 mm needle is the most common needle used to perform the block. The aim of this study was to demonstrate the efficacy of a 12.5 mm needle in performing peribulbar blockade for phacoemulsification surgery. Methods: After obtaining the hospital research and the Human Ethics Committees' approval, 200 patients undergoing the phacoemulsification procedure under local anesthesia were enrolled in this descriptive study. Peribulbar blockade was performed with a 27 G, 12.5-mm-long needle. The needle was inserted transcutaneously through the lower eyelid into the inferotemporal quadrant. Digital pressure was applied by the thumb and index fingers around the needle hub during injection. After negative aspiration, a local anesthetic solution was injected until total drop of the upper eyelid was achieved. Ocular akinesia was assessed 10 min after the block using the simple akinesia score. A score of 3 or less was accepted to provide adequate analgesia for the surgical procedure to be performed. If the block was inadequate for surgery after 10 min, supplementary anesthesia was provided using the same needle. Results: Adequate analgesia after the first injection was reported in 90.5% of the patients while 9.5% required supplementary anesthesia. There were no major sight or life-threatening complications. Conclusion: Using a 12.5-mm-long needle for peribulbar blockade produced satisfactory results. This technique is effective for phacoemulsification surgery. [source] A hub covering model for cargo delivery systemsNETWORKS: AN INTERNATIONAL JOURNAL, Issue 1 2007Pinar Z. Tan Abstract The hub location problem appears in a variety of applications including airline systems, cargo delivery systems, and telecommunication network design. When we analyze the application areas separately, we observe that each area has its own characteristics. In this research we focus on cargo delivery systems. Our interviews with various cargo delivery firms operating in Turkey enabled us to determine the constraints, requirements, and criteria of the hub location problem specific to the cargo delivery sector. We present integer programming formulations and large-scale implementations of the models within Turkey. The results are compared with the current structure of a cargo delivery firm operating in Turkey. © 2006 Wiley Periodicals, Inc. NETWORKS, Vol. 49(1), 28,39 2007 [source] Increased ,-globin gene expression in ,-thalassemia intermedia patients correlates with a mutation in 3,HS1AMERICAN JOURNAL OF HEMATOLOGY, Issue 11 2007Adamantia Papachatzopoulou We report a novel set of genetic markers in the DNaseI hypersensitive sites comprising the human ,-globin locus chromatin hub (CH), namely HS-111 and 3,HS1. The HS-111 (,21 G>A) and 3,HS1 (+179 C>T) transitions form CH haplotypes, which occur at different frequencies in ,-thalassemia intermedia and major patients and normal (nonthalassemic) individuals. We also show that the 3,HS1 (+179 C>T) variation results in a GATA-1 binding site and correlates with increased fetal hemoglobin production in ,-thalassemia intermedia patients. In contrast, the HS-111 (+126 G>A) transition, found in three normal chromosomes, is simply a rare polymorphism. We conclude that the CH haplotypes are useful genetic determinants for ,-thalassemia major and intermedia patients, while the 3,HS1 (+179 C>T) mutation may have functional consequences in ,-globin genes expression. Am. J. Hematol., 2007. © 2007 Wiley-Liss, Inc. [source] Latest news and product developmentsPRESCRIBER, Issue 23-24 2007Article first published online: 8 JAN 200 Cervical cancer risk falls after COC use ends Combined oral contraceptives (COCs) are associated with a slight increase in the risk of cervical cancer but this diminishes with time after use ends, an international study has shown (Lancet 2007;370:1609,21). Analysis of data for 16 573 women with and 35 509 women without cervical cancer confirmed that using a COC for 10 years between the ages of 20 and 30 increases the incidence of invasive cervical cancer from 3.8 to 4.5 per 1000 by age 50. However, the excess risk disappears 10 years after cessation of use. , A new analysis of the US Nurses' Health Study suggests that protection against ovarian cancer does not persist beyond 20 years after cessation of COC use. This study also showed that tubal ligation is associated with reduced risk of ovarian cancer (Am J Epidemiol 2007; 166;894,901). Pharmaceutical services fund moves to PCTs The ,global sum' that provides central funding for NHS pharmaceutical services is being shifted to PCTs. The Government has included legislation for the change in the recent Health and Social Care Bill. The fund pays the fees and allowances for pharmacy contractors and appliance contractors. The Government says this is a ,natural progression and in keeping with moves to devolve NHS funds to the frontline' that will enable PCTs to manage pharmacy services better by ,encouraging best prescribing practice'. Fewer fluoroquinolones in the community Restricting prescribing of fluoroquinolone antibacterials does not increase hospital admissions for infection among older people, say Canadian researchers (Am J Med 2007;120:893,900). Their analysis of an Ontario medical database shows that, in a community where fluoroquinolones were the most widely prescribed antibacterials, a one-third reduction in prescribing was not followed by an increase in hospital admissions for infectious episodes in the over,65s. On the contrary, there was a 32 per cent reduction in admissions for gastrointestinal conditions. FDA reports increased TB risk with infliximab The US Food and Drug Administration has published an analysis of cases of TB associated with infliximab (Remicade) detected via its spontaneous adverse event reporting scheme (Ann Intern Med 2007;147: 699,702). In 2001 the FDA placed a warning about the risk of TB on product labelling for infliximab and advised testing for TB before initiating treatment. This analysis of 130 cases of TB since reported in patients treated with infliximab found that 45 per cent had developed extra-pulmonary disease; risk factors included use of immunosuppressants (including methotrexate), a history of TB and time spent in an endemic area. Of 67 cases in which treatment was initiated after the warning was issued, 34 with a negative tuberculin skin test developed TB after receiving infliximab. MHRA announces anticounterfeit strategy The UK is a transit point, distribution hub and end-user of counterfeit medicines, says the MHRA in its first anti-counterfeiting strategy (www.mhra.gov.uk). Counterfeits have been detected in the legitimate supply chain with increasing frequency since 2004, resulting in nine batch recalls and a further five incidents detected at wholesale level. The MHRA's proposed approach includes: communication to raise awareness of the risk and facilitate reporting, collaboration with the WHO, the industry and law enforcement agencies, and targeted surveillance, prosecution and regulation. Evidence lacking for choosing DMARD There is insufficient evidence to choose one DMARD or biological agent over another in patients with RA, US investigators say (www.annals.org/cgi/content/abstract/0000605,20080115000192v1). Their systematic review of meta-analyses and intervention and observational trials found no evidence of differences among DMARDs or anti-TNF agents. Mono-therapy with an anti-TNF agent was associated with superior radiographic but not clinical outcomes; methotrexate plus an anti-TNF agent was superior in clinical and functional terms to either drug given alone. Be alert to psychiatric ADRs with rimonabant Clinicians should remain alert for the development of anxiety, depression and an increased risk of suicide with rimonabant (Acomplia), say Danish investigators (Lancet 2007;370:1706,13). Their meta-analysis of four randomised trials involving a total of 4105 patients showed that rimonabant was associated with an increased risk of serious adverse events (odds ratio 1.4; number needed to harm, NNH, 59), including a 2.5,fold increased risk of depression (NNH 49) and a threefold increased risk of anxiety (NNH 166). Following a warning from the FDA of an increased risk of suicide with rimonabant, the authors say their findings indicate a need for ,increased alertness by physicians to these potentially severe psychiatric adverse reactions'. New strategy for NHS medicines information The UK Medicines Information Service (www.ukmi.nhs.uk) has published its new management strategy setting out how it will respond to recent developments in the NHS. Developments include greater access to information for patients, support for nontraditional prescribers and new commissioning arrangements. New antiretroviral Maraviroc (Celsentri) is the first CCR5 antagonist to be introduced for the treatment of HIV infection. CCR5 is one of two co-receptors to which the HIV virus must attach to achieve cell entry. Maraviroc is licensed for use by treatment-experienced patients in whom only CCR5-tropic HIV-1 is detectable. The recommended dose ranges from 150 to 600mg twice daily depending on interactions with concurrent medication. Dimeticone superior Dimeticone 4 per cent lotion (Hedrin) is superior to malathion 0.5 per cent in the eradication of head lice, a UK study in 58 children and 15 adults has shown (PLoS ONE 2007;2: e1127. doi:10.1371/journal.pone. 0001127). Two applications of dimeticone lotion one week apart cleared active infestation in 70 per cent of participants compared with 33 per cent in those who used a single application of malathion. Copyright © 2007 Wiley Interface Ltd. [source] SPLASH: Systematic proteomics laboratory analysis and storage hubPROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 6 2006Siaw Ling Lo Abstract In the field of proteomics, the increasing difficulty to unify the data format, due to the different platforms/instrumentation and laboratory documentation systems, greatly hinders experimental data verification, exchange, and comparison. Therefore, it is essential to establish standard formats for every necessary aspect of proteomics data. One of the recently published data models is the proteomics experiment data repository [Taylor, C. F., Paton, N. W., Garwood, K. L., Kirby, P. D. et,al., Nat. Biotechnol. 2003, 21, 247,254]. Compliant with this format, we developed the systematic proteomics laboratory analysis and storage hub (SPLASH) database system as an informatics infrastructure to support proteomics studies. It consists of three modules and provides proteomics researchers a common platform to store, manage, search, analyze, and exchange their data. (i),Data maintenance includes experimental data entry and update, uploading of experimental results in batch mode, and data exchange in the original PEDRo format. (ii),The data search module provides several means to search the database, to view either the protein information or the differential expression display by clicking on a gel image. (iii),The data mining module contains tools that perform biochemical pathway, statistics-associated gene ontology, and other comparative analyses for all the sample sets to interpret its biological meaning. These features make SPLASH a practical and powerful tool for the proteomics community. [source] AHEC in West Virginia: A Case StudyTHE JOURNAL OF RURAL HEALTH, Issue 1 2003Lamont D. Nottingham MPH The outcome is an evolving universitycommunity partnership designed to meet changing workforce and community health needs in the heart of rural Appalachia. West Virginia University's (WVU's) application of the original Carnegie Commission AHEC recommendations (1970) resulted in the Charleston AHEC, now part of the Robert C. Byrd Health Sciences Center of WVU. AHEC today trains more than 135 residents and interns, and one-third of the third-year and fourth-year WVU medical students. Charleston offers clinical and continuing education for nurses, dentists, pharmacists, and allied health professionals. A health sciences library, distance learning, and a neiwork of primary care clinics help define Charleston's unique AHEC role. This AHEC hub continues to meet the classic Carnegie goals of recruiting and retaining health professionals, and providing access to care in the original service area and statewide. Based on the Charleston experience, four new federally funded AHECs are being developed to link rural primary care residencies with the state-funded West Virginia rural health education partnerships. These rural consortia AHECs are applying the concept of community competency, a performance-based methodology, to integrate learning while achieving the goals of Healthy People 2010. [source] Patent Policy for Human Embryonic Stem Cell Research in TaiwanTHE JOURNAL OF WORLD INTELLECTUAL PROPERTY, Issue 4 2010Jerry I.-H. The potential of human embryonic stem cell (ESC) research could prove to provide immense therapeutic value for illnesses not curable under currently existing therapies. However, human ESC research is controversial as it touches the fundamental value of human life. Taiwan has been aiming to become the biotech hub of Asia-Pacific and is becoming a major player in human ESC research. Whether or not the research results from human ESC are patentable could have a profound impact on the progress in this field. In this article, the science of human ESC research is clarified and tested against the existing murky Taiwan patent standards. In particular, this article distinguishes between therapeutic cloning and reproductive cloning techniques, asks questions about the patentability of totipotent human ESCs and explores the meaning of the word embryo. This article draws comparison with the European practice on ethical standards and concludes that patenting human ESC research might not be so controversial, but Taiwan has to make its patent law clearer in this field to fulfill the country's intended goal. [source] Urban Otaku: Electric Lighting and the NoctambulistARCHITECTURAL DESIGN, Issue 5 2009John Culmer Bell Abstract Street lighting extends the life of the city far beyond nightfall, perpetuating the day's activities while also making the metropolis a hub for leisure and entertainment. What if, however, it was necessary to curtail the use of electric lighting to conserve energy and to limit the impact of global warming? John Culmer Bell, founder of FXV, a studio concerned with researching the potential of new technologies and media in design, looks at how significant the lumination of the city is for urban culture. Copyright © 2009 John Wiley & Sons, Ltd. [source] | ||||||||||||||||||||||||||||||||||