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Homosexual Men (homosexual + man)
Selected AbstractsRisk Factors of Sexual Aggression and Victimization Among Homosexual Men,JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 7 2001Barbara Krahé This study examined risk factors of sexual aggression and victimization among homosexual men (N= 310). They completed the Homosexual Experiences Survey to record sexual aggression and victimization and provided information about 2 groups of potential risk factors: childhood abuse and sexual lifestyle (number of partners, age at first intercourse, age at coming out, accepting or paying of money for sex, and rape proclivity). One in 4 respondents reported severe forms of sexual victimization; 17% reported moderate victimization. Prevalence of perpetration of sexual aggression was almost 20% for severe aggression and 9% for moderate aggression. The risk of victimization increased as a function of childhood abuse as well as high number of partners and acceptance of money for sex. The risk of committing sexual aggression was positively related to childhood abuse, acceptance and payment of money for sex, high number of sexual partners, and rape proclivity. The findings are discussed in relation to evidence on heterosexual aggression. [source] Clinical and Magnetic Resonance Imaging Regression of Progressive Multifocal Leukoencephalopathy in an AIDS Patient After Intensive Antiretroviral TherapyJOURNAL OF NEUROIMAGING, Issue 3 2001Rita A. Shapiro DO ABSTRACT A 36-year-old homosexual man with 6 months of visual symptoms and headaches had right homonymous hemianopia, mild new learning impairment, and alexia with agraphia. The initial brain magnetic resonance imaging (MRI) scan was reported consistent with left occipital infarction. Subsequent MRI demonstrated abnormal demyelination in the subcortical white matter and deep parieto-occipital white matter bilaterally, but primarily left. Human immunodeficiency virus testing and cerebrospinal fluid polymerase chain reaction for JC virus DNA were both positive, consistent with progressive multifocal leukoencephalopathy (PML) with AIDS. His clinical status steadily deteriorated, and MRI white matter abnormalities worsened despite high-dose antiretroviral therapy. After the antiretroviral regimen was intensified by the addition of a protease inhibitor, rapid clinical and radiographic improvement occurred with subsequent MRI studies revealing only residual left parieto-occipital encephalomalacia. PML in AIDS patients has been associated with a nearly uniformly poor prognosis until recent reports of improved outcomes after highly active antiretroviral therapy. This patient with PML and AIDS similarly showed a robust clinical and MRI response to intensive antiretroviral combination therapy, which has been maintained for more than 3 years. [source] Highly active antiretroviral therapy (HAART) among HIV-infected drug users: a prospective cohort study of sexual risk and injecting behaviourADDICTION, Issue 3 2006Colette Smit ABSTRACT Aims To study sexual risk and injecting behaviour among HIV-infected drug users (DU) receiving highly active antiretroviral therapy (HAART)., Design and setting As part of an ongoing prospective cohort study, HIV-infected DU who commenced HAART (n = 67) were matched with those not starting HAART (n = 130) on CD4 cell counts, duration of cohort participation, age and calendar year of visit. Immunological and virological responses of the HAART-treated DU were compared with the HAART-treated homosexual men from the same cohort (n = 212). Measurements Trends in behaviour and therapeutic response were tested with a logistic regression model adjusted for repeated measurements and a piecewise random effects model, respectively. Findings Non-HAART users reported more episodes of injecting than HAART users. In both groups injecting declined over time with no effect of HAART initiation. Before HAART initiation an increase in sexual risk behaviour was observed among those who had been assigned to receive HAART; their sexual risk behaviour declined thereafter. No change in sexual risk behaviour was found among non-HAART users. Relative to homosexual men, DU had a similar initial therapeutic response, but DU started HAART at lower CD4 cell counts and higher viral load levels. Conclusion DU who are treated with HAART are not increasing their risk behaviour, and their early response to HAART is similar to homosexual men. However, before the treated DU received HAART they were seen to inject less often than those not treated with HAART. This suggests that selection of potential HAART starters is based on limited drug use. Although the DU who commence HAART are a selected group, our results show that HIV-infected DU can be treated effectively. [source] Determinants of response to first HAART regimen in antiretroviral-naïve patients with an estimated time since HIV seroconversionHIV MEDICINE, Issue 1 2006R Thiébaut Objective To study the determinants of immunological and virological response to highly active antiretroviral therapy (HAART) in naïve patients, adjusting for time since HIV-1 seroconversion. Design Data from HIV-cohort studies where dates of seroconversion have been reliably estimated. Methods In previously untreated patients, short- and long-term marker responses from HAART initiation (three or more antiretroviral drugs) to the end of follow-up or any treatment modification were considered using mixed effects models accounting for undetectable HIV viral load and informative dropout. Results In total, 943 patients were treated with a first HAART regimen for a median of 29 months. In adjusted analyses, compared with a reference group of homosexual men without AIDS initiating treatment 4 years after seroconversion, injecting drug users (IDUs) were treated at similar CD4 and HIV RNA levels but had poorer short-term virological response (2.54 vs 2.13 log10 HIV-1 RNA copies/mL at 1.5 months, P=0.03) and poorer long-term immunological response (522 vs 631 cells/,L at 24 months, P<0.0001). Although individuals with AIDS at HAART initiation had lower CD4 counts (206 vs 382 cells/,L, P<0.0001), their immunological responses were similar to those of individuals without AIDS. Similarly, individuals further from seroconversion started HAART at lower CD4 counts (e.g. 311 vs 382 cells/,L at vs before 9 years from seroconversion, P<0.0001), but had similar CD4 responses. However, they experienced poorer long-term virological response (0.67 log10 copies/mL/year smaller decline, P<0.0001) compared to those treated before 9 years from seroconversion. Conclusion Taking into account the time elapsed since seroconversion, this study suggests that careful choices of initial treatment should be made and intensive follow-up carried out in high-risk subgroups such as IDUs who have poorer responses. [source] Risk Factors of Sexual Aggression and Victimization Among Homosexual Men,JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 7 2001Barbara Krahé This study examined risk factors of sexual aggression and victimization among homosexual men (N= 310). They completed the Homosexual Experiences Survey to record sexual aggression and victimization and provided information about 2 groups of potential risk factors: childhood abuse and sexual lifestyle (number of partners, age at first intercourse, age at coming out, accepting or paying of money for sex, and rape proclivity). One in 4 respondents reported severe forms of sexual victimization; 17% reported moderate victimization. Prevalence of perpetration of sexual aggression was almost 20% for severe aggression and 9% for moderate aggression. The risk of victimization increased as a function of childhood abuse as well as high number of partners and acceptance of money for sex. The risk of committing sexual aggression was positively related to childhood abuse, acceptance and payment of money for sex, high number of sexual partners, and rape proclivity. The findings are discussed in relation to evidence on heterosexual aggression. [source] Changes in circulation of B and non-B HIV strains: Spotlight on a reference centre for infectious diseases in Northern ItalyJOURNAL OF MEDICAL VIROLOGY, Issue 6 2008Fausto Baldanti Abstract Stored demographic data and HIV RT and protease sequences of 877 HIV patients attending for the first time the HIV/AIDS outpatient clinics of a reference Infectious Diseases centre in Northern Italy between 1999 and 2006 were stratified by 3-year spanning periods according to date of HIV infection. In the period 1980,1982, new infections were entirely caused by HIV-1 subtype B strains and were all diagnosed in injection drug users, 88.9% of whom were males. Injection drug users accounted for 12.8% of new infections in 2004,2006. The frequency of heterosexually-transmitted infections consistently increased until 2000 (from almost none to 51.5%) remaining stable afterwards. About half of heterosexual patients were females. HIV infections among homosexual men increased from 0% in 1980,1982 to 15,21% between 1998 and 2006. Overall, the frequency of non-B subtypes HIV strains increased from 0% in 1980,1982 to 20.3% in 2004,2006 with a greater impact in heterosexuals (from 0% in 1980,1982 to 30.5% in 2004,2006). In conclusion, a picture of the changing scenario of circulating HIV types and subtypes in a reference Infectious Diseases centre in Northern Italy over the past 26 years is provided. A progressive modification in risk factors for HIV infection and a significant increase in the frequency of non-B HIV strains were observed. J. Med. Virol. 80:947,952, 2008. © 2008 Wiley-Liss, Inc. [source] Different transmission patterns of hepatitis A virus for two main risk groups as evidenced by molecular cluster analysis,JOURNAL OF MEDICAL VIROLOGY, Issue 5 2007Grace Tjon Abstract Men who have sex with men and traveling children are the most important risk groups for transmission of hepatitis A virus (HAV) in Amsterdam, The Netherlands. Between these two risk groups, different HAV genotypes are found. In this study the patterns of introduction and transmission of HAV were investigated in the two groups. HAV sequences from Amsterdam patients were divided according to risk: (I) travelers and their contacts, (II) homosexual men and their contacts. The sequences in each risk group were then grouped into clusters based on the genetic distances between the sequences. Among travelers many sporadic cases were found, the clusters were small, and introduced frequently into the population, mostly in the second half of each calendar year, indicating a seasonal pattern of introduction and transmission after the summer holidays. Among men who have sex with men the clusters were bigger and remained present for a longer time; sporadic cases were few, and introduction of new strains occurred only occasionally but throughout the year. Our findings indicate that new HAV strains are frequently imported into Amsterdam by travelers, but they are limited in the extent and season of their spread. In contrast, HAV is only occasionally imported into the male homosexual and bisexual population, but remains endemic and spreads to a large number of individuals without a seasonal pattern. J. Med. Virol. 79:488,494, 2007. © 2007 Wiley-Liss, Inc. [source] Molecular epidemiological studies show that hepatitis A virus is endemic among active homosexual men in EuropeJOURNAL OF MEDICAL VIROLOGY, Issue 4 2007Kathrine Stene-Johansen Abstract Large outbreaks of hepatitis A have occurred in Denmark, Germany, the Netherlands, Norway, Spain, Sweden, and the United Kingdom during the period 1997,2005 affecting homosexual men. A collaborative study was undertaken between these countries to determine if the strains involved in these hepatitis A outbreaks were related genetically. The N-terminal region of VP1 and the VP1/P2A region of the strains were sequenced and compared. The majority of the strains found among homosexual men from the different European countries formed a closely related cluster, named MSM1, belonging to genotype IA. Different HAV strains circulated among other risk groups in these countries during the same period, indicating that specific strains were circulating among homosexual men exclusively. Similar strains found among homosexual men from 1997 to 2005 indicate that these HAV strains have been circulating among homosexual men for a long time. The homosexual communities are probably too small within the individual countries to maintain HAV in their population over time, whereas the homosexual communities across Europe are probably sufficiently large to sustain continued circulation of homologous HAV strains for years resulting in an endemic situation among homosexual men. J. Med. Virol. 79:356,365, 2007. © 2007 Wiley-Liss, Inc. [source] Molecular epidemiology of hepatitis B virus in Amsterdam 1992,1997,JOURNAL OF MEDICAL VIROLOGY, Issue 2 2002J.E. van Steenbergen Abstract To gain insight into the spread of hepatitis B among various risk groups in Amsterdam a 6-year (1992,1997) retrospective DNA sequencing study was carried out on isolates from stored sera from reported primary cases of acute hepatitis B infection. Cases were classified according to risk behavior, as determined in interviews. Of the available serum, a selected region of hepatitis B-virus-DNA was amplified and sequenced. The nucleotide alignments were subjected to phylogenetic tree analysis. When nucleotide alignments were subjected to phylogenetic analysis, the strains of 54 isolates, 26% of the 204 reported primary cases, clustered in five genotypes: A, C, D, E, and F. In genotype A, a cluster related to men having sex with men was identified. In genotype D, two subclusters could be identified: one was related to injecting drug use and another was related to the Moroccan population in Amsterdam. The remaining strains showed a high genetic variability within three different genotypes: F, E, and C. Of the 14 identical isolates in the "homosexual men cluster," one was isolated from a female heterosexual. Of the 14 identical strains in the "drug users strain," six were from non-drug using heterosexual active individuals. In the cluster of twelve isolates related to hepatitis B-endemic areas, probable modes of transmission were varied. Sequence analysis provides important insight into the spread of hepatitis B among various high-risk groups. The analysis indicates that the prevention strategy in The Netherlands fails to stop transmission of hepatitis B from persistently infected individuals originating from hepatitis Bendemic countries. J. Med. Virol. 66:159,165, 2002. © 2002 Wiley-Liss, Inc. [source] Lymphogranuloma venereum proctitis masquerading as inflammatory bowel disease in 12 homosexual menALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 1 2010S. Soni Aliment Pharmacol Ther 2010; 32: 59,65 Summary Background, Lymphogranuloma venereum (LGV) is a recognized cause of proctitis. Symptoms, endoscopy and histology findings are similar in IBD and LGV proctitis. Aims, To characterize the clinical, endoscopic and histological features seen in men diagnosed initially with IBD and subsequently with LGV proctitis, and to attempt isolation of Chlamydia trachomatis DNA from the stored rectal biopsy specimens of these patients using real-time PCR. Methods, Clinical data were collated from confirmed or suspected cases of LGV proctitis where endoscopy and biopsy had been performed as part of the investigation of clinical symptoms. LGV was confirmed by the detection of LGV-specific DNA from rectal swab specimens, with supportive evidence from Chlamydial serology. Stored histological specimens from rectal biopsies were analysed retrospectively for LGV-specific DNA with molecular techniques. Results, Rectal biopsies had been obtained from twelve cases of LGV proctitis. Mucosal ulcers, cryptitis, crypt abscesses and granulomas were common histological findings. Extraction of LGV-specific DNA from rectal biopsy specimens enabled confirmation of three suspected cases. Conclusions, During the recent LGV proctitis epidemic among UK men who have sex with men, it has become apparent that this infection may closely resemble IBD. Gastroenterologists should remain alert to LGV as a cause of proctitis in this group. [source] Homophobia and Conservative Religion: Toward a More Nuanced UnderstandingAMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 1 2007Christopher H. Rosik PhD The failure of homophobia scales to consider the normative assumptions of religious communities may result in findings that are less useful in addressing this problem. In this study, 155 undergraduate students at a Christian university were surveyed, separately assessing attitudes toward celibate versus sexually active homosexual men and women. Results of multiple regression analyses found that participants who emphasized a person-behavior distinction (an accepted tenet of conservative religious ideology) held more negative attitudes toward lesbian women than those who were comparatively more accepting and did not emphasize such a distinction. However, participants who emphasized the person-behavior distinction held more positive attitudes toward gay men than those who were comparatively more rejecting and did not emphasize such a distinction. These relationships were significant even after accounting for variance attributable to general measures of religious commitment. Attempts to reduce homophobia within conservative religious communities may benefit from a more sensitive approach to their belief systems. [source] | ||||||||||