			Home About us Contact

Healthy Full-term Newborns (healthy + full-term_newborn)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Prediction of hyperbilirubinaemia in the healthy term newborn

ACTA PAEDIATRICA, Issue 2 2001
X Carbonell
The aim is to establish the correlation between transcutaneous bilirubin (TCB) and serum bilirubin (TSB) and its predictive value for significant hyperbilirubinaemia ,290 mcmol/L (17mg/dL). We studied a total of 2004 healthy full-term newborns, weight 3.230g ± 491g; 90% received breast milk. The study was performed in two phases. In the first phase (610 newborns), the following tests were carried out: hematocrit and bilirubin in umbilical cord blood; TCB at 24 h, 48 h and between 60 h and 96 h at the forehead and over the sternum; TSB was measured along with this last test. In the second phase (1394 newborns), the predictive value of TCB and TSB was validated. The incidence of bilirubin >290 mcmol/L was 2.95% and 3.2%. The correlation between TSB and TCB is high (n= 996; r = 0.92; y = 5.916 + 0.804x; p < 0.000). There was a better correlation between TCB and TSB with sternal compared to forehead determination (< 24 h: 0.81 vs 0.77; 24,48 h: 0.887 vs 0.83; and >48 h: 0.94 vs 0.83). The study showed the scant sensitivity of umbilical cord blood bilirubin and good predictive value at 24 h of TSB > 102 mcmol/L (6mg/dL) and at 48 h of TSB > 154 mcmol/L (9mg/dL) and TCB > 13 (equivalent to 154 mcmol/L). Conclusion: There is a good correlation between TCB and TSB. In infants with TSB 102 mcmol/L at 24 h or TSB > 154 mcmol/L or transcutaneous readings > 13 h at 48 h, a TSB test must be performed after 48 h of life. [source]

Indicators Nurses Employ in Deciding to Test for Hyperbilirubinemia

JOURNAL OF OBSTETRIC, GYNECOLOGIC & NEONATAL NURSING, Issue 6 2001
Anita J. Gagnon RN
Objective: To identify the indicators nurses employ in deciding to test healthy full-term newborns for total serum bilirubin in the absence of a written protocol. Design: Secondary analysis of data available on 130 mother-newborn pairs and informal interviews of 30 postpartum unit nurses. Setting: Two university teaching hospitals. Participants: All tested newborns and a 33% random sample of remaining newborns from a control group data set created during a previous study and a convenience sample of postpartum nurses from all shifts. Measurement: Outcome data were obtained from a review of records. Background data were obtained from a review of records and questionnaires. Nurse data were obtained through a modified form of participant observation. Results: Ninety-one percent of newborns tested for bilirubin were tested unnecessarily. In logistic regression analyses, variables predictive of nurse-driven total serum bilirubin testing were presence of jaundice, odds ratio (OR) = 31.95 (95% confidence interval, 6.71, 152.03), and feeding frequency, OR = 0.28 (0.11, 0.72). Identifying both presence and location of jaundice simultaneously did not significantly predict testing, OR = 1.82 (0.66, 5.04). Fifty-three percent of nurses who were interviewed identified both the presence of jaundice and feeding as indicators to consider for testing. Conclusion: Newborns are overtested for bilirubin. Indicators used by nurses in deciding to test a healthy newborn for total serum bilirubin are the presence of jaundice and feeding frequency. Nurses who assess feeding frequency are less likely to order bilirubin testing. [source]

Serum pro-hepcidin levels in term and preterm newborns with sepsis

PEDIATRICS INTERNATIONAL, Issue 2 2009
Ece Yapakç
Abstract Background:, An iron regulatory peptide hormone, hepcidin, is also part of the innate immune system and is strongly induced during infections and inflammation. The aim of the present study was to determine serum levels of the 60 aa pro-hormone form of hepcidin (pro-hepcidin) in full-term and preterm newborns with sepsis and to determine the possible relationships between pro-hepcidin levels and serum iron and complete blood count parameters. Methods:, Fifteen preterm newborns with sepsis, 17 healthy preterm, six full-term newborns with sepsis and 16 healthy full-term newborns were included the study. Blood samples were collected from patients with sepsis at the time of clinical diagnosis. Each blood sample was analyzed for complete blood count, serum iron and ferritin concentrations, iron-binding capacity, and pro-hepcidin level. Results:, The mean serum pro-hepcidin level (mean ± SD) in preterm neonates with sepsis and in healthy preterm newborns was 565.4 ± 519.5 ng/mL and 279.8 ± 227.6 ng/mL, respectively (P < 0.05). The mean serum pro-hepcidin level in full-term newborns with sepsis and in healthy full-term neonates was 981.4 ± 415.4 ng/mL and 482 ± 371.9 ng/mL, respectively (P < 0.05). Although the mean serum ferritin levels in the two groups with sepsis were higher when compared with the healthy groups, the difference was not statistically significant in full-term newborns. No statistically significant correlations were found between serum pro-hepcidin levels and any other parameters in each group. Conclusions:, Serum pro-hepcidin levels were higher in newborns with sepsis (either premature or full-term) than they were in healthy newborns at the time of clinical diagnosis. [source]

Labour increases the surface expression of two toll-like receptors in the cord blood monocytes of healthy term newborns

ACTA PAEDIATRICA, Issue 6 2009
Chung-Min Shen
Abstract Aim: Mode of delivery may influence the innate immune system in newborns. We investigated the effect of maternal labour on the expression of two toll-like receptors, TLR2 and TLR4, in monocytes obtained from healthy full-term newborns. Methods: Monocytes were obtained from cord blood of 48 newborns that have been vaginally delivered (VD) and 14 newborns delivered by elective caesarean section (CS) without labour. Peripheral blood was also obtained from 17 healthy adults. Surface expression of TLR2 and TLR4 in the monocytes was measured by antihuman TLR2 or TLR4 monoclonal antibody and immunofluorescence flow cytometry. TLR2 and TLR4 mRNA levels were evaluated by real-time PCR. Results: CS newborns had a significantly lower level of TLR2 and TLR4 surface expression on monocytes than VD newborns. No significant difference was found between the surface expression of VD newborns and healthy adults. TLR2 and TLR4 mRNA levels in monocytes did not vary among the three study groups. Conclusion: Labour may up-regulate TLR2 and TLR4 on the cord blood monocytes of newborns at the protein level. Since TLRs are an important part of the innate immune system, our findings suggest that labour may be immunologically beneficial to normal newborns. [source]