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Hexane Fraction (hexane + fraction)

Distribution by Scientific Domains
Medical Sciences75%

Selected Abstracts

Novel selective cytotoxicity of wild sarsaparilla rhizome extract

JOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 10 2006
Y. G. Huang
Among six fractions, including total extract and fractions of hexane, ethyl acetate, butanol, water and boiling water extracted and separated from wild sarsaparilla rhizome, the hexane fraction (HRW) was the most effective in eliminating four different human cancer cell lines with cellular viability less than 6.8%. HRW exhibited the highest potency against human leukaemia cells with an IC50 (concentration that inhibited the growth rate of cells by 50%) of 3.3 ± 0.3 ,g mL,1, which was 17.6-fold smaller than that against normal human umbilical vein endothelial cells (IC50, 58.0 ± 1.5 ,g mL,1). For its rich natural resources, simple extraction procedure and high yield (3.2%), HRW has the potential to be developed as a selective anti-cancer nutraceutical or pharmaceutical natural health product with low side effects and high economical return. [source]

Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents

PHYTOTHERAPY RESEARCH, Issue 4 2007
Zsuzsanna Hajdú
Abstract From the n -hexane fraction of the fruits of Vitex agnus-castus, two labdane-type diterpenes, vitetrifolin B and C, were isolated by means of multiple chromatographic separations, together with the previously identified rotundifuran, vitexilactone and the sesquiterpene spathulenol. From the EtOAc fraction, eupatorin was identified for the first time, besides the known casticin, penduletin, vitexin and orientin. The n -hexane, EtOAc and MeOH,H2O fractions of the MeOH extract of Agni-casti fructus were subjected to in vitro antioxidant assays. The EtOAc extract displayed a significant concentration-dependent effect when tested by 1,1-diphenyl-2-picrylhydrasyl (DPPH) free radical assay (IC50 = 68 µg/mL) and against the autooxidation of a standard rat brain homogenate (IC50 = 14 µg/mL). The MeOH,H2O fraction was less active with 3643 µg/mL (DPPH test) and IC50 = 125 µg/mL (rat brain homogenate), while the n -hexane phase proved to be inactive. The main flavonoid constituents of the EtOAc extract, casticin, vitexin and orientin were assayed for antioxidant activity and found that only casticin possesses a marked lipid peroxidation inhibitory effect (IC50 = 0.049 mm) compared with that of the positive control ascorbic acid (IC50 = 0.703 mm). Copyright © 2007 John Wiley & Sons, Ltd. [source]

Seasonal variation of the lipoidal matters and hypolipidaemic activity of the red alga Corallina officinalis L.

PHYTOTHERAPY RESEARCH, Issue 1 2003
N. E. Awad
Abstract The lipoidal matters of Corallina officinalis L. showed a seasonal nonsignificant quantitative variation. However, the fatty acids revealed a relative increase in the summer and winter, while unsaponifiable matter exhibited a slight increase in the spring. The GC/MS analysis of saponifiable and unsaponifiable matter of the algal samples collected in different seasons revealed that samples collected in the spring contained a low cholesterol content and high steroidal compounds as well as high polyunsaturated fatty acids. The alcohol extract, hexane extract and fatty acid fraction of this algal sample exhibited a significant hypolipidaemic activity. Also, two biologically active fractions of hydrocarbons were isolated by CC technique from the hexane fraction of C. officinalis L. and identified by GC/MS. Copyright © 2003 John Wiley & Sons, Ltd. [source]

Suppression of Root Rotting Fungi and Root Knot Nematode of Chili by Seaweed and Pseudomonas aeruginosa

JOURNAL OF PHYTOPATHOLOGY, Issue 7-8 2008
V. Sultana
Abstract Solvent fractions (i.e. n -hexane, chloroform and methanol) of the ethanol extracts of the seaweeds Codium iyengarii, Jania capillacea, Stokeyia indica and Solieria robusta caused more than 50% mortality of Meloidogyne javanica juveniles within 24 h at 10 mg/ml. Nematode mortality increased with an increase in fraction concentration or exposure time. The n -hexane fractions from S. indica, J. capillacea and C. iyengarii and the chloroform fraction from S. robusta also resulted in more than 50% mortality within 48 h at 1.0 mg/ml. In a screen-house experiment application of S. indica and S. robusta as soil amendments alone or with Pseudomonas aeruginosa, a plant growth promoting rhizobacterium (PGPR), significantly suppressed infection of chili roots by root-infecting fungi Macrophomina phaseolina, Rhizoctonia solani, Fusarium solani and the root knot nematode Meloidogyne javanica. Seaweed alone or with PGPR also increased plant growth. Suppressive effect on root pathogens and growth enhancement potential of seaweeds and P. aeruginosa were also effective in field plots. [source]