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Heterocyclic Analogues (heterocyclic + analogue)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

ChemInform Abstract: Tandem Furo[3,4-b]pyridine Formation,Diels,Alder Reaction: An Approach to the Synthesis of Nitrogen Containing Heterocyclic Analogues of 1-Arylnaphthalene Lignans.

CHEMINFORM, Issue 12 2008
Gouranga P. Jana
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Design and Structure,Activity Relationship of Heterocyclic Analogues of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones as Inhibitors of Receptors Tyrosine Kinases.

CHEMINFORM, Issue 29 2006
Cynthia M. Shafer
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Heterocyclic Analogues of 5,12-Naphthacenequinone.

CHEMINFORM, Issue 17 2006
Part 1.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Novel Heterocyclic Analogues of the HIV-1 Protease Inhibitor, Ritonavir.

CHEMINFORM, Issue 50 2004
Perry T. Kaye
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Transition Metal Complexes with Heterocyclic Analogues of Fluorene.

CHEMINFORM, Issue 5 2004
Part 1.
No abstract is available for this article. [source]

Synthesis of Cholesteryl Esters of Heterocyclic Analogues of Cinnamic Acid and Hetaroyloxycinnamic Acids by the Wittig Reaction.

CHEMINFORM, Issue 34 2003
V. N. Listvan
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Heterocyclic Analogues of Pleiadiene.

CHEMINFORM, Issue 19 2003
Part 72.
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Heterocyclic Analogues of Pleiadene.

CHEMINFORM, Issue 19 2003
Part 73.
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

ChemInform Abstract: On the Coupling of Aryldiazonium Salts with N,N-Disubstituted 2-Aminothiophenes and Some of Their Carbocyclic and Heterocyclic Analogues.

CHEMINFORM, Issue 20 2001
Horst Hartmann
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Modular chemical geometry and symbolic calculation

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Issue 1 2006
Michael P. Barnett
Abstract We discuss (a) the construction of formulas for the puckering of 4 and 5 atom rings from simple geometrical principles; (b) the application of these formulas to the study of cyclobutanes and heterocyclic analogues; (c) the way the derivations are represented (i.e., the style facilitates symbolic calculations for many more chemical topics; (d) interfacing the Gaussian package and Mathematica; and (e) some representations of molecular properties in Mathematica and algorithmic operations on these. © 2005 Wiley Periodicals, Inc. Int J Quantum Chem, 2006 [source]

Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type,II Dehydroquinase

CHEMMEDCHEM, Issue 2 2007
Verónica F.
Abstract Isomeric nitrophenyl and heterocyclic analogues of the known inhibitor (1S,3R,4R)-1,3,4-trihydroxy-5-cyclohexene-1-carboxylic acid have been synthesized and tested as inhibitors of M.,tuberculosis and S.,coelicolor type,II dehydroquinase, the third enzyme of the shikimic acid pathway. The target compounds were synthesized by a combination of Suzuki and Sonogashira cross-coupling and copper(I)-catalyzed 2,3-dipolar cycloaddition reactions from a common vinyl triflate intermediate. These studies showed that a para -nitrophenyl derivative is almost 20-fold more potent as a competitive inhibitor against the S.,coelicolor enzyme than that of M.,tuberculosis. The opposite results were obtained with the meta isomer. Five of the bicyclic analogues reported herein proved to be potent competitive inhibitors of S.,coelicolor dehydroquinase, with inhibition constants in the low nanomolar range (4,30,nM). These derivatives are also competitive inhibitors of the M.,tuberculosis enzyme, but with lower affinities. The most potent inhibitor against the S.,coelicolor enzyme, a 6-benzothiophenyl derivative, has a Ki value of 4,nM,over 2000-fold more potent than the best previously known inhibitor, (1R,4R,5R)-1,5-dihydroxy-4-(2-nitrophenyl)cyclohex-2-en-1-carboxylic acid (8,,M), making it the most potent known inhibitor against any dehydroquinase. The binding modes of the analogues in the active site of the S.,coelicolor enzyme (GOLD,3.0.1), suggest a key , -stacking interaction between the aromatic rings and Tyr,28, a residue that has been identified as essential for enzyme activity. [source]