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Amniotic Membrane Transplantation (amniotic + membrane_transplantation)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Amniotic membrane transplantation in the surgical management of symblepharon following toxic epidermal necrolysis

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 2 2006
L Atzori
[source]

Amniotic membrane transplantation in a perforated corneal graft: clinical and histopathological findings

ACTA OPHTHALMOLOGICA, Issue 2 2010
Mario Nubile
No abstract is available for this article. [source]

Amniotic membrane transplantation associated with a corneal patch in a paediatric corneal perforation

ACTA OPHTHALMOLOGICA, Issue 2 2010
Gustavo Savino
No abstract is available for this article. [source]

Donor age and gestational age influence on growth factor levels in human amniotic membrane

ACTA OPHTHALMOLOGICA, Issue 6 2010
Maria J. López-Valladares
Acta Ophthalmol. 2010: 88: e211,e216 Abstract. Purpose:, Amniotic membrane (AM) is used as a biomaterial for reconstruction in ocular surface surgery. This study investigated the influence of interdonor variations and processing and preservation procedures applied to the AM on growth factors and protein levels. Methods:, Samples of human AM from thirteen donors were analysed. Collected donor data were age, parity and gestational age. Total protein amount was measured in extracts of intact AM nonpreserved, lyophilized and cryopreserved, at ,80°C and in liquid nitrogen. An enzyme-linked immunosorbent assay (ELISA) was used to assay growth factors protein levels for epidermal growth factor, basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), transforming growth factor beta1 (TFG-,1) and nerve growth factor (NGF). Univariate and multivariate statistical analyses were used to study the influence of the preservation method applied and interdonor variations on growth factors levels. Results:, We detected important variations in growth factors and protein concentrations between samples from different donors. Total protein amount, bFGF, HGF, KGF and TGF-,1 showed lower levels in samples from donors with higher gestational ages and donor ages, for all groups. Conclusion:, The variability in the biochemical composition of AM from different donors is considerable, and it is related with donor factors as donor age and gestational age. As AM biochemical composition has a role in its therapeutic effects, these variations could affect the clinical results of amniotic membrane transplantation and must be taken into account in donor selection processes. [source]

Clinical decision paths in KPro Surgery

ACTA OPHTHALMOLOGICA, Issue 2009
G GRABNER
Purpose To analyse the currently available methods for treating very severe anterior segment disease, such as stem cell transplantation with amniotic membrane transplantation, lamellar and penetrating keratoplasty techniques, and the different Kpro´s currently available, in regard to the initial clinical findings, the potential complications encountered and the surgical requirements needed for the different techniques. Factors considered are: uni- or bilaterality, limbal stem cell status, dry eye status and availability of healthy teeth. Methods A systematic analysis of surgical options available for different stages of a variety of anterior segment diseases and currently published results of VA and complications Results With a systematic approach it becomes clear that some popular reconstructive surgical techniques should be avoided in cases where a very low chance of success is to be expected (e.g. amniotic membrane and stem cell transplantation and /or PKP in very dry eyes ,> these would have to be treated with OOKP). Conclusion Following a simple the clinical decision path the anterior segment surgeon will be presented with standardized guidelines for treating those patients where conventional surgical procedures have to be avoided and replaced by rather rarely performed KPro techniques. [source]

Evolution of amniotic membrane transplantation

CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 2 2007
Scheffer CG Tseng MD
No abstract is available for this article. [source]

Amniotic membrane grafting in the surgical management of primary pterygium

CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 5 2004
Rohan W Essex FRANZCO
Abstract Background:,To evaluate the efficacy of amniotic membrane transplantation in primary pterygium surgery. Methods:,Patients presenting to the outpatient clinic of the Royal Victorian Eye and Ear Hospital with primary pterygium requiring surgical management were included in this study. The pterygia were excised to bare sclera and the conjunctival defects were closed with amniotic membrane grafts. The primary outcome was pterygium recurrence. Results:,Twenty-eight pterygia of 26 patients were included. Twenty-three patients (88%, 25 eyes) completed 12 months follow up. By 12 months postoperatively 16 of these eyes (64%) had developed corneal recurrence and a further two had developed a limbal recurrence (9%). Five required repeat surgery during the 12 month follow-up period. No association was found between pterygium recurrence and pterygium size (P = 0.33), amniotic membrane graft dimension (P = 0.12), patient age (P = 0.53) or patient sex (P = 0.63). Conclusion:,Amniotic membrane grafting for primary pterygium was associated with an unacceptably high recurrence rate in this population. [source]