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Amide Bond Formation (amide + bond_formation)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

ChemInform Abstract: Amide Bond Formation with a New Fluorous Carbodiimide: Separation by Reverse Fluorous Solid-Phase Extraction.

CHEMINFORM, Issue 12 2008
Carlos del Pozo
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Amide Bond Formation Using an Air-Stable Source of AlMe3.

CHEMINFORM, Issue 46 2006
Andrew Novak
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Microwave-Assisted Sequential Amide Bond Formation and Intramolecular Amidation: A Rapid Entry to Functionalized Oxindoles.

CHEMINFORM, Issue 30 2005
Rajamohan R. Poondra
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Concise Total Synthesis of the Thiazolyl Peptide Antibiotic GE2270,A

CHEMISTRY - A EUROPEAN JOURNAL, Issue 8 2008
Oscar Delgado Dr.
Abstract The potent antibiotic thiazolylpeptide GE2270,A was synthesized starting from N - tert -butyloxycarbonyl protected valine in a longest linear sequence of 20 steps and with an overall yield of 4.8,%. Key strategy was the assembly of the 2,3,6-trisubstituted pyridine core by consecutive cross-coupling reactions starting from 2,6-dibromo-3-iodopyridine. The complete Southern fragment was installed by Negishi cross-coupling of 3-zincated 2,6-dibromopyridine at the terminal 2-iodothiazole of a trithiazole (87,%). The substituent at C-6 representing the Northern part of the molecule was introduced in form of the truncated tert -butyl 2-bromothiazole-4-carboxylate after metalation to a zinc reagent by another Negishi cross-coupling (48,%). Decisive step of the whole sequence was the macrocyclization to a 29-membered macrolactam, which was conducted as an intramolecular Stille cross-coupling occurring at C-2 of the pyridine core and providing the desired product in 75,% yield. The required stannane was obtained by amide bond formation (87,%) between a complex dithiazole fragment representing the Eastern part of GE2270,A and a 3,6-disubstituted 2-bromopyridine. Final steps included attachment of a serine-proline amide dipeptide to the Northern part of the molecule (65,%), formation of the oxazoline ring and silyl ether deprotection (55,% overall). [source]