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Growth Regulatory Activity (growth + regulatory_activity)
Selected AbstractsChemInform Abstract: Preparation of N,-[2-(5,6-Dimethylbenzothiazolyl)]-N-furfuryloxamide with Plant Growth Regulatory Activity.CHEMINFORM, Issue 5 2001Tokujiro Kitagawa Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Study on Structure and Biological Activities of Novel Triazole Compounds Containing 1,3-Dithiolane RingCHINESE JOURNAL OF CHEMISTRY, Issue 10 2005Liang-Zhong Xu Abstract Seven novel triazole compounds containing 1,3-dithiolane groups were synthesized according to the biological isosterism. Their structures were confirmed by means of elemental analysis, MS, 1H NMR, IR and X-ray crystallography. The results of preliminary biological tests showed that all of these compounds possess some antifungal and plant growth regulatory activities. [source] Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway,JOURNAL OF CELLULAR PHYSIOLOGY, Issue 2 2010Ricardo E. Perez Tumor-derived mutant forms of p53 compromise its DNA binding, transcriptional, and growth regulatory activity in a manner that is dependent upon the cell-type and the type of mutation. Given the high frequency of p53 mutations in human tumors, reactivation of the p53 pathway has been widely proposed as beneficial for cancer therapy. In support of this possibility p53 mutants possess a certain degree of conformational flexibility that allows for re-induction of function by a number of structurally different artificial compounds or by short peptides. This raises the question of whether physiological pathways for p53 mutant reactivation also exist and can be exploited therapeutically. The activity of wild-type p53 is modulated by various acetyl-transferases and deacetylases, but whether acetylation influences signaling by p53 mutant is still unknown. Here, we show that the PCAF acetyl-transferase is down-regulated in tumors harboring p53 mutants, where its re-expression leads to p53 acetylation and to cell death. Furthermore, acetylation restores the DNA-binding ability of p53 mutants in vitro and expression of PCAF, or treatment with deacetylase inhibitors, promotes their binding to p53-regulated promoters and transcriptional activity in vivo. These data suggest that PCAF-mediated acetylation rescues activity of at least a set of p53 mutations. Therefore, we propose that dis-regulation of PCAF activity is a pre-requisite for p53 mutant loss of function and for the oncogenic potential acquired by neoplastic cells expressing these proteins. Our findings offer a new rationale for therapeutic targeting of PCAF activity in tumors harboring oncogenic versions of p53. J. Cell. Physiol. 225: 394,405, 2010. © 2010 Wiley-Liss, Inc. [source] Synthesis and evaluation of novel ferrocene-substituted triadimenol analoguesAPPLIED ORGANOMETALLIC CHEMISTRY, Issue 12 2006Jianxin Fang Abstract In search of potent 1H -1,2,4-triazole derivatives with improving antifungal activity, a class of novel ferrocene,triadimenol analogues was synthesized and their biological potential evaluated. Screening data revealed that these new derivatives did not have the antifungal activities of parent compounds, but showed unexpectedly promising plant growth regulatory activity. Copyright © 2006 John Wiley & Sons, Ltd. [source] | ||||||||||