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Greatest Promise (greatest + promise)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Assessing the validity of potential alcohol-related non-fatal injury indicators

ADDICTION, Issue 3 2008
John Langley
ABSTRACT Aim To assess critically the face validity of the World Health Organization's (WHO's) International Guide for Monitoring Alcohol Consumption and Related Harm (MACRH) for deriving indicators, for the purposes of developing non-fatal alcohol-related injury indicators in New Zealand. Design MACRH's five solutions for deriving indicators are: (i) use only alcohol-specific cases; (ii) identify subsets of events known to be highly alcohol-related; (iii) utilize control indicators that are rarely alcohol-related; (iv) estimate alcohol attributable fractions (AAFs) and adjust indicators accordingly; and (v) develop composite indicators. These were assessed in terms of their face validity with particular reference to New Zealand. Findings There are significant face validity issues with each of the five options. Solution 4 offers the greatest promise, provided that: (i) valid AAFs can be derived and they are updated regularly; and (ii) appropriate adjustment is made for extraneous influences on the estimates of alcohol-related harm. To date, the latter has not been carried out. Conclusions Most potential sources of data on alcohol-related harm are subject to extraneous influences, which vary over time and space. While the attempt by WHO to offer solutions to this problem is laudable, the solutions do not address the problem adequately. MACRH guidelines need to be revised to include criteria for a valid outcome indicator. [source]

Theories of drug craving, ancient and modern

ADDICTION, Issue 1 2001
D. Colin Drummond
This paper reviews the principal theoretical models of drug craving and provides some directions for future research. The main models are classified broadly into three categories: (1) phenomenological models; based on clinical observation and description; these have been influential in classification systems of addictive disorders and in the development of pharmacological therapies; (2) conditioning models: based on conditioning theory; these have been influential in the development of cue exposure treatments; (3) cognitive theories; based on cognitive social learning theory: these have been influential in the development of cognitive therapies of addiction. It is concluded that no one specific theory provides a complete explanation of the phenomenon of craving. However, theories of craving grounded in general theories of human behaviour offer greatest promise, and generate more specific and testable research hypotheses. Theories that do not require craving to be present for relapse to occur have more empirical support than those that provide simplistic causal explanations. The cue-reactivity model shows promise in the exploration of the relationship between craving and relapse. However, further attention to the phenomenology of craving could help to advise the future measurement and study of drug craving, particularly in the context of research in which drugs are available to human subjects, with adequate ethical safeguards. There is a need for further study of the temporal dynamics of craving and consensus in the field on the most appropriate methods of measurement. Finally, new psychotherapies such as cue exposure and pharmacotherapies that aim to attenuate drinking behaviour, such as naltrexone and acamprosate, provide opportunities to improve understanding of the nature and significance of craving. However, the relatively uncritical assumption that craving is the underlying basis of addiction and represents the most appropriate target for treatment is challenged. [source]

Computation of an unsteady complex geometry flow using novel non-linear turbulence models

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 9 2003
Paul G. Tucker
Abstract Non-linear zonal turbulence models are applied to an unsteady complex geometry flow. These are generally found to marginally improve predicted turbulence intensities. However, relative to linear models, convergence is mostly difficult to achieve. Clipping of some non-linear Reynolds stress components is required along with velocity field smoothing or alternative measures. Smoothing is naturally achieved through multilevel convergence restriction operators. As a result of convergence difficulties, generally, non-linear model computational costs detract from accuracy gains. For standard Reynolds stress model results, again computational costs are prohibitive. Also, mean velocity profile data accuracies are found worse than for a simple mixing length model. Of the non-linear models considered, the explicit algebraic stress showed greatest promise with respect to accuracy and stability. However, even this shows around a 30% error in total (the sum of turbulence and unsteadiness) intensity. In strong contradiction to measurements the non-linear and Reynolds models predict quasi-steady flows. This is probably a key reason for the total intensity under-predictions. Use of LES in a non-linear model context might help remedy this modelling aspect. Copyright © 2003 John Wiley & Sons, Ltd. [source]

Biotic homogenization: a new research agenda for conservation biogeography

JOURNAL OF BIOGEOGRAPHY, Issue 12 2006
Julian D. Olden
Abstract Aim, Biotic homogenization describes the process by which species invasions and extinctions increase the genetic, taxonomic or functional similarity of two or more biotas over a specified time interval. The study of biotic homogenization is a young and rapidly emerging research area in the budding field of conservation biogeography, and this paper aims to synthesize our current knowledge of this process and advocate a more systematic approach to its investigation. Methods, Based on a comprehensive examination of the primary literature this paper reviews the process of biotic homogenization, including its definition, quantification, underlying ecological mechanisms, environmental drivers, the empirical evidence for different taxonomic groups, and the potential ecological and evolutionary implications. Important gaps in our knowledge are then identified, and areas of new research that show the greatest promise for advancing our current thinking on biotic homogenization are highlighted. Results, Current knowledge of the patterns, mechanisms and implications of biotic homogenization is highly variable across taxonomic groups, but in general is incomplete. Quantitative estimates are almost exclusively limited to freshwater fishes and plants in the United States, and the principal mechanisms and drivers of homogenization remain elusive. To date research has focused on taxonomic homogenization, and genetic and functional homogenization has received inadequate attention. Trends over the past decade, however, suggest that biotic homogenization is emerging as a topic of greater research interest. Main conclusions, My investigation revealed a number of important knowledge gaps and priority research needs in the science of biotic homogenization. Future studies should examine the homogenization process for different community properties (species occurrence and abundance) at multiple spatial and temporal scales, with careful attention paid to the various biological mechanisms (invasions vs. extinctions) and environmental drivers (environmental alteration vs. biotic interactions) involved. Perhaps most importantly, this research should recognize that there are multiple possible outcomes resulting from the accumulation of species invasions and extinctions, including biotic differentiation whereby genetic, taxonomic or functional similarity of biotas decreases over time. [source]

From gap gazing to promising cases: Moving toward equity in urban education reform,

JOURNAL OF RESEARCH IN SCIENCE TEACHING, Issue 10 2001
Alberto J. Rodriguez
A case analysis of the Miami-Dade Urban Systemic Initiative is presented in this article, citing this initiative as one of the sites with the greatest promise for affecting equity issues. Using a grounded-theory methodological approach, a general framework for systemic reform was developed as a tool to examine the particulars of systemic reform initiatives and their potential to impact the teaching and learning of science and mathematics in diverse school contexts. It was found that to better understand the effectiveness of systemic reform initiatives requires answering two basic questions: What is the (pedagogical and ideological) systemic conceptual clarity guiding the reform efforts? And, what is the operational approach? Once answers to these questions are found, it becomes easier to explore how key officials are implementing or not implementing other aspects of systemic reform. The article also explains why less attention should be given to student outcomes (based on standardized tests) as the main indicator of success in systemic reform. Instead, it is proposed that insights gained from studying the particulars of promising initiatives can help others stimulate systemic reform in their own contexts, especially in urban contexts, which usually have few resources and a large population of students who are traditionally underserved. © 2001 John Wiley & Sons, Inc. J Res Sci Teach 38: 1115,1129, 2001 [source]

Approaches to the identification of susceptibility genes

PARASITE IMMUNOLOGY, Issue 5 2009
A. COLLINS
SUMMARY Although previous studies have revealed a great deal about the genetic basis of susceptibility and resistance to parasite infection, there is now an opportunity to considerably enhance understanding through genome-wide association mapping. The application of association mapping to complex inheritance has recently become achievable given reduced costs, sophisticated genotyping platforms and powerful statistical methods which build upon increased knowledge of the linkage disequilibrium structure of the human genome. Linkage mapping and related approaches remain useful for the localization of the rarer genetic variants and candidate region association studies can be a very cost-effective route to progress. However, genome-wide association offers the greatest promise, despite the challenges posed by phenotype complexity, ensuring genotype coverage/quality and robust statistical analysis. The available approaches for mapping genes underlying susceptibility are reviewed here, emphasizing their relative merits and drawbacks and highlighting specific software tools and resources that enable successful mapping. [source]

Informatics and Knowledge Translation

ACADEMIC EMERGENCY MEDICINE, Issue 11 2007
Michael J. Bullard MD
To ensure that the benefits of knowledge translation synthesis are accessible to care providers at the point of decision-making, fast, efficient, usable clinical information systems are required. Medical informatics appears to hold the greatest promise to be able to create systems with the necessary capacity and functionality. Emergency medicine needs to be actively engaged at all levels of the process. This includes driving the development and filtering of emergency-specific synopses and summaries. It requires advocating for hardware and software that suit the needs of the emergency department environment. It is increasingly important to educate and participate on committees with funders and policy-makers to ensure they support this growing evolution. To determine the outcome of these initiatives, careful evaluation is required to inform the discussion. End-users need to be actively involved in the development and usability testing of clinical information retrieval technology and clinical decision-support systems and make certain relevant best evidence is readily accessible and formatted to meet the needs of the working emergency physician. The integration of knowledge translation into clinical practice, and the impact of delivering electronic clinical decision-support, requires methodologically sound studies to confirm or refute its benefits and guide future development of medical informatics. [source]

Anxiety and Its Disorders: Implications for Pharmacotherapy

CLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 2 2010
Jonathan S. Abramowitz
[Clin Psychol Sci Prac 17: 104,106, 2010] Otto, McHugh, and Kantak (2010) have crafted a model to account for the observation that pharmacologic treatments do not reliably add to the effectiveness of cognitive-behavioral therapy (CBT) for anxiety disorders. In this commentary, we discuss the nature of anxiety and its disorders and review three approaches to the pharmacotherapy of these psychological disorders. When the implications of these approaches are considered, the use of N -methyl- d -aspartate agonists, in theory, holds the greatest promise for a pharmacological treatment to complement CBT for anxiety disorders. [source]