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Greater Significance (greater + significance)
Selected AbstractsPerceptions of nurses, families, and residents in nursing homes concerning residents' needsINTERNATIONAL JOURNAL OF NURSING PRACTICE, Issue 3 2008Merav Ben Natan RN PhD StudentArticle first published online: 5 MAY 200 This study examined the congruence between needs identified as significant by older adults in comparison with caregivers (nurses) and elders' families. The study involved 44 patients, 94 nurses and 44 families from the Shoham Geriatric Center in Pardes Hanna, Israel. The findings are based on data gathered through questionnaires distributed at the nursing home. The findings indicate a discrepancy between residents' needs as identified by the staff, the families and the elderly residents themselves. An analysis based on primary needs showed that in comparison with the residents and their families, the nurses attributed greater significance to values and personal outlook of the residents, provision of proficient physical care, skilled mental support, social life and institutional requirements. Families attributed the most significance to the provision of information and family involvement, and in contrast, according to the residents, the most important area was skilled mental/emotional support. Also discussed are the research and practical implications of these findings. [source] Sexual conflict and indirect benefitsJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 5 2003E. Cameron Abstract Recent work on sexual selection and sexual conflict has explored the influence of indirect effects on the evolution of female mating behaviour. It has been suggested that the importance of these effects has been underestimated and that the influence of indirect effects may actually be of relatively greater significance than direct effects. Additionally, it has also been suggested that all indirect effects, both good genes and sexy son, are qualitatively equivalent. Here a counterpoint to these suggestions is offered. We argue two main points: (1) it is unlikely that indirect effects will commonly outweigh direct effects, and (2) that there are important differences between good genes and sexy son indirect effects that must be recognized. We suggest that acknowledgement of these distinctions will lead to increased understanding of processes operating in both sexual conflict and sexual selection. [source] Inflammatory bowel disease: new insights into pathogenesis and treatmentJOURNAL OF INTERNAL MEDICINE, Issue 6 2002S. Ardizzone Abstract., Ardizzone S, Bianchi Porro G (,L. Sacco' University Hospital, Milan, Italy). Inflammatory bowel disease: new insights into pathogenesis and treatment (Review). J Intern Med 2002; 252: 475,496. Despite all the advances in our understanding of the pathophysiology of inflammatory bowel disease (IBD), we do not know the cause. Some of the most recently available data have been discussed here and yet it is now becoming increasingly accepted that immunogenetics play an important role in the predisposition, modulation, and perpetuation of IBD. The mucosal immune system is the central effector of intestinal inflammation and injury, with cytokines playing a central role in modulating inflammation. The role of intestinal milium, and enteric flora in particular, appears to be of greater significance than previously held. A review is made of the main areas of research exploring the mechanisms more intimately associated with the development of IBD, providing advances in the agents currently used, and identifying a host of new therapeutic agents potentially interacting with or interrupting specific targets in the genesis of IBD. [source] Proteomic strategies to elucidate pathogenic mechanisms of spirochetesPROTEOMICS - CLINICAL APPLICATIONS, Issue 9 2007Jarlath E. Nally Dr. Abstract Spirochetes are a unique group of bacteria that include several motile and highly invasive pathogens that cause a multitude of acute and chronic disease processes. Nine genomes of spirochetes have been completed, which provide significant insights into pathogenic mechanisms of disease and reflect an often complex lifestyle associated with a wide range of environmental and host factors encountered during disease transmission and infection. Characterization of the outer membrane of spirochetes is of particular interest since it interacts directly with the host and environs during disease and likely contains candidate vaccinogens and diagnostics. In concert with appropriate fractionation techniques, the tools of proteomics have rapidly evolved to characterize the proteome of spirochetes. Of greater significance, studies have confirmed the differential expression of many proteins, including those of the outer membrane, in response to environmental signals encountered during disease transmission and infection. Characterization of the proteome in response to such signals provides novel insights to understand pathogenic mechanisms of spirochetes. [source] Effectiveness of participation as a defendant: the attorney,juvenile client relationship,BEHAVIORAL SCIENCES & THE LAW, Issue 2 2003Melinda G. Schmidt M.A. Recent changes in the processing of juveniles in the justice system place greater significance on children's capacities to participate in legal contexts. Effective participation as a defendant encompasses abilities beyond those legally required for adjudicative competence, which may nevertheless influence the quality and nature of a defendant's participation in the trial process. Based in developmental judgment theory, the current study compares 203 juveniles and 110 adults detained pre-trial using a hypothetical attorney,client vignette to examine how psychosocial factors are reflected in decision-making processes and link to decision outcomes and effective participation within the attorney,client relationship. Age-related differences in legally relevant decision-making processes and outcomes are identified, and implications for policy are made. Copyright © 2003 John Wiley & Sons, Ltd. [source] Stem cell-based composite tissue constructs for regenerative medicineBIOTECHNOLOGY & BIOENGINEERING, Issue 3 2005Mohamed N. Rahaman Abstract A major task of contemporary medicine and dentistry is restoration of human tissues and organs lost to diseases and trauma. A decade-long intense effort in tissue engineering has provided the proof of concept for cell-based replacement of a number of individual tissues such as the skin, cartilage, and bone. Recent work in stem cell-based in vivo restoration of multiple tissue phenotypes by composite tissue constructs such as osteochondral and fibro-osseous grafts has demonstrated probable clues for bioengineered replacement of complex anatomical structures consisting of multiple cell lineages such as the synovial joint condyle, tendon-bone complex, bone-ligament junction, and the periodontium. Of greater significance is a tangible contribution by current attempts to restore the structure and function of multitissue structures using cell-based composite tissue constructs to the understanding of ultimate biological restoration of complex organs such as the kidney or liver. The present review focuses on recent advances in stem cell-based composite tissue constructs and attempts to outline challenges for the manipulation of stem cells in tailored biomaterials in alignment with approaches potentially utilizable in regenerative medicine of human tissues and organs. © 2005 Wiley Periodicals, Inc. [source] | |||||||||||||