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Greater Occurrence (greater + occurrence)
Selected AbstractsComparison of Fracture, Cardiovascular Event, and Breast Cancer Rates at 3 Years in Postmenopausal Women with OsteoporosisJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 9 2004Stuart L. Silverman MD Objectives: To compare event rates for osteoporotic fractures, cardiovascular events, and breast cancer in postmenopausal women with osteoporosis. Design: A prospective, observational study of the placebo group in the double-blind, randomized Multiple Outcomes of Raloxifene Evaluation trial. Setting: One hundred eighty clinical research centers in 25 countries. Participants: Postmenopausal women (n=2,565, mean age=67) with osteoporosis were given calcium (500 mg/d) and vitamin D (400,600 IU/d) supplements. Measurements: The occurrence of at least one new fracture, cardiovascular event, or breast cancer diagnosis at 3 years was identified and adjudicated. Results: The occurrence of any fracture was the most common event in these women. In women without prevalent vertebral fractures (n=1,627), the event rates per 1,000 patient-years were 45.4 for any fracture, 15.2 for vertebral fracture, 4.7 for clinical vertebral fracture, 0.9 for hip fracture, 8.3 for any cardiovascular event, and 5.2 for all breast cancer. In women with prevalent vertebral fractures (n=938), the event rates per 1,000 patient-years were 117.4 for any new fracture, 77.1 for new vertebral fracture, 25.7 for clinical vertebral fracture, 5.8 for hip fracture, 15.1 for any cardiovascular event, and 2.6 for all breast cancer. The effect of prevalent fracture status on event rates was not dependent on whether women were older or younger than 65, but women aged 65 and older had a 3.6 times greater occurrence of cardiovascular events than younger women, irrespective of prevalent fracture status. Conclusion: These data on the relative incidence of clinically significant skeletal and extra-skeletal outcomes may be useful in choosing an agent for health maintenance for postmenopausal women with osteoporosis. [source] Sex Modulates the Arrhythmogenic Substrate in Prepubertal Rabbit Hearts with Long QT 2JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 5 2005Ph.D., TONG LIU M.D. Females have a greater susceptibility to Torsade de Pointes in congenital and drug-induced long QT syndrome (LQTS) that has been attributed to the modulation of ion channel expression by sex hormones. However, little is known regarding sex differences in pre-puberty, that is, before the surge of sexual hormones. In patients with congenital LQTS types 1 and 2, male children tend to have a greater occurrence of adverse events, especially in 10,15 year olds, than their female counterpart. To evaluate whether the rabbit model of drug-acquired LQTS exhibits similar age dependences, hearts of prepubertal rabbits were perfused, mapped optically to record action potentials (APs) and treated with an IKr blocker, E4031 to elicit LQTS2. As expected, AP durations (APD) were significantly longer in female (n = 18) than male hearts (n = 10), at long cycle length. Surprisingly, E4031 (50,250 nM) induced a greater prolongation of APDs in male than in female hearts, and in both genders reversed the direction of repolarization (apex , base to base , apex), enhancing dispersions of repolarization. Furthermore, in male hearts, E4031 (0.5 ,M) elicited early afterdepolarizations (EADs) that progressed to polymorphic ventricular tachycardia (PVT) (n = 7/10) and were interrupted by isoproterenol (40 nM) and prevented by propranolol (0.5,2.5 ,M). In female hearts, E4031 (0.5 ,M) produced marked prolongations of APDs yet few EADs with no progression to PVT (n = 16/18). Thus, sex differences are opposite in prepubertal versus adult rabbits with respect to E4031-induced APD prolongation, EADs and PVT, underscoring the fact that APD prolongation alone is insufficient to predict arrhythmia susceptibility. [source] Density and habitat associations of Henslow's Sparrows wintering in saline soil barrens in southern ArkansasJOURNAL OF FIELD ORNITHOLOGY, Issue 4 2008William C. Holimon ABSTRACT Although the habitat requirements of breeding populations of Henslow's Sparrow (Ammodramus henslowii) have been examined, less is known about their habitat requirements and ecology during the nonbreeding season. We estimated population densities and quantified habitat associations of Henslow's Sparrows wintering in saline soil barrens in southern Arkansas. Densities of Henslow's Sparrows in the saline soil barrens were similar to those in the Longleaf Pine (Pinus palustris) Ecosystem of the southeastern United States, considered by many to be their primary wintering habitat. Henslow's Sparrows were closely associated with open areas with greater cover of Aristida spp. and globe beaksedge (Rhynchospora globularis), greater stem density at 11,20 cm above ground, more lichens, more herbaceous cover, more bare ground, greater occurrence of little bluestem (Schizacyrium scoparium) as the tallest vegetation, less moss, and less shrub cover than randomly selected sites. In contrast to the results of studies conducted in the Longleaf Pine Ecosystem, the presence of Henslow's Sparrows in our study was not correlated with the height of the tallest vegetation. Our results indicate that saline soil barrens of southern Arkansas support a high density of wintering Henslow's Sparrows and do so for longer postdisturbance periods than longleaf pine savanna. We also found that stem density near the ground was similar to that reported from longleaf pine savanna, but only about half that observed on their breeding grounds. Areas used by Henslow's Sparrows had more lichen and less moss cover, suggesting that those areas were drier than random sites within the barrens. Further research is needed to determine if large populations of Henslow's Sparrows winter in other saline soil barrens and if fire influences habitat associations and densities in the barrens. SINOPSIS Aunque los requisitos de hábitat para las poblaciones reproductivas de Ammodramus henslowii han sido determinadas, se conoce muy poco sobre su ecología y requerimientos de hábitat durante la temporada no-reproductiva. Estimamos la densidad poblacional y cuantificamos el hábitat asociado a Gorrión de Henslow que pasan el invierno en un salitral con suelo empobrecido en el sur de Arkansas. La densidad de las aves en el salitral resultó similar a lo encontrado en Ecosistemas de Pinos (Pinus palustris) en el sureste de los EUA, considerado por muchos como el principal hábitat invernal para la especie. Los gorriones estuvieron altamente asociados a áreas abiertas con covertura de Aristida spp. y Rhynchospora globularis, con mayor densidad de tallos, altura entre 11,20 cm sobre el suelo, mayor cantidad de líquenes, mayor cubierta herbácea, más suelo desnudo, mayor presencia de Schzacyrium scoparium (como la vegetación de mayor tamańo), menos musgos, y menos arbustos que localidades seleccionadas al azar. En contraste a los resultados de estudios conducidos en Ecosistemas de Pinos, la presencia del gorrión en nuestra área de estudio no estuvo correlacionada con la altura de la vegetación de mayor tamańo. Nuestros resultados indican que las salinas en Arkansas sostienen una alta densidad de aves invernales, y lo hacen por periodos más largos, después de disturbios, que en las savanas de pinos. También encontramos que la densidad de tallos, cerca del suelo, era similar a la informada en savanas de pinos, pero tan solo la mitad de lo indicado para lugares en donde las aves se reproducen. Las áreas utilizadas tienen más líquenes, pero menos musgos, lo que sugiere que dichas áreas son más secas que lugares con suelo empobrecido muestreados al azar. Se necesitan más trabajos para determinar si otras grandes poblaciones del gorrión de Henslow pasan el invierno en otras salinas con suelos empobrecidos y si eventos como fuegos incluyen en la asociación del hábitat y densidades en los lugares con suelo empobrecido. [source] Pre- and postnatal diagnosis and outcome of fetuses and neonates with esophageal atresia and tracheoesophageal fistulaPRENATAL DIAGNOSIS, Issue 3 2010E. M. de Jong Abstract Objectives Clinical symptoms and ultrasound signs during pregnancy could suggest the presence of esophageal atresia (EA). However, most often EA is diagnosed postnatally. The aim of our study is to evaluate the course and outcome for prenatally and postnatally diagnosed EA. In addition, we studied the outcome of isolated versus nonisolated EA. Methods In a retrospective data analysis, ultrasound characteristics, maternal and neonatal variables as well as clinical outcome were compared for fetuses/neonates with prenatal (n = 30) or postnatal (n = 49) diagnosis of EA. Clinical outcome in terms of morbidity and mortality of isolated EA was compared with that of EA complicated by chromosomal or structural anomalies. Results Prenatally diagnosed children were born 2 weeks earlier than postnatally diagnosed children (36.4 weeks vs 38.2 weeks; P = 0.02). The former had higher mortality rates (30 vs 12%; P = 0.05) and more associated anomalies (80 vs 59%; P = 0.04). In both subsets, there was a high morbidity rate in the survivors (not significant). Nonisolated EA was associated with greater occurrence of polyhydramnios (53 vs 27%; P = 0.04) and higher mortality rate (28 vs 0%; P = 0.002). Conclusions Mortality was significantly higher in prenatally diagnosed infants and in infants with additional congenital anomalies. Isolated EA is associated with good outcome. Copyright © 2010 John Wiley & Sons, Ltd. [source] | |||||||||||||