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Selected AbstractsAlteration of proteins expression in apoptotic FL cells induced by MCLRENVIRONMENTAL TOXICOLOGY, Issue 4 2008Ming-Luan Xing Abstract Microcystins (MCs) are a family of monocyclic heptapeptide hepatotoxins produced by freshwater species of cyanobacteria. Microcystin-LR (MCLR) is the most frequently studied and most toxic in over 80 MC congeners. Great deals of studies have demonstrated that MCLR can induce apoptosis in a wide variety of cell types. Although much evidence indicates that mitochondria play a pivotal role in MCLR-induced apoptosis, the complicated apoptosis mechanisms induced by MCLR have not been completely characterized. It is possible that there are other apoptotic pathways existing in MCLR-induced apoptosis. The present study was undertaken to determine the expression of PP2A, CHOP, Bax, Bcl-2, and p53 proteins in MCLR-induced apoptosis in FL cells. The results showed that MCLR could induce apoptosis in FL cells and the process was accompanied with the upregulation of PP2A, Bax, and p53 proteins and the downregulation of Bcl-2 proteins. In addition, the CHOP protein was upregulated at most treatment groups and decreased at the highest concentration group. These results, especially the alteration of PP2A and CHOP proteins might provide new insights into MCLR-induced apoptosis. © 2008 Wiley Periodicals, Inc. Environ Toxicol 2008. [source] Health Monitoring of Rehabilitated Concrete Bridges Using Distributed Optical Fiber SensingCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 6 2006Wei Zhang As newly developed techniques, distributed optical fiber sensing (DOFS) have gradually played a prominent role in structural health monitoring for the last decade. This article focuses on the employment of two types of DOFS, namely fiber Bragg grating (FBG) and Brillouin optical time domain reflectometry (BOTDR), into an integrated HMS for rehabilitated RC girder bridges by means of a series of static and dynamic loading tests to a simply supported RC T-beam strengthened by externally post-tensioned aramid fiber reinforced polymer (AFRP) tendons. Before the loading tests, a calibration test for FBG and another one for BOTDR were implemented to, respectively, obtain good linearity for both of them. Monitoring data were collected in real time during the process of external strengthening, static loading, and dynamic loading, respectively, all of which well identified the relevant structural state. The beam was finally vibrated for 2 million cycles and then loaded monotonously to failure. Based on the bending strength of externally prestressed members, ultimate values for the test specimen were numerically computed via a newly developed simplified model, which satisfactorily predicted the ultimate structural state of the beam. And then the alert values were adopted to compare with the monitoring results for safety alarm. The investigation results show a great deal of applicability for the integrated SHM by using both DOFS in rehabilitated concrete bridges strengthened by external prestressing. [source] Making sense of CSR communicationCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 3 2009Paul Ziek Abstract Although a great deal of research has focused on communicating Corporate Social Responsibility (CSR), the literature is diverse and encompasses a plethora of theories and approaches. It is still unclear what communicative behaviors carry the messages of organizational virtuosity and the implementation of responsible initiatives. What is missing is a simple, inclusive assessment of how organizations explicitly communicate the behaviors that constitute CSR. Accordingly, the purpose of this paper is to provide an illustration of the accounts that constitute CSR communication. Fifty US firms are examined for CSR moves within a variety of organizational contexts. The results show that communicating CSR is limited to large organizations and primarily, that they communicate CSR by conveying information about classically accepted responsible and virtuous behaviors. This patterned communicative behavior is a process that organizations engage in to make sense of CSR. Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment. [source] Transgenic mice for studies of the renin,angiotensin system in hypertensionACTA PHYSIOLOGICA, Issue 4 2004J. L. Lavoie Abstract Hypertension is a polygenic and multi-factorial disorder that is extremely prevalent in western societies, and thus has received a great deal of attention by the research community. The renin,angiotensin system has a strong impact on the control of blood pressure both in the short- and long-term, making it one of the most extensively studied physiological systems. Nevertheless, despite decades of research, the specific mechanisms implicated in its action on blood pressure and electrolyte balance, as well as its integration with other cardiovascular pathways remains incomplete. The production of transgenic models either over-expressing or knocking-out specific components of the renin,angiotensin system has given us a better understanding of its role in the pathogenesis of hypertension. Moreover, our attention has recently been refocused on local tissue renin,angiotensin systems and their physiological effect on blood pressure and end-organ damage. Herein, we will review studies using genetic manipulation of animals to determine the role of the endocrine and tissue renin,angiotensin system in hypertension. We will also discuss some untraditional approaches to target the renin,angiotensin system in the kidney. [source] 5-Aminolevulinic Acid Photodynamic Therapy: Where We Have Been and Where We Are GoingDERMATOLOGIC SURGERY, Issue 8 2004Michael H. Gold MD Background. Photodynamic therapy, utilizing the topical administration of 20% 5-aminolevulinic acid, has generated a great deal of interest in the dermatology community over the past several years. Objective. The purpose of this article is to review the history of photodynamic therapy in dermatology and to review recent new advances with this technology that will increase its appeal to all dermatologists. Methods. A literature review and results of new clinical trials with regards to photorejuvenation and acne vulgaris treatments with 5-aminolevulinic acid photodynamic therapy are presented. Results. Short-contact, full-face 5-aminolevulinic acid photodynamic therapy treatments with a variety of lasers and light sources have shown to be successful in treating all facets of photorejuvenation and the associated actinic keratoses as well as disorders of sebaceous glands, including acne vulgaris. The treatments are relatively pain-free, efficacious, and safe. They are also making already available laser/light source therapies work better for acne vulgaris and photorejuvenation. Conclusions. The use of 5-aminolevulinic acid photodynamic therapy with short-contact, full-face broad-application therapy is now able to bridge the world of medical and cosmetic dermatologic surgery. This therapy is available for all dermatologists to utilize in the care of their patients. [source] Families and children with hearing loss: Grief and copingDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 4 2003Ellen Kurtzer-White Abstract Parental coping with the diagnosis of their child's hearing impairment has not received a great deal of research attention, despite the evident importance of it. Parental coping has been changing with the inception of newborn screening as we move from a parent-initiated model of diagnosis to an institution-initiated model. Coping now begins without any preparation, and without any time for parents to "enjoy" their child as "normal." The grief models, based on the death experience, usually employed to describe parental reactions to the diagnosis may also be inappropriate. Death grief is terminable whereas parental grief is chronic. There is not sufficient research on the long-term effects of chronic grief and how that impacts on parent-child bonding. There is evidence that our screening endeavors have far outstripped our habilitation efforts, leaving parents with a diagnosis but without support. This gap must be closed. MRDD Research Reviews 2003;9:232,235. © 2003 Wiley-Liss, Inc. [source] Insulin resistance, diabetes and cardiovascular risk: approaches to treatmentDIABETES OBESITY & METABOLISM, Issue 6 2005Daniel E. Rosenberg Abstract:, The prevalence of diabetes is increasing worldwide. Insulin resistance and diabetes mellitus are major predictors of cardiovascular ischaemic disease. Other risk factors for cardiovascular death including hypertension, dyslipidaemia, smoking and visceral obesity are especially lethal in diabetics. C-reactive protein, plasminogen activator inhibitor-1, matrix metalloproteinases and other emerging risk factors and their roles are continually being researched and discovered. Treatment of this syndrome must be aimed at lifestyle modification, glycaemic control and management of concomitant risk factors. Diet and exercise play a vital role in the treatment of diabetes and the metabolic syndrome. Weight reduction and increased physical activity will improve insulin resistance, hyperglycaemia, hypertension and dyslipidaemia. Hypertension management has been shown to be especially important in diabetics to prevent cardiovascular events. Likewise, multiple clinical trials show that reduction of cholesterol is even more vital in diabetics than the general population for risk reduction of coronary disease. There is a great deal of evidence that tight control of glycaemia is essential to treatment of this condition. There are a variety of available pharmacological agents available including metformin, insulin secretagogues, alpha-glucosidase inhibitors, thiazolidinediones and insulin. The mechanisms and side effects of these medications are discussed. As macrovascular disease is the major cause of morbidity and mortality, an early, aggressive, multi-factorial approach to treatment of the metabolic syndrome and diabetes is vital to prevent adverse cardiac outcomes. [source] Our Knowledge of Numbers as Self-Subsistent ObjectsDIALECTICA, Issue 2 2005William Demopoulos A feature of Frege's philosophy of arithmetic that has elicited a great deal of attention in the recent secondary literature is his contention that numbers are ,self-subsistent' objects. The considerable interest in this thesis among the contemporary philosophy of mathematics community stands in marked contrast to Kreisel's folk-lore observation that the central problem in the philosophy of mathematics is not the existence of mathematical objects, but the objectivity of mathematics. Although Frege was undoubtedly concerned with both questions, a goal of the present paper is to argue that his success in securing the objectivity of arithmetic depends on a less contentious commitment to numbers as objects than either he or his critics have supposed. As such, this paper is an articulation and defense of both Frege's analysis of arithmetic and Kreisel's observation. [source] Are fish oils an effective therapy in mental illness , an analysis of the dataACTA PSYCHIATRICA SCANDINAVICA, Issue 1 2000Ian D. Maidment Objective: To review the literature regarding the use of fish oils in the treatment of psychiatric illness. Method: A Medline search was conducted in September 1999. Results: Five papers have investigated omega-3 fatty acids levels in depression. One study used omega-3 fatty acids as an adjunctive therapy in bipolar disorder. Four studies used fatty acids as an adjunctive therapy in schizophrenia. Conclusion: There is a great deal of current research in this field. While omega-3 fatty acids levels may be lowered in depression, there are no data suggesting that omega-3 fatty acids are effective. One paper indicates that omega-3 fatty acids are effective in bipolar disorders. The data on schizophrenia are conflicting. Omega-3 and omega-6 fatty acids have proved effective. Most of the evidence suggests that the main effect is an improvement in negative symptoms. One recent study showed that omega-3 fatty acids had no effect on negative symptoms. [source] Female Adolescents and Their Sexuality: Notions of Honour, Shame, Purity and Pollution during the FloodsDISASTERS, Issue 1 2000Sabina Faiz Rashid This paper explores the experiences of female adolescents during the 1998 floods in Bangladesh, focusing on the implications of socio-cultural norms related to notions of honour, shame, purity and pollution. These cultural notions are reinforced with greater emphasis as girls enter their adolescence, regulating their sexuality and gender relationships. In Bangladeshi society, adolescent girls are expected to maintain their virginity until marriage. Contact is limited to one's families and extended relations. Particularly among poorer families, adolescent girls tend to have limited mobility to safeguard their ,purity'. This is to ensure that the girl's reputation does not suffer, thus making it difficult for the girl to get married. For female adolescents in Bangladesh, a disaster situation is a uniquely vulnerable time. Exposure to the unfamiliar environment of flood shelters and relief camps, and unable to maintain their ,space' and privacy from male strangers, a number of the girls were vulnerable to sexual and mental harassment. With the floods, it became difficult for most of the girls to be appropriately `secluded'. Many were unable to sleep, bathe or get access to latrines in privacy because so many houses and latrines were underwater. Some of the girls who had begun menstruation were distressed at not being able to keep themselves clean. Strong social taboos associated with menstruation and the dirty water that surrounded them made it difficult for the girls to wash their menstrual cloths or change them frequently enough. Many of them became separated from their social network of relations, which caused them a great deal of anxiety and stress. Their difficulty in trying to follow social norms have had far-reaching implications on their health, identity, family and community relations. [source] Conservation Biogeography: assessment and prospectDIVERSITY AND DISTRIBUTIONS, Issue 1 2005Robert J. Whittaker ABSTRACT There is general agreement among scientists that biodiversity is under assault on a global basis and that species are being lost at a greatly enhanced rate. This article examines the role played by biogeographical science in the emergence of conservation guidance and makes the case for the recognition of Conservation Biogeography as a key subfield of conservation biology delimited as: the application of biogeographical principles, theories, and analyses, being those concerned with the distributional dynamics of taxa individually and collectively, to problems concerning the conservation of biodiversity. Conservation biogeography thus encompasses both a substantial body of theory and analysis, and some of the most prominent planning frameworks used in conservation. Considerable advances in conservation guidelines have been made over the last few decades by applying biogeographical methods and principles. Herein we provide a critical review focussed on the sensitivity to assumptions inherent in the applications we examine. In particular, we focus on four inter-related factors: (i) scale dependency (both spatial and temporal); (ii) inadequacies in taxonomic and distributional data (the so-called Linnean and Wallacean shortfalls); (iii) effects of model structure and parameterisation; and (iv) inadequacies of theory. These generic problems are illustrated by reference to studies ranging from the application of historical biogeography, through island biogeography, and complementarity analyses to bioclimatic envelope modelling. There is a great deal of uncertainty inherent in predictive analyses in conservation biogeography and this area in particular presents considerable challenges. Protected area planning frameworks and their resulting map outputs are amongst the most powerful and influential applications within conservation biogeography, and at the global scale are characterised by the production, by a small number of prominent NGOs, of bespoke schemes, which serve both to mobilise funds and channel efforts in a highly targeted fashion. We provide a simple typology of protected area planning frameworks, with particular reference to the global scale, and provide a brief critique of some of their strengths and weaknesses. Finally, we discuss the importance, especially at regional scales, of developing more responsive analyses and models that integrate pattern (the compositionalist approach) and processes (the functionalist approach) such as range collapse and climate change, again noting the sensitivity of outcomes to starting assumptions. We make the case for the greater engagement of the biogeographical community in a programme of evaluation and refinement of all such schemes to test their robustness and their sensitivity to alternative conservation priorities and goals. [source] Responsible alcohol service: lessons from evaluations of server training and policing initiativesDRUG AND ALCOHOL REVIEW, Issue 3 2001TIM STOCKWELL Abstract Responsible alcohol service programmes have evolved in many countries alongside a general increase in the availability of alcohol and a greater focus on the prevention of alcohol-related road crashes. They also recognize the reality that a great deal of high-risk drinking and preventable harm occurs in and around licensed premises or as drinkers make their way home. Early US efficacy studies of programmes which trained managers and barstaff to limit customers' levels of intoxication and prevent drink driving showed promise. Studies of effectiveness of these programmes in the wider community, and in the absence of the enforcement of liquor laws, found little benefit. The data will be interpreted as suggesting that, in reality, skills deficits in the serving of alcohol are not a significant problem compared with the motivational issue for a commercial operation of abiding by laws that are rarely enforced and which are perceived as risking the goodwill of their best customers. Australian, UK and US experiences with liquor law enforcement by police will be discussed along with outcomes from the Australian invention of Alcohol Accords, informal agreements between police, licensees and local councils to trade responsibly. It will be concluded that the major task involved in lifting standards of service and preventing harm is to institutionalize legal and regulatory procedures which impact most on licensed premises. A number of strategies are suggested also for creating a political and social climate which supports the responsible service of alcohol and thereby supports the enactment and enforcement of appropriate liquor laws. [source] The Influence of Critical Care Medicine on the Development of the Specialty of Emergency Medicine: A Historical PerspectiveACADEMIC EMERGENCY MEDICINE, Issue 9 2005David Somand MD Abstract Through their largely concurrent development, the specialties of emergency medicine and critical care medicine have exerted a great deal of influence on each other. In this article, the authors trace the commonalities that emergency medicine and critical care medicine have shared and report on the historical relationship between the two specialties. As issues between emergency medicine and critical care medicine continue to emerge, the authors hope to inform the current discussion by bringing to light the controversies and questions that have been debated in the past. [source] A NEW ROLE FOR CONSUMERS' PREFERENCES IN THE PROVISION OF HEALTHCAREECONOMIC AFFAIRS, Issue 3 2006Harry Telser In the present allocation of resources in healthcare, preferences of consumers as the ultimate financiers of healthcare services are judged to be of little relevance. This state of affairs is being challenged because the past decade has seen great progress in the measurement of preferences, or more precisely, willingness-to-pay (WTP) as applied to healthcare services. This article reports evidence on WTP of the Swiss population with regard to three hypothetical modifications of the drug benefit to be covered by social health insurance: delaying access to the most recent therapeutic innovations (among them, drugs) by two years in exchange for a reduction of the monthly premium; substituting original preparations by generics, again in return for a lowered premium; and the exclusion of preparations for the treatment of minor complaints from the drug benefit. Using discrete-choice experiments, WTP and its determinants are estimated. Average WTP for avoiding such a delay (which acts across the board) is much higher than for eschewing the exclusive use of generics (which are claimed to be largely equivalent to the original) or the retention of ,unimportant' drugs in the list of benefits , a rating predicted by economic theory. In addition, a great deal of preference heterogeneity between the French-speaking minority and the German-speaking majority was found, pointing to considerable efficiency losses caused by uniformity of social health insurance. [source] Beyond English Literature A Level: The silence of the seminar?ENGLISH IN EDUCATION, Issue 3 2009A study of an undergraduate literary theory seminar Abstract This paper presents data from a doctoral study of the relationships between A Level English Literature and university English, a study which examines the experiences of one class of first year university English students. It argues that, whilst the socio-cultural emphases of literary study in the university have the potential to offer a great deal to students, full attention to the interplay between curriculum and pedagogy, and an understanding of the values and assumptions which students and lecturers bring to the literature classroom, are vital if students are to be genuinely engaged in the theoretical aspects of the discipline. [source] Teaching and Learning MetaphorENGLISH IN EDUCATION, Issue 3 2003Matthew Pollard Abstract In this study I look at recent work done by psychologists in the field of metaphor comprehension as well as longer-established philosophical theories. I suggest that there is a great deal that English teachers can gain by having a broader understanding of metaphor. I look at how Year 7 pupils, in particular, can benefit a great deal from such notions. [source] Non-Monotonicity of the Tversky-Kahneman Probability-Weighting Function: A Cautionary NoteEUROPEAN FINANCIAL MANAGEMENT, Issue 3 2008Jonathan Ingersoll C91; D10; D81; G19 Abstract Cumulative Prospect Theory has gained a great deal of support as an alternative to Expected Utility Theory as it accounts for a number of anomalies in the observed behavior of economic agents. Expected Utility Theory uses a utility function and subjective or objective probabilities to compare risky prospects. Cumulative Prospect Theory alters both of these aspects. The concave utility function is replaced by a loss-averse utility function and probabilities are replaced by decision weights. The latter are determined with a weighting function applied to the cumulative probability of the outcomes. Several different probability weighting functions have been suggested. The two most popular are the original proposal of Tversky and Kahneman and the compound-invariant form proposed by Prelec. This note shows that the Tversky-Kahneman probability weighting function is not increasing for all parameter values and therefore can assign negative decision weights to some outcomes. This in turn implies that Cumulative Prospect Theory could make choices not consistent with first-order stochastic dominance. [source] Uncertainty, lack of control and emotional functioning in women with metastatic breast cancer: a review and secondary analysis of the literature using the critical appraisal techniqueEUROPEAN JOURNAL OF CANCER CARE, Issue 5 2010M. WARREN msc, clinical nurse specialist WARREN M. (2010) European Journal of Cancer Care19, 564,574 Uncertainty, lack of control and emotional functioning in women with metastatic breast cancer: a review and secondary analysis of the literature using the critical appraisal technique A diagnosis of metastatic (or secondary) breast cancer is frequently more distressing than the diagnosis of a primary tumour since it indicates that the cancer is no longer curable. Relatively little is known, however, about women's experiences of this condition in comparison with those diagnosed with primary breast cancer. This paper therefore reports findings from a secondary analysis of the published literature on the topic using tools from the critical appraisal skills programme to identify and analyse appropriate papers, and the constant comparative method as a means of identifying any overarching or dominant themes emerging from the literature. Uncertainty, lack of control and poor emotional functioning emerged as the main themes affecting women with metastatic breast cancer. These are discussed in relation to their antecedents in the original studies and their implications for nursing care. The themes demonstrate that living with metastatic (or secondary) breast cancer is a multifaceted experience that is influenced by a large number of factors, many of which are under-researched in comparison with those affecting women diagnosed with primary disease. It is clear, however, that women affected by the condition need a great deal more support than they currently receive, and new services may be required to meet these needs. [source] Subnational political opportunity structures and the success of the radical right: Evidence from the March 2004 regional elections in FranceEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 6 2007ELINA KESTILÄ The concept of ,political opportunity structure' refers to the degree of openness of a particular political system and the external institutional or socio-economic constraints and opportunities that it sets for political parties. Comparative analysis across subnational units is conducted where the 94 departments of mainland France are the units of analysis. The significance of electoral institutions (district magnitude), party competition (effective number of parties), electoral behaviour (turnout) and socioeconomic conditions (immigration and unemployment) on the ability of the FN to gather votes across the departments is assessed by means of multiple regression. The empirical results show that the subnational political opportunity structures have been of great importance for the FN. Some four out of the five independent variables are statistically significant and explain a great deal of the variance in the two dependent variables (electoral support for FN list and index of electoral success). Turnout and district magnitude are negatively correlated with the electoral fortunes of the FN, while unemployment and the effective number of party lists are positively correlated with the success of the FN in the regional elections. The variable that indicates the share of non-European immigrants does not provide additional explanatory power in a statistically significant way. [source] Political opportunity structures and right-wing extremist party successEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 3 2006KAI ARZHEIMER West European right-wing extremist parties have received a great deal of attention over the past two decades due to their electoral success. What has received less coverage, however, is the fact that these parties have not enjoyed a consistent level of electoral support across Western Europe during this period. This article puts forward an explanation of the variation in the right-wing extremist party vote across Western Europe that incorporates a wider range of factors than have been considered previously. It begins by examining the impact of socio-demographic variables on the right-wing extremist party vote. Then, it turns its attention to a whole host of structural factors that may potentially affect the extreme right party vote, including institutional, party-system and conjunctural variables. The article concludes with an assessment of which variables have the most power in explaining the uneven electoral success of right-wing extremist parties across Western Europe. The findings go some way towards challenging the conventional wisdom as to how the advance of the parties of the extreme right may be halted. [source] Familiarity and person construal: Individuating knowledge moderates the automaticity of category activation,EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 5 2009Kimberly A. Quinn In this experiment, we examined how perceivers' familiarity with targets moderates person construal. Based on evidence from object categorization that level of construal varies with expertise in a manner that maximizes cue validity, we reasoned that although social (i.e., group-level) categorization is functional for construing unfamiliar others (about whom little or no individuating information is available), it is less functional for familiar others (about whom a great deal of individuating information is available). Results from an automatic priming paradigm provided evidence for our reasoning: Participants categorized unfamiliar faces according to the most salient categorical dimension available in the visual information (in this case, sex), but did not do so for familiar faces. Implications for models of person perception are discussed. Copyright © 2009 John Wiley & Sons, Ltd. [source] PECTIVE: HERE'S TO FISHER, ADDITIVE GENETIC VARIANCE, AND THE FUNDAMENTALTHEOREM OF NATURAL SELECTIONEVOLUTION, Issue 7 2002James F. Crow Abstract Fisher's fundamental theorem of natural selection, that the rate of change of fitness is given by the additive genetic variance of fitness, has generated much discussion since its appearance in 1930. Fisher tried to capture in the formula the change in population fitness attributable to changes of allele frequencies, when all else is not included. Lessar's formulation comes closest to Fisher's intention, as well as this can be judged. Additional terms can be added to account for other changes. The "theorem" as stated by Fisher is not exact, and therefore not a theorem, but it does encapsulate a great deal of evolutionary meaning in a simple statement. I also discuss the effectiveness of reproductive-value weighting and the theorem in integrated form. Finally, an optimum principle, analogous to least action and Hamilton's principle in physics, is discussed. [source] What Do Teens Want to Know About Money,A Comparison of 1998 and 2008FAMILY & CONSUMER SCIENCES RESEARCH JOURNAL, Issue 4 2010Karen P. Varcoe Research indicates that the financial literacy of U.S. teens is low, yet they have access to and spend a great deal of money each year. Teens were surveyed in 1998 (N = 323) and again in 2008 (N = 558) to determine what teens wanted to know about money and how they wanted to learn. Data were collected regarding teens' sources of income, why money was important, the types of financial information they would like to learn, and how they would like to learn from seven counties in California,Alameda, Kern, Los Angeles, Riverside, San Diego, San Luis Obispo, and Santa Barbara. The findings indicate that teens are still interested in learning about many of the same financial topics identified in 1998, but their desire for web education has increased. These data can be used to develop programs that will interest teens. [source] Novel insights into the osmotic stress response of yeastFEMS YEAST RESEARCH, Issue 3 2002Willem H Mager Abstract Response to hyperosmolarity in the baker's yeast Saccharomyces cerevisiae has attracted a great deal of attention of molecular and cellular biologists in recent years, from both the fundamental scientific and applied viewpoint. Indeed the underlying molecular mechanisms form a clear demonstration of the intricate interplay of (environmental) signalling events, regulation of gene expression and control of metabolism that is pivotal to any living cell. In this article we briefly review the cellular response to conditions of hyperosmolarity, with focus on the high-osmolarity glycerol mitogen-activated protein kinase pathway as the major signalling route governing cellular adaptations. Special attention will be paid to the recent finding that in the yeast cell also major structural changes occur in order to ensure maintenance of cell integrity. The intriguing role of glycerol in growth of yeast under (osmotic) stress conditions is highlighted. [source] Abundance and microhabitats of freshwater sponges (Spongillidae) in a Danubean floodplain in AustriaFRESHWATER BIOLOGY, Issue 6 2007IRIS DRÖSCHER Summary 1. This study examined the abundance and distribution of freshwater sponges (Spongillidae) at 32 sites in a floodplain on the Danube within the ,Donau-Auen' National Park east of Vienna, Austria. Ranked from abundant to rare, the species inventory comprised Ephydatia fluviatilis, Spongilla lacustris, Ephydatia mülleri, Eunapius fragilis and Trochospongilla horrida. 2. The presence of hard substratum was essential for the growth of sponges. Timber stands near the water and drifting dead wood increased the abundance of E. fragilis, E. fluviatilis and E. mülleri, whereas stony substrata were important for S. lacustris. A small fraction of E. fluviatilis was collected from macrophytes (Phragmites). 3. Based on the area colonised, the abundance of S. lacustris, E. fragilis and E. fluviatilis was highest (94.2,100% of the total) in floodplain waters where hydrological connectivity with the Danube was low (0,6 days year,1), whereas E. mülleri and T. horrida made up 20.3,35.9% of the total at sites connected for up to 179 days year,1. Moreover, the area colonised by T. horrida at a current velocity >0.20 m s,1 was larger than in the remaining species. Sites with E. mülleri and T. horrida had a higher silicon concentration (0.9 mg L,1) than sites where the remaining three species were collected (0.4,0.6 mg L,1). 4. In most species, the length of macroscleres (the larger spicules) was positively correlated with conductivity and negatively with pH. With respect to aberrant macroscleres, hooks were observed most frequently, whereas the proportion of centrotylotes (ie with the one on more globular swellings along the spicule) was lowest. 5. Freshwater sponges have a great deal of potential as bioindicators and restoration measures that improve floodplain connectivity will favour rare species, such as E. mülleri and T. horrida, while impairing others (e.g. E. fragilis, S. lacustris and E. fluviatilis). [source] Microsatellites versus single-nucleotide polymorphisms in confidence interval estimation of disease lociGENETIC EPIDEMIOLOGY, Issue 1 2006Charalampos Papachristou Abstract With cost-effective high-throughput Single Nucleotide Polymorphism (SNP) arrays now becoming widely available, it is highly anticipated that SNPs will soon become the choice of markers in whole genome screens. This optimism raises a great deal of interest in assessing whether dense SNP maps offer at least as much information as their microsatellite (MS) counterparts. Factors considered to date include information content, strength of linkage signals, and effect of linkage disequilibrium. In the current report, we focus on investigating the relative merits of SNPs vs. MS markers for disease gene localization. For our comparisons, we consider three novel confidence interval estimation procedures based on confidence set inference (CSI) using affected sib-pair data. Two of these procedures are multipoint in nature, enabling them to capitalize on dense SNPs with limited heterozygosity. The other procedure makes use of markers one at a time (two-point), but is much more computationally efficient. In addition to marker type, we also assess the effects of a number of other factors, including map density and marker heterozygosity, on disease gene localization through an extensive simulation study. Our results clearly show that confidence intervals derived based on the CSI multipoint procedures can place the trait locus in much shorter chromosomal segments using densely saturated SNP maps as opposed to using sparse MS maps. Finally, it is interesting (although not surprising) to note that, should one wish to perform a quick preliminary genome screening, then the two-point CSI procedure would be a preferred, computationally cost-effective choice. Genet. Epidemiol. 30:3,17, 2006. © 2005 Wiley-Liss, Inc. [source] THEORIZING GLOBAL BUSINESS SPACESGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2009Andrew Jones ABSTRACT. Over the last decade, geographers have paid a great deal of attention to transnational firms (TNCs) and global production networks (GPNs) in the global economy, to the emergence of a mobile transnational business class and also to the development of global or globalizing cities. All three literatures have made important contributions to understanding the spatiality of global economic activity, but each adopts a fairly discreet theoretical and empirical focus. This article aims to outline a number of theoretical dimensions for thinking about how these key strands to the globalization debate can be brought together through the concept of global business spaces. It will propose a framework for understanding the spatialities of global economic activity that seeks to capture the complex interaction of material, social, organizational and virtual spaces that form the context through which it is constituted. With reference to business travel as a key form of economic practice which plays a central role in (re)producing these spaces, it assesses how these emerging spaces of global economic activity present problems for the conceptual categories commonly used by both urban and economic geographers. In so doing, it proposes a series of ways in which a different research agenda can produce new insight into the complex forms of social practice at the centre of global economic activity. [source] PUBLIC MEMORY AND POLITICAL POWER IN GUATEMALA'S POSTCONFLICT LANDSCAPEGEOGRAPHICAL REVIEW, Issue 4 2003MICHAEL K. STEINBERG ABSTRACT. Landscape interpretation, or "reading" the landscape, is one of cultural geography's standard practices. Relatively little attention, however, has been paid to reading landscapes transformed by insurgency movements or civil wars. Those landscapes can tell us a great deal about past and present political and social relationships as well as continuing power struggles. Guatemala presents a complicated postwar landscape "text" in which the struggle for power continues by many means and media, including how the war is portrayed on memorials, and in which the Catholic Church and the military/state are the two main competing powers. This essay explores some of the images and the text presented in Guatemala's postconflict landscape through contrasting landmarks and memorials associated with the country's thirty-six-year-long civil war that formally ended in 1996. [source] The Elephant in the Corner?GEOGRAPHY COMPASS (ELECTRONIC), Issue 2 2010Reviewing India-Africa Relations in the New Millennium As countries of the ,global South' seek to challenge existing uneven architectures of economic, political and institutional power, now under different circumstances to those prevailing during the Cold War, relations between African countries and various ,Rising Powers' have drawn a great deal of academic and public attention. This scrutiny has been heavily tilted towards analysis of China's African activities. This paper aims to partially redress this balance with an introductory review of India's contemporary relations with sub-Saharan Africa. A number of analysts suggest that in the longer term, India may well achieve a more prosperous and stable economy than China, while in the shorter term, its economic and political profile may result in a more productive relationship for many different African countries, sectors and constituencies. But India will also bring its own challenges in its African commercial interactions, bilateral relations and through its part in shaping the multilateral polity and global economy. This paper therefore aims to critically review contemporary India-Africa relations on four broad thematic points. 1Changing geographies of Indo-African relations; 2Trade and foreign direct investment; 3Development cooperation; and 4Geopolitics and diplomacy. India's confidence as a global political and economic actor is apparent in its African diplomacy and economic engagements, but claims to exceptionalism (relative both to Chinese and Western actors) in such relations are not as self-evident as some have asserted. Whether recent shifts in relations between African nations and India will work in the interests of less privileged citizens, workers and consumers in Africa and in India also remain unclear. [source] Teaching and Learning Guide for: Memoryscape: How Audio Walks Can Deepen Our Sense of Place by Integrating Art, Oral History and Cultural GeographyGEOGRAPHY COMPASS (ELECTRONIC), Issue 5 2008Toby Butler Author's Introduction This article is concerned with the history and practice of creating sound walks or ,memoryscapes': outdoor trails that use recorded sound and spoken memory played on a personal stereo or mobile media to experience places in new ways. It is now possible to cheaply and easily create this and other kinds of located media experience. The development of multi-sensory-located media (,locedia') presents some exciting opportunities for those concerned with place, local history, cultural geography and oral history. This article uses work from several different disciplines (music, sound art, oral history and cultural geography) as a starting point to exploring some early and recent examples of locedia practice. It also suggests how it might give us a more sophisticated, real, embodied and nuanced experience of places that the written word just can not deliver. Yet, there are considerable challenges in producing and experiencing such work. Academics used to writing must learn to work in sound and view or image; they must navigate difficult issues of privacy, consider the power relations of the outsider's ,gaze' and make decisions about the representation of places in work that local people may try and have strong feelings about. Creating such work is an active, multi-sensory and profoundly challenging experience that can offer students the chance to master multi-media skills as well as apply theoretical understandings of the histories and geographies of place. Author Recommends 1.,Perks, R., and Thomson, A. (2006). The oral history reader, 2nd ed. London: Routledge. This is a wonderful collection of significant writing concerned with oral history. Part IV, Making Histories features much of interest, including a thought-provoking paper on the challenges of authoring in sound rather than print by Charles Hardy III, and a moving interview with Graeme Miller, the artist who created the Linked walk mentioned in the memoryscape article. These only feature in the second edition. 2.,Cresswell, T. (2004). Place: a short introduction. Oxford, UK: Blackwell. A refreshingly clear and well-written guide to the different theoretical takes on what makes places , a good starting point for further reading. 3.,Carlyle, A. (ed.). (2008). Autumn leaves: sound and the environment in artistic practice. Paris, France: Double Entendre. This is a collection of short essays and examples of located sonic media art; it includes interviews with practitioners and includes Hildegard Westekamp's Soundwalking, a practical guide to leading students on a mute walk. Lots of thought provoking, applied reading material for students here. 4.,Blunt, A., et al. (eds) (2003). Cultural geography in practice. London: Arnold. A great book for undergraduate and postgraduate students , concepts explained and lots of examples of actually doing cultural geography. The chapter on mapping worlds by David Pinder is particularly useful in this context. 5.,Pinder, D. (2001). Ghostly footsteps: voices, memories and walks in the city. Ecumene 8 (1), pp. 1,19. This article is a thoughtful analysis of a Janet Cardiff sound walk in Whitechapel, East London. Online Materials http://www.memoryscape.org.uk This is my project website, which features two online trails, Dockers which explores Greenwich and the memories of the London Docks that are archived in the Museum of London, and Drifting which is a rather strange experiment-combining physical geography and oral history along the Thames at Hampton Court, but still makes for an interesting trail. Audio, maps and trails can be downloaded for free, so students with phones or iPods can try the trails if you are within reach of Surrey or London. The site features an online version, with sound-accompanying photographs of the location. http://www.portsofcall.org.uk This website has three more trails here, this time of the communities surrounding the Royal Docks in East London. The scenery here is very dramatic and anyone interested in the regeneration of East London and its impact on local communities will find these trails interesting. Like Dockers, the walks feature a lot of rare archive interviews. This project involved a great deal of community interaction and participation as I experimented with trying to get people involved with the trail-making process. The site uses Google maps for online delivery. http://www.soundwalk.com This New York-based firm creates exceptionally high-quality soundwalks, and they are well worth the money. They started by producing trails for different districts of New York (I recommend the Bronx Graffiti trail) and have recently made trails for other cities, like Paris and Varanassi in India. http://www.mscapers.com This website is run by Hewlett Packard, which has a long history of research and development in located media applications. They currently give free licence to use their mscape software which is a relatively easy to learn way of creating global positioning system-triggered content. The big problem is that you have to have a pricey phone or personal digital assistant to run the software, which makes group work prohibitively expensive. But equipment prices are coming down and with the new generations of mobile phones developers believe that the time when the player technology is ubiquitous might be near. And if you ask nicely HP will lend out sets of equipment for teaching or events , fantastic if you are working within reach of Bristol. See also http://www.createascape.org.uk/ which has advice and examples of how mscape software has been used for teaching children. Sample Syllabus public geography: making memoryscapes This course unit could be adapted to different disciplines, or offered as a multidisciplinary unit to students from different disciplines. It gives students a grounding in several multi-media techniques and may require support/tuition from technical staff. 1.,Introduction What is a located mediascape, now and in the future? Use examples from resources above. 2.,Cultural geographies of site-specific art and sound Theories of place; experiments in mapping and site-specific performance. 3.,Walk activity: Westergard Hildekamp , sound walk, or one of the trails mentioned above The best way , and perhaps the only way , to really appreciate located media is to try one in the location they have been designed to be experienced. I would strongly advise any teaching in this field to include outdoor, on-site experiences. Even if you are out of reach of a mediascape experience, taking students on a sound walk can happen anywhere. See Autumn Leaves reference above. 4.,Researching local history An introduction to discovering historical information about places could be held at a local archive and a talk given by the archivist. 5.,Creating located multimedia using Google maps/Google earth A practical exercise-based session going through the basics of navigating Google maps, creating points and routes, and how to link pictures and sound files. 6.,Recording sound and oral history interviews A practical introduction to the techniques of qualitative interviewing and sound recording. There are lots of useful online guides to oral history recording, for example, an online oral history primer http://www.nebraskahistory.org/lib-arch/research/audiovis/oral_history/index.htm; a more in depth guide to various aspects of oral history http://www.baylor.edu/oral%5fhistory/index.php?id=23566 or this simple oral history toolkit, with useful links to project in the North of England http://www.oralhistorynortheast.info/toolkit/chapter1.htm 7.,Sound editing skills Practical editing techniques including working with clips, editing sound and creating multi-track recordings. The freeware software Audacity is simple to use and there are a lot of online tutorials that cover the basics, for example, http://www.wikieducator.org/user:brentsimpson/collections/audacity_workshop 8.,Web page design and Google maps How to create a basic web page (placing pictures, text, hyperlinks, buttons) using design software (e.g. Dreamweaver). How to embed a Google map and add information points and routes. There is a great deal of online tutorials for web design, specific to the software you wish to use and Google maps can be used and embedded on websites free for non-profit use. http://maps.google.com/ 9,and 10. Individual or group project work (staff available for technical support) 11.,Presentations/reflection on practice Focus Questions 1What can sound tell us about the geographies of places? 2When you walk through a landscape, what traces of the past can be sensed? Now think about which elements of the past have been obliterated? Whose past has been silenced? Why? How could it be put back? 3Think of a personal or family story that is significant to you. In your imagination, locate the memory at a specific place. Tell a fellow student that story, and describe that place. Does it matter where it happened? How has thinking about that place made you feel? 4What happens when you present a memory of the past or a located vision of the future in a present landscape? How is this different to, say, writing about it in a book? 5Consider the area of this campus, or the streets immediately surrounding this building. Imagine this place in one of the following periods (each group picks one): ,,10,000 years ago ,,500 years ago ,,100 years ago ,,40 years ago ,,last Thursday ,,50 years time What sounds, voices, stories or images could help convey your interpretation of this place at that time? What would the visitor hear or see today at different points on a trail? Sketch out an outline map of a located media trail, and annotate with what you hear/see/sense at different places. Project Idea small group project: creating a located mediascape Each small group must create a located media experience, reflecting an aspect of the history/geography/culture of an area of their choosing, using the knowledge that they have acquired over the course of the semester. The experience may be as creative and imaginative as you wish, and may explore the past, present or future , or elements of each. Each group must: ,,identify an area of interest ,,research an aspect of the area of the groups choosing; this may involve visiting local archives, libraries, discussing the idea with local people, physically exploring the area ,,take photographs, video or decide on imagery (if necessary) ,,record sound, conduct interviews or script and record narration ,,design a route or matrix of media points The final project must be presented on a website, may embed Google maps, and a presentation created to allow the class to experience the mediascape (either in the classroom or on location, if convenient). The website should include a brief theoretical and methodological explanation of the basis of their interpretation. If the group cannot be supported with tuition and support in basic website design or using Google mapping with sound and imagery, a paper map with locations and a CD containing sound files/images might be submitted instead. For examples of web projects created by masters degree students of cultural geography at Royal Holloway (not all sound based) see http://www.gg.rhul.ac.uk/MA/web-projects.html [source] | |||||||||||||||||||||||||||||||||||||