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Great Advances (great + advance)
Selected AbstractsEthical problems in cytologyCYTOPATHOLOGY, Issue 1 2004. Znidar Great advances in medical science have raised a number of ethical issues, many of which affect cytopathology. Some of the main issues addressed in this paper relate to the organization of a cytology laboratory: internal and external quality control, adequate staffing levels and staff education, cytopathology reporting format and contents, confidentiality issues, relationship with the clinicians and involvement of cytopathologists in clinical management teams. Quality control has to be provided within cytology departments but external quality assurance is also essential, with national monitoring. New technologies should be used according to the best scientific methods, following cytological analysis. Scientific work in cytology has to respect the general principles of scientific ethics. The patient's interest has to be the main reason for such work. [source] Genetics of basal cell carcinomaAUSTRALASIAN JOURNAL OF DERMATOLOGY, Issue 2 2010Sally E De Zwaan ABSTRACT Basal cell carcinoma is the most common human malignancy in populations of European origin, and Australia has the highest incidence of basal cell carcinoma in the world. Great advances in the understanding of the genetics of this cancer have occurred in recent years. Mutations of the patched 1 gene (PTCH1) lead to basal cell carcinoma predisposition in Gorlin syndrome. PTCH1 is part of the hedgehog signalling pathway, and derangements within this pathway are now known to be important in the carcinogenesis of many different cancers including sporadic basal cell carcinoma. The molecular biology of the hedgehog pathway is discussed, and mouse models of basal cell carcinoma based on this pathway are explored. New developments in non-surgical treatment of basal cell carcinoma are based on this knowledge. Other genes of importance to basal cell carcinoma development include the tumour suppressor gene P53 and the melanocortin-1 receptor gene. In addition, we discuss molecules of possible importance such as the glutathione-S-transferases, DNA repair genes, cyclin-dependent kinase inhibitor 2A, Brahma and connexins. Evidence of familial aggregation of this cancer is explored and supports the possibility of genetic predisposition to this common malignancy. [source] Evolution and regeneration of the planarian central nervous systemDEVELOPMENT GROWTH & DIFFERENTIATION, Issue 3 2009Yoshihiko Umesono More than 100 years ago, early workers realized that planarians offer an excellent system for regeneration studies. Another unique aspect of planarians is that they occupy an interesting phylogenetic position with respect to the nervous system in that they possess an evolutionarily primitive brain structure and can regenerate a functional brain from almost any tiny body fragment. Recent molecular studies have revisited planarian regeneration and revealed key information about the cellular and molecular mechanisms underlying brain regeneration in planarians. One of our great advances was identification of a gene, nou-darake, which directs the formation of a proper extrinsic environment for pluripotent stem cells to differentiate into brain cells in the planarian Dugesia japonica. Our recent findings have provided mechanistic insights into stem cell biology and also evolutionary biology. [source] Agricultural and Rural Development in China: Achievements and Challenges Entwicklung der Landwirtschaft und des ländlichen Raums in China: Erfolge und Herausforderungen Le développement agricole et rural en Chine : résultats et défisEUROCHOICES, Issue 2 2009Chen Xiaohua Summary Agricultural and Rural Development in China: Achievements and Challenges China has made great advances in its agricultural and rural development since the reforms and opening-up that began in 1978. It has not only fed its population of 1.3 billion, but has also contributed to international agricultural development and food security. Agricultural production registered great development, providing sufficient food and clothes for 21 per cent of the world's population with 9 per cent of the arable land. In the process farmers' living standards improved remarkably and rural public utilities and services were greatly enhanced. China is now in a key transition period of accelerating the transformation and modernisation of traditional agriculture and rural society. It is facing significant challenges. Agriculture is still one of the weakest industries in China and it is proving difficult to sustain increases in grain output and farmers' incomes. The problems of uneven development in rural areas have become increasingly prominent and the gap between urban and rural development is tending to widen. The Chinese government will respond strategically to these challenges and will firmly pursue the construction of a new efficient and sustainable socialist countryside, along the path of modernisation with Chinese characteristics. It will also make greater contributions to world agriculture and rural development. Les progrès de la Chine en termes de développement agricole et rural depuis le début des réformes et l'ouverture en 1978 ont été considérables. Non seulement le pays a nourrit une population de 1.3 millions d'habitants mais il a contribué au développement et à la sécurité alimentaire au niveau international. La production agricole a fortement augmenté et a fournit suffisamment de nourriture et de vêtements à 21 pour cent de la population du monde avec 9 pour cent des terres cultivables. Ce processus s'est accompagné d'une hausse considérable du niveau de vie des agriculteurs et d'une grande amélioration des services publics dans les zones rurales. La Chine est maintenant à un moment clé de sa période de transition, caractérisé par une accélération de la transformation et de la modernisation de l'agriculture et de la société rurale traditionnelles. Des défis importants se présentent à elle. L'agriculture reste une des industries chinoises les plus fragiles et il se révèle difficile de continuer à augmenter la production céréalière et les revenus des agriculteurs. Les problèmes d'inégalité de développement dans les zones rurales deviennent de plus en plus visibles et l'écart de développement entre les zones urbaines et les zones rurale tend à s'accroître. Les pouvoirs publics chinois vont apporter une réponse stratégique à ces défis et vont poursuivre fermement la construction d'une nouvelle campagne socialiste efficace et durable, en suivant une voie de modernisation typiquement chinoise. Ils vont aussi accroître les contributions de la Chine au développement agricole et rural mondial. Seit Beginn der Reformen und der Öffnungspolitik 1978 hat sich Chinas Landwirtschaft und ländlicher Raum enorm weiterentwickelt. China hat seitdem nicht nur seine 1.3 Milliarden Einwohner ernährt, sondern auch zur internationalen Agrarentwicklung und Ernährungssicherung beigetragen. Die Agrarproduktion wurde erheblich ausgeweitet und deckt nun 21 Prozent des weltweiten Bedarfs an Lebensmitteln und Kleidung bei gerade einmal 9 Prozent der Weltackerfläche. Dabei haben sich die Lebensbedingungen für die Landwirte sowie das Angebot an öffentlichen Einrichtungen und Dienstleistungen im ländlichen Raum deutlich verbessert. China durchläuft gerade eine wichtige Übergangsphase, in der sich der Wandel und die Modernisierung der traditionellen Landwirtschaft und der Landbevölkerung noch schneller vollziehen, und steht großen Herausforderungen gegenüber. Die Landwirtschaft ist nach wie vor einer der schwächsten Sektoren in China, und es erweist sich als schwierig, die Steigerungsraten bei der Getreideerzeugung und den Einkommen in der Landwirtschaft aufrecht zu erhalten. Die Probleme der ungleichmäßigen Entwicklung in ländlichen Gebieten werden immer offensichtlicher, und die Kluft zwischen städtischer und ländlicher Entwicklung droht sich auszuweiten. Die chinesische Regierung wird diesen Herausforderungen strategisch begegnen und , ganz im Sinne einer Modernisierung mit chinesischen Merkmalen , daran festhalten, einen neuen sozialistischen ländlichen Raum effizient und nachhaltig zu gestalten. Sie wird ebenfalls einen noch größeren Beitrag zur Weltlandwirtschaft und zur Entwicklung des ländlichen Raums leisten. [source] Further understanding of the ,-globin locus regulation at the molecular level: looping or linking models?GENES TO CELLS, Issue 9 2002Yi Tang The human ,-globin locus is a classic model of the eukaryotic multigene family with tissue- and temporally specific expression. Over the past few years, great advances have been achieved in studies of ,-globin locus regulation. The dominant role of the ,-globin locus control region (LCR) in chromatin opening and developmental switching has been challenged, and elements beyond the LCR have been studied in depth. More recently, the fields of research have been expanded to intergenic transcription, nuclear localization and histone modification. Several models have been proposed to elucidate the regulation mechanism; among them, the looping and linking models are the most prevalent. Different models are the summarization of the observations made at different times and a persuasive model must be based on a systematic understanding of the numerous observations. The objective of this review is to provide an overview of progress in the area of ,-globin regulation and then to discuss models for it. [source] On Constraining Pilot Point Calibration with Regularization in PESTGROUND WATER, Issue 6 2009Michael N. Fienen Ground water model calibration has made great advances in recent years with practical tools such as PEST being instrumental for making the latest techniques available to practitioners. As models and calibration tools get more sophisticated, however, the power of these tools can be misapplied, resulting in poor parameter estimates and/or nonoptimally calibrated models that do not suit their intended purpose. Here, we focus on an increasingly common technique for calibrating highly parameterized numerical models,pilot point parameterization with Tikhonov regularization. Pilot points are a popular method for spatially parameterizing complex hydrogeologic systems; however, additional flexibility offered by pilot points can become problematic if not constrained by Tikhonov regularization. The objective of this work is to explain and illustrate the specific roles played by control variables in the PEST software for Tikhonov regularization applied to pilot points. A recent study encountered difficulties implementing this approach, but through examination of that analysis, insight into underlying sources of potential misapplication can be gained and some guidelines for overcoming them developed. [source] Depression and practice guidelinesHUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 1 2001John S Mcintyre Abstract Over the past two decades there have been great advances in the understanding of depression and in the development of pharmacological agents and psychosocial treatments that have demonstrated efficacy in the treatment of this common and disabling illness. Unfortunately, this knowledge and evidence is not consistently translated into actual treatment, and depression remains undiagnosed in a large percentage of patients, and when it is accurately diagnosed, it often is suboptimally treated. The frequent failure to properly diagnose depression may be due to the continuing stigma of mental illness, the persistence of the biomedical, rather than the biopsychosocial, paradigm of illness and treatment, educational issues and the time constraints in the typical medical practice. The suboptimal treatment may be due to all of these issues plus the difficulty in changing physician behaviours even when there exists much evidence that would seem to dictate such a change. The development of a criteria-based nomenclature and the subsequent development and dissemination of evidence-based practice guidelines addresses some of these issues. Copyright © 2001 John Wiley & Sons, Ltd. [source] Computer-based morphometry of brainINTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY, Issue 2 2010Bang-Bon Koo Abstract Over the past decade, the importance of probing the anatomy of the brain has reemerged as an important field of neuroscience. In combination with functional imaging techniques, the rapid advancement of neuroimaging techniques,such as magnetic resonance imaging,and their growing applicability in studying brain morphometry has led to great advances in neuroscience research. Considering the requirements of the diverse technologies,from image processing to statistics,in performing morphometry of the brain, it is critical to have an overall understanding of this subject. The major objective of this review is to provide a practical introduction to this field. The review starts by covering basic concepts and techniques that are commonly used in morphometry of structural magnetic resonance imaging and then extends to further technical perspectives. © 2010 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 20, 117,125, 2010 [source] Atrial fibrillation: insights from clinical trials and novel treatment optionsJOURNAL OF INTERNAL MEDICINE, Issue 6 2007Y. Blaauw Abstract., Blaauw Y, Crijns HJGM (University Hospital Maastricht, Maastricht, The Netherlands). Atrial fibrillation: insights from clinical trials and novel treatment options (Review). J Intern Med 2007; 262: 593,614. Atrial fibrillation (AF) is the most common encountered sustained arrhythmia in clinical practice. The last decade the result of large ,rate' versus ,rhythm' control trials have been published that have changed the current day practise of AF treatment. It has become clear that rate control is at least equally effective as a rhythm control strategy in ameliorating morbidity as well as mortality. Moreover, in each individual patient the risk of thromboembolic events should be assessed and antithrombotic treatment be initiated. There have also been great advances in understanding the mechanisms of AF. Experimental studies showed that as a result of electrical and structural remodelling of the atria, ,AF begets AF'. Pharmacological prevention of atrial electrical remodelling has been troublesome, but it seems that blockers of the renin angiotensin system, and perhaps statins, may reduce atrial structural remodelling by preventing atrial fibrosis. Clinical studies demonstrated that the pulmonary veins exhibit foci that can act as initiator and perpetuator of the arrhythmia. Isolation of the pulmonary veins using radiofrequency catheter ablation usually abolishes AF. The most promising advances in the pharmacological treatment of AF include atrial specific antiarrhythmic drugs and direct thrombin inhibitors. In the present review we will describe the results of recent experimental studies, discuss the latest clinical trials, and we will focus on novel treatment modalities. [source] Poverty, underdevelopment and infant mental health,JOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 4 2003LM Richter Abstract: Very great advances have occurred in disciplinary and professional knowledge of infant development and its influence on subsequent development. This expertise includes the ways in which early experiences affect the capacity of mature individuals for social adjustment and productive competence, and promising methods of intervention to promote infant mental health and prevent adverse sequelae of risk conditions. However, very little of this knowledge has been applied in work among infants and children living in conditions of poverty and underdevelopment. This lack of application continues despite the enormous threats to the well-being of infants and young children brought about by the combined effects of poverty and the AIDS pandemic, especially in southern Africa. Protein,energy malnutrition, maternal depression, and institutional care of infants and small children are cited as illustrative of areas in which interventions, and their evaluation, are desperately needed in resource-poor countries. An argument is made for the critical importance of considering and addressing psychological factors in care givers and children in conditions of extreme material need. An example is provided of a simple intervention model based on sound developmental principles that can be implemented by trained non-professionals in conditions of poverty and underdevelopment. [source] Vascular fluid dynamics and vascular biology and diseaseMATHEMATICAL METHODS IN THE APPLIED SCIENCES, Issue 17-18 2001C. G. Caro My tribute to James Lighthill, one of the world's great mathematical scientists, is offered with admiration and sadness,he was both colleague and friend. I met James in 1964, through an introduction by Sir Geoffrey (G.I.) Taylor. He was then Royal Society Research Professor at Imperial College and I was a lecturer in medicine at St. Thomas's Hospital, with a particular interest in cardiovascular and respiratory mechanics. Within a short while we began to collaborate and about a year later James proposed to Imperial College that it should take the then almost unique step of setting up an activity in physiological flow. The Physiological Flow Studies Unit was started at the College in 1966,on an experimental basis with a staff of one (the writer). Looking back over a period of more than 30 years, I have three outstanding, interrelated impressions. First, that the field of physiological fluid dynamics has grown hugely worldwide, attesting in no small measure to James Lighthill's prescience and contributions. Second, that close collaboration between life scientists and doctors and engineers and physical scientists, has led to great advances in the understanding of normal and disturbed biology and of the relevant fluid dynamics. Third, that recognition that mechanical stresses play a key role in cellular and molecular biology, has given a tremendous boost to physiological mechanics. My aim in this note is to describe some earlier and current work on vascular fluid dynamics and vascular biology and disease and, where appropriate, to trace its descent from early studies undertaken with James. Copyright © 2001 John Wiley & Sons, Ltd. [source] The pathology of ageing: concepts and mechanisms,THE JOURNAL OF PATHOLOGY, Issue 2 2007JE Martin Abstract The rising numbers and proportion of aged individuals in the population is a global demographic trend. The diseases associated with ageing are becoming more prevalent, and the associated healthcare costs are having a significant economic impact in all countries. With these changes have come great advances in our understanding of the mechanisms of ageing. The mechanisms of cellular ageing at a genetic, protein and organelle level are becoming clearer, as are some of the more complex associations between environment and ageing. System ageing is also becoming better understood, and the potential biological advantages of ageing are being explored. Many of the advances in these fields are opening up the prospect of targeted therapeutic intervention for ageing and age related disease. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [source] Heating of the solar and stellar coronae: a reviewASTRONOMISCHE NACHRICHTEN, Issue 8 2007R. Erdélyi Abstract Despite great advances in observations and modelling, the problem of solar and stellar heating still remains one of the most challenging problems of space physics. To find a definite answer to what sort of mechanisms act to heat the plasma to a few million degrees requires a collaborative effort of small scales observations, large capacity numerical modelling and complicated theoretical approaches. A unique theory should incorporate aspects such as the generation of energy, its transport and dissipation. Up to now, the first two problems are rather clarified. However, the modality of transfer of magnetic or kinetic energy into heat is a question still awaiting for an answer. In the present paper we review the various popular heating mechanisms put forward in the existing extensive literature. The heating processes are, somewhat arbitrarily, classified as hydrodynamic, magnetohydrodynamic or kinetic based on the characteristics of the model medium. These mechanisms are further divided based on the time scales of the ultimate dissipation involved (i.e. AC and DC heating, turbulent heating). In particular, special attention is paid to discuss shock dissipation, mode coupling, resonant absorption, phase mixing, and, reconnection. Finally, we briefly review the various heating mechanisms proposed to heat other stars. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] THE WESTERN AUSTRALIAN POWER DILEMMA,AUSTRALIAN ECONOMIC PAPERS, Issue 4 2009PAUL SIMSHAUSER From 1984 gas-fired power generation had been gradually increasing its share of the electricity market in Western Australia (WA) starting at 1 per cent and rising to about 50 per cent by 2008. Had it continued on this trajectory, the WA power system would have made great advances in terms of cost and environmental efficiencies given the looming commencement of the Carbon Pollution Reduction Scheme in Australia from 2011. However, more recently the cost of natural gas has increased from $3/GJ to $7/GJ following the sudden collapse of the East Spar gas field in the North West Shelf. In this article, we analyse the impact of the gas price increase and demonstrate that despite being the most environmentally efficient conventional technology, natural gas combined cycle plant has been squeezed out of the market which in turn will increase forward electricity price risks to WA consumers through greater exposure to CO2 pricing in the long run. [source] Bridging Experiments and Simulations in Oblique Angle PolymerizationCHEMICAL VAPOR DEPOSITION, Issue 4-6 2009Murat Cetinkaya Abstract In this paper, we report the growth of nanostructured poly(p-xylylene) (PPX) films by oblique angle polymerization at various deposition angles. Additionally, a two-dimensional computational (Monte Carlo) model is implemented to study the nanostructured growth process. The morphology of the nanostructured polymer films are characterized by atomic force microscopy and scanning electron microscopy. Based on the experimental results, a competitive growth model is proposed and quantified in terms of column geometry (i.e., diameter and height), column spacing (i.e., periodicity), and column packing (i.e., number of columns per unit area). We show that the nanostructured polymer growth obeys a universal power-law scaling mechanism at various deposition angles. The computational model predicts similar nanostructured morphologies to the oblique angle polymerization obtained experimentally. Nanostructured polymer films may provide great advances in sensing and biomedical applications. [source] | ||||||||||||||||