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Good Thing (good + thing)
Selected AbstractsArchitecture of Disbelief: Is Architectural Speciation a Good Thing?ARCHITECTURAL DESIGN, Issue 3 2009Neil Spiller Abstract Can visionary architects have their cake and eat it, luxuriating in pecuniary success while also continuing to assert their avant-gardism? Neil Spiller attended a conference in Cornell that brought the role of the architectural visionary under the spotlight and gave him much food for thought. Copyright © 2009 John Wiley & Sons, Ltd. [source] Cascade Reactions in an All-Enzyme NanoreactorCHEMISTRY - A EUROPEAN JOURNAL, Issue 46 2009Guillaume Delaittre Dr. Good things come in small packages! Giant amphiphiles, consisting of a polymeric hydrophobic tail and a horseradish peroxidase head, were simultaneously synthesized and self-assembled into vesicles. During the self-assembly process, glucose oxidase was encapsulated to create enzymatic cascade nanoreactors (see picture; ABTS= 2,2,-azido-bis(3-ethylbenzthiazoline-6-sulfonic acid)). [source] Social Security in Rwanda: Overcoming IndifferenceINTERNATIONAL SOCIAL SECURITY REVIEW, Issue 3-4 2003François-Xavier Ngarambe The current social security system in Rwanda, set up in 1962, has until recently been viewed with indifference by most Rwandans. This is because employees in the formal sense, who are the ones concerned by the pension and occupational risk branches, represent only a tiny minority of the population, attempts to provide medical cover for the population are still in their infancy, and in a context where unemployment is the rule and work the exception, the risk of unemployment is uninsurable. Faced with this situation the first challenge was to increase people's awareness of the problem by launching a debate in which social security was seen as part of efforts to combat poverty and underdevelopment. The greater awareness which this produced has enabled us to introduce a plan which we hope, on the basis of the first results, will lead to better things in future. Fundamental changes have just been made to the pension scheme, the management institution has been restructured and modernized, and efforts in the field of healthcare are producing their first fruits. Perhaps now, at long last, after years of indifference and inertia, a new day is dawning for social security in Rwanda! [source] Strategic Decisions of New Technology Adoption under Asymmetric Information: A Game-Theoretic Model*DECISION SCIENCES, Issue 4 2003Kevin Zhu ABSTRACT In this paper we explore strategic decision making in new technology adoption by using economic analysis. We show how asymmetric information affects firms' decisions to adopt the technology. We do so in a two-stage game-theoretic model where the first-stage investment results in the acquisition of a new technology that, in the second stage, may give the firm a competitive advantage in the product market. We compare two information structures under which two competing firms have asymmetric information about the future performance (i.e., postadoption costs) of the new technology. We find that equilibrium strategies under asymmetric information are quite different from those under symmetric information. Information asymmetry leads to different incentives and strategic behaviors in the technology adoption game. In contrast to conventional wisdom, our model shows that market uncertainty may actually induce firms to act more aggressively under certain conditions. We also show that having better information is not always a good thing. These results illustrate a key departure from established decision theory. [source] Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogenEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2003P. J. McCaffery Abstract Retinoic acid (RA) is essential for both embryonic and adult growth, activating gene transcription via specific nuclear receptors. It is generated, via a retinaldehyde intermediate, from retinol (vitamin A). RA levels require precise regulation by controlled synthesis and catabolism, and when RA concentrations deviate from normal, in either direction, abnormal growth and development occurs. This review describes: (i) how the pattern of RA metabolic enzymes controls the actions of RA; and (ii) the type of abnormalities that result when this pattern breaks down. Examples are given of RA control of the anterior/posterior axis of the hindbrain, the dorsal/ventral axis of the spinal cord, as well as certain sex-specific segments of the spinal cord, using varied animal models including mouse, quail and mosquitofish. These functions are highly sensitive to abnormal changes in RA concentration. In rodents, the control of neural patterning and differentiation are disrupted when RA concentrations are lowered, whereas inappropriately high concentrations of RA result in abnormal development of cerebellum and hindbrain nuclei. The latter parallels the malformations seen in the human embryo exposed to RA due to treatment of the mother with the acne drug Accutane (13- cis RA) and, in cases where the child survives beyond birth, a particular set of behavioural anomalies can be described. Even the adult brain may be susceptible to an imbalance of RA, particularly the hippocampus. This report shows how the properties of RA as a neural induction agent and organizer of segmentation can explain the consequences of RA depletion and overexpression. [source] A Postmodern Reply to Perez ZagorinHISTORY AND THEORY, Issue 2 2000Keith Jenkins This article engages with the arguments forwarded by Perez Zagorin against the possible consequences of postmodernism for history as it is currently conceived of particularly in its "proper" professional/academic form ("History, the Referent, and Narrative: Reflections on Postmodernism Now,"History and Theory 38 [1999], 1-24). In an overtly positioned response which issues from a close reading of Zagorin's text, I argue that his all-too-typical misunderstandings of postmodernism need to be "corrected",not, however, to make postmodernism less of a threat to "history as we have known it," or to facilitate the assimilation of its useful elements while exorcising its "extremes." My "corrections" instead forward the claim that, understood positively and integrated into those conditions of postmodernity which postmodernism variously articulates at the level of theory, such theory signals the possible "end of history," not only in its metanarrative styles (which are already becoming increasingly implausible) but also in that particular and peculiar professional genre Zagorin takes as equivalent to history per se. And I want to argue that if this theory is understood in ways which choose not to give up (as Derrida urges us not to give up) the "discourse of emancipation" after the failure of its first attempt in the "experiment of modernity," then this ending can be considered "a good thing." [source] Mild cognitive impairment in the older population: Who is missed and does it matter?INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 8 2008Blossom C. M. Stephan Abstract Objectives Classifications of mild cognitive impairment (MCI) vary in the precision of the defining criteria. Their value in clinical settings is different from population settings. This difference depending on setting is to be expected, but must be well understood if population screening for dementia and pre-dementia states is to be considered. Of importance is the impact of missed diagnosis. The magnitude of missed ,at-risk' cases in the application of different MCI criteria in the population is unknown. Methods Data were from the Medical Research Council Cognitive Function and Ageing Study, a large population based study of older aged individuals in the UK. Prevalence and two-year progression to dementia in individuals whose impairment failed to fulfil published criteria for MCI was evaluated. Results Prevalence estimates of individuals not classified from current MCI definitions were extremely variable (range 2.5,41.0%). Rates of progression to dementia in these non-classified groups were also very variable (3.7,30.0%), reflecting heterogeneity in MCI classification requirements. Conclusions Narrow definitions of MCI developed for clinical settings when applied in the population result in a large proportion of individuals who progress to dementia being excluded from MCI classifications. More broadly defined criteria would be better for selection of individuals at risk of dementia in population settings, but at the possibility of high false positive rates. While exclusion may be a good thing in the population since most people are presumably ,normal', over-inclusion is more likely to be harmful. Further work needs to investigate the best classification system for application in the population. Copyright © 2008 John Wiley & Sons, Ltd. [source] Proliferative drive and liver carcinogenesis: Too much of a good thing?JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 12 2009Narci C Teoh Abstract There have been innumerable studies published in the attempt to identify gene expression signatures in hepatocellular carcinoma (HCC). When all the regulators and targets of the differentially expressed genes are analyzed from larger studies, the most striking theme is upregulation of mitosis-promoting and cell proliferation genes in HCC compared with ,liver-specific gene clusters' in non-tumorous tissue. A major limitation of expression profiling is that it only provides a ,snapshot' of what is an evolving process and thus cannot distinguish the differences in gene expression that are primary effectors of dysregulated growth from those that represent downstream consequences. The development of HCC in a chronically diseased liver, often referred to as hepatocarcinogenesis, is a multistep process characterized by the progressive accumulation and interplay of genetic alterations causing aberrant growth, malignant transformation of liver parenchymal cells, followed by vascular invasion and metastasis. This review will discuss HCC precursor lesions, draw on the ,proliferation cluster' genes highlighted from HCC expression profiling studies, relate them to a selection of regulatory networks important in liver regeneration, cell cycle control and their potential significance in the pathogenesis of HCC or primary liver cancer. [source] Too much of a good thing: the ,problem' of political communications in a mass media democracyJOURNAL OF PUBLIC AFFAIRS, Issue 3 2007Ivor Gaber Francis Fukuyama asks: ,,,is liberal democracy prey to serious internal contradictions, contradictions so serious that they will eventually undermine it as a political system?' This paper argues that one of these ,internal contradictions' is the political communications process and it can be sufficiently serious to undermine the democratic system,but such an undermining is not inevitable. The problem can be described as follows: Democratic systems require that citizens are kept fully informed by governments (and others) in the interests of transparency and ultimately accountability. Hence, all political communications have, as their final objective, the accountability of politicians at the ballot box. Thus all political communications have what can be described as ,above' and ,below' the line content. The above-the-line is the actual content of the message, the below-the-line is the implicit one of ,think better of me and my colleagues think worse of my opponents'. Consequently, no matter how personally honest and open an individual politician might be, the democratic system requires her or him to be always thinking about securing a successful result at the ballot box. Thus we have the ,political communications paradox'. Voters want politicians to be honest and accountable but this very demand means that politicians, implicitly, always have to have another agenda in operation when they are communicating with the public, i.e. securing their approval and then their support. As a result the trust which is a fundamental to the workings of a democratic system is constantly being undermined. This has two effects. First, that governments are obliged to make communications, rather than delivery, their real priority and second trust, not just in politicians but in the political system as a whole, tends to wane over time, which in turn endangers the very system it was designed to underpin. But this decline is not inevitable because the system has some in-built self-correcting mechanisms These include: the rise of new parties and/or leaders who portray themselves as ,new' and ,untainted',New Labour, New Conservatives, etc., an almost regular ,re-balancing' of the power relationship that exists between politicians and the civil service, particularly in the communications field, the rise of new forms of communication that seek to by-pass the institutional roadblocks that are perceived as being the cause of the problems and finally increased attention by journalists and academics to the process of political communications makes it more difficult for politicians to continue with ,business as usual' as far as their communication activities are concerned. Copyright © 2007 John Wiley & Sons, Ltd. [source] An analysis of the effect of a reliability paradigm shift on leading British aerospace companiesQUALITY AND RELIABILITY ENGINEERING INTERNATIONAL, Issue 4 2002J. A. Jones Abstract The aerospace industry is moving towards a new paradigm for the statement of reliability specifications. This paradigm is not a technical metric inherent to a system in isolation, but rather encompasses the wider objectives, operational profile and logistic priorities of its customer. This customer focus is encapsulated in the metrics Failure Free Operating Period and Maintenance Free Operating Period. These metrics describe the duration of effective system operation, in the first case for systems where faults and maintenance are permitted and in the second for systems where faults may not be repaired. As part of the Department of Trade and Industry (DTI) funded Aerospace Project for Insertion of Reliability (ASPIRE) research programme, which itself is part of the Ultra Reliable Aircraft (URA) programme, representatives of leading aerospace companies were interviewed about their opinion n how this new reliability paradigm and associated concepts would affect their way of doing business and their engineering processes. It would appear that the aerospace industry is ready for a move to a more realistic set of reliability metrics and away from the old style MTBF based metrics. This sea change would most likely be welcomed by customers, but as yet the manufacturing companies are unconvinced that such a radical move would be a good thing. Much of the resistance to change is due to old-fashioned, but well entrenched, beliefs in the traditional way of doing things. A move away from this would bring freshness to the industry and lead to cost and time savings as the traditional approach is dropped in favour of a more planned and thought out approach. Copyright © 2002 John Wiley & Sons, Ltd. [source] Book Review Feature: Two Reviews of The Challenge of Affulence: Self-Control and Well-Being in the United States and Britain Since 1950,THE ECONOMIC JOURNAL, Issue 521 2007Andrew J. Oswald Is affluence a good thing? The book The Challenge of Affluence by Avner Offer (2006) argues that economic prosperity weakens self-control and undermines human well-being. Consistent with a pessimistic view, we show that psychological distress has been rising through time in modern Great Britain. Taking over-eating as an example, our data reveal that half the British population view themselves as overweight, and that happiness and mental health are worse among fatter people in Britain and Germany. Comparisons also matter. We discuss problems of inference and argue that longitudinal data are needed. We suggest a theory of obesity imitation where utility depends on relative weight. [source] Prospects for the Two-party System in a Pluralising Political WorldAUSTRALIAN JOURNAL OF PUBLIC ADMINISTRATION, Issue 2 2002Andrew Norton Political commentators argue that the major political parties are in decline. This article sets out evidence for this view: minor parties and independents securing 20 percent of the vote at federal elections, declining strength of voters' party identification, and issue movements playing a large role in setting the political agenda. Possible causes for these trends range from the political, such as policy failure, undermining traditional constituencies, and ignoring public opinion, to sociological forces, such as postmaterialism, individualism and serious disaffection. However, the article argues Labor and the Coalition will be the dominant political players for the foreseeable future. In most lower houses, the electoral system favours the major parties which on balance is a good thing. The major parties have taken concerns of interest groups into account, while balancing these against majority opinion. They simplify choice for an electorate only moderately interested in politics, and can be held accountable in a way minor parties and independents cannot. [source] p53 and ageing: too much of a good thing?BIOESSAYS, Issue 7 2002Thomas B.L. Kirkwood A recent report by Tyner et al.1 suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild-type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows that there is a strong positive association between DNA repair-mediated protection against cancer and ageing. So what are we to make of the new data with regard to overall understanding of the mechanisms of ageing? BioEssays 24:577,579, 2002. © 2002 Wiley Periodicals, Inc. [source] Is artificial light at night too much of a good thing?CLINICAL AND EXPERIMENTAL OPTOMETRY, Issue 4 2005Barry A J. Clark BSc MAppSc PhD DipMechE Director No abstract is available for this article. [source] Design and analysis for the Gaussian process model,QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL, Issue 5 2009Bradley Jones Abstract In an effort to speed the development of new products and processes, many companies are turning to computer simulations to avoid the time and expense of building prototypes. These computer simulations are often complex, taking hours to complete one run. If there are many variables affecting the results of the simulation, then it makes sense to design an experiment to gain the most information possible from a limited number of computer simulation runs. The researcher can use the results of these runs to build a surrogate model of the computer simulation model. The absence of noise is the key difference between computer simulation experiments and experiments in the real world. Since there is no variability in the results of computer experiments, optimal designs, which are based on reducing the variance of some statistic, have questionable utility. Replication, usually a ,good thing', is clearly undesirable in computer experiments. Thus, a new approach to experimentation is necessary. Published in 2009 by John Wiley & Sons, Ltd. [source] Silence in the Context of ,Child Voice'CHILDREN & SOCIETY, Issue 1 2010Ann Lewis Recent decades have seen growing enthusiasm internationally for the concept and practice of ,child voice'. This was encapsulated in, and stimulated, by Article 12 of the 1989 United Nations Convention on the Rights of the Child. This article presents the case for incorporating the equally important concept of ,child silence' in both research and applied contexts. ,Child voice' has become a powerful moral crusade and consequently criticism of voice has been muted. This is despite the growing articulation of reservations about ,child voice' in various research and applied contexts. Two particular sets of emerging concerns are discussed: one set is around the purposes behind such engagement with children; and one set relates to the ethical protocols involved. Finally, the article makes a series of recommendations for researchers working in the fields of ,child voice'. These concern five methodological aspects: recognising, noting, responding to, interpreting and reporting silence from children. It is concluded that it is timely to take a step back from assumed support for ,child voice' as necessarily ,a good thing'. Rather, we need to consider more reflexively how, why and when ,child voice' is realised in co-constructed research and professional contexts. [source] Good Enough Governance: Poverty Reduction and Reform in Developing CountriesGOVERNANCE, Issue 4 2004Merilee S. Grindle The good governance agenda is unrealistically long and growing longer over time. Among the multitude of governance reforms that "must be done" to encourage development and reduce poverty, there is little guidance about what's essential and what's not, what should come first and what should follow, what can be achieved in the short term and what can only be achieved over the longer term, what is feasible and what is not. If more attention is given to sorting out these questions, "good enough governance" may become a more realistic goal for many countries faced with the goal of reducing poverty. Working toward good enough governance means accepting a more nuanced understanding of the evolution of institutions and government capabilities; being explicit about trade-offs and priorities in a world in which all good things cannot be pursued at once; learning about what's working rather than focusing solely on governance gaps; taking the role of government in poverty alleviation seriously; and grounding action in the contextual realities of each country. [source] | ||||||||||||||||||||||