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Global Spread (global + spread)
Selected AbstractsPrevention of pneumococcal disease in children.ACTA PAEDIATRICA, Issue 5 2001Pneumococcal conjugate vaccines: their use globally could have a major impact on public health Pneumococcal disease is a major cause of morbidity and mortality in infants and young children worldwide. New pneumococcal conjugate vaccines include 7 to 11 serotypes, which are the most common cause of paediatric disease in most parts of the world. The efficacy of a 7-valent conjugate vaccine was 97.4% (95% CI, 82.7,99.9) against invasive pneumococcal disease, and 57% (95% CI, 44,67) against otitis media, caused by vaccine serotypes. Evidence shows that the vaccine has the potential to prevent pneumonia. Pneumococcal conjugate vaccination has also been shown to reduce nasopharyngeal carriage of vaccine serotypes (particularly serotypes associated with antibiotic resistance). Thus widespread use of pneumococcal conjugate vaccine could substantially reduce the burden of invasive disease and would have the potential to control the global spread of antibiotic resistance in pneumococci. Conclusion: It is important that these highly effective vaccines should be made available to children in the developing countries. [source] Cross-country experiences and policy implications from the global financial crisisECONOMIC POLICY, Issue 62 2010Stijn Claessens Summary The financial crisis of 2007--2008 is rooted in a number of factors, some common to previous financial crises, others new. Analysis of post-crisis macroeconomic and financial sector performance for 58 advanced countries and emerging markets shows a differential impact of old and new factors. Factors common to other crises, like asset price bubbles and current account deficits, help to explain cross-country differences in the severity of real economic impacts. New factors, such as increased financial integration and dependence on wholesale funding, help to account for the amplification and global spread of the financial crisis. Our findings point to vulnerabilities to be monitored and areas of needed national and international reforms to reduce risk of future crises and cross-border spillovers. They also reinforce a (sad) state of knowledge: much of how crises start and spread remains unknown. --- Stijn Claessens, Giovanni Dell'Ariccia, Deniz Igan and Luc Laeven [source] International patterns of environmental policy change and convergenceENVIRONMENTAL POLICY AND GOVERNANCE, Issue 2 2005Per-Olof Busch Abstract The article gives an empirical overview of the international spread of 22 environmental policy innovations. The policy innovations examined in the article include administrative institutions (e.g. environmental ministries, scientific advisory bodies), laws (e.g. soil protection laws, packaging waste laws), instruments of environmental policy integration (e.g. national environmental policy plans, environmental impact assessment), energy taxes and eco-labels. On this empirical basis, recurring patterns in the global spread of environmental policy innovations are identified and linked to specific causal mechanisms through which this change occurs. In particular, the paper demonstrates how and to what extent non-obligatory diffusion, legal harmonization and coercive imposition matter as mechanisms of global environmental policy convergence. Copyright © 2005 John Wiley & Sons, Ltd and ERP Environment. [source] The establishment of an urban bird populationJOURNAL OF ANIMAL ECOLOGY, Issue 5 2008Christian Rutz Summary 1Despite the accelerating global spread of urbanized habitats and its associated implications for wildlife and humans, surprisingly little is known about the biology of urban ecosystems. 2Using data from a 60-year study period, this paper provides a detailed description of how the northern goshawk Accipiter gentilis L. , generally considered a shy forest species , colonized the city of Hamburg, Germany. Six non-mutually exclusive hypotheses are investigated regarding the environmental factors that may have triggered this invasion. 3The spatio-temporal analysis of 2556 goshawk chance observations (extracted from a total data set of 1 174 493 bird observations; 1946,2003) showed that hawks regularly visited the city centre decades before the first successful breeding attempts were recorded. Many observations were made in parts of the city where territories were established in later years, demonstrating that these early visitors had encountered, but not used, potential nest sites. 4Pioneer settlement coincided with: (i) an increase in (legal) hunting pressure on goshawks in nearby rural areas; (ii) an increase in avian prey abundance in the city; and (iii) a succession of severe winters in the Greater Hamburg area. On the other hand, there was no evidence to suggest that the early stages of the invasion were due to: (i) decreasing food availability in rural areas; (ii) major habitat changes in the city; or (iii) rural intraguild dynamics forcing hawks into urban refugia. While breeding numbers of a potential rural source population were at a long-term low when the city was colonized, prior to first settlement there was a sharp increase of goshawk chance observations in the city and its rural periphery. 5The urban population expanded rapidly, and pair numbers began to stabilize after about 10 years. Ringing data (219 ringed nestlings from 70 urban broods; 1996,2000) demonstrated that most urban recruits had fledged in the city, but also confirmed considerable gene flow between urban and rural habitats. Analysis of chance observations (as raw data or as detrended time series) suggested a tight coupling of population dynamics inside and outside the city. 6City-colonizations such as the one described here provide a valuable opportunity to study some fundamental aspects of population ecology on a scale at which detailed monitoring is logistically feasible. Furthermore, a good understanding of urban ecology has become essential for efficient wildlife conservation in modern, human-altered environments. [source] Evaluation of a new, fully automated immunoassay for detection of HTLV-I and HTLV-II antibodiesJOURNAL OF MEDICAL VIROLOGY, Issue 3 2008Xiaoxing Qiu Abstract Screening blood donations for human T-lymphotropic virus types I and II (HTLV-I/II) continues to be important in protecting the safety of blood products and controlling the global spread of these retroviruses. We have developed a fully automated, third generation chemiluminescent immunoassay, ARCHITECT rHTLV-I/II, for detection of antibodies to HTLV-I/II. The assay utilizes recombinant proteins and synthetic peptides and is configured in a double antigen sandwich assay format. Specificity of the assay was 99.98% (9,254/9,256, 95% CI,=,99.92,100%) with the negative specimens from the general population including blood donors, hospital patients and pregnant women from the US, Japan and Nicaragua. The assay demonstrated 100% sensitivity by detecting 498 specimens from individuals infected with HTLV-I (n,=,385) and HTLV-II (n,=,113). ARCHITECT rHTLV-I/II results were in complete agreement with the Murex HTLV-I/II reference assay and 99.7% agreement with the Genelabs HTLV Blot 2.4 confirmatory assay. Analytical sensitivity of the assay was equivalent to Murex HTLV-I/II assay based on end point dilutions. Furthermore, using a panel of 397 specimens from Japan, the ARCHITECT rHTLV-I/II assay exhibited distinct discrimination between the antibody negative (Delta Value,=,,7.6) and positive (Delta Value,=,7.6) populations. Based on the excellent specificity and sensitivity, the new ARCHITECT rHTLV-I/II assay should be an effective test for the diagnosis of HTLV-I/II infection and also for blood donor screening. J. Med. Virol. 80:484,493, 2008. © 2008 Wiley-Liss, Inc. [source] Detection of unusual rotavirus genotypes G8P[8] and G12P[6] in South KoreaJOURNAL OF MEDICAL VIROLOGY, Issue 1 2008Van Phan Le Abstract Five hundred four fecal specimens, collected between 2004 and 2006 from young children with acute diarrhea, were screened for rotavirus by ELISA with VP6-specific antibody. Of these samples, 394 (78.2%) were confirmed as group A rotavirus and they underwent G- and P typing using a combination of ELISA, RT-PCR, and sequence analysis methods. The dominant circulating G serotype was G1 (35.6%) followed by G3 (26.4%), G4 (14.7%), and G2 (11.9%). There was a low prevalence of G9 (1.0%) and of unusual G type rotavirus, in particular, G12 (0.5%) and G8 (0.3%). Of the P genotype rotavirus in circulation, P[8] (53.0%) was most common followed by P[6] (15.5%), P[4] (15.2%), and P[9] (2.3%). Determination of G- and P type combinations revealed that G1P[8] strains were most prevalent (25.4%), amid G3P[8] (16.8%), G2P[4] (6.3%), and G4P[6] (6.1%) strains. Unusual or rare combinations such as G2P[6], G2P[8], G3P[4], G2P[9], G1P[9], G3P[9], G12P[6], G1P[4], G3P[6], and G8P[8] were also found. Owing to the recent emergence of G8 and G12 rotavirus, the findings from this study are important since they provide new information concerning the local and global spread of rotavirus genotypes. J. Med. Virol. 80:175,182, 2008. © 2007 Wiley-Liss, Inc. [source] Epidemiology of meningococcal disease in AustraliaJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 2001J Jelfs Abstract: A review of the epidemiology of meningococcal disease (MD) in Australia was undertaken, with particular emphasis on the 1990s, when national strain differentiation data became available. The data included a review of clinical and laboratory notification data and published reports on clusters and outbreaks. There have been considerable changes in the patterns of MD in the 1990s. In some cases, these changes can be related to the dominance of a particular phenotype. In the early 1990s, widely scattered urban and rural clusters were associated with the phenotype C:2b:P1.2 and strains were closely genetically related. Larger urban clusters and increased numbers of cases in adolescents and young adults were most obvious in New South Wales in the mid-1990s and were associated with a phenotype C:2a:P1.5. This ET-15 clone of the ET-37 complex caused similar patterns of MD to those seen in other countries as part of the global spread of the clone. In contrast, the B:4:P1.4 phenotype, with close genetic similarities to New Zealand strains, did not cause the hyperendemic disease seen in New Zealand this decade. The epidemiology of MD will continue to exhibit considerable variation due, at least in part, to the genetic flexibility of meningococci. Information about strain variation expands our understanding of changing patterns of disease. [source] Leaders without ethics in global business: Corporate psychopathsJOURNAL OF PUBLIC AFFAIRS, Issue 3 2010Clive R. P. Boddy This paper introduces the concept of Corporate Psychopaths as ruthless employees who can successfully gain entry to organizations and can then get promoted within those organizations to reach senior managerial and leadership positions. What little empirical research currently exists supports the view that Corporate Psychopaths are more commonly found at senior levels of organizations. This paper presents further empirical evidence that supports this view. It discusses how, in a quantitative sample of 346 white-collar workers, in 2008, research using a psychopathy scale identified greater levels of psychopathy at more senior levels of corporations than at more junior levels. The paper goes on to propose that this is a universal issue that can pose various ethical problems for corporations because of the ruthless, selfish and conscience-free approach to life that Corporate Psychopaths have. Other ethical issues are to do with their moral accountability and with the problems associated with the possibility of screening employees for psychopathy. The paper reviews the literature on psychopathy and concludes that while psychopaths appear to be universal in occurrence, they may well be environmentally limited in their possible actions in more collectivist societies. However, the global spread of western, individualistically oriented corporations may pose a threat to any collectivist societies in which they operate. Copyright © 2010 John Wiley & Sons, Ltd. [source] Mitochondrial DNA reveals multiple Northern Hemisphere introductions of Caprella mutica (Crustacea, Amphipoda)MOLECULAR ECOLOGY, Issue 5 2008GAIL V. ASHTON Abstract Caprella mutica (Crustacea, Amphipoda) has been widely introduced to non-native regions in the last 40 years. Its native habitat is sub-boreal northeast Asia, but in the Northern Hemisphere, it is now found on both coasts of North America, and North Atlantic coastlines of Europe. Direct sequencing of mitochondrial DNA (cytochrome c oxidase subunit I gene) was used to compare genetic variation in native and non-native populations of C. mutica. These data were used to investigate the invasion history of C. mutica and to test potential source populations in Japan. High diversity (31 haplotypes from 49 individuals), but no phylogeographical structure, was identified in four populations in the putative native range. In contrast, non-native populations showed reduced genetic diversity (7 haplotypes from 249 individuals) and informative phylogeographical structure. Grouping of C. mutica populations into native, east Pacific, and Atlantic groups explained the most among-region variation (59%). This indicates independent introduction pathways for C. mutica to the Pacific and Atlantic coasts of North America. Two dominant haplotypes were identified in eastern and western Atlantic coastal populations, indicating several dispersal routes within the Atlantic. The analysis indicated that several introductions from multiple sources were likely to be responsible for the observed global distribution of C. mutica, but the pathways were least well defined among the Atlantic populations. The four sampled populations of C. mutica in Japan could not be identified as the direct source of the non-native populations examined in this study. The high diversity within the Japan populations indicates that the native range needs to be assessed at a far greater scale, both within and among populations, to accurately assess the source of the global spread of C. mutica. [source] Molecular characterization of CTX-M-15-producing clinical isolates of Escherichia coli reveals the spread of multidrug-resistant ST131 (O25:H4) and ST964 (O102:H6) strains in NorwayAPMIS, Issue 7 2009UMAER NASEER Nationwide, CTX-M-producing clinical Escherichia coli isolates from the Norwegian ESBL study in 2003 (n=45) were characterized on strain and plasmid levels. BlaCTX-M allele typing, characterization of the genetic environment, phylogenetic groups, pulsed field gel electrophoresis (PFGE), serotyping and multilocus sequence typing were performed. Plasmid analysis included S1 -nuclease-PFGE, polymerase chain reaction-based replicon typing, plasmid transfer and multidrug resistance profiling. BlaCTX-M-15 (n=23; 51%) and blaCTX-M-14 (n=11; 24%) were the major alleles of which 18 (78%) and 6 (55%), respectively, were linked to ISEcp1. Thirty-two isolates were of phylogenetic groups B2 and D. Isolates were of 29 different XbaI-PFGE-types including six regional clusters. Twenty-three different O:H serotypes were found, dominated by O25:H4 (n=9, 20%) and O102:H6 (n=9, 20%). Nineteen different STs were identified, where ST131 (n=9, 20%) and ST964 (n=7, 16%) were dominant. BlaCTX-M was found on ,100 kb plasmids (39/45) of 10 different replicons dominated by IncFII (n=39, 87%), FIB (n=20, 44%) and FIA (n=19, 42%). Thirty-nine isolates (87%) displayed co-resistance to other classes of antibiotics. A transferable CTX-M phenotype was observed in 9/14 isolates. This study reveals that the majority of CTX-M-15-expressing strains in Norway are part of the global spread of multidrug-resistant ST131 and ST-complex 405, associated with ISEcp1 on transferrable IncFII plasmids. [source] The value of commodity biographies: integrating tribal farmers in India into a global organic agro-food networkAREA, Issue 1 2010Martin Franz The production of organic food has been regarded for a long time as being synonymous with ecological regional production systems. However, the increased production of organic food products has led to an ongoing industrialisation and also to a global spread of network structures within this segment of agriculture. This paper provides a case study of the integration of organic pepper farmers from an indigenous tribe in Kerala, India, into global agro-food networks, linking them to a German producer of organic meat products. The results of this study show that the importance of the territorial embeddedness and the abandonment of the exercise of power can be crucial for the success of global organic agro-food networks. [source] Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class AntibioticsCHEMMEDCHEM, Issue 7 2006Berthold Hinzen The therapy of life-threatening infections is significantly weakened by the global spread of antibiotic resistance. Synthetic exploration of enopeptin type acyldepsipeptide antibiotics revealed a remarkable structure,activity relationship. New compounds with improved in,vitro antibiotic activity against Gram-positive pathogens (including multiresistant strains) and in,vivo activity in mouse models of lethal infection are described. 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