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Giant Cell Lesions (giant + cell_lesion)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Quantitative analysis of argyrophilic nuclear organizer regions in giant cell lesions of jaws

JOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 5 2010
Donia Sadri
J Oral Pathol Med (2010) 39: 431,434 Background:, Giant cell lesions of the jaws are considerably similar according to histopathologic characteristics yet show different clinical behaviors. These lesions include central giant cell granuloma (CGCG), aneurysmal bone cyst, Cherubism, and Brown tumor associated with hyperparathyroidism. The present study aimed to investigate AgNORs count in these lesions as a proliferative marker and to determine whether it can be used to discriminate between them or not. Methods:, Forty-one cases of giant cell lesions of jaws were retrived from Oral Pathology Department (1987,2007). They included 21 cases of CGCG, eight cases of aneurysmal bone cyst (ABC), six cases of Cherubism, six cases of Brown tumor. The mean AgNORs count was calculated for all cases. To compare mean AgNORs in groups of lesions, ANOVA test was performed. Results:, Mean AgNOR counts were: (0/85 ± 0/29) in CGCG, (0/76 ± 0/32) in ABC (0/87 ± 0/10) in Cherubism and (0/82 ± 0/16) in Brown tumor. A significant difference was not observed in AgNOR counts among these groups of lesions. Conclusions:, Jaws giant cell containing lesions have no acceptable differences in mean AgNORs. [source]

NFATc1 and TNF, expression in giant cell lesions of the jaws

JOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 3 2010
Fabrício Rezende Amaral
J Oral Pathol Med (2010) 39: 269,274 Background:, Activation mutations of SH3BP2 gene have been demonstrated in cherubism and central giant cell lesion (CGCL). In the present study we first attempted to investigate the SH3BP2 gene in peripheral giant cell lesion (PGCL). The effect of SH3BP2 gene mutations on the transcription of the downstream genes nuclear factor of activated T cells (NFATc1) and the cytokine tumor necrosis factor-, (TNF-,) was also investigated together with the immunolocalization of NFATc1 protein in a set of cases of PGCL, CGCL and cherubism with and without SH3BP2 mutation. Method:, Fresh samples of five PGCL, five CGCL and one cherubism cases were included in this study. One of the samples of CGCL presented a somatic heterozygous mutation c.1442A>T in exon 11. The cherubism case showed a heterozygotic substitution c.320C>T in both blood and lesion. These mutations were previously published. All coding and flanking regions of the SH3BP2 gene were sequenced in the cases of PGCL. The real-time polymerase chain reaction (RT-PCR) was performed to analyze the transcription of NFATc1 and TNF-, genes. The immunohistochemical analysis of the NFATc1 protein was also performed. Results:, No SH3BP2 gene mutation was found in PGCL. The RT-PCR showed increased expression of NFATc1 and decreased transcription of TNF-, in all the samples. The immunohistochemical analysis of the NFATc1 protein showed a predominant nuclear staining in the multinucleated giant cells. Conclusion:, The development of giant cells lesions of the jaws and cherubism are possibly mediated by overexpression of NFAT in the nucleus of the multinucleated cells. [source]

Noonan syndrome with giant cell lesions

INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, Issue 1 2006
J. De Lange
No abstract is available for this article. [source]

Quantitative analysis of argyrophilic nuclear organizer regions in giant cell lesions of jaws

JOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 5 2010
Donia Sadri
J Oral Pathol Med (2010) 39: 431,434 Background:, Giant cell lesions of the jaws are considerably similar according to histopathologic characteristics yet show different clinical behaviors. These lesions include central giant cell granuloma (CGCG), aneurysmal bone cyst, Cherubism, and Brown tumor associated with hyperparathyroidism. The present study aimed to investigate AgNORs count in these lesions as a proliferative marker and to determine whether it can be used to discriminate between them or not. Methods:, Forty-one cases of giant cell lesions of jaws were retrived from Oral Pathology Department (1987,2007). They included 21 cases of CGCG, eight cases of aneurysmal bone cyst (ABC), six cases of Cherubism, six cases of Brown tumor. The mean AgNORs count was calculated for all cases. To compare mean AgNORs in groups of lesions, ANOVA test was performed. Results:, Mean AgNOR counts were: (0/85 ± 0/29) in CGCG, (0/76 ± 0/32) in ABC (0/87 ± 0/10) in Cherubism and (0/82 ± 0/16) in Brown tumor. A significant difference was not observed in AgNOR counts among these groups of lesions. Conclusions:, Jaws giant cell containing lesions have no acceptable differences in mean AgNORs. [source]

NFATc1 and TNF, expression in giant cell lesions of the jaws

JOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 3 2010
Fabrício Rezende Amaral
J Oral Pathol Med (2010) 39: 269,274 Background:, Activation mutations of SH3BP2 gene have been demonstrated in cherubism and central giant cell lesion (CGCL). In the present study we first attempted to investigate the SH3BP2 gene in peripheral giant cell lesion (PGCL). The effect of SH3BP2 gene mutations on the transcription of the downstream genes nuclear factor of activated T cells (NFATc1) and the cytokine tumor necrosis factor-, (TNF-,) was also investigated together with the immunolocalization of NFATc1 protein in a set of cases of PGCL, CGCL and cherubism with and without SH3BP2 mutation. Method:, Fresh samples of five PGCL, five CGCL and one cherubism cases were included in this study. One of the samples of CGCL presented a somatic heterozygous mutation c.1442A>T in exon 11. The cherubism case showed a heterozygotic substitution c.320C>T in both blood and lesion. These mutations were previously published. All coding and flanking regions of the SH3BP2 gene were sequenced in the cases of PGCL. The real-time polymerase chain reaction (RT-PCR) was performed to analyze the transcription of NFATc1 and TNF-, genes. The immunohistochemical analysis of the NFATc1 protein was also performed. Results:, No SH3BP2 gene mutation was found in PGCL. The RT-PCR showed increased expression of NFATc1 and decreased transcription of TNF-, in all the samples. The immunohistochemical analysis of the NFATc1 protein showed a predominant nuclear staining in the multinucleated giant cells. Conclusion:, The development of giant cells lesions of the jaws and cherubism are possibly mediated by overexpression of NFAT in the nucleus of the multinucleated cells. [source]