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General Agreement (general + agreement)
Selected AbstractsThe Impact of Trade Liberalization on Regional Disparities in MexicoGROWTH AND CHANGE, Issue 1 2002Javier Sánchez-Reaza After a long period of industrialization based on import substitution (ISI), Mexico started to open up its economy by accessing the General Agreement on Tariffs and Trade (GATT) in 1986. The export-promotion strategy was transformed into one of regional integration with the signing of the North American Free Trade Agreement (NAFTA) in 1994. The paper explores the impact of the opening of the economy on regional disparities in Mexico using , and ,-convergence analyses. Four different samples have been employed to control for possible data bias linked to the inclusion of oil-producing and maquiladora-based states. The results show that whereas the final stages of the ISI period were dominated by convergence trends, trade liberalization (GATT) and economic integration (NAFTA) have led to divergence. In particular, the NAFTA period is related to divergence regardless of the type of analysis chosen and the sample used. [source] The Power of the Chair: Formal Leadership in International CooperationINTERNATIONAL STUDIES QUARTERLY, Issue 1 2010Jonas Tallberg This article addresses the influence wielded by the formal leaders of international cooperation,those state or supranational representatives that chair and direct negotiations in the major decision bodies of multilateral organizations and conferences. This is a topic that so far has received limited systematic attention by IR theorists, who have tended to treat bargaining parties as functionally and formally equivalent, leaving little theoretical space for formal leadership. Drawing on rational choice institutionalism, I introduce a theory that develops a coherent argument for the delegation of authority to the chairmanship, the power resources of negotiation chairs, and the influence of formal leaders over outcomes. I assess the explanatory power of this theory through evidence on formal leadership in three alternative organizational settings: the European Union, the General Agreement on Tariffs and Trade/the World Trade Organization, and the United Nations environmental conferences. I find in favor of the chairmanship as a source of independent influence in international cooperation. Formal leaders perform functions of agenda management, brokerage, and representation that make it more likely for negotiations to succeed, and possess privileged resources that may enable them to steer negotiations toward the agreements they most prefer. [source] Can Remittances Spur Development?INTERNATIONAL STUDIES REVIEW, Issue 1 2006A Critical Survey The increasing volume of global remittances has impressed policymakers and social scientists alike. Besides outpacing official development assistance and private capital flows, remittances have proven markedly stable and counter-cyclical. They represent an essential nondebt creating, safety-net vehicle administered by extended families and local communities rather than provincial and national governments. This essay surveys the recent pattern of remittances and critically examines the theoretical and empirical literature on their determinants and welfare impact. The argument is made that the developmental contribution of remittances can be significantly enhanced through complementary macroeconomic policies in labor exporting countries and financial innovations in remittance transmission. Enhanced policy coordination on temporary transnational worker migration,as facilitated by Mode 4 of the General Agreement on Trade in Services,can prove instrumental in helping remittances offset the traditional brain drain besetting developing economies. [source] The ,Enfant Terrible': Australia and the Reconstruction of the Multilateral Trade system, 1946,8AUSTRALIAN ECONOMIC HISTORY REVIEW, Issue 1 2000Ann Capling In recent years Australia has been recognized as a prominent player in the General Agreement on Tariffs and Trade (GATT) and its successor, the World Trade Organization (WTO). Less well known is Australia's activism during the establishment of the GATT. This article, based on archival sources and contemporary accounts, examines Australia's role in the birth of the multilateral trade system. It seeks to nuance the two conventional interpretations of this period, the first which argues that countries joined the GATT because it was in their economic interests to do so, and the second which suggests that the United States hegemony imposed its trade liberalization objectives on less powerful allies and trade partners. [source] Free Trade Agreements and the Prospects for Regional Integration in East AsiaASIAN ECONOMIC POLICY REVIEW, Issue 2 2006Razeen SALLY Trade policy in East Asia has switched from non-discriminatory unilateral liberalization, reinforced by General Agreements on Tariffs and Trade/World Trade Organization (GATT/WTO) commitments, to discriminatory free trade agreements (FTA). The paper surveys the FTA activity of the major regional players: China, the ASEAN countries, Japan, and South Korea. It concludes that emerging FTAs are weak and partial. A hub-and-spoke pattern of dirty FTAs will not drive regional economic integration or further integration with the global economy. Rather, it could be a force of regional economic disintegration , especially if the multilateral trading system weakens further. At the same time, FTA activity is distracting attention from the WTO, and, more fundamentally, from unilateral liberalization and domestic structural reforms. Hence, East Asian trade policies need to be rebalanced, with better-quality FTAs and more focus on the WTO. However, more important than the WTO and FTAs is a fresh spurt of unilateral liberalization and structural reform outside trade negotiations. [source] Electronic Structure of the Ground and Excited States of ,-CarbolineCHEMPHYSCHEM, Issue 6 2008Vicente Pérez Mondéjar Abstract Coupled-cluster calculations are used to compute the energy of conversion between the neutral and the zwitterionic forms of ,-carboline. The stability of the different species is discussed in terms of charge separation and aromatic character, which is related to magnetic criteria. By means of a linear response formalism the vertical excitation energies and oscillator strengths of the lowest singlet states of both structures as well as of the cationic species are determined. General agreement of the relative position and intensity of the different peaks with experimental data is achieved, but the overall spectra are slightly displaced because of solvent effects. [source] FS13.5 Occupational contact dermatitis: printer worker's viewpointsCONTACT DERMATITIS, Issue 3 2004Terry Brown Introduction:, Occupational contact dermatitis (OCD) is very common in the printing industry due to contact with chemicals, paper, and wet work. It can be avoided by adequate protective measures, but the effectiveness of intervention depends heavily on the employer's and employee's awareness of this health risk. Objectives:, The study aimed to collect information on the knowledge, attitudes and beliefs of print workers about the risk of OCD and methods of prevention. Methods:, A series of focus groups were held with print workers, health and safety officers and managers to discuss their awareness of dermal risk factors, risk behaviour at work, attitudes to health and safety and options on possible preventive measures. A number of companies were also visited to observe, overtly and covertly, the normal work practices. Results:, OCD was not perceived to be either a major problem or a health and safety priority. There was general agreement about the processes and work practices that could cause skin problems. However, work practices varied considerably and did not always reflect this awareness. There was general concern about the type and availability of personal protective equipment, especially gloves and after-work skin cream. The provision of an occupational health service was generally felt to be inadequate, and no company had a policy in place that specifically addressed skin care. Conclusions:, These findings highlight the urgency to intensify health and safety education on skin care within the printing industry. Recommendations were developed for the evaluation of a series of risk reduction strategies. [source] Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseasesDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 6 2006Eugenio Cersosimo Abstract Cardiovascular disease affects approximately 60% of the adult population over the age of 65 and represents the number one cause of death in the United States. Coronary atherosclerosis is responsible for the vast majority of the cardiovascular events, and a number of cardiovascular risk factors have been identified. In recent years, it has become clear that insulin resistance and endothelial dysfunction play a central role in the pathogenesis of atherosclerosis. Much evidence supports the presence of insulin resistance as the fundamental pathophysiologic disturbance responsible for the cluster of metabolic and cardiovascular disorders, known collectively as the metabolic syndrome. Endothelial dysfunction is an important component of the metabolic or insulin resistance syndrome and this is demonstrated by inadequate vasodilation and/or paradoxical vasoconstriction in coronary and peripheral arteries in response to stimuli that release nitric oxide (NO). Deficiency of endothelial-derived NO is believed to be the primary defect that links insulin resistance and endothelial dysfunction. NO deficiency results from decreased synthesis and/or release, in combination with exaggerated consumption in tissues by high levels of reactive oxygen (ROS) and nitrogen (RNS) species, which are produced by cellular disturbances in glucose and lipid metabolism. Endothelial dysfunction contributes to impaired insulin action, by altering the transcapillary passage of insulin to target tissues. Reduced expansion of the capillary network, with attenuation of microcirculatory blood flow to metabolically active tissues, contributes to the impairment of insulin-stimulated glucose and lipid metabolism. This establishes a reverberating negative feedback cycle in which progressive endothelial dysfunction and disturbances in glucose and lipid metabolism develop secondary to the insulin resistance. Vascular damage, which results from lipid deposition and oxidative stress to the vessel wall, triggers an inflammatory reaction, and the release of chemoattractants and cytokines worsens the insulin resistance and endothelial dysfunction. From the clinical standpoint, much experimental evidence supports the concept that therapies that improve insulin resistance and endothelial dysfunction reduce cardiovascular morbidity and mortality. Moreover, interventional strategies that reduce insulin resistance ameliorate endothelial dysfunction, while interventions that improve tissue sensitivity to insulin enhance vascular endothelial function. There is general agreement that aggressive therapy aimed simultaneously at improving insulin-mediated glucose/lipid metabolism and endothelial dysfunction represents an important strategy in preventing/delaying the appearance of atherosclerosis. Interventions that 1 correct carbohydrate and lipid metabolism, 2 improve insulin resistance, 3 reduce blood pressure and restore vascular reactivity, and 4 attenuate procoagulant and inflammatory responses in adults with a high risk of developing cardiovascular disease reduce cardiovascular morbidity and mortality. Whether these benefits hold when the same prevention strategies are applied to younger, high-risk individuals remains to be determined. Copyright © 2006 John Wiley & Sons, Ltd. [source] On the justification for civil commitmentACTA PSYCHIATRICA SCANDINAVICA, Issue 399 2000G. Hřyer This paper explores some of the controversies in the debate regarding the justification of civil commitment. The sometimes conflicting values reflected in the mental health legislation, human rights principles, moral philosophy and psychiatric professional standards are discussed. In spite of the often substantial use of civil commitment in many countries, there are almost no scientifically sound studies addressing the outcome of coercive treatment. The paper establishes that the traditional arguments in favour of civil commitment, like lack of insight and competence as well as the effectiveness of civil commitment, are poorly founded. The paper concludes that there seems to be a general agreement that civil commitment of patients who are dangerous to themselves or others should be the responsibility of the mental health care system, while civil commitment for treatment purposes is more controversial and hard to justify. [source] Conservation Biogeography: assessment and prospectDIVERSITY AND DISTRIBUTIONS, Issue 1 2005Robert J. Whittaker ABSTRACT There is general agreement among scientists that biodiversity is under assault on a global basis and that species are being lost at a greatly enhanced rate. This article examines the role played by biogeographical science in the emergence of conservation guidance and makes the case for the recognition of Conservation Biogeography as a key subfield of conservation biology delimited as: the application of biogeographical principles, theories, and analyses, being those concerned with the distributional dynamics of taxa individually and collectively, to problems concerning the conservation of biodiversity. Conservation biogeography thus encompasses both a substantial body of theory and analysis, and some of the most prominent planning frameworks used in conservation. Considerable advances in conservation guidelines have been made over the last few decades by applying biogeographical methods and principles. Herein we provide a critical review focussed on the sensitivity to assumptions inherent in the applications we examine. In particular, we focus on four inter-related factors: (i) scale dependency (both spatial and temporal); (ii) inadequacies in taxonomic and distributional data (the so-called Linnean and Wallacean shortfalls); (iii) effects of model structure and parameterisation; and (iv) inadequacies of theory. These generic problems are illustrated by reference to studies ranging from the application of historical biogeography, through island biogeography, and complementarity analyses to bioclimatic envelope modelling. There is a great deal of uncertainty inherent in predictive analyses in conservation biogeography and this area in particular presents considerable challenges. Protected area planning frameworks and their resulting map outputs are amongst the most powerful and influential applications within conservation biogeography, and at the global scale are characterised by the production, by a small number of prominent NGOs, of bespoke schemes, which serve both to mobilise funds and channel efforts in a highly targeted fashion. We provide a simple typology of protected area planning frameworks, with particular reference to the global scale, and provide a brief critique of some of their strengths and weaknesses. Finally, we discuss the importance, especially at regional scales, of developing more responsive analyses and models that integrate pattern (the compositionalist approach) and processes (the functionalist approach) such as range collapse and climate change, again noting the sensitivity of outcomes to starting assumptions. We make the case for the greater engagement of the biogeographical community in a programme of evaluation and refinement of all such schemes to test their robustness and their sensitivity to alternative conservation priorities and goals. [source] A minimum sample size required from Schmidt hammer measurementsEARTH SURFACE PROCESSES AND LANDFORMS, Issue 13 2009Tomasz Niedzielski Abstract The Schmidt hammer is a useful tool applied by geomorphologists to measure rock strength in field conditions. The essence of field application is to obtain a sufficiently large dataset of individual rebound values, which yields a meaningful numerical value of mean strength. Although there is general agreement that a certain minimum sample size is required to proceed with the statistics, the choice of size (i.e. number of individual impacts) was usually intuitive and arbitrary. In this paper we show a simple statistical method, based on the two-sample Student's t -test, to objectively estimate the minimum number of rebound measurements. We present the results as (1) the ,mean' and ,median' solutions, each providing a single estimate value, and (2) the empirical probability distribution of such estimates based on many field samples. Schmidt hammer data for 14 lithologies, 13,81 samples for each, with each sample consisting of 40 individual readings, have been evaluated, assuming different significance levels. The principal recommendations are: (1) the recommended minimum sample size for weak and moderately strong rock is 25; (2) a sample size of 15 is sufficient for sandstones and shales; (3) strong and coarse rocks require 30 readings at a site; (4) the minimum sample size may be reduced by one-third if the context of research allows for higher significance level for test statistics. Interpretations based on less than 10 readings from a site should definitely be avoided. Copyright © 2009 John Wiley & Sons, Ltd. [source] Estimating metabolic biotransformation rates in fish from laboratory dataENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 2 2008Jon A. Arnot Abstract A method is proposed for estimating metabolic biotransformation rate constants for nonionic organic chemicals from measured laboratory bioconcentration and dietary bioaccumulation data in fish. Data have been selected based on a quality review to reduce uncertainty in the measured values. A kinetic mass balance model is used to estimate rates of chemical uptake and elimination. Biotransformation rate constants are essentially calculated as the difference between two quantities, a measured bio-concentration factor or elimination rate constant, and a model-derived bioconcentration factor or elimination rate constant estimated assuming no biotransformation. Model parameterization exploits key empirical data when they are available and assumes default values when study specific data are unavailable. Uncertainty analyses provide screening level assessments for confidence in the biotransformation rate constant estimates. The uncertainty analyses include the range for 95% of the predicted values and 95% confidence intervals for the calculated biotransformation values. Case studies are provided to illustrate the calculation and uncertainty methods. Biotransformation rate constants calculated by the proposed method are compared with other published estimates for 31 chemicals that range in octanol,water partition coefficients from approximately 101 to 108 and represent over four orders of magnitude in biotransformation potential. The comparison of previously published values with those calculated by the proposed method shows general agreement with 82% of the estimated values falling within a factor of three. [source] Murray's law and the hydraulic vs mechanical functioning of woodFUNCTIONAL ECOLOGY, Issue 6 2004K. A. McCULLOH Summary 1Murray's law states that the hydraulic conductance per blood volume of the cardiovascular system is maximized when the sum of the vessel radii cubed (, r3) is conserved. 2We hypothesize that Murray's law will apply to xylem conduits as long as they only transport water and do not also help support the plant. Specifically, the less volume of wood occupied by conduits, the more the conduits should conform to Murray's law. 3We tested the applicability of Murray's law along a continuum of decreasing conduit fraction from coniferous (91% conduits) to diffuse-porous (24% conduits) to ring-porous wood (12% conduits), using anatomical and functional tests. The anatomical test compared the , r3 conservation across branch points by direct measurements of conduit radii. The functional test compared the hydraulic conductivity between branches of different ages. 4As predicted, Murray's law was rejected in conifer wood where hydraulic function is coupled to mechanical support. The angiosperm wood did not deviate as strongly from Murray's law, especially the ring-porous type. For comparison we report previously published results from compound leaves and vines which showed general agreement with Murray's law. 5Deviation from Murray's law was associated with fewer, narrower conduits distally causing a decrease in , r3 distally. Although less efficient hydraulically, this configuration is not top-heavy and is more mechanically stable. With the evolution of vessels and fibres, angiosperm wood can more closely approach Murray's law while still meeting mechanical requirements. [source] Analytical and 3-D numerical modelling of Mt. Etna (Italy) volcano inflationGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 2 2005A. Bonaccorso SUMMARY Since 1993, geodetic data obtained by different techniques (GPS, EDM, SAR, levelling) have detected a consistent inflation of the Mt. Etna volcano. The inflation, culminating with the 1998,2001 strong explosive activity from summit craters and recent 2001 and 2002 flank eruptions, is interpreted in terms of magma ascent and refilling of the volcanic plumbing system and reservoirs. We have modelled the 1993,1997 EDM and GPS data by 3-D pressurized sources to infer the position and dimension of the magma reservoir. We have performed analytical inversions of the observed deformation using both spheroidal and ellipsoidal sources embedded in a homogeneous elastic half-space and by applying different inversion methods. Solutions for these types of sources show evidence of a vertically elongated magma reservoir located 6 km beneath the summit craters. The maximum elevation of topography is comparable to such depth and strong heterogeneities are inferred from seismic tomography; in order to assess their importance, further 3-D numerical models, employing source parameters extracted from analytical models, have been developed using the finite-element technique. The deformation predicted by all the models considered shows a general agreement with the 1993,1997 data, suggesting the primary role of a pressure source, while the complexities of the medium play a minor role under elastic conditions. However, major discrepancies between data and models are located in the SE sector, suggesting that sliding along potential detachment surfaces may contribute to amplify deformation during the inflation. For the first time realistic features of Mt. Etna are studied by a 3-D numerical model characterized by the topography and lateral variations of elastic structure, providing a framework for a deeper insight into the relationships between internal sources and tectonic structures. [source] Effective-medium theories for fluid-saturated materials with aligned cracksGEOPHYSICAL PROSPECTING, Issue 5 2001J.A. Hudson There is general agreement between different theories giving expressions for the overall properties of materials with dry, aligned cracks if the number density of cracks is small. There is also very fair agreement for fluid-filled isolated cracks. However, there are considerable differences between two separate theories for fluid-filled cracks with equant porosity. Comparison with recently published experimental data on synthetic sandstones gives a good fit with theory for dry samples. However, although the crack number density in the laboratory sample is such that first-order theory is unlikely to apply, expressions correct to second order (in the number density) provide a worse fit. It also appears that the ratio of wavelength to crack size is not sufficiently great for any detailed comparison with effective-medium theories, which are valid only when this ratio is large. The data show dispersion effects for dry cracks and scattering, neither of which will occur at sufficiently long wavelengths. Data from the water-saturated samples indicate that the effect of equant porosity is significant, although the two theories differ strongly as to just how significant. Once again, and in spite of the reservations mentioned above, a reasonable fit between theory and observation can be shown. [source] Trust, commitment and team working: the paradox of virtual organizationsGLOBAL NETWORKS, Issue 4 2004Alf Crossman The findings of a case study in an international information technology consultancy indicate that multiple relationships arising from the alliance-based structure require clear commitment to enable the development of trust as a basis for longer-term partnership. Paradoxically, the perceived low level of commitment from the organization does not engender the high level of trust and commitment required from virtual teams to maximize their performance. However, over time and with extended exchanges, the commitment level and form may evolve, thus necessitating a realignment of existing psychological understanding and trust between the actors. If there is general agreement that an upward shift from short-term to long-term commitment is beneficial to all, then the virtual arrangement will continue to be effective. [source] Inter- and intra-observer reliability of radiographic scores commonly used for the evaluation of haemophilic arthropathyHAEMOPHILIA, Issue 3 2008M. SILVA Summary., Although the severity of haemophilic arthropathy is commonly assessed using established radiographic scoring systems, there is limited available information about their inter- and intra-observer reliability. The purpose of the present study was to establish the inter-observer reliability (IEOR) and intra-observer reliability (IAOR) of three different methods available for the classification of haemophilic arthropathy, including the Arnold and Hilgartner classification, a modification to the Arnold and Hilgartner system described by Luck et al., and the classification described by Pettersson et al. Antero-posterior and lateral radiographs of 54 haemophilic joints were included for the analysis. To determine the IEOR for each one of the three radiographic systems, the radiographs were randomly evaluated by four observers, including two orthopaedic surgeons, one orthopaedic resident and one haematologist. For the determination of IAOR, all four reviewers repeated the assessment in a similar fashion, after a period of at least 2 weeks. IEOR and IAOR for the three classification systems was established using kappa (,) statistics. A Spearman rank correlation was used to determine the similarities between each reviewer's own interpretative scales. The IEOR was low for the Arnold and Hilgartner system (, = 0.35, P , 0.001) and the Luck system (, = 0.38, P , 0.001), but even lower for the Pettersson system (, = 0.06, P = 0.1). For the Pettersson system, particularly low , values were observed for the presence or absence of osteoporosis (, = 0.11, P = 0.0027), enlarged epiphysis (, = 0.10, P = 0.0039), erosion of joint margins (, = 0.11, P = 0.0018), and joint deformity (, = 0.16, P = 0.00001). However, a relatively high Spearman rank correlation for all three scales [rs = 0.75 (P < 0.001) for Arnold and Hilgartner system, rs = 0.74 (P < 0.001) for the Luck system and rs = 0.81 (P < 0.001) for Pettersson system] indicated an overall, general agreement among the reviewers with regard to the severity of the haemophilic arthropathy. There was a moderate IAOR value for both, the Arnold and Hilgartner system (, = 0.57, P = 0.00001) and the Luck system (, = 0.62, P = 0.00001) with a low IAOR value for the Pettersson system [, = 0.22, P = 0.00001). Currently available radiographic scoring systems for haemophilic arthropathy have low inter- and intra-observer reliability rates. Improvements, either through education or modification of the scoring systems, are critical in an era where correlations between clinical and radiographic scores have received significant attention. [source] Quantifying contributions to storm runoff through end-member mixing analysis and hydrologic measurements at the Panola Mountain Research Watershed (Georgia, USA)HYDROLOGICAL PROCESSES, Issue 10 2001Douglas A. Burns Abstract The geographic sources and hydrologic flow paths of stormflow in small catchments are not well understood because of limitations in sampling methods and insufficient resolution of potential end members. To address these limitations, an extensive hydrologic dataset was collected at a 10 ha catchment at Panola Mountain Research Watershed near Atlanta, GA, to quantify the contribution of three geographic sources of stormflow. Samples of stream water, runoff from an outcrop, and hillslope subsurface stormflow were collected during two rainstorms in the winter of 1996, and an end-member mixing analysis model that included five solutes was developed. Runoff from the outcrop, which occupies about one-third of the catchment area, contributed 50,55% of the peak streamflow during the 2 February rainstorm, and 80,85% of the peak streamflow during the 6,7 March rainstorm; it also contributed about 50% to total streamflow during the dry winter conditions that preceded the 6,7 March storm. Riparian groundwater runoff was the largest component of stream runoff (80,100%) early during rising streamflow and throughout stream recession, and contributed about 50% to total stream runoff during the 2 February storm, which was preceded by wet winter conditions. Hillslope runoff contributed 25,30% to peak stream runoff and 15,18% to total stream runoff during both storms. The temporal response of the three runoff components showed general agreement with hydrologic measurements from the catchment during each storm. Estimates of recharge from the outcrop to the riparian aquifer that were independent of model calculations indicated that storage in the riparian aquifer could account for the volume of rain that fell on the outcrop but did not contribute to stream runoff. The results of this study generally indicate that improvements in the ability of mixing models to describe the hydrologic response accurately in forested catchments may depend on better identification, and detailed spatial and temporal characterization of the mobile waters from the principal hydrologic source areas that contribute to stream runoff. Copyright © 2001 John Wiley & Sons, Ltd. [source] A Profession Awry or Poised for the Future?INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY, Issue 3 2010Professional Identity, Work Psychology The commentaries provided an array of perspectives on identity management in our profession. However, there was general agreement on what should be central and distinctive about our field and on the need to cultivate a positive identity for the profession. The commentators also suggested a number of ways to cultivate this identity. For us, the commentaries also stimulated further reflection on our approach to training graduate students. We share our reflections and encourage readers to take the time to reflect on their own efforts to contribute to the profession's management of identity. [source] MRI measurement of time-resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictionsJOURNAL OF MAGNETIC RESONANCE IMAGING, Issue 2 2003Panorea Papathanasopoulou MSc Abstract Purpose To study pulsatile fluid flow in a physiologically realistic model of the human carotid bifurcation, and to derive wall shear stress (WSS) vectors. Materials and Methods WSS vectors were calculated from time-resolved 3D phase-contrast (PC) MRI measurements of the velocity field. The technique was first validated with sinusoidal flow in a straight tube, and then used in a model of a healthy human carotid bifurcation. Velocity measurements in the inflow and outflow regions were also used as boundary conditions for computational fluid dynamics (CFD) calculations of WSS, which were compared with those derived from MRI alone. Results The straight tube measurements gave WSS results that were within 15% of the theoretical value. WSS results for the phantom showed the main features expected from fluid dynamics, notably the low values in the bulb region of the internal carotid artery, with a return to ordered flow further downstream. MRI was not able to detect the high WSS values along the divider wall that were predicted by the CFD model. Otherwise, there was good general agreement between MRI and CFD. Conclusion This is the first report of time-resolved WSS vectors estimated from 3D-MRI data. The technique worked well except in regions of disturbed flow, where the combination with CFD modeling is clearly advantageous. J. Magn. Reson. Imaging 2003;17:153,162. © 2003 Wiley-Liss, Inc. [source] Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatoninJOURNAL OF PINEAL RESEARCH, Issue 2 2009Eloisa Gitto Abstract:, Newborns, and especially those delivered preterm, are probably more prone to oxidative stress than individuals later in life. Also during pregnancy, increased oxygen demand augments the rate of production of reactive oxygen species (ROS) and women, even with normal pregnancies, experience elevated oxidative stress and lipid peroxidation compared with nonpregnant women. Also, there appears to be an increase in ROS generation in the placenta of pre-eclamptic women. In comparison with healthy adults, newborn infants have lower levels of plasma antioxidants such as vitamin E, ,-carotene, and sulphydryl groups, lower levels of plasma metal binding proteins including ceruloplasmin and transferrin, and reduced activity of erythrocyte superoxide dismutase. This review summarizes conditions of newborns where there is elevated oxidative stress. Included in this group of conditions is asphyxia, respiratory distress syndrome and sepsis and the review also summarizes the literature related to clinical trials of antioxidant therapies and of melatonin, a highly effective antioxidant and free radical scavenger. The authors document there is general agreement that short-term melatonin therapy may be highly effective and that it has a remarkably benign safety profile, even when neonates are treated with pharmacological doses. Significant complications with long-term melatonin therapy in children and adults also have not been reported. None of the animal studies of maternal melatonin treatment or in postnatal life have shown any treatment-related side effects. The authors conclude that treatment with melatonin might result in a wide range of health benefits, improved quality of life and reduced healthcare costs and may help reduce complications in the neonatal period. [source] Two-component diffusion tensor MRI of isolated perfused heartsMAGNETIC RESONANCE IN MEDICINE, Issue 6 2001Edward W. Hsu Abstract Nonmonoexponential MR diffusion decay behavior has been observed at high diffusion-weighting strengths for cell aggregates and tissues, including the myocardium; however, implications for myocardial MR diffusion tensor imaging are largely unknown. In this study, a slow-exchange-limit, two-component diffusion tensor model was fitted to diffusion-weighted images obtained in isolated, perfused rat hearts. Results indicate that there are at least two distinct components of anisotropic diffusion, characterized by a "fast" component whose principal diffusivity is comparable to that of the perfusate, and a highly anisotropic "slow" component. It is speculated that the two components correspond to tissue compartments and have a general agreement with the orientations of anisotropy, or fiber orientations, in the myocardium. Moreover, consideration of previous studies of myocardial diffusion suggests that the presently observed fast component may likely be dominated by diffusion in the vascular space, whereas the slow component may include the intracellular and interstitial compartments. The implications of the results for myocardial fiber orientation mapping and limitations of the current two-component model used are also discussed. Magn Reson Med 45:1039,1045, 2001. © 2001 Wiley-Liss, Inc. [source] Mesoscale simulations of atmospheric flow and tracer transport in Phoenix, ArizonaMETEOROLOGICAL APPLICATIONS, Issue 3 2006Ge Wang Abstract Large urban centres located within confining rugged or complex terrain can frequently experience episodes of high concentrations of lower atmospheric pollution. Metropolitan Phoenix, Arizona (United States), is a good example, as the general population is occasionally subjected to high levels of lower atmospheric ozone, carbon monoxide and suspended particulate matter. As a result of dramatic but continuous increase in population, the accompanying environmental stresses and the local atmospheric circulation that dominates the background flow, an accurate simulation of the mesoscale pollutant transport across Phoenix and similar urban areas is becoming increasingly important. This is particularly the case in an airshed, such as that of Phoenix, where the local atmospheric circulation is complicated by the complex terrain of the area. Within the study presented here, a three-dimensional time-dependent mesoscale meteorological model (HOTMAC) is employed for simulation of lower-atmospheric flow in Phoenix, for both winter and summer case-study periods in 1998. The specific purpose of the work is to test the model's ability to replicate the atmospheric flow based on the actual observations of the lower-atmospheric wind profile and known physical principles. While a reasonable general agreement is found between the model-produced flow and the observed one, the simulation of near-surface wind direction produces a much less accurate representation of actual conditions, as does the simulation of wind speed over 1,000 metres above the surface. Using the wind and turbulence output from the mesoscale model, likely particle plume trajectories are simulated for the case-study periods using a puff dispersion model (RAPTAD). Overall, the results provide encouragement for the efforts towards accurately simulating the mesoscale transport of lower-atmospheric pollutants in environments of complex terrain. Copyright © 2006 John Wiley & Sons, Ltd. [source] Bereitschaftspotential and movement-related potentials: Origin, significance, and application in disorders of human movementMOVEMENT DISORDERS, Issue 5 2007James G. Colebatch MB Abstract The existence of a slow negative wave, the Bereitschaftspotential ("BP"), preceding voluntary movement by 1 second or more was first reported more than 40 years ago. There appears to be considerable interindividual differences, but there is general agreement that the initial negativity actually consists of two distinct phases. Uncertainty remains about many other properties and features of the response, including nomenclature, which makes the existing literature difficult to synthesize. The duration of the premovement negativity raises questions about how and when voluntary movement is initiated. Premovement negativities can also be seen before (predictably) externally paced movement, and these have similarities to the BP. Although lateralized generators exist, it is likely that the majority of the early component of the BP (BP1 or early BP), arises from the anterior supplementary motor area (SMA) and more rostral pre-SMA. The late phase of the BP (BP2 or late BP) is probably generated by activity in both the SMA proper and the contralateral motor cortex. Changes in the BP occur in several movement disorders, notably Parkinson's disease, in which the pattern is consistent with a failure of pre-SMA activation. The presence (or absence) of a clear preceding negativity can also have diagnostic importance for certain movement disorders. © 2007 Movement Disorder Society [source] Structural and functional changes in spastic skeletal muscle,MUSCLE AND NERVE, Issue 5 2004Richard L. Lieber PhD Abstract This review summarizes current information regarding the changes in structure or function that occur in skeletal muscle secondary to spasticity. Most published studies have reported an increase in fiber size variability in spastic muscle. There is no general agreement regarding any shift in fiber type distribution secondary to spasticity. Mechanical studies in whole limbs as well as in isolated single cells support the notion of an intrinsic change in the passive mechanical properties of muscle after spasticity in addition to the more widely reported neural changes that occur. Evidence is presented for changes within both the muscle cell and extracellular matrix that contribute to the overall changes in the tissue. Taken together, the literature supports the notion that, although spasticity is multifactorial and neural in origin, significant structural alterations in muscle also occur. An understanding of the specific changes that occur in the muscle and extracellular matrix may facilitate the development of new conservative or surgical therapies for this problem. Muscle Nerve 29: 615,627, 2004 [source] Contractile properties of human motor units in health, aging, and diseaseMUSCLE AND NERVE, Issue 9 2001FRCPC, K. Ming Chan MD Abstract The primary function of skeletal muscle is to produce force for postural control and movement. Although the contractile properties of the whole muscle are useful functional indicators, they do not accurately reflect the heterogeneity of the constituent motor units (MUs) and their changes in health and disease. However, data on the contractile properties of human MUs, in comparison to other animal species, are relatively sparse. This, in part, is due to greater methodological challenges of in vivo studies of MUs in the human. The purpose of this review is to critically appraise the methods used in humans; to describe the normative data from different muscle groups; to discuss differences between data from healthy humans and other animal species; and, last, to characterize changes of the MU contractile properties in aging, disease, and in response to intervention. Because the spike-triggered averaging technique can only be used to study the twitch properties, other methods were subsequently developed to measure a wider range of contractile properties. Although there is general agreement between human data and those from other animal species, major differences do exist. Potential reasons for these discrepancies include true biological differences, but differences in the techniques used may also be responsible. Although limited, measurement of MU contractile properties in humans has provided insight into the changes associated with aging and motoneuronal diseases and provides a means of gauging their adaptive capacity for training and immobilization. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1113,1133 [source] MEN, WOMEN, AND MANAGERS: ARE STEREOTYPES FINALLY CHANGING?PERSONNEL PSYCHOLOGY, Issue 4 2006EMILY E. DUEHR As the number of women in management roles increases and organizations place a greater emphasis on diversity, a subsequent change in perceptions of women as leader-like is expected. To test this notion, we examined gender and management stereotypes of male and female managers and students. Results reveal considerable change in male managers' views of women over the past 30 years, as evidenced by greater congruence between their perceptions of women and successful managers and stronger endorsement of agentic and task-oriented leadership characteristics for women. Stereotypes held by male students changed less, remaining strikingly similar to stereotypes held by male managers 15 years ago. Across samples, there was general agreement in the characteristics of managers but less agreement about the characteristics of women. We also found men somewhat less likely than women to attribute successful manager characteristics to women. Respondents with positive past experiences with female managers tended to rate women higher on management characteristics. [source] Verifying the RTE model: ortho-positronium lifetime measurement on controlled pore glassesPHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 10 2007S. Thraenert Abstract In porous media, the vacuum lifetime of ortho-positronium (o-Ps) of , = 142 ns can be reduced markedly by pick-off annihilation (interaction with electrons of the host material). So the o-Ps lifetime is determined by the pore size which can be extracted by utilising approved models like the Tao-Eldrup model for pore sizes smaller than 1 nm and the Tokyo model or RTE model for larger pore sizes. The RTE model contains an explicit temperature dependence of the o-Ps lifetime. Experiments on controlled pore glasses (CPG) with different pore sizes (2-70 nm) at different temperatures (50-500 K) were performed to verify the RTE model. A general agreement for T = 300 K could be found. The temperature dependence of the lifetime, especially for low temperatures, could not be approved sufficiently. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Disclosing Conflicts of Interest in Clinical Research: Views of Institutional Review Boards, Conflict of Interest Committees, and InvestigatorsTHE JOURNAL OF LAW, MEDICINE & ETHICS, Issue 3 2006Kevin P. Weinfurt Ph.D. Strategies for disclosing investigators' financial interests to potential research participants have been adopted by many research institutions. However, little is known about how decisions are made regarding disclosures of financial interests to potential research participants, including what is disclosed and the rationale for making these determinations. We sought to understand the attitudes, beliefs, and practices of institutional review board chairs, conflict of interest committee chairs, and investigators regarding disclosure of financial interests to potential research participants. Several themes emerged, including general attitudes toward conflicts of interest, circumstances in which financial interests should be disclosed, rationales and benefits of disclosure, what should be disclosed, negative effects of and barriers to disclosure, and timing and presentation of disclosure. Respondents cited several rationales for disclosure, including enabling informed decision making, promoting trust in researchers and research institutions, and reducing legal liability. There was general agreement that disclosure should happen early in the consent process. Respondents disagreed about whether to disclose the amounts of particular financial interests. Clarifying the goals of disclosure and understanding how potential research participants use the information will be critical in efforts to ensure the integrity of clinical research and to protect the rights and interests of participants. [source] Testing Association with Interactions by Partitioning Chi-SquaresANNALS OF HUMAN GENETICS, Issue 1 2009Y. Yang Summary Gene-gene interaction plays an important role in association studies for complex diseases. There have been different approaches to incorporating gene-gene interactions in candidate gene or genome-wide association studies, especially for those genes with no marginal effects but with interaction effects. However, there is no general agreement on how interaction should be tested and how main effects and interaction effects act on a significance signal. In this paper, we propose a test of the null hypothesis of no association in terms of interaction effects for two unlinked loci, which is a 4 degrees of freedom (df) chi-square for two SNPs. The test, derived by contrasting inter-locus disequilibrium measures between cases and controls, can be viewed as the interaction component of the total Pearson chi-square. The remaining portion of the total chi-square can also be used for association analysis, which emphasizes main effects. Simulation studies show that in most situations our interaction test is similar in power to the test based on a logistic regression model but has more power when the genes have no marginal effects. Results also show that single-locus marginal tests can lose much power if interaction effects dominate main effects. For some specific genetic models, the interaction test may be further partitioned into four 1-df chi-squares for individual interaction effect. The interaction pattern can best be demonstrated by the 1-df chi-square components. Simulation results show that there is substantial power gain if interaction patterns are properly incorporated in association analysis. [source] | |||||||||||||||||||||||||||||||||||||