Home About us Contact
|
Home About us Contact | ||
|
|
||
Future
Kinds of Future Terms modified by Future Selected AbstractsTHE MOLECULAR FUTURE IN CYTOLOGYCYTOPATHOLOGY, Issue 2006M. Salto-Tellez Molecular diagnosis is the application of molecular biology techniques and knowledge of the molecular mechanisms of disease to diagnosis, prognostication and treatment of diseases. Molecular Diagnosis is, arguably, the fastest growing area of diagnostic medicine. The US market for molecular testing generated $1.3 billion in 2000, which was predicted to increase to about $4.2 billion by 2007.1 We proposed the term Diagnostic Molecular Cytopathology to define the application of molecular diagnosis to cytopathology2. Diagnostic Molecular Cytopathology is essential for the following reasons: (i) Molecular testing is sometimes indispensable to establish an unequivocal diagnosis on cell preparations; (ii) Molecular testing provides extra information on the prognosis or therapy of diseases diagnosed by conventional cytology; (iii) Molecular testing provides genetic information on the inherited nature of diseases that can be directly investigated in cytology samples, by either exfoliation or by fine needle aspiration; (iv) Sometimes the cytopathology sample is the most convenient (or the only available) source of material for molecular testing; (v). Direct molecular interrogation of cells allows for a diagnostic correlation that would otherwise not be possible. Parallel to this direct diagnostic implication, cytopathology is increasing important in the validation of biomarkers for specific diseases, and in therefore of significant importance in the overall translational research strategies. We illustrate its application in some of the main areas of oncology molecular testing, such as molecular fingerprinting of neoplasms,3 lymphoreticular diseases,2 sarcomas4 and lung cancer,5 as well as translational research using diagnostic cytopathology techniques. The next years will see the consolidation of Diagnostic Molecular Cytopathology, a process that will lead to a change of many paradigms. In general, diagnostic pathology departments will have to reorganize molecular testing to pursue a cost-efficient operation. Sample preparation will have to take into account optimal preservation of nuclear acids. The training of technical staff and the level of laboratory quality control and quality assurance would have to follow strict clinical (not research) laboratory parameters. And, most importantly, those pathologists undertaking molecular diagnosis as a discipline would have to develop their professional expertise within the same framework of fellowships and professional credentials that is offered in other sub-specialties. The price to pay if this effort is not undertaken is too important for the future of diagnostic pathology in general. The increasing characterization of molecular biomarkers with diagnostic, prognostic or therapeutic value is making the analysis of tissue and cell samples prior to treatment a more complex exercise. If cytopathologists and histopathologists allow others to take charge of molecular diagnosis, our overall contribution to the diagnostic process will be diminished. We may not become less important, but we may become less relevant. However, those within the discipline of diagnostic pathology who can combine the clinical background of diseases with the morphological, immunocytochemical and molecular diagnostic interpretation will represent bona fide diagnostic specialists. Such ,molecular cytopathologists' would place themselves at the centre of clinical decision-making. Reference:, 1. Liz Fletcher. Roche leads molecular diagnostics charge. Nature Biotechnol 20, 6,7; 2002 2. Salto-Tellez M and Koay ESC. Molecular Diagnostic Cytopathology - Definitions, Scope and Clinical Utility. Cytopathology 2004; 15:252,255 3. Salto-Tellez M, Zhang D, Chiu LL, Wang SC, Nilsson B, and Koay ESC. Immunocytochemistry Versus Molecular Fingerprinting of Metastases. Cytopathology, 2003 Aug; 14(4):186,90. 4. Chiu LL, Koay SCE, Chan NL and Salto-Tellez M. Molecular Cytopathology: Sequencing of the EWS-WT1 Gene Fusion Transcript in the Peritoneal Effusion of a Patient with Desmoplastic Small Round Cell Tumour. Diagnostic Cytopathology, 2003 Dec; 29(6): 341,3. 5. TM Chin, D Anuar, R Soo, M Salto-Tellez, WQ Li, B Ahmad, SC Lee, BC Goh, K Kawakami, A Segal, B Iacopetta, R Soong. Sensitive and Cost-Effective deptection of epidermal growth factor Receptor Mutations in Small Biopsies by denaturing High Performance Liquid Chromatography. (In press). [source] THINKING OUTSIDE THE BOX: A NECESSARY COURSE FOR THE FUTURE OF ALCOHOL RESEARCHADDICTION, Issue 5 2010ROGER E. MEYER No abstract is available for this article. [source] HISTORICAL LESSONS FOR EUROPE'S FUTURE IN THE WAKE OF THE EU CONVENTIONECONOMIC AFFAIRS, Issue 1 2004Paul Robinson The EU's leaders are not taking constitutional reform seriously. An analysis of the history of the development of federal states suggests that they are unlikely to do so until a crisis precipitates action. The current constitutional arrangements and those proposed by the constitutional convention are a recipe for continued integration. Paradoxically, a brief, well-drafted federal constitution might stop the process of integration. [source] GLOBALISATION AND THE FUTURE OF INDIGENOUS FOOTBALL CODESECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 4 2004LIONEL FROST Much of the debate about the future of indigenous football codes such as Australian Rules and Gaelic football has centred on the possibility that in the future their popularity will be eroded by the increasing power of soccer. Several commentators have envisaged a future in which sports that operate in a global marketplace will ,crowd out' sports that have been traditionally popular in certain parts of the world. This article will examine these predictions critically, and will suggest several reasons why in the future, the range of sports that is played, watched, and followed with passion, is likely to continue to vary from nation to nation, and even from region to region. The article will argue that the success of any particular football code is most likely to be affected by the effectiveness of its own organisation and management, rather than whether or not there are ,global' competitors to it. [source] THE PAST AND THE FUTURE OF COMPETITION LAWECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 1 2004Allan Fels This paper reviews the evolution and significance of the Trade Practices Act for the development of competition policy in Australia. The paper also discusses the role of the ACCC in the enforcement of competition law and speculates on future challenges facing the ACCC in this role. [source] [Commentary] RESEARCH ASSESSMENTS: INSTRUMENTS OF BIAS AND BRIEF INTERVENTIONS OF THE FUTURE?ADDICTION, Issue 8 2009JIM McCAMBRIDGE No abstract is available for this article. [source] FAMILY DISPUTE RESOLUTION: CHARTING A COURSE FOR THE FUTUREFAMILY COURT REVIEW, Issue 3 2009Amy Holtzworth-Munroe This article summarizes ideas for future directions in the field of family dispute resolution, as discussed by legal experts, social scientists, and other participants at the Indiana University,Bloomington conference on family dispute resolution. Five major categories of future directions were discussed: (1) clarifying differing goals for work in this field; (2) recognizing, understanding, and assessing for heterogeneity among couples and families facing divorces, break ups in adult relationships, and reconfigurations of adult relationships with the children ("relationship dissolution"); (3) testing our assumptions and commonly held beliefs about relationship dissolution; (4) empirically testing the efficacy of interventions for families experiencing relationship dissolution; and (5) disseminating research findings to those on the frontline. [source] LANDSCAPE-SCALE ANALYSIS AND MANAGEMENT OF CUMULATIVE IMPACTS TO RIPARIAN ECOSYSTEMS: PAST, PRESENT, AND FUTURE,JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 6 2001Eric D. Stein ABSTRACT: Analyses of cumulative impacts to riparian systems is an important yet elusive goal. Previous analyses have focused on comparing the number of hectares impacted to the number of hectares restored, without addressing the loss of riparian function or the effect of the spatial distribution of impacts. This paper presents an analysis of the spatial distribution of development-related impacts to riparian ecosystems, that were authorized under Section 404 of the Clean Water Act. Impacts on habitat structure, contiguity, and landscape context were evaluated using functional indices scaled to regional reference sites. Impact sites were mapped using GIS and analyzed for spatial associations. Positive spatial autocorrelation (i.e. clustering of impact sites) resulted from the piecemeal approach to impact assessment, which failed to prevent cumulative impacts. Numerous small projects in close proximity have resulted in adverse impacts to entire stream reaches or have fragmented the aquatic resources to a point where overall functional capacity is impaired. Additionally, the ecological functions of unaffected areas have been diminished due to their proximity to degraded areas. A proactive approach to managing cumulative impacts is currently being used in Orange County, California as part of a Corps of Engineers sponsored Special Area Management Plan (SAMP). The SAMP process is evaluating the ecological conditions and physical processes of the study watersheds and attempting to plan future development in a manner that will guard against cumulative impacts. [source] HEIDEGGER AND TEILHARD DE CHARDIN: THE CONVERGENCE OF HISTORY AND FUTUREMODERN THEOLOGY, Issue 1 2008TODD S. MEI The intent of this essay is to place the thinking of Martin Heidegger and Pierre Teilhard de Chardin in dialogue with one another in order to thresh out the latent aspects of each thinker's work that are often seen to be problematic. I argue that Teilhard's discussion of unity that differentiates illuminates a positive teleology in Heidegger's notion of Appropriation, while Heidegger's conception of retrieval/repetition discloses the significance of historical reinterpretation in Teilhard's Christology. I therefore reply to accusations that Heidegger's philosophy succumbs to relativism and reduction into Being and that Teilhard neglects history in his treatment of Omega Point. [source] A FUTURE FOR MUSEUM ANTHROPOLOGY?MUSEUM ANTHROPOLOGY, Issue 1 2010Chip Colwell-Chanthaphonh First page of article [source] ANAESTHESIA AND ANALGESIA: CONTRIBUTION TO SURGERY, PRESENT AND FUTUREANZ JOURNAL OF SURGERY, Issue 7 2008Edward Shipton Anaesthetists provide comprehensive perioperative medical care to patients undergoing surgical and diagnostic procedures, including postoperative intensive care when needed. They are involved in the management of perioperative acute pain as well as chronic pain. This manuscript considers some of the recent advances in modern anaesthesia and their contribution to surgery, from the basic mechanisms of action, to the delivery systems for general and regional anaesthesia, to the use of new drugs and new methods of monitoring. It assesses the resulting progress in acute and chronic pain services and looks at patient safety and risk management. It speculates on directions that may shape its future contributions to the management of the patient undergoing surgery. [source] LAPAROSCOPIC HEPATECTOMY: FAD, FOOLHARDY OR FUTUREANZ JOURNAL OF SURGERY, Issue 11 2007FRACS, Jonathan B. Koea MD No abstract is available for this article. [source] AL01 PACIFIC ISLANDS PROJECT , PAST PRESENT AND FUTUREANZ JOURNAL OF SURGERY, Issue 2007D. A. K. Watters The Pacific Islands Project began in 1995 and in its early years had a focus on providing specialist services that were not available in the 10 island nations visited. In 2002 Nauru was added and PIP Phase III will end its 9 month bridging/extension phase in September 2007. During the last 12 years Fiji School of Medicine has commenced a postgraduate medical training program in surgery similar to that has been in existence in PNG since 1975. There are now a growing number of Pacific-trained surgeons who can select suitable cases, do some of the surgery, and supervise the postoperative care. Increasingly visiting teams have focused on transferring skills and building local capabilities (capacity building). The RACS, the Project Director and the speciality coordinators have managed the first three phases of the project in Australia. Phase III had on-going evaluation by an internal RACS committee under the chairmanship of Professor Hamish Ewing. AusAid also externally reviewed the project late in 2006. That review was generally complimentary as to what has been achieved but also points to some new goals for the future. At the time of writing this abstract the future direction of PIP is yet to be decided and designed. This will be done mid 2007. However, it is to be hoped there will be a new program, focused on capacity building, that is managed in the Pacific and employs the skills of Pacific Island Specialists wherever possible. RACS is likely to continue to play an important role in sourcing visiting specialists, organising training positions, arranging courses. We have much expertise to offer but there is no longer any need for us to set the agendas. [source] FUTURE OF MAGNETIC RESONANCE IMAGING AND MAGNETIC RESONANCE SPECTROSCOPY IN ONCOLOGYANZ JOURNAL OF SURGERY, Issue 6 2005Ferenc Jolesz MD No abstract is available for this article. [source] URBAN HISTORY AND THE FUTURE OF AUSTRALIAN CITIESAUSTRALIAN ECONOMIC HISTORY REVIEW, Issue 1 2009Lionel Frost Australian cities; sustainability; urban history; urbanisation Urban growth is a major theme in economic development and a policy imperative for developed countries that seek to create sustainable cities. We argue that the past weighs heavily on the ability of societies to sustainably manage urban environments. The policy implications of urban history are revealed in comparisons of cities across times and between places. The special issue presents some of the best recent work on the economic and social history of Australian cities. We aim to encourage historians to incorporate urban variables into studies of historical processes and to persuade policymakers to consider historical trends in their analysis. [source] THE ROLE OF THE HIGH COURT IN FEDERAL ARBITRATION DURING THE GREAT DEPRESSION: PRESERVING A FUTURE FOR ,REASON AND MORAL SUASION'?AUSTRALIAN ECONOMIC HISTORY REVIEW, Issue 2 2008Rohan Price arbitration; Australia; depression; legal institutions; wage fixation Between 1929 and 1933 the Australian federal system of conciliation and arbitration came under economic and political strain. This article reveals that arbitration proved to be an adaptable industrial relations framework for dealing with economic depression. While the monetary entitlements of workers were reduced, the legal instrumentality that conferred the wage cuts, the Arbitration Court, itself defied abolition and evolved to be a protective body. There was a subtle and previously unremarked interaction in the regulatory functions of the High Court, the Arbitration Court, and the Commonwealth Parliament characterised by the purposeful abstention of the High Court and Scullin Government and the activism of the Arbitration Court. [source] THE FUTURE OF BIOETHICS: THREE DOGMAS AND A CUP OF HEMLOCKBIOETHICS, Issue 5 2010ANGUS DAWSON ABSTRACT In this paper I argue that bioethics is in crisis and that it will not have a future unless it begins to embrace a more Socratic approach to its leading assumptions. The absence of a critical and sceptical spirit has resulted in little more than a dominant ideology. I focus on three key issues. First, that too often bioethics collapses into medical ethics. Second, that medical ethics itself is beset by a lack of self-reflection that I characterize here as a commitment to three dogmas. Third, I offer a more positive perspective by suggesting how bioethics may benefit from looking towards public health ethics as a new source of inspiration and direction. [source] LIFE-CENTERED ETHICS, AND THE HUMAN FUTURE IN SPACEBIOETHICS, Issue 8 2009MICHAEL N. MAUTNER ABSTRACT In the future, human destiny may depend on our ethics. In particular, biotechnology and expansion in space can transform life, raising profound questions. Guidance may be found in Life-centered ethics, as biotic ethics that value the basic patterns of organic gene/protein life, and as panbiotic ethics that always seek to expand life. These life-centered principles can be based on scientific insights into the unique place of life in nature, and the biological unity of all life. Belonging to life then implies a human purpose: to safeguard and propagate life. Expansion in space will advance this purpose but will also raise basic questions. Should we expand all life or only intelligent life? Should we aim to create populations of trillions? Should we seed other solar systems? How far can we change but still preserve the human species, and life itself? The future of all life may be in our hands, and it can depend on our guiding ethics whether life will fulfil its full potentials. Given such profound powers, life-centered ethics can best secure future generations. Our descendants may then understand nature more deeply, and seek to extend life indefinitely. In that future, our human existence can find a cosmic purpose. [source] WHAT IS THE FUTURE OF PROSTATE-SPECIFIC ANTIGEN FOR THE EARLY DETECTION OF PROSTATE CANCER?BJU INTERNATIONAL, Issue 2 2008Robert Getzenberg No abstract is available for this article. [source] REMEMBERING THE FOUNDATIONS AND BUILDING FOR THE FUTUREBRITISH JOURNAL OF PSYCHOTHERAPY, Issue 2 2010Bruce Irvine abstract The paper draws on the influence of the thinking of Isabel Menzies Lyth on the development of new approaches to events within group relations conferences sponsored by The Grubb Institute of Behavioural Studies. [source] PLANNING FOR THE FUTURE: Planning for the 2040s: everybody's businessBRITISH JOURNAL OF SPECIAL EDUCATION, Issue 1 2008Peter Mittler As we mark the publication of the 35th issue of the British Journal of Special Education, Peter Mittler, Emeritus Professor of Special Needs Education at the University of Manchester, looks into the future and asks a series of challenging questions: What kind of a future do we want to see for a baby born with a significant disability today? What changes will be needed in society and in our schools both for the child and for the family? What reforms might this year's newly qualified staff bring about in our schools and services and in society as a whole by the time they retire in the 2040s? Professor Mittler proposes that the time is ripe to take advantage of new international and national opportunities to lay the foundations for a society that fully includes disabled people and safeguards their basic human rights. He argues that each one of us can help to determine the values and priorities of the society in which today's baby will grow up and suggests that the Make Poverty History movement has provided powerful evidence that the voice of ordinary citizens can shape policies and set priorities. He encourages us all to think globally and to act locally on a host of issues, including supporting families, planning for transition, promoting quality of life, professional development and challenging inequality. [source] ADDRESS OF HIS HOLINESS POPE BENEDICT XVI TO PARTICIPANTS OF THE SYMPOSIUM ON THE THEME: ,STEM CELLS: WHAT FUTURE FOR THERAPY?CELL PROLIFERATION, Issue 2008SCIENTIFIC ASPECTS AND BIOETHICAL PROBLEMS' No abstract is available for this article. [source] INFORMATION AND NOISE IN FINANCIAL MARKETS: EVIDENCE FROM THE E-MINI INDEX FUTURESTHE JOURNAL OF FINANCIAL RESEARCH, Issue 3 2008Alexander Kurov Abstract I examine the informational contributions and effects on transitory volatility of trades initiated by different types of traders in three actively traded index futures markets. The results show that trades initiated by exchange member firms account for more than 60% of price discovery during the trading day. These institutional trades appear to be more informative than trades of individual exchange members or off-exchange traders. I also find that off-exchange traders introduce more noise into the prices than do exchange members. My findings provide new evidence on the role of different types of traders in the price formation process. [source] THE PARENTAL OBLIGATION TO EXPAND A CHILD'S RANGE OF OPEN FUTURES WHEN MAKING GENETIC TRAIT SELECTIONS FOR THEIR CHILDBIOETHICS, Issue 4 2007ERIC B. SCHMIDT ABSTRACT As parents become increasingly able to make genetic trait selections on behalf of their children, they will need ethical guidance in deciding what genetic traits to select. Dena Davis has argued that parents act unethically if they make selections that constrain their child's range of futures. But some selections may expand the child's range of futures. And other selections may shift the child's range of futures, without either constraining or expanding that range. I contend that not only would parents act unethically if they make selections that constrain the range of their child's futures, they would act unethically if they make selections that shift the range of their child's futures, because selections that shift the range of the child's futures would allow parents to over-determine their child's futures. Thus, I contend that parents would act ethically only if they make selections that expand their child's range of futures. [source] Need for Integrated Research for a Sustainable Future in Tropical Dry ForestsCONSERVATION BIOLOGY, Issue 2 2005G. ARTURO SÁNCHEZ-AZOFEIFA No abstract is available for this article. [source] Minding the Children: Knowledge Transfer and the Future of Sustainable AgricultureCONSERVATION BIOLOGY, Issue 4 2002Kenneth R. Young No abstract is available for this article. [source] Legitimacy Crisis and the Future of Democracy in IranCONSTELLATIONS: AN INTERNATIONAL JOURNAL OF CRITICAL AND DEMOCRATIC THEORY, Issue 3 2009Ramin Jahanbegloo No abstract is available for this article. [source] Geriatric Emergency Medicine and the 2006 Institute of Medicine Reports from the Committee on the Future of Emergency Care in the U.S. Health SystemACADEMIC EMERGENCY MEDICINE, Issue 12 2006Scott T. Wilber MD Abstract Three recently published Institute of Medicine reports, Hospital-Based Emergency Care: At the Breaking Point, Emergency Medical Services: At the Crossroads, and Emergency Care for Children: Growing Pains, examined the current state of emergency care in the United States. They concluded that the emergency medicine system as a whole is overburdened, underfunded, and highly fragmented. These reports did not specifically discuss the effect the aging population has on emergency care now and in the future and did not discuss special needs of older patients. This report focuses on the emergency care of older patients, with the intent to provide information that will help shape discussions on this issue. [source] Remember the Future: The Pastoral Theology of Paul the Apostle , By Jacob W. EliasCONVERSATIONS IN RELIGION & THEOLOGY, Issue 1 2007Wayne G. Rollins First page of article [source] Taking Stock of Corporate Governance Research While Looking to the FutureCORPORATE GOVERNANCE, Issue 3 2009Igor Filatotchev ABSTRACT Manuscript Type: Editorial Research Question/Issue: This essay identifies some key issues for the analysis of corporate governance based on the articles within this special review issue coupled with our own perspectives. Our aim in this issue is to distil some research streams in the field and identify opportunities for future research. Research Findings/Results: We summarize the eight papers included in this special issue and briefly highlight their main contributions to the literature which collectively deal with the role and impact of corporate boards, codes of corporate governance, and the globalization of corporate governance systems. In addition to the new insights offered by these reviews, we attempt to offer our own ideas on where future research needs to be targeted. Theoretical Implications: We highlight a number of research themes where future governance research may prove fruitful. This includes taking a more holistic approach to corporate governance issues and developing an inter-disciplinary perspective by building on agency theory while considering the rich new insights offered by complementary theories, such as behavioral theory, institutional theory and the resource-based views of the firm. In particular, future corporate governance research needs to be conducted in multiple countries, particularly in emerging economies, if we want to move closer to the journal's aim of producing a global theory of corporate governance. Practical Implications: Our analysis suggests that analytic and regulatory approaches to corporate governance issues should move from a "one-size-fits-all" template to taking into account organizational, institutional and national contexts. [source] | |||||||||||||||||||||||||||||||||||||